Acceleration Patterns Research Articles

Quantifying Hand Motion Complexity in Simulated Sailing Using Inertial Sensors.

The control of hand movement during sailing is important for performance. To quantify the amount of regularity and the unpredictability of hand fluctuations during the task, the mathematical algorithm Approximate Entropy (ApEn) of the hand acceleration can be used. Approximate Entropy is a mathematical algorithm that depends on the combination of two input parameters including (1) the length of the sequences to be compared (m), and (2) the tolerance threshold for accepting similar patterns between two segments (r). The aim of this study is to identify the proper combinations of 'm' and 'r' parameter values for ApEn measurement in the hand movement acceleration data during sailing. Inertial Measurement Units (IMUs) recorded acceleration data for both the mainsail (non-dominant) and tiller (dominant) hands across the X-, Y-, and Z-axes, as well as vector magnitude. ApEn values were computed for 24 parameter combinations, with 'm' ranging from 2 to 5 and 'r' from 0.10 to 0.50. The analysis revealed significant differences in acceleration ApEn regularity between the two hands, particularly along the Z-axis, where the mainsail hand exhibited higher entropy values (p = 0.000673), indicating greater acceleration complexity and unpredictability. In contrast, the tiller hand displayed more stable and predictable acceleration patterns, with lower ApEn values. ANOVA results confirmed that parameter 'm' had a significant effect on acceleration complexity for both hands, highlighting differing motor control demands between the mainsail and tiller hands. These findings demonstrate the utility of IMU sensors and ApEn in detecting nuanced variations in acceleration dynamics during sailing tasks. This research contributes to the understanding of hand-specific acceleration patterns in sailing and provides a foundation for further studies on adaptive sailing techniques and motor control strategies for both novice and expert sailors.

Spurious Accelerations in Finite Element Analysis of Geotechnical Problems: Cause and Remedy

Present study investigates the response of the two distinct geotechnical problems under earthquake loading. These two problems are: 1) nailed soil slope and 2) 1-D site response analysis. The aim of the study is to understand the cause of spurious accelerations and suggest a remedy. Two distinct interface conditions were considered in modelling the nailed soil slope. In first, the soil nail interface was considered to be perfectly bonded. In second case, the sliding at the interface was allowed. The analysis resulted into the physically acceptable deformations. However, the dumbbell shaped spurious acceleration pattern was observed in perfect bonding case. Further, the maximum acceleration was found to span from 4 g to 13 g. Such extremely high accelerations are unphysical and hence, unacceptable. In case of 1-D site response analysis, misleading acceleration spike of magnitude twice that of true acceleration was noted. The introduction of the numerical damping successfully removed the spurious accelerations and resulted in physically acceptable response for both problems.

Research on Train-Induced Vibration of High-Speed Railway Station with Different Structural Forms.

Elevated stations are integral components of urban rail transit systems, significantly impacting passengers' travel experience and the operational efficiency of the transportation system. However, current elevated station designs often do not sufficiently consider the structural dynamic response under various operating conditions. This oversight can limit the operational efficiency of the stations and pose potential safety hazards. Addressing this issue, this study establishes a vehicle-bridge-station spatial coupling vibration simulation model utilizing the self-developed software GSAP V1.0, focusing on integrated station-bridge and combined station-bridge elevated station designs. The simulation results are meticulously compared with field data to ensure the fidelity of the model. Analyzing the dynamic response of the station in relation to train parameters reveals significant insights. Notably, under similar travel conditions, integrated stations exhibit lower vertical acceleration in the rail-bearing layer compared to combined stations, while the vertical acceleration patterns at the platform and hall layers demonstrate contrasting behaviors. At lower speeds, the vertical acceleration at the station concourse level is comparable for both station types, yet integrated stations exhibit notably higher platform-level acceleration. Conversely, under high-speed conditions, integrated stations show increased vertical acceleration at the platform and hall levels compared to combined stations, particularly under unloaded double-line working conditions, indicating a superior dynamic performance of combined stations in complex operational scenarios. However, challenges such as increased station height due to bridge box girder maintenance, track layer waterproofing, and track girder support maintenance exist for combined stations, warranting comprehensive evaluation for station selection. Further analysis of integrated station-bridge structures reveals that adjustments in the floor slab thickness at the rail-bearing and platform levels significantly reduce dynamic responses, whereas increasing the rail beam height notably diminishes displacement responses. Conversely, alterations in the waiting hall floor slab thickness and frame column cross-sections exhibit a minimal impact on the station dynamics. Overall, optimizing structural dimensions can effectively mitigate dynamic responses, offering valuable insights for station design and operation.

