Academy Of Sciences Research Articles

Application and prospect of BSA method based on bibliometrics in crop breeding.

In order to understand the progress and frontier in the application of BSA(bulked segregant analysis) method in crop breeding and to reflect objectively the contribution of different countries, institutions and researchers in this field at home and abroad, this study analyzed 2111 items in the WOS (Web of Science) database from 2000 to 2023 and 446 items in the CNKI (China National through Knowledge Infrastructure) database from 2003 to 2023, regarding the researches of the application of BSA in crop breeding, basing on bibliometric analysis methods using CiteSpace software including keyword co-occurrence analysis, highlight word analysis, keyword clustering analysis, clustering timeline analysis and author co-citation. The results showed that there was an consistent increasing trend in the publication number of the application of BSA in crop breeding both in the domestic and foreign journals year by year. Ranking of the top countries according to the number of publications was China, the United States and India. The Huazhong Agricultural University displayed the highest number of publications in the CNKI database, while the Chinese Academy of Agricultural Sciences was found to have the highest number of publications in the WOS database. The published articles related to the application of BSA in crop breeding abroad mainly focused on the disciplines such as plant science, agronomy, horticulture and genetics, while those in China mainly concentrated on such disciplines as plant science, plant protection, horticulture and biology. The top three authors in terms of influence in the field of appling BSA in crop breeding were Michelmore RW, Kosambi DD and Li H, while Michelmore RW, Lander ES and Li H had closer cooperations with other authors. The top three crops relating to the studies of BSA were rice(Oryza sativa), soybean(Glycine max), corn(Zea mays L.) with the hot spot traits of disease resistance and plant height domestically. The top three crops involving the studies of BSA were rice, Arabidopsis thaliana and wheat(Triticum aestivum L.) with hot spot traits of disease resistance abroad. Up to now, BSA was mainly used to localize and functionally verify the candidate genes linking target traits and the mutated genes in crops in the domestical documents, while the foreign published studies based on BSA were mainly focused on the fine mapping and functional verification of target trait genes aiming at the revelation of genetic mechanisms in crops. Research frontier analysis indicated that rice, peanuts(Arachis hypogaea L.), upland cotton(Gossypium hirsutum L.) would be the main objects of studies concerning application of BSA in crop breeding with the hot topics of crop mutants and crop metabolites in the future.

Heavy Neutral Leptons in Gauged $U(1)_{L_\mu-L_\tau}$ at Muon Collider

Abstract Heavy neutral leptons $N$ are the most appealing candidates to generate the tiny neutrino masses. In this paper, we study the signature of heavy neutral leptons in gauged $U(1)_{L_\mu-L_\tau}$ at a muon collider. Charged under the $U(1)_{L_\mu-L_\tau}$ symmetry, the heavy neutral leptons can be pair produced via the new gauge boson $Z'$ at muon collider as $\mu^+\mu^-\to Z^{\prime *}\to NN$ and $\mu^+\mu^-\to Z^{\prime (*)} \gamma\to NN\gamma$. We then perform a detailed analysis on the lepton number violation signature $\mu^+\mu^-\to NN\to \mu^\pm\mu^\pm W^\mp W^\mp$ and $\mu^+\mu^-\to NN \gamma\to \mu^\pm\mu^\pm W^\mp W^\mp \gamma$ at the 3 TeV muon collider, where the hadronic decays of $W$ boson are treated as fat-jets $J$. These lepton number violation signatures have quite clean backgrounds at the muon collider. Our simulation shows that a wide range of viable parameter space is within the reach of the 3 TeV muon collider. For instance, with new gauge coupling $g'=0.6$ and an integrated luminosity of 1000 fb$^{-1}$, the $\mu^\pm\mu^\pm JJ$ signal could probe $m_{Z'}\lesssim 13$ TeV. Meanwhile, if the gauge boson mass satisfies $2 m_N<m_{Z'}<\sqrt{s}$, the $\mu^\pm\mu^\pm JJ\gamma$ signature would be more promising than the $\mu^\pm\mu^\pm JJ$ signature. Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI. Article funded by SCOAP3 and published under licence by Chinese Physical Society and the Institute of High Energy Physics of the Chinese Academy of Science and the Institute of Modern Physics of the Chinese Academy of Sciences and IOP Publishing Ltd.

