Acceptable Alternatives Research Articles

Greener sample preparation method for direct determination of Cd(II) and Pb(II) in river sediment based on an aqueous biphasic system with functionalized ionic liquids

Although sample preparation, as an unavoidable step of the analytical process should be simple, it is very often identified as a bottleneck. Simplicity of sample preparation based on cost-effective and non-hazardous materials is mandatory for any sustainable and environmental friendly approach. Aqueous biphasic systems (ABS), based on functionalized ionic liquids (FILs) are acceptable alternatives to classical extraction procedures, due to the replacement of organic solvent with diluted aqueous-soluble ionic liquids. In this work, two water soluble FILs based on 2-mercaptobenzothiazolate anion, [mbt]: 1-butyl-3-methylimidazolium [mbt] ([bmim][mbt]) and 1-ethyl-3-methylimidazolium [mbt] ([emim][mbt]), were designed and synthesized in order to selectively extract Cd(II) and Pb(II) from the river sediment. It was found that [mbt]– anion acts as the ligand and forms complexes with Cd(II) and Pb(II) which are responsible for their efficient extraction, while cation is more responsible for the formation of ABS. Partition coefficients of 408 and 180 for Cd(II) and Pb(II), respectively, were obtained using ABS based on [bmim][mbt]. Direct extraction of Cd(II) and Pb(II) from the river sediment has been investigated and obtained optimal conditions are: 60 min direct contact of the aqueous solution of [bmim][mbt] and the sediment sample at 90 °C, followed by formation of ABS upon addition of potassium citrate. Using AGRE and AGREEprep tools greenness of the proposed method for direct extraction of Cd(II) and Pb(II) from the sediment are calculated. Obtained values of 0.69 and 0.71 for Cd(II) and Pb(II) extraction, respectively, showed a high level of the greenness of the proposed method.

Participatory approaches for planning nature-based solutions in flood vulnerable landscapes

In vulnerable areas, where floods are frequent, decision-making through participatory workshops has proved highly applicable and yielded positive results in integrated management issues. This paper examines Nature-Based Solutions (NBS) to provide flood risk mitigation and proactive adaptation options. The case study concerns the Kalloni river basin (Lesvos Island, Greece) which represents a highly flood-prone area. Participatory methods and community-based approaches according the methodology developed in "Vulnerability and Capacity Assessment (VCA)", are used to evaluate NΒS options and determine their design and implementation framework. As part of this approach, a diverse group of local stakeholders, experts and decision-makers joined a series of interviews and workshops aimed at prioritizing NBS’s proposed practices based on their sustainability at social, economic and environmental level. The small-scale mountainous dams, afforestation and planting measures appeared to be the most acceptable alternatives. After the examination of the digital elevation model and the estimated water and sediment flow, the construction sites of five gabion and three wooden wall dams in river tributaries’ bottlenecks were selected. For every selected site, the slope stability and suitable spillway, as well as the frontage and cross-section were calculated and finally their construction cost was estimated. This solution proved to be the most effective measure that provides environmental and social benefits. Ultimately, NBS strategies can drive the desired sustainable change through a combination of solutions for the wider basin resulting from a complex participatory and modeling approach, strongly depended on stakeholder’s active contribution and government intervention.

Diagnostic approach in 46, XY DSD: an endocrine society of bengal (ESB) consensus statement.