Identification of cutter flat wear for rock TBMs using vibration signal of shield

Identification of cutter wear status is one of the critical issues for the successful operation of tunnel boring machines (TBM). This study proposed a novel model for predicting the locations of cutters experiencing flat wear, leveraging measured vibration signals from the TBM shield. Field tests were conducted to collect vibration acceleration data using accelerometers. This paper outlines the equipment and setup for monitoring vibration acceleration and develops procedures for signal processing. Analysis of vibration acceleration patterns reveals distinct characteristics corresponding to varying numbers and locations of cutters with flat wear. A linear relationship can be identified between the frequency of different vibration acceleration peak intervals and the extent of flat wear on the cutters (number and location of wear cutters). The proposed model is then applied to a TBM tunnelling section in Guangzhou, China, and validated using on-site wear data. This method offers real-time insight into the potential need for cutter replacement during tunnelling operations in challenging hard rock conditions.

Comparison of professional and everyday wearable technology at different body positions in terms of recording gait perturbations.

Falls are a significant health problem in older people, so preventing them is essential. Since falls are often a consequence of improper reaction to gait disturbances, such as slips and trips, their detection is gaining attention in research. However there are no studies to date that investigated perturbation detection, using everyday wearable devices like hearing aids or smartphones at different body positions. Sixty-six study participants were perturbed on a split-belt treadmill while recording data with hearing aids, smartphones, and professional inertial measurement units (IMUs) at various positions (left/right ear, jacket pocket, shoulder bag, pants pocket, left/right foot, left/right wrist, lumbar, sternum). The data were visually inspected and median maximum cross-correlations were calculated for whole trials and different perturbation conditions. The results show that the hearing aids and IMUs perform equally in measuring acceleration data (correlation coefficient of 0.93 for the left hearing aid and 0.99 for the right hearing aid), which emphasizes the potential of utilizing sensors in hearing aids for head acceleration measurements. Additionally, the data implicate that measurement with a single hearing aid is sufficient and a second hearing aid provides no added value. Furthermore, the acceleration patterns were similar for the ear position, the jacket pocket position, and the lumbar (correlation coefficient of about 0.8) or sternal position (correlation coefficient of about 0.9). The correlations were found to be more or less independent of the type of perturbation. Data obtained from everyday wearable devices appears to represent the movements of the human body during perturbations similar to that of professional devices. The results suggest that IMUs in hearing aids and smartphones, placed at the trunk, could be well suited for an automatic detection of gait perturbations.

Investigating Acceleration and Deceleration Patterns in Elite Youth Football: The Interplay of Ball Possession and Tactical Behavior

The main objective of this study was (1) to analyze the patterns of acceleration (Ac) and deceleration (Dec) during football matches in elite youth football, both within and between different segments of the match; and (2) to investigate the impact of ball possession and various playing positions on these acceleration and deceleration patterns. To provide a broader explanatory context, the influence of tactical space management was assessed in terms of depth and width. A descriptive comparative design was used, and data were collected during two friendly matches. Player and ball tracking data were collected using a local positioning system. In the attack phase, differences were obtained in the average Ac (first half: 0.42 ± 0.06 m·s−2, second half: 0.38 ± 0.07 m·s−2; p = 0.021, d = 0.50) and average Dec (first half: −0.44 ± 0.09 m·s−2, second half: −0.36 ± 0.08 m·s−2; p = 0.001, d = 0.84). Wingers in the attack phase obtained higher values in maximum Ac (1.65 ± 0.65 m·s−2; p = 0.007, η2 = 0.03), and in the total number of both Ac (68.7 ± 45.22; p = 0.001, η2 = 0.10) and Dec (70.6 ± 45.70; p = 0.001, η2 = 0.10). In the defense phase, full-backs obtained higher values in average Ac (0.53 ± 0.17 m·s−2; p = 0.001, η2 = 0.07) and average Dec (−0.49 ± 0.18 m·s−2; p = 0.001, η2 = 0.05) and wingers in the total number of Ac (43.9 ± 27.30; p = 0.001, η2 = 0.11) and Dec (43.8 ± 28.60; p = 0.001, η2 = 0.10). In young football players, Ac and Dec do not follow a decreasing end throughout the match, and their behavior is uneven depending on ball possession and the position assigned to the player, with the highest demands on Ac/Dec in winger and full-back positions.