Raising awareness on global environmental challenges by bringing polar research closer to the society

The effects of climate change are much more rapid and visible in the Arctic than in the rest of the globe. The Arctic is extremely attractive scientifically and cognitively. Therefore, polar regions may serve as some of the most captivating natural settings capable of engage society in discussions on environmental changes. The primary objective of this paper is to present selected initiatives implemented by the Institute of Geophysics, Polish Academy of Sciences that aimed to connect polar research with schools and society, and show evidence on their effectiveness, with special focus on pupils from primary and secondary schools. In this paper, an overview of the educational and science communication initiatives undertaken by the Institute of Geophysics PAS for schools and whole society is presented, with the focus on polar research. Next, some results of the evaluation studies for those projects, that conducted detailed impact assessment, are discussed. Based on the evaluation studies and on general not-structured feedback received from diverse audiences of Institute’s activities, positive impact of bringing polar research closer to the society was observed. Using the Arctic and polar research as a vehicle to inspire interest in science and to raise societal awareness of the environmental challenges in various groups of non-specialists may be a very effective mean of science communication.

State Public Scientific and Technological Library of the Siberian Branch of the Russian Academy of Sciences in the scientific and information space of the East of Russia

The scientific libraries participate in building the information and communication infrastructure being an integral part of the scientific, educational,socio-cultural and industrial complex of the region. The authors review in brief the evolution of the State Public Scientific and Technological Library of the Siberian Branch of the Russian Academy of Sciences (SPSTL SB RAS) – the leading information and library center of Siberia in the context of changing scientific and educational environment.The Siberian Branch of the USSR Academy of Sciences, established in 1957, contributes to the active development of science in the east of the country. Implementing strategic objectives, among the priority measures the Branch heads laid the new system foundations of research information support, which met the demands of science development and the specific character of the institution activity within the Siberian Branch of the USSR Academy of Sciences. Big efforts to expand the network of libraries of research institutes were undertaken. The State Public Scientific Technological Library of the SB USSR AS, which began its activities in the region in 1958, was designed as the central library of the USSR SB AS (SB RAS). For 65 years, it has been providing information and methodological support for multidisciplinary research. The Library also acts as an institutional center in the library science, bibliography and bibliology, book history, and the largest library and information, cultural, educational, educational center, shaping the modern information, scientific, educational and cultural environment.

Wheat Yield Estimation Study Using Hyperspectral Vegetation Indices

Wheat is the main grain crop in our country, and the traditional wheat yield estimation method is time-consuming and laborious. By estimating wheat yield efficiently, quickly and non-destructively, agricultural producers can quickly obtain information about wheat yield, manage wheat fields more scientifically and accurately, and ensure national food security. Taking the Xinxiang Experimental Base of the Crop Science Research Institute, Chinese Academy of Agricultural Sciences as an example, hyperspectral data for the critical growth stages of wheat were pre-processed. A total of 27 vegetation indices were calculated from the experimental plots. These indices were then subjected to correlation analysis with measured wheat yield. Vegetation indices with Pearson correlation coefficients greater than 0.5 were selected. Five methods, including multiple linear regression, stepwise regression, principal component regression, neural networks and random forests, were used to construct wheat yield estimation models. Among the methods used, multiple linear regression, stepwise regression and the models developed using principal component analysis showed a lower modelling accuracy and validation precision. However, the neural network and random forest methods both achieved a modelling accuracy R2 greater than 0.6, with validation accuracy R2 values of 0.729 and 0.946, respectively. In addition, the random forest method had a lower cross-validation RMSE value, with values of 869.8 kg/hm−2, indicating a higher model accuracy. In summary, the random forest method provided the optimal estimation for wheat yield, enabling the timely and accurate pre-harvest wheat yield prediction, which has significant value for precision agriculture management and decision making.

