Rational regulation of the composition and structure of electrocatalysts is crucial to the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). Herein, a new electrocatalyst of nickel phosphate microprism (VSB/NiPO) is developed via a simple solvothermal reaction. The microprism is mainly composed of Versailles-Santa Barbara-5 (VSB-5, molecular sieve) with unique nanochannels, which contribute to accelerating mass transfer and exposing more active sites, thus displaying excellent HER activity. Subsequently, the crystallinity and electronic structure of the framework are modulated by incorporating Fe with the combination of calcination and impregnation. The nanochannels are converted to the amorphous arrangement, and the Ni centers are regulated to the higher valence. The resultant Fe-VSB/NiPO-500 exhibits a low OER overpotential of 227mV at 50mA cm-2 . Interestingly, an integrated electrolyzer assembled by VSB/NiPO(-) and Fe-VSB/NiPO-500(+) performs well for overall water splitting, which requires only 1.487V to achieve 10mA cm-2 , and remains stable at 100mA cm-2 over 100 h. This finding opens a new avenue for developing VSB-5 in the field of electrocatalysis.