Background: Self-medication is the practice of treating any ailment or symptom that a person diagnoses for themselves without first visiting a physician. Different communities display different behaviours; hence the purpose of this study is to statistically investigate the patterns and prevalence of self-medication usage. Although health literacy practices have been increasingly recommended in public health literature, there is a lack of studies that examine the relationships between health literacy and self-medication. Methodology: A quantitative, descriptive, cross-sectional, community-based research approach was used in a sample of 316 participants. Health literacy was measured by Single Item Literacy Screener. Data was analysed using SPSS 29.0 version. Results: A total of 316 participants agreed to participate (63.9% were females). The results showed that more than half, 53.4% had adequate health literacy. The prevalence of self-medication was 74%, in these 52% had used medicines by previous prescription and 8% used alternative medicine. There was a significant relationship between the overall health literacy level and practice of self-medication. Conclusion: Improving the health literacy level of the public can reduce inappropriate self-medication Therefore, the design and implementation of training programs are necessary to increase the perception on the risk of self-medication. Appropriate reading skills are important for accessing health information, using health care services, and achieving desirable health outcomes.