DURATION OF PRODUCTIVE LONGEVITY OF SOWS OF DIFFERENT LEVELS OF ADAPTATION AND VIABILITY

The work aimed to investigate the reproductive qualities of sows of different levels of adaptation and viability. The research was carried out in the conditions of the breeding breeder for breeding pigs of the large white breed of the experimental farm and the laboratory of animal husbandry and fodder production of the Institute of Agriculture of the Northeast of the National Academy of Sciences, as well as the laboratory of animal husbandry of the State University “Institute of Grain Crops of the National Academy of Sciences”. The work was carried out by the program of scientific research of the National Academy of Agrarian Sciences of Ukraine No. 31, “Genetic improvement of agricultural animals, their reproduction and preservation of biodiversity” (“Genetics, conservation, and reproduction of biological resources in animal husbandry”) and No. 30 “System of organizational and technological solutions for adaptation of animals to climate change for the production of animal husbandry products (“Climate-adaptive and organic animal husbandry”). The object of the study was sows of a large white breed of French origin. The evaluation of the animals of the specified production group by indicators of reproductive qualities was carried out taking into account the following characteristics: total farrowing, live piglets total, weight, fertility, weight, milk yield, kg; weight of the nest at the time of weaning at the age of 28 days, kg, preservation, %. The viability index was calculated according to the method of V. P. Kovalenko et al. (2012), index “level of adaptation” – Smirnova V.S. (2003), selection index of reproductive qualities of the sow (SIRQS) – O. M. Tsereniuka et al. (2010). It was established that the difference between sows of different adaptation levels by age and fertile insemination is (17.0 days; td=2.70), life span (17.0 months; td=9.04), the number of farrowing obtained (3.3 of farrowing; td=13.20), the number of live piglets obtained (46.2 head.; td=10.52), multifertility (1.2 head; td=4.00), litter weight at the time of weaning at the age of 28 days (3.5 kg; td=3.21). Animals of the specified production group with a viability index variability of 90.75-144.55 points prevailed over peers with a viability index of 39.75-77.46 points in terms of age and fertile insemination, number of live piglets obtained, multifertility, nest weight at the time of weaning at the age of 28 days and conservation by an average of 11.43%. The correlation between life expectancy, duration of breeding use, signs of reproductive qualities of sows, and indices of "adaptation level" (RA) and viability (I) ranges from –0.758±0.0371 (tr=20.45) to +0.859 ±0.0228 (tr=37.62). The maximum increase in additional production was obtained from sows of the 1st experimental group of intrabreed differentiation according to the index "level of adaptation" (+3.31%) and according to the viability index (+11.24%), and its value is +155.80 and +529.08 hryvnias obtained from 1 animal for one farrowing.

Perspective: Advancing the science regarding temporomandibular disorders

This Special Issue was initiated in response to the call for improved research by the National Academies of Sciences, Engineering, and Medicine (NASEM) (United States) Consensus Study Report on Temporomandibular Disorders (TMDs), a set of putatively localized musculoskeletal conditions. In this Special Issue, the importance of systems biology for TMDs emerges from each of three separate publications. The importance of systems biology to patients is anchored in two domains—laboratory research and clinical observation. The three publications fully speak to the underlying goals in the NASEM recommendations for initiatives: that research on TMDs needs to broaden, that integration between basic and clinical science needs to improve, and that while better evidence is needed, clinicians need to utilize the evidence that already exists. All three of these initiatives, taken together, would lead to better understanding of these complex diseases and to better care of patients with these diseases.

Determination of Earthquake Depths Using Data of Cross-Sectional and Areal Deep Seismic Studies in Siberia

Abstract ––Information on the distribution of earthquake hypocenters for many seismically active zones of Siberia remains insufficient, which is associated with sparse networks of seismological observations. The paper presents the results of determining the earthquake depths in several seismogenic areas in the Altai-Sayan region, Cisbaikalia, Transbaikalia, and Yakutia using the travel time of longitudinal refracted waves from the Mohorovičič discontinuity (Pn waves) from earthquakes and the recently obtained information about the deep structure of these regions. The depth determination algorithm is tested using data from aftershocks of large earthquakes occurring in Tuva in 2011 and 2012 (ML = 6.7 and 6.8), recorded both by the regional seismological network and by a local group of seismic stations. Different methods are applied to reveal that some aftershock depths have a close match, including those for the main shocks – the Tuva-1 and Tuva-2 earthquakes. Another good match of earthquake depths is obtained using Рn waves with materials from regional and detailed studies of the Baikal branch of the Geophysical Survey of the Russian Academy of Sciences in the Muyakan activation site in the Baikal rift zone. The resulting data complement the information on the hypocenter of the main shock and confirm the change of the Muyakan activation cluster from large depths to shallow ones since the onset of activation in 2014. New information on the earthquake depths using Рn waves is obtained in Yakutia along the border of the largest Eurasian and Okhotsk tectonic plates. It is revealed that they decrease to 6–12 km as compared to higher depths of 20–30 km in adjacent areas. The resulting series of new information on the distribution of earthquake hypocenters using Рn waves is extremely important mostly because it indicates the possibility of identifying and redefining earthquake hypocenters using previous seismological observations in seismically active zones of Siberia.