The influence of accelerated brain aging on coactivation pattern dynamics in Parkinson's disease.

Aging is widely acknowledged as the primary risk factor for brain degeneration, with Parkinson's disease (PD) tending to follow accelerated aging trajectories. We aim to investigate the impact of structural brain aging on the temporal dynamics of a large-scale functional network in PD. We enrolled 62 PD patients and 32 healthy controls (HCs). The level of brain aging was determined by calculating global and local brain age gap estimates (G-brainAGE and L-brainAGE) from structural images. The neural network activity of the whole brain was captured by identifying coactivation patterns (CAPs) from resting-state functional images. Intergroup differences were assessed using the general linear model. Subsequently, a spatial correlation analysis between the L-brainAGE difference map and CAPs was conducted to uncover the anatomical underpinnings of functional alterations. Compared to HCs (-3.73 years), G-brainAGE was significantly higher in PD patients (+1.93 years), who also exhibited widespread elevation in L-brainAGE. G-brainAGE was correlated with disease severity and duration. PD patients spent less time in CAPs involving activated default mode and the fronto-parietal network (DMN-FPN), as well as the sensorimotor and salience network (SMN-SN), and had a reduced transition frequency from other CAPs to the DMN-FPN and SMN-SN CAPs. Furthermore, the pattern of localized brain age acceleration showed spatial similarities with the SMN-SN CAP. Accelerated structural brain aging in PD adversely affects brain function, manifesting as dysregulated brain network dynamics. These findings provide insights into the neuropathological mechanisms underlying neurodegenerative diseases and imply the possibility of interventions for modifying PD progression by slowing the brain aging process.

Hypergravity Impact on Fertility of Apis mellifera carnica Queens – Case Study

The launch is considered the most stressful rocket flight stage due to the hypergravity occurrences. The possibility of using honey bees (Apis mellifera) as the extraterrestrial pollinator depends on their ability to reproduce correctly after experiencing hypergravity. The described study aims to verify the impact of a launching rocket’s acceleration on honey bee queen’s egg-laying behavior. Four artificially inseminated A. mellifera carnica queens were placed in the Human Training Centrifuge and given to the acceleration pattern of the launching Soyuz rocket. Next, the data on the number of food stores, eggs, larvae, and worker and drone pupae were collected from the test and control hives using the modified Liebefeld method. The pilot study results imply that accelerated queen’s egg-laying behavior may change twofold: limiting or maximizing the number of laid eggs, with the control queen egg-laying rate remaining stable for all samples. The number of drone pupae is greater for the test sample colonies, with its earlier appearance in the hive. No impact on overwintering success was observed. Authors indicate limitations of the results and a need to continue the study to verify the occurrence of anomalies potentially related to the examined factor.

Numerical Simulation Study of the Vibrational Response of Continuous Arch Tunnels under the Action of Overlying Train Loads

With the rapid development of transportation infrastructure in China, continuous arch tunnels passing under existing operational railways are increasingly encountered. This paper primarily investigates the mechanical response patterns of the lining of continuous arch tunnels under the vibrational loads generated by trains traveling on railways. To this end, a three-dimensional finite element model of the dynamic response of continuous arch tunnels under train vibrational loads was constructed using Midas GTS/NX software. This model explores the patterns of acceleration, dynamic displacement, and dynamic strain responses of continuous arch tunnels under the action of moving train loads. The study reveals that under train vibrational loads, the vertical acceleration, vertical displacement, and strain time history curves at various monitoring points in the continuous arch tunnel exhibit vibrational characteristics. The acceleration, vertical displacement, and dynamic strain increase as the train enters, fluctuate within a certain range, and then decrease to zero as the train exits. Under high-speed train loads, the acceleration peak values at the arch feet and outer sidewalls of the left and right tunnels are larger, with a greater peak value difference. The vertical displacement peak values at the arch shoulders and crown are larger, whereas those at the middle partition wall and base slab are smaller. During the process from the train's entry to its exit, the dynamic strain exhibits a trend of initially increasing, then stabilizing, and finally decreasing to zero, all while displaying vibrational characteristics. The strain response on the tunnel side where the train enters is greater than that on the side where it exits.