46, XY difference/disorder of sex development (DSD) is a relatively uncommon group of heterogeneous disorders with varying degree of underandrogenization ofmale genitalia. Such patients should be approached systematically to reach an aetiological diagnosis. However, we lack, at present, a clinical practice guideline on diagnostic approach in 46, XY DSD from this part of the globe. Moreover, debate persists regarding the timing and cut-offs of different hormonal tests, performed in these cases. The consensus committee consisting of 34 highly experienced endocrinologists with interest and experience in managing DSD discussed and drafted a consensus statement on the diagnostic approach to 46, XY DSD focussing on relevant history, clinical examination, biochemical evaluation, imaging and genetic analysis. The consensus was guided by systematic reviews of existing literature followed by discussion. An initial draft was prepared and distributed among the members. The members provided their scientific inputs, and all the relevant suggestions were incorporated. The final draft was approved by the committee members. The diagnostic approach in 46, XY DSD should be multidisciplinary although coordinated by an experienced endocrinologist. We recommend formal Karyotyping, even if Y chromosome material has been detected by other methods. Meticulous history taking and thorough head-to-toe examination should initially be performed with focus on external genitalia, including location of gonads. Decision regarding hormonal and other biochemical investigations should be made according to the age and interpreted according to age-appropriate norms Although LC-MS/MS is the preferred mode of steroid hormone measurements, immunoassays, which are widely available and less expensive, are acceptable alternatives. All patients with 46, XY DSD should undergo abdominopelvic ultrasonography by a trained radiologist. MRI of the abdomen and/or laparoscopy may be used to demonstrate the Mullerian structure and/or to localize the gonads. Genetic studies, which include copy number variation (CNV) or molecular testing of a candidate gene or next generation sequencing then should be ordered in a stepwise manner depending on the clinical, biochemical, hormonal, and radiological findings. The members of the committee believe that patients with 46, XY DSD need to be approached systematically. The proposed diagnostic algorithm, provided in the consensus statement, is cost effective and when supplemented with appropriate genetic studies, may help to reach an aetiological diagnosis in majority of such cases.

Perception of Light in Museum Environments: Comparison between Real-Life and Virtual Visual Experiences

Alternative environments to real-life have been in recent demand in regard to lighting design and in museums. In this study, the effectiveness of the perception of the museum space in simulations or virtual-based environments is studied. Answers to a questionnaire regarding lighting in four different visual experiences are compared: Real-life, virtual-video-based, virtual-photo-based and virtual-render-based. A total of 117 participants were divided into four visual experience groups. Each group answered the same lighting related questions for four exhibition halls in the Natural History Museum of the University of Pisa (Italy), which is housed in the Monumental Charterhouse of Calci. The answers were analyzed using ANOVA and a T-test. The results show that virtual experiences can be acceptable alternatives to real-life experience as the answers were indifferent in more than half of the criteria, and no criterion was affected significantly by experience, regardless of the hall’s characteristics. However, it was found that the hall’s characteristics also had an impact on the perception of the criteria in different experiences. Controlled artificial lighting or uniformly distributed lighting (full day or artificial light) were found to be more indifferent to the experience.

Accepting Living Kidney Donors with Preexisting Diabetes Mellitus: A Perspective on the Recent OPTN Policy Change-July 2022.

Accepting Living Kidney Donors with Preexisting Diabetes Mellitus: A Perspective on the Recent OPTN Policy Change-July 2022.

A family of distances for preference–approvals

A preference–approval on a set of alternatives consists of a weak order on that set and, additionally, a cut-off line that separates acceptable and unacceptable alternatives. In this paper, we propose a new method for defining the distance between preference–approvals taking into account jointly the disagreements in preferences and approvals for each pair of alternatives. The proposed distance is compared to the existing distance functions to deal with clustering problems. Specifically, we prove that our metric improves the estimated clusters in terms of both stability and accuracy.

Co-creating safe spaces: Study protocol for translational research on innovative alternatives to the emergency department for people experiencing emotional distress and/or suicidal crisis.

Safe spaces are an alternative to emergency departments, which are often unable to provide optimum care for people experiencing emotional distress and/or suicidal crisis. At present, there are several different safe space models being trialled in Australia. However, research examining the effectiveness of safe space models, especially in community settings, is rare. In this paper, we present a protocol for a study in which we will investigate the implementation, effectiveness, and sustainability of safe space models as genuine alternatives for people who might usually present to the emergency department or choose not to access help due to past negative experiences. We will use a mixed methods, co-designed study design, conducted according to the principles of community-based participatory research to obtain deep insights into the benefits of different safe space models, potential challenges, and facilitators of effective practice. We developed the study plan and evaluation framework using the RE-AIM framework, and this will be used to assess key outcomes related to reach, effectiveness, adoption, implementation, and maintenance. Data collection will comprise quantitative measures on access, use, satisfaction, (cost) effectiveness, distress, and suicidal ideation; and qualitative assessments of service implementation, experience, feasibility, acceptability, community awareness, and the fidelity of the models to service co-design. Data will be collected and analysed concurrently throughout the trial period of the initiatives. This study will enable an extensive investigation of safe spaces that will inform local delivery and provide a broader understanding of the key features of safe spaces as acceptable and effective alternatives to hospital-based care for people experiencing emotional distress and/or suicidal crisis. This study will also contribute to a growing body of research on the role and benefits of peer support and provide critical new knowledge on the successes and challenges of service co-design to inform future practice.