Investigation of clinicopathological characteristics and prognosis of abdominal Desmoid tumors

BackgroundAbdominal desmoid tumors (DTs) are rare soft-tissue neoplasms known for their relatively high local recurrence rate. This study aims to elucidate the clinicopathological features and investigate prognostic factors related to abdominal DTs across various tumor locations.MethodsFrom January 2000 to January 2021, patients diagnosed with abdominal DTs who underwent complete resection at the Cancer Hospital, Chinese Academy of Medical Sciences, were included in this study. Thorough collection and review of clinicopathologic characteristics and follow-up data were performed. Prognostic factors, including age at presentation, sex, tumor location, size, and proximity to nerves or vasculature, were meticulously analyzed to assess their impact on recurrence-free survival.ResultsA cohort of 226 patients diagnosed with abdominal DTs was categorized into two groups based on tumor site: the abdominal wall group (n = 132) and the intra-abdominal cavity group (n = 94). Distinct clinicopathological features and prognoses were observed between abdominal wall DTs and intra-abdominal DTs. During a median follow-up of 60 months, 24 patients (10.2%) experienced local recurrence. Univariate and multivariate analyses identified intra-abdominal tumors, tumor size >10cm, and positive margins as independent risk factors associated with poor prognosis.ConclusionAbdominal wall DTs demonstrate different clinicopathological characteristics and better prognoses compared to intra-abdominal DTs. By achieving negative margins, patients with abdominal wall DTs can achieve favorable therapeutic outcomes and prognosis through curative resection.

Evaluating the psychometric properties of the simplified Chinese version of PROMIS-29 version 2.1 in patients with hematologic malignancies

The Patient-Reported Outcomes Measurement Information System 29-item Profile version 2.1 (PROMIS-29 V2.1) is a widely utilized self-reported instrument for assessing health outcomes from the patients’ perspectives. This study aimed to evaluate the psychometric properties of the PROMIS-29 V2.1 Chinese version among patients with hematological malignancy. Conducted as a cross-sectional, this research was approved by the Medical Ethical Committee of the Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (registration number QTJC2022002-EC-1). We employed convenience sampling to enroll eligible patients with hematological malignancy from four tertiary hospitals in Tianjin, Shandong, Jiangsu, and Anhui province in China between June and August 2023. Participants were asked to complete a socio-demographic information questionnaire, the PROMIS-29 V2.1, and the Functional Assessment of Cancer Therapy-General (FACT-G). We assessed the reliability, ceiling and floor effects, structural, convergent discriminant and criterion validity of the PROMIS-29 V2.1. A total of 354 patients with a mean age of 46.93 years was included in the final analysis. The reliability of the PROMIS-29 V2.1 was affirmed, with Cronbach’s α for the domains ranging from 0.787 to 0.968. Except sleep disturbance, the other six domains had ceiling effects, which were seen on physical function (26.0%), anxiety (37.0%), depression (40.4%), fatigue (18.4%), social roles (18.9%) and pain interference (43.2%), respectively. Criterion validity was supported by significant correlations between the PROMIS-29 V2.1 and FACT-G scores, as determined by the Spearman correlation test (P < 0.001). Confirmatory factor analysis (CFA) indicated a good model fit, with indices of χ2/df (2.602), IFI (0.960), and RMSEA (0.067). The Average Variance Extracted (AVE) values for the seven dimensions of PROMIS-29 V2.1, ranging from 0.500 to 0.910, demonstrated satisfactory convergent validity. Discriminant validity was confirmed by ideal √AVE values. The Chinese version of the PROMIS-29 V2.1 profile has been validated as an effective instrument for assessing symptoms and functions in patients with hematological malignancy, underscoring its reliability and applicability in this specific patient group.

