The mechanism of uplift and collapse is critical for understanding orogenic evolution within the Wilson cycle. The Central Asian Orogenic Belt (CAOB) represents one of the largest Phanerozoic accretionary orogens on Earth, experiencing terminal soft collision following the closure of the Paleo-Asian Ocean. However, the timing and mechanism of crustal thickening and thinning in the eastern CAOB remain unclear. Here, we present geochronological, mineralogical, geochemical, and Sr-Nd-Hf isotopic data of the newly identified Late Triassic bimodal dike associations in the easternmost CAOB. The ca. 236−230 Ma mafic dikes can be divided into two groups based on petrographic and geochemical characteristics. Major element modeling using the MELTS software indicates that they evolved via independent differentiation paths. Trace element and isotope simulations reveal that the ca. 236−230 Ma mafic dikes originated from the 4%−10% partial melting of spinel- to garnet-lherzolite lithospheric mantle sources over a range of depths, with varying inputs of asthenospheric mantle materials. Coeval ca. 233 Ma felsic dikes exhibit adakitic geochemical characteristics and strong imprints of crust-mantle interaction, suggesting derivation from melting of a heated juvenile mafic lower crust as a result of the upwelling of asthenospheric mantle. The formation of bimodal dike associations records the transition from lithospheric mantle thinning to delamination. Integrating a large dataset and employing multiple geochemical proxies, our results reveal that the crust of the easternmost CAOB reached a thickness of 54 ± 3 km at ca. 280−255 Ma, likely resulting from magmatic underplating due to rollback of the subducting Paleo-Asian Oceanic slab. This region underwent a further slight increase in crustal thickness to 61 ± 2 km at ca. 254−237 Ma in response to limited tectonic shortening associated with soft collision orogeny before it thinned to 45 ± 13 km at ca. 236−210 Ma due to lithospheric delamination during post-collisional extension. Our findings reveal that the uplift of the eastern CAOB was primarily driven by magmatic underplating, with minimal contribution from tectonic shortening. Lithospheric delamination emerged as an important factor leading to the eventual collapse of the eastern CAOB. Compared to typical hard collisional orogens (e.g., the Himalaya-Tibet orogen), the CAOB experienced significantly weaker tectonic shortening followed by similar lithospheric delamination during post-collisional extension. This study highlights the importance of integrating geochemical and isotopic data in quantifying the complex evolutionary histories of ancient collisional orogenic belts.