The Impact of High-Intensity Interval Exercise Including Acceleration/Deceleration Patterns on Redox Status of Healthy Male Adults

High-intensity interval exercise (HIIE) is a type of structured physical training characterized by repeated bouts of high-intensity exercise interspersed with recovery periods. Although HIIE was found to improve physical performance in a relatively short period of time, there is emerging evidence suggesting that acute HIIE may induce oxidative stress. The purpose, therefore, of the present study was to examine the effect of intermittency and/or acceleration during HIIE on oxidative stress in male participants. Nine healthy males [(age: 21.0 ± 3.0 years; height: 180.0 ± 4.0 cm; body mass: 79.4 ± 7.9 kg; maximal oxygen uptake (V˙O2max) 52.0 ± 6.0 mL·kg−1·min−1)] were recruited to perform six distinct exercise protocols of various intermittency (high, medium, and low) and acceleration (high, medium, and low) while a control session was also included. Blood samples were obtained to determine oxidative stress indices (lipid hydroperoxides, superoxide dismutase, and total glutathione) at rest, 1 h, 2 h, and 24 h following exercise on a non-motorized treadmill. The intra-individual variability of participants was observed in lipid hydroperoxides at baseline, ranging from 1.80 to 20.69 μmol·L−1. No significant differences among the six different exercise protocols in any of the oxidative stress indices evaluated were observed (p > 0.05). These results suggest that the influence of various intermittency levels and acceleration patterns upon exercise-induced oxidative stress is negligible.

Gravity's impact on visual search asymmetries: Is visual gravitational motion a distinct visual feature or a familiar dynamic event?

A wealth of converging research lines has led support to the notion that specialized neural processes output a priori information about the expected effects of gravity to fine-tune motor and perceptual responses to dynamic events. Arguably, these putative internal models of gravity might modulate the efficiency in visual search for objects conforming or not to gravitationally coherent dynamics. In the present work, we explored this possibility with a visual search task involving arrays of two to eight objects moving periodically back and forth. The target could be an accelerating/decelerating ball (as if bouncing on earth's surface-1g) with distractors moving at a constant speed (0g) or the reverse. Moreover, the direction of the gravitational pull, as implied by the 1g motion patterns, could be aligned or misaligned with Earth's gravity. Overall, searches for 1g targets were more efficient than 0g targets except, notably, when stimuli displays were congruent with Earth's gravitational pull, in which case the visual search asymmetry is significantly reduced. Outcomes are interpreted as reflecting the joint and mutually cancelling contribution of low-level detection of acceleration patterns and higher level detection of unexpected violations of gravitational motion. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Discovery of Astrometric Accelerations by Dark Companions in the Globular Cluster ω Centauri

We present results from the search for astrometric accelerations of stars in ω Centauri using 13 yr of regularly scheduled Hubble Space Telescope WFC3/UVIS calibration observations in the cluster core. The high-precision astrometry of ∼160,000 sources was searched for significant deviations from linear proper motion. This led to the discovery of four cluster members and one foreground field star with compelling acceleration patterns. We interpreted them as the result of the gravitational pull by an invisible companion and determined preliminary Keplerian orbit parameters, including the companion’s mass. For the cluster members, our analysis suggests periods ranging from 8.8 to 19+ yr and dark companions in the mass range of ∼0.7 to ∼1.4M ☉. At least one companion could exceed the upper mass boundary of white dwarfs and can be classified as a neutron star candidate.