Sensory Perception Nudge: Insect-Based Food Consumer Behavior

The negative impact that animal protein sources have on the environment is a critical world problem. Finding new acceptable alternatives is crucial. Nevertheless, numerous factors influence the decision to try an unknown food. By adopting a consumer behavior perspective as well as approaching the possibility of overcoming neophobia, this research examined the influence of sensory perception on consumer behavior with regard to the experimentation with new foods, focusing on entomophagy. A theoretical model was developed, and path analysis and factor influence were based on the structural equation model (PLS-SEM), designed in SmartPLS, to test the model relationships. Despite the low level of awareness concerning the benefits of entomophagy, this study considered that many aspects influence experimentation with new food, specifically our sensorial system. Sensory perception is founded on the senses, such as the tactile, olfactory, visual, and gustatory senses, which can influence perception. In line with these assumptions, this research identified the three most important and decisive factors that can influence individuals’ sensory perceptions: preparation, visual and related aspects, and the presentation of the shape of food have an influence on sensory perception regarding entomophagy consumer behavior. People like to know the method of preparation as well as the ingredients and the color of the food. These findings are crucial to food business practitioners, policymakers, and marketers, who can adopt some food process strategies following sensory perception, that will contribute to changing the habits of consumers.

American Radium Society (ARS) Appropriate Use Criteria (AUC) for Locoregional Gastric Adenocarcinoma: Systematic Review and Guidelines.

The objective of this study was to systematically evaluate the data regarding the use of neoadjuvant, perioperative, surgical, and adjuvant treatment options in localized gastric cancer patients and to develop Appropriate Use Criteria recommended by a panel of experts convened by the American Radium Society. Preferred reporting items for systematic reviews and meta-analyses methodology was used to develop an extensive analysis of peer-reviewed phase 2/2R/3 trials, as well as meta-analyses found within the Ovid Medline database between 2010 and 2020. The expert panel then rated the appropriateness of various treatments in 5 representative clinical scenarios through a well-established consensus methodology (modified Delphi). For patients with medically operable locally advanced gastric cancer, the strongest recommendation was for perioperative chemotherapy based on high-quality data. Acceptable alternatives included surgery followed by either chemotherapy or concurrent chemoradiotherapy (CRT). For patients with upfront resection of stages I to III gastric cancer (no neoadjuvant therapy), the group strongly recommended adjuvant therapy with either chemotherapy alone or CRT, based on high-quality data. For patients with locally advanced disease who received preoperative chemotherapy without tumor regression, the group strongly recommended postoperative chemotherapy or postoperative CRT. Finally, for medically inoperable gastric cancer patients, there was moderate consensus recommending definitive concurrent CRT. The addition of chemotherapy and/or radiation, either in the neoadjuvant, adjuvant, or perioperative setting, results in improved survival rates for patients compared with surgery alone. For inoperable patients, definitive CRT is a reasonable treatment option, though largely palliative.

Efficacy of Transarterial Chemoembolization Combined with Molecular Targeted Agents for Unresectable Hepatocellular Carcinoma: A Network Meta-Analysis.

Simple SummaryLiver cancer is the second most common cause of cancer-related death, with hepatocellular carcinoma (HCC) being the most prevalent subtype. Transarterial chemoembolization (TACE) in combination with different tyrosine kinase inhibitors (TKIs) has recently been widely used for unresectable HCC (uHCC). However, studies investigating different combinations of agents have shown inconsistent results. Thus, we conducted a network meta-analysis to assess and compare the response of different agents in an uHCC setting. According to our results, TACE plus lenvatinib provides optimal treatment for uHCC, with the highest ranking based on OS, PFS, and DCR rates and the second-best ranking based on ORR rates.Transarterial chemoembolization (TACE) combined with tyrosine kinase inhibitors (TKIs) is the mainstay treatment for unresectable hepatocellular carcinoma (uHCC). However, studies investigating different combinations of agents have shown inconsistent results. Here, we used network meta-analysis (NMA) to compare different agents across 41 studies (36 cohort studies and five RCTs) in 11,540 patients. Multiple RCTs and cohort studies were searched to evaluate TACE combined with different TKIs. Outcomes of interest included overall survival (OS), progression-free survival (PFS), and tumor response. NMA used a random-effects consistency model to pool evidence from direct and indirect comparisons. Hazard ratio (HR) and relative risks (RR) with 95% confidence intervals (CI) were analyzed. Further, heterogeneity and publication bias analyses were performed and agents were ranked. TACE plus lenvatinib provided the maximal OS (Rank probability: 0.7559), PFS (Rank probability: 0.8595), CR (Rank probability: 0.4179), and DCR (Rank probability: 0.3857). TACE plus anlotinib demonstrated the highest PR (p = 0.62649) and ORR (p = 0.51158). SD was more often associated with TACE plus sorafenib (Rank probability: 0.601685). TACE plus lenvatinib provides optimal treatment for uHCC based on the highest ranking of OS, PFS, and DCR rates. However, given the lack of statistically significant OS benefit, shared decision making should include other TKIs as acceptable alternatives.