Новый взгляд на национально-государственные преобразования на юге РСФСР: Рец. на: Гунаев Е. А. Национальные автономии Юга России в советский период: территориальное устройство и система управления (на примере Калмыкии) / отв. ред. К. Н. Максимов. Элиста: КалмНЦ РАН, 2022. 400 с.

The review was devoted to the monograph by E. A. Gunaev (Kalmyk Scientific Center of the Russian Academy of Sciences) “National Autonomies of the South of Russia in the Soviet period: Territorial Structure and Management System (on the example of Kalmykia)” (Elista: KalmSC RAS, 2022. 400 p.). The monograph was written on the basis of a wide range of sources and literature, including 30 files from 6 funds of 3 state archives, 425 publications of documents and research. E.A. Gunaev identified three stages in changing the administrative-territorial structure and management system in the national autonomies of the South of Russia: 1920–1943, 1944–1976, 1977–1991. Each stage is presented in a separate chapter of the monograph. The author proposed a historical and legal analysis of the problems under consideration with an emphasis on the study of regulatory aspects. Of significant interest is the study of the problem of legal succession between national autonomies, recreated after the rehabilitation of repressed peoples, and their national-state formations before forced eviction. E.A. Gunaev distinguishes between the categories of continuity, legal continuity and succession, and analyzes the possibilities of their use within the framework of the issue under consideration.

Review of the textbook by MD, PhD, Professor Gantsev K.Sh, MD, PhD, Associate Professor Kzyrgalin Sh.R., MD, PhD, Professor Moiseenko F.V., MD, PhD, Associate Professor Yamidanov R.S. edited by MD, PhD, Professor, Full Member (Academician) of the Academy of Sciences of the Republic of Bashkortostan Gantsev Sh.Kh. "Oncology 2.0"

The article contains a review of the educational publication “Oncology 2.0”, prepared by a group of authors edited by Gantsev Sh.Kh. This work is intended to train doctors in the specialty of oncology, as well as improve the skills of practicing specialists in the field of cancer treatment. The publication represents an up-to-date and comprehensive presentation of the authors on oncology as a science, its place in medicine, as well as the discussion of the prerequisites for modern methods of treating malignant tumors and the ways of their development.

«Печально зимой в Булуне»: А. В. Боголепов о повседневности заполярной Якутии в 1913–1916 гг.

Goals. The article introduces an unknown manuscript by A. Bogolepov titled ‘Bulun Village of Verkhoyansk District (Yakutsk Oblast)’ and compiled during an exile to the isolated Arctic locality of Yakutia. The narrative was written before the revolutionary events of 1917 and is of certain interest since it lacks any political bias, being characterized by restrained neutrality and sufficient depth of observations over everyday realias of the small northern settlement. A. Bogolepov’s text is attractive for the breadth of issues covered, its consonance with the social and cultural problems faced by the era and discussed by the advanced public. So, it seems reasonable enough to publish the identified document for further discussion in an interdisciplinary perspective. Materials and methods. The manuscript was discovered at the State Archive of Irkutsk Oblast (Coll. 293 ‘East Siberian Department of the Russian Geographical Society’). Furthermore, in search of additional data on the former’s author we investigated the State Archive of Altai Krai (Barnaul), State Archive of Krasnoyarsk Krai (Krasnoyarsk), National Archive of Sakha-Yakutia (Yakutsk), Archive of the Russian Academy of Sciences (Moscow) and its St. Petersburg Branch, and the efforts have yielded a variety of precious finds. The methodological basis rests on the principles characteristic of the field the researchers are actually engaged in — cryoanthropology. Results. The discovered materials open a previously unknown page in the Yakut pre-Soviet Northern studies. A. Bogolepov’s manuscript is rich in data on natural conditions, economic and cultural activities in the small remote settlement somewhat representing the polar world in miniature. The author highlights the interpenetration of Russian and Yakut cultures, mentions some specific local sociocultural phenomena resulting from the geographical location and climatic features. The long cold period — as is stressed by A. Bogolepov — shapes the entire life cycle of the settlement: it completely determines the functioning of the transport network, household and trade agendas, everyday life and leisure pursuits of locals. The isolation and scarcity of social activity, temporal and event-based ‘frozen’ everyday life of the northern society are emphasized. The manuscript is an important source for the research of cryoanthropology, and also contains valuable information on Yakutia’s socioeconomic and cultural history throughout the early decades of the twentieth century.