Behavioral Patterns of Drivers under Signalized and Unsignalized Urban Intersections

Under the general trend of mixed traffic flow, an in-depth understanding of the driving behaviors of traditional vehicles is of great significance for the design of autonomous vehicles and the improvement in the safety and acceptance of autonomous vehicles. This study first obtained microdata on the behaviors of drivers through driving simulation experiments and conducted research in stages. Then, generalized linear mixed-effects models were constructed to study the main effects and interaction effects of driver attributes and traffic conditions on driving behaviors. The data analysis shows that the overall speed of drivers passing through intersections follows a “deceleration acceleration” mode, but the fluctuations are more pronounced at signalized intersections, and the signal control significantly changes the position of the lowest speed when turning left. According to the different signal control and driving tasks, there are significant differences in a driver’s acceleration patterns between the entry and exit stages. A driver’s heart rate fluctuates greatly during the exit phase, especially during straight tasks. Compared with other indicators, the change in the gaze duration is not significant. In addition, interaction effects were observed between driver attributes and traffic conditions, with participants exhibiting different behavioral patterns based on their different attributes. The research results can provide a basis for the design of driving assistance systems and further improve the interactions between autonomous vehicles and traditional vehicles at intersections.

Local Dynamic Stability of Trunk During Gait is Responsive to Rehabilitation in Subjects with Primary Degenerative Cerebellar Ataxia

This study aimed to assess the responsiveness to the rehabilitation of three trunk acceleration-derived gait indexes, namely the harmonic ratio (HR), the short-term longest Lyapunov’s exponent (sLLE), and the step-to-step coefficient of variation (CV), in a sample of subjects with primary degenerative cerebellar ataxia (swCA), and investigate the correlations between their improvements (∆), clinical characteristics, and spatio-temporal and kinematic gait features. The trunk acceleration patterns in the antero-posterior (AP), medio-lateral (ML), and vertical (V) directions during gait of 21 swCA were recorded using a magneto-inertial measurement unit placed at the lower back before (T0) and after (T1) a period of inpatient rehabilitation. For comparison, a sample of 21 age- and gait speed-matched healthy subjects (HSmatched) was also included. At T1, sLLE in the AP (sLLEAP) and ML (sLLEML) directions significantly improved with moderate to large effect sizes, as well as SARA scores, stride length, and pelvic rotation. sLLEML and pelvic rotation also approached the HSmatched values at T1, suggesting a normalization of the parameter. HRs and CV did not significantly modify after rehabilitation. ∆sLLEML correlated with ∆ of the gait subscore of the SARA scale (SARAGAIT) and ∆stride length and ∆sLLEAP correlated with ∆pelvic rotation and ∆SARAGAIT. The minimal clinically important differences for sLLEML and sLLEAP were ≥ 36.16% and ≥ 28.19%, respectively, as the minimal score reflects a clinical improvement in SARA scores. When using inertial measurement units, sLLEAP and sLLEML can be considered responsive outcome measures for assessing the effectiveness of rehabilitation on trunk stability during walking in swCA.

Experimental and numerical study of corrugated steel-plain concrete composite structures under contact explosions

This paper investigates the dynamic response and blast resistance of corrugated steel-plain concrete (CSPC) composite structures subjected to contact blast. A series of explosive tests were conducted to investigate the acceleration, deformation, and damage patterns of CSPC plates under varying blast loads and arrangements of shear connectors, and these findings were compared with reinforced concrete (RC) plates. The results suggested that CSPC plates exhibited superior ductility and blast resistance, and effectively mitigated concrete collapse. The CSPC slab primarily underwent elastic deformation when the TNT charge was small, with the rebound deformation of the concrete and steel plates acting as a significant mode of energy dissipation. As for larger TNT charges, the maximum deformation of the plate progressively increased, especially when exceeding 0.3 kg, the deformation rebound ratio decreased significantly, and the plastic deformation increased. For further increased explosive loads, the concrete and steel plates exhibited a pronounced strain rate effect with a slowed growth rate of deformation. By examining different configurations of shear connectors, it was discovered that the adhesive strength between concrete and steel plates was closely related to the energy dissipation mode, and the elastic recovery capability and deformation resistance of the CSPC structure significantly deteriorated when the shear connectors were shorter, sparser or thinner. A numerical model based on LS-DYNA was designed to further analyze the blast resistance characteristics of CSPC plates. An engineering collapse coefficient Kz was established to predict the failure level of the CSPC plates. This paper provides useful insights for the optimal design and damage assessment of CSPC composite structures.