Prevention Is the Best Intervention: Proactive Strategies for Supporting Students Who Engage in Escalated Behaviors

Strategies for preventing the escalation of problematic student behavior in inclusive school settings are detailed. These strategies include utilizing proactive behavioral interventions, implementing function-based behavioral interventions that address root causes of escalated student behaviors, and teaching and reinforcing socially acceptable alternatives to escalated student behaviors. Each strategy is described in practical detail using case study vignettes about students who engage in escalated behaviors within inclusive school settings.

Extended Anticoagulation after Radical Cystectomy Using Direct Acting Oral Anticoagulants: A Single-Institutional Experience.

Extended prophylactic anticoagulation therapy with enoxaparin 40 mg daily is effective in reducing the incidence of venous thromboembolism (VTE) after radical cystectomy. In an effort to improve compliance, we modified our extended anticoagulation options to direct oral anticoagulants (DOAs; eg apixaban 2.5 mg twice daily or rivaroxaban 10 mg daily). This study assesses our experience with extended VTE prophylaxis using DOAs. This is a retrospective review that included all patients who underwent radical cystectomy at our institution between January 2007 and June 2021. Multivariable logistic regression models were constructed to test the hypothesis that use of extended DOAs is similar to enoxaparin in terms of VTE events and risk of gastrointestinal bleeding. In 657 patients, the median age was 71 years. Of the 101 patients who received extended VTE prophylaxis, 46 (45.5%) patients received rivaroxaban/apixaban. At 90 days of followup, 40 patients (7.2%) who did not receive extended prophylaxis on discharge developed a VTE compared to 2 patients (3.6%) in the enoxaparin group and 0 patients in the DOA group (p=0.11). Seven patients (1.3%) who did not receive extended anticoagulation developed gastrointestinal bleeding compared to 0 patients in the enoxaparin group and 1 (2.2%) in the DOA group (p=0.60). On multivariable analysis, both enoxaparin and DOAs were associated with similar reductions in the risk of developing VTE compared to controls (enoxaparin: OR 0.33, p=0.09 and DOAs: OR 0.19, p=0.15). These preliminary data suggest that oral apixaban and rivaroxaban are acceptable alternatives to enoxaparin with similar safety and efficacy profiles.

Physical and Mechanical Properties Analysis of Wood-waste Composite Panels

The timber industry takes an important place in our modern life, and there has been an increased interest in it for a long time, especially in industrially developed countries. The concerns of the environmental organization regarding the plant wealth preservation have caused scientific trends to search for sources or industries that can achieve acceptable alternatives to natural wood. The materials in this article are related to industrial timber manufacturing of greenhouse wood waste, low density polyethylene and non-standard joinery waste. Moreover, panel samples made from the above materials were briefly subjected to tests as well as tested by fresh and salt water absorption.The density calculation results for all samples have shown the possibility of obtaining a wide range of wooden planks from the lightest to the heaviest ones, depending on the type of filler used. Additionally, the conducted research has shown the possibility of producing artificial wood panels made from the studied materials with good quality and fully satisfactory physical and mechanical properties.

