The Cilento Group (Langhian-to-Tortonian) is a thick turbiditic succession of the Southern Apennines foreland region that unconformably overlain the Lucanian oceanic terranes. The San Mauro Formation (SMF) form the uppermost portions of the Cilento Group, and consists of 1400–1600 m thick turbiditic succession including quartzolithic, volcanolithic, and quartzofeldspathic sandstones with several carbonatoclastic layers interbedded, passing upward from distal-to proximal-facies associations. Here, based on the vertical changes of texture and petrology in the succession, the SMF was divided in two main sections. The key depositional features and the main post-depositional processes, of lower- and upper-part of SMF, are compared with the most significant petrophysical properties with the purpose to elucidate the major controls on the porosity and permeability evolution during burial. With this aim, fifty-four thin sections were petrographically investigated, while mercury intrusion analysis was performed on twenty-four samples. Compaction, cementation, dissolution and fracturing occurred in the SMF, altering porosity and permeability. The main authigenic minerals are: 1) carbonates, mainly calcite and less dolomite, dominantly occurring as replacement of framework grains; 2) Phyllosilicates, mainly developing in the upper part of SMF as pore-filling cement or as small and incomplete grain coatings; 3) Fe-oxides occurring as coatings or localized crystals. The relationship between the compactional porosity loss (COPL) and the cementational porosity loss (CEPL) testifies the primary role of compaction in decreasing porosity, reducing the intergranular volume (IGV) to 11.1% in the lower SMF and to 16.7 % in the upper SMF. The coarse upper SMF samples exhibit lower mean porosity and permeability (6 % and 215 mD, respectively) than the fine lower SMF samples (9.2 % and 774.2 mD, respectively). In the upper section of SMF, a comparatively more widespread pore-filling cementation and the abundant detrital matrix affect depositional intergranular porosity, reducing the pore size and interconnectivity. Moreover, the higher amount of rigid grains (petrofacies dependent) and their brittle deformation produce an intricate fragmentation and micro-fracturing system, altering pores geometry and affecting permeability. On the contrary in the lower SMF, ductile components suffer compaction more than rigid ones, leading the lowest IGV. In addition, a higher volume of authigenic carbonates occur as replacement on framework components, hence playing a minor occluding role and less affecting the pore system. Composition and tectonics rule the effects of diagenetic processes in the San Mauro turbiditic succession, following the vertical evolution of depositional facies association and petrology.