Women Movement Behaviors During Pregnancy and 2 Years After Childbirth: Physical Activity, Sedentary Time, Sleep, and Rhythm Changes in a Brazilian Birth Cohort

Objective: To describe physical activity (PA), sleep, and rhythm patterns during 24-hr cycles from the second trimester of pregnancy up to 2 years after childbirth. Methods: This longitudinal study used data from mothers of the 2015 Pelotas Birth Cohort (Brazil). Women were invited to wear the accelerometer during 7 days on the nondominant wrist during the second trimester of pregnancy and 2 years after childbirth. Data collected included PA, sleep, and rhythm variables. We compared the means/medians of variables during the pregnancy and 2 years after the childbirth. We also describe the shape of acceleration across the day in the two evaluated periods and stratified this curve according to covariables. Results: This study includes data from 1,293 women with valid accelerometer data for both periods. The nonbouted moderate-to-vigorous PA average was 94 min during pregnancy and increased to 122 min 2 years after childbirth (p < .001). Sleep decreased by 11 min (388–377 min; p < .001) in the evaluated period. The pattern of acceleration across the day did not change in the evaluated period with two marked spikes of activity at 10 a.m. and 6 p.m. The amount of activity, however, increased. Conclusions: These findings may be helpful to better understand changes in PA and sleep during this specific period of life and assist in planning recommendations.

Assessment and indicators of kinematic behavior and perceived fatigability.

The objective of this study was to investigate the relationship between upper limb kinetics and perceived fatigability in elderly individuals during an upper limb position sustained isometric task. A total of 31 elderly participants, 16 men (72.94±4.49 years) and 15 women (72.27±6.05 years), performed a upper limb position sustained isometric task. Upper-limb acceleration was measured using an inertial measurement unit. Perceived fatigability was measured using the Borg CR10 scale. Higher mean acceleration in the x-axis throughout the activity was associated with higher final perceived fatigability scores. Moderate correlations were observed between perceived fatigability variation and mean acceleration cutoffs in all axes during the second half of the activity. In women, significant correlations were found between all perceived fatigability cutoffs and mean acceleration in the y- and x-axes. However, in men, the relationships between perceived fatigability variation and mean acceleration were more extensive and stronger. The acceleration pattern of the upper limb is linked to perceived fatigability scores and variation, with differences between sexes. Monitoring upper limb acceleration using a single inertial measurement unit can be a useful and straightforward method for identifying individuals who may be at risk of experiencing high perceived fatigability or task failure.

Fear of falling in community-dwelling older adults: What their gait acceleration pattern reveals

BackgroundFear of Falling (FOF) is common among community-dwelling older adults and is associated with increased fall-risk, reduced activity, and gait modifications. ObjectiveIn this cross-sectional study, we examined the relationships between FOF and gait quality. MethodsOlder adults (N=232; age 77±6; 65 % females) reported FOF by a single yes/no question. Gait quality was quantified as (1) harmonic ratio (smoothness) and other time-frequency spatiotemporal variables from triaxial accelerometry (Vertical-V, Mediolateral-ML, Anterior-Posterior -AP) during six-minute walk; (2) gait speed, step-time CoV (variability), and walk-ratio (step-length/cadence) on a 4-m instrumented walkway. Mann Whitney U-tests and Random forest classifier compared gait between those with and without FOF. Selected gait variables were used to build Support Vector Machine (SVM) classifier and performance was evaluated using AUC-ROC. ResultsIndividuals with FOF had slower gait speed (103.66 ± 17.09 vs. 110.07 ± 14.83 cm/s), greater step time CoV (4.17 ± 1.66 vs. 3.72 ± 1.24 %), smaller walk-ratio (0.53 ± 0.08 vs. 0.56 ± 0.07 cm/steps/minute), smaller standard deviation V (0.15 ± 0.06 vs. 0.18 ± 0.09 m/s2), and smaller harmonic-ratio V (2.14 ± 0.73 vs. 2.38 ± 0.58), all p<.01. Linear SVM yielded an AUC-ROC of 67 % on test dataset, coefficient values being gait speed (-0.19), standard deviation V (-0.23), walk-ratio (-0.36), and smoothness V (-0.38) describing associations with presence of FOF. ConclusionOlder adults with FOF have reduced gait speed, acceleration adaptability, walk-ratio, and smoothness. Disrupted gait patterns during fear of falling could provide insights into psychosocial distress in older adults. Longitudinal studies are warranted.