Challenges in global education in post COVID-19 era and its remedy

The whole planet has been put in danger by COVID 19. In every facet of life, it has wreaked disaster in its wake. There isn't a single industry that hasn't been touched. One of the most impacted areas is education. Around 1.54 billion children, including 743 million girls, have been infected by this outbreak, according to a UNESCO assessment. Because they lack the wherewithal to continue their education, the most disadvantaged members of society are the first to feel the effects of this policy. In these circumstances, the post-COVID-19 situation seems to be more difficult. There is a worldwide effort to assure the continuation of learning through online platforms, alternative modes of providing education, while also preparing for the opening of schools, colleges and universities. COVID 19's effects can only be mitigated if all parties involved, including students, instructors, school administration, and parents, work together to develop acceptable alternatives in concert with government authorities and educational resources. This paper will discuss about the global education system's potential problems and solutions in the years after COVID-19. Using online and virtual classrooms, it comments on the increasing reliance on technology in the classroom.

“Voluntary Return” without Civil Society?

This article looks at the implementation of so-called “assisted voluntary return” policies in Austria and Britain, where state agencies have recently replaced nongovernmental organizations as providers of return counseling. To better understand how such a shift affects the in/voluntariness of return, I identify three dimensions along which the “quality” of voluntariness can be assessed and relate them to concrete aspects of return counseling practice: absence of coercion; availability of acceptable alternatives; and access to adequate and trusted information. Based on original qualitative data, I show that even within an overall restrictive and oppressive regime, return counselors can make room for voluntariness by upholding ethical and procedural standards—if they retain substantial independence from the government.

Negation and Speculation in NLP: A Survey, Corpora, Methods, and Applications

Negation and speculation are universal linguistic phenomena that affect the performance of Natural Language Processing (NLP) applications, such as those for opinion mining and information retrieval, especially in biomedical data. In this article, we review the corpora annotated with negation and speculation in various natural languages and domains. Furthermore, we discuss the ongoing research into recent rule-based, supervised, and transfer learning techniques for the detection of negating and speculative content. Many English corpora for various domains are now annotated with negation and speculation; moreover, the availability of annotated corpora in other languages has started to increase. However, this growth is insufficient to address these important phenomena in languages with limited resources. The use of cross-lingual models and translation of the well-known languages are acceptable alternatives. We also highlight the lack of consistent annotation guidelines and the shortcomings of the existing techniques, and suggest alternatives that may speed up progress in this research direction. Adding more syntactic features may alleviate the limitations of the existing techniques, such as cue ambiguity and detecting the discontinuous scopes. In some NLP applications, inclusion of a system that is negation- and speculation-aware improves performance, yet this aspect is still not addressed or considered an essential step.

Proximalization of Arterial Inflow Versus Banding for the Management of Hemodialysis Access Steal Syndrome

Clinical findings in dialysis access steal syndrome (DASS) include asymptomatic flow reversal, hand ischemia, and tissue loss. Treatment options include proximalization of the arterial inflow (PAI) and banding, both of which have been established as acceptable alternatives to distal revascularization with interval ligation. We directly compared outcomes among patients undergoing PAI and banding for symptomatic DASS.

Viral RNA Load and Infectivity of SARS-CoV-2 in Paired Respiratory and Oral Specimens from Symptomatic, Asymptomatic, or Postsymptomatic Individuals.

ABSTRACTIn the present study, we assessed the diagnostic sensitivity and determined the viral RNA load and infectivity of SARS-CoV-2 in paired respiratory (nasopharyngeal and anterior nares) and oral samples (saliva and sublingual swab). Samples were collected from 77 individuals of which 75 were diagnosed with COVID-19 and classified as symptomatic (n = 29), asymptomatic (n = 31), or postsymptomatic (n = 15). Specimens were collected at one time point from each individual, between day 1 and 23 after the initial COVID-19 diagnosis, and included self-collected saliva (S), or sublingual (SL) swab, and bilateral anterior nares (AN) swab, followed by health care provider collected nasopharyngeal (NP) swab. Sixty-three specimen sets were tested using five assay/platforms. The diagnostic sensitivity of each assay/platform and specimen type was determined. Of the 63 specimen sets, SARS-CoV-2 was detected in 62 NP specimens, 52 AN specimens, 59 saliva specimens, and 31 SL specimens by at least one platform. Infectious SARS-CoV-2 was isolated from 21 NP, 13 AN, 12 saliva, and one SL specimen out of 50 specimen sets. SARS-CoV-2 isolation was most successful up to 5 days after initial COVID-19 diagnosis using NP specimens from symptomatic patients (16 of 24 positives, 66.67%), followed by specimens from asymptomatic patients (5 of 17 positives, 29.41%), while it was not very successful with specimens from postsymptomatic patients. Benefits of self-collected saliva and AN specimens balance the loss of sensitivity relative to NP specimens. Therefore, saliva and AN specimens are acceptable alternatives for symptomatic SARS-CoV-2 diagnostic testing or surveillance with increased sampling frequency of asymptomatic individuals.IMPORTANCE The dynamics of infection with SARS-CoV-2 have a significant impact on virus infectivity and in the diagnostic sensitivity of molecular and classic virus detection tests. In the present study we determined the diagnostic sensitivity of paired respiratory (nasopharyngeal and anterior nares swabs) and oral secretions (saliva and sublingual swab) and assessed infectious virus shedding patterns by symptomatic, asymptomatic, or postsymptomatic individuals. Understanding the diagnostic performance of these specimens and the patterns of infectious virus shedding in these bodily secretions provides critical information to control COVID-19, and may help to refine guidelines on isolation and quarantine of positive individuals and their close contacts identified through epidemiological investigations.

