Objective: The objective of this study is to analyze the vision and mission statements of universities in the context of their alignment with the Global Sustainable Development Goals (SDGs) to provide insights for strategic direction development in higher education institutions. Theoretical Reference: This study is grounded in strategic planning theory and its application within higher education, focusing on how institutional vision and mission statements can guide universities towards sustainable development. Method: A meta-synthesis approach is employed, synthesizing findings from multiple qualitative studies. Data collection includes a comprehensive literature review on higher education trends, best practices, and challenges, along with document analysis of vision and mission statements from various universities. Thematic analysis is utilized to identify key themes, trends, and challenges. Results and Conclusion: Key findings reveal current trends such as digitalization, globalization, and the integration of technology in teaching and learning. Emerging challenges include financial sustainability, accountability, and alignment with labor market demands. Best practices in vision and mission development emphasize stakeholder engagement, alignment with institutional values, concise and inspirational language, and adaptability to changing circumstances. The proposed vision and mission statements for the state university reflect aspirations for global recognition, interdisciplinary collaboration, innovation, entrepreneurship, ethical leadership, and fostering sustainable and inclusive communities. Implications of Research: The study underscores the importance of strategic planning and innovation in higher education. Engaging stakeholders and fostering collaboration are identified as critical strategies for addressing the highlighted challenges. These findings provide evidence-based recommendations for the state university's strategic direction, ensuring it remains adaptive, resilient, and aligned with both global and national goals. Originality/Value: This research offers a novel synthesis of qualitative studies on strategic planning in higher education, providing valuable insights into effective vision and mission development. It contributes to the discourse on aligning university strategies with global sustainability objectives, offering practical recommendations for higher education leaders.