IN-VEHICLE SENSORS TO DETECT CHANGES IN DRIVING BEHAVIORS WITH EMERGENCE OF MCI

Abstract Driving is a complex behavior requiring attention, judgment, orientation, memory, processing speed, visual acuity, adequate limb strength, and other functional abilities. It has been suggested that a change in driving behavior may be an early indicator of cognitive decline in the aging brain. The literature suggests that older drivers will drive less and more slowly as their cognitive skills begin to decline. In the “In-Vehicle Sensors to Detect Cognitive Change in Older Drivers” study, sensors are installed in participant vehicles and data is downloaded every three months at which time a carefully curated battery of cognitive tests is also administered. Records of those suggesting mild cognitive impairment (MCI) are reviewed by a Consensus Diagnostic Panel for confirmation. In the first 100 participants who have been followed over a year, nine participants evidenced existing or emerging MCI. Of these, six have experienced a decline in cognition in the last year. A comparison of driving behaviors over the year evidenced the previously reported slower, less frequent driving but also a previously unreported increase in hard braking and hard turns. The uniqueness of our longitudinal study is the continuous tracking of vehicle acceleration patterns over time, revealing significant relationships between g-force acceleration and cognition.

Non-hyperaemic coronary flow velocity acceleration indices correlate with hyperaemic microvascular resistance in patients with INOCA

Abstract Background Coronary microvascular dysfunction (CMD) is associated with an overall worse prognosis. While the diagnosis and endo-typing of CMD currently rely on hyperaemic physiological indices, the search for accurate non-hyperaemic techniques continues. Flow velocity acceleration pattern is mechanistically associated with changes in shear stress, endothelial function, arterial stiffness and pressure in pulsatile flow systems (1-3). Purpose We aim to interrogate whether resting flow velocity acceleration indices correlate with hyperaemic microvascular resistance (HMR) in patients with Ischemia and no obstructive coronary artery disease (INOCA). Methods In 21 Patients with INOCA (all of whom had presented with typical angina pectoris, had no significant epicardial stenoses but positive myocardial perfusion scan test for ischemia) invasive physiological assessment was performed by means of intracoronary Doppler. Hyperaemia was induced with intracoronary adenosine administration. Coronary flow reserve (CFR) and HMR were calculated per their definitions. Flow velocity acceleration indices were derived from the first derivative of the averaged resting flow velocity waveforms with respect to time. We have defined 6 wave peaks of interest in all patients (peak diastolic acceleration (initial prominent peak with ventricular relaxation, referred as A), early diastolic deceleration (B), early re-acceleration wave (C), peak presystolic deceleration (seen just before initial systolic acceleration peak, J), initial systolic acceleration peak (X) and pre-diastolic deceleration nadir (Z)) and calculated the ratios between them as well as adjusted them with respect to resting mean flow velocity (Figure 1). Results The mean age was 59 ± 8 years and the majority of the study group was female (%81). Cardiovascular risk factors were common amongst the study group.All patients had CFR &amp;lt; 2.5. Mean CFR and HMR were 2.05 ± 0.32 and 2.20 ± 0.60 mmHg.cm.sec-1 respectively. Raw C peak magnitude was significantly correlated with APVh (rho:-0.457 p:0.037) and HMR (rho:0.612 p:0.004). Adjusting the C magnitudes with APVb at patient level yielded better correlations (APVh rho:-0.496 p:0.022 ; HMR:0.642 p:0.002). The ratio between diastolic reacceleration peak (C) and presystolic peak deceleration (J), C/J , adjusted with the APVb ((C/J)/APVb) showed the most pronounced correlation with HMR (rho: 0.758 p &amp;lt; 0.001) (unadjusted C/J – HMR rho: 0.718 p&amp;lt;0.001)(Figure 2). Conclusion(s) Acceleration characteristics of resting coronary flow velocity correlate with hyperaemic microvascular resistance indicating structurally impaired coronary microcirculation, hence their utilisation may aid developing non-hyperaemic physiological markers for coronary microvascular dysfunction in patients with INOCA.Derived Acceleration WaveformsCorrelations between HMR and C/J Ratio