Analysis of the efficacy and prognostic factors of allogeneic hematopoietic stem cell transplantation in patients with myelodysplastic syndrome with blastomycosis and survival comparison of different subtypes after the WHO 2022 reclassification

Objective: To evaluate the efficacy and prognostic factors of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with myelodysplastic syndrome accompanied by myelodysplasia (MDS-EB) and to compare the prognosis of different subtypes of patients classified by World Health Organization (WHO) 2022. Methods: A total of 282 patients with MDS-EB who underwent allo-HSCT at the Hematology Hospital of the Chinese Academy of Medical Sciences from October 2006 to December 2022 were included in the study. The WHO 2022 diagnostic criteria reclassified MDS into three groups: myelodysplastic tumors with type 1/2 of primitive cell proliferation (MDS-IB1/IB2, 222 cases), MDS with fibrosis (MDS-f, 41 cases), and MDS with biallelic TP53 mutation (MDS-biTP53, 19 cases). Their clinical data were retrospectively analyzed. Results: ① The median age of 282 patients was 46 (15-66) years, with 191 males and 91 females. Among them, 118 (42% ) and 164 (58% ) had MDS-EB1 and MDS-EB2, respectively. ②Among the 282 patients, 256 (90.8% ) achieved hematopoietic reconstruction after transplantation, with 11 (3.9% ) and 15 (5.3% ) having primary and secondary implantation dysfunctions, respectively. The cumulative incidence of acute graft-versus-host disease (GVHD) 100 days post-transplantation was (42.6±3.0) %, and the cumulative incidence of grade Ⅱ-Ⅳ acute GVHD was (33.0±2.8) %. The cumulative incidence of chronic GVHD 1 year post-transplantation was (31.0±2.9) %. Post-transplantation, 128 (45.4% ), 63 (22.3% ), 35 (12.4% ), and 17 patients (6.0% ) developed cytomegalovirus infection, bacteremia, pulmonary fungal infection, and Epstein-Barr virus infection. ③The median follow-up time post-transplantation was 22.1 (19.2-24.7) months, and the 3-year overall survival (OS) and disease-free survival (DFS) rates were 71.9% (95% CI 65.7% -78.6% ) and 63.6% (95% CI 57.2% -70.7% ), respectively. The 3-year non-recurrent mortality rate (NRM) is 17.9% (95% CI 13.9% -22.9% ), and the 3-year cumulative recurrence rate (CIR) is 9.8% (95% CI 6.7% -13.7% ). The independent risk factors affecting OS post-transplantation include monocyte karyotype (P=0.004, HR=3.26, 95% CI 1.46-7.29), hematopoietic stem cell transplantation complication index (HCI-CI) of ≥3 points (P<0.001, HR=2.86, 95% CI 1.72-4.75), and the occurrence of acute gastrointestinal GVHD of grade Ⅱ-Ⅳ (P<0.001, HR=5.94, 95% CI 3.50-10.10). ④The 3-year OS and DFS rates in the MDS-IB1/IB2 group post-transplantation were better than those in the MDS-biTP53 group [OS: 72.0% (95% CI 63.4% -80.7% ) vs 46.4% (95% CI 26.9% -80.1% ), P=0.020; DFS: 67.4% (95% CI 60.3% -75.3% ) vs 39.7% (95% CI 22.3% -70.8% ), P=0.015]. The 3-year CIR was lower than that of the MDS-biTP53 group [7.3% (95% CI 4.3% -11.4% ) vs 26.9% (95% CI 9.2% -48.5% ), P=0.004]. The NRM at 3 years post-transplantation in the MDS-IB1/IB2, MDS-f, and MDS-biTP53 groups were 16.7% (95% CI 12.1% -22.1% ), 20.5% (