Multicenter Clinical Evaluation of Modified Two-Tiered Testing Algorithms for Lyme Disease Using Zeus Scientific Commercial Assays.

Modified two-tiered testing (MTTT) algorithms for Lyme disease (LD), which involve the sequential use of orthogonal enzyme immunoassays (EIAs) without immunoblotting, are acceptable alternatives to standard two-tiered testing (STTT; EIA followed by immunoblots) provided the EIAs have been FDA-cleared for this intended use. We evaluated four Zeus Scientific LD EIAs used in two distinct MTTT algorithms for FDA review. MTTT 1 used a VlsE1/pepC10 polyvalent EIA followed by a whole-cell sonicate (WCS) polyvalent EIA. MTTT 2 used the same first-tier EIA followed by separate IgM and IgG WCS EIAs. In a retrospective phase, we compared each MTTT algorithm to STTT using archived samples from LD patients or control subjects. In a prospective phase, we used the same algorithms to analyze consecutive excess samples submitted for routine LD serology to three clinical laboratories. For the retrospective phase, MTTTs 1 and 2 were more sensitive (56% and 74%) than STTT (41%; P ≤ 0.03) among 61 patients with acute erythema migrans (EM). In LD patients with neuroborreliosis, carditis, or arthritis (n = 75), sensitivity was comparable between algorithms (96 to 100%; P = 1.0). Among 190 control subjects without past LD, all algorithms were highly and comparably specific (≥99%, P = 0.48). For the prospective phase, (n = 2,932), positive percent-agreement (PPA), negative percent-agreement (NPA), and overall agreement of MTTT 1 with STTT were 93%, 97.7% and 97.4% (kappa 0.80). MTTT 2 yielded higher PPA (98%) but lower NPA (96.1%) and overall agreement (96.2%, kappa 0.74; all P < 0.05). Compared with STTT, both MTTT algorithms provided increased sensitivity in EM patients, comparable sensitivity in later disease and non-inferior specificity.

Investigation of the performance of okra fiber in woven fabric

There has been an increase interest in natural plant fibers over the last decades with the intension to identify the ecologically acceptable alternatives to reduce the dependency on synthetic fibers. Naturally extracted okra fiber (Abelmoschus esculentus) was used in this study. Since okra is a stiff fiber, yarns with 100% Okra fiber was not possible to produce and tried to blend with polyester. The maximal ratio of okra was 20% with polyester to spin yarns in traditional ring spinning system. This study explores, for the first time, the possibility of manufacturing woven fabric with polyester-okra (80/20) yarns at weft direction with 100% cotton yarn at warp direction in order to prominent blend effect at weft direction. The properties of produced fabrics were compared with the same produced widely-used polyester-linen (PL) (80/20) counterpart. The both PO and PL woven fabrics were characterized in terms of fabric weight, thickness, abrasion, pilling, fuzzing, air permeability, tensile strength and tear strength. In addition, the morphological aspects of the fiber alignment in the woven fabric structure were observed using optical microscopic images. The performance of PO woven fabric was in acceptable ranges and can be considered as a sustainable blended woven fabric to meet the actual demand in the textile weaving industries.