Moisture and cracking damages are two of the most common asphalt pavement distresses in the United States. The use of stone matrix asphalt mixture has gained popularity due to its high durability, resistance to permanent deformation and cracking, and reduced noise pollution. Warm-mix additives and nanomaterials have also gained significant interest as promising asphalt binder additives. In order to achieve enhanced resistance to moisture and cracking in extremely wet regions, this study investigated the effects of three warm-mix additives, an anti-stripping agent, and one nanomaterial (graphene nanoplatelet) on the cracking and moisture resistance performance of stone matrix asphalt. Fourier transform infrared spectroscopy and sessile drop tests were used to evaluate the functional groups and moisture susceptibility of the modified asphalt binder blends, respectively. The indirect tensile asphalt cracking test and the modified Lottman tests were used to evaluate the mixtures' resistance to cracking and stripping damage. A cost-effectiveness analysis as well as a two-dimensional performance interaction diagram were employed based on the laboratory performance of the mixtures. Results indicated that the graphene nanoplatelet modification of the asphalt binder had the highest wettability potential, adhesion, and debonding properties, as well as moisture resistance potential compared to other additives. In terms of mixture cracking performance, both the graphene nanoplatelet and a chemical warm-mix asphalt significantly improved the mix cracking performance by 34.1 and 30.0 %, respectively, compared to the control mix. However, the graphene nanoplatelet modification had a tensile strength ratio of 0.76, which is below the acceptance threshold of 0.80 set by AASHTO T 283 for moisture damage resistance of asphalt mixture. Overall, all mixtures with warm-mix additives showed adequate cracking and stripping damage resistance performance and are expected to be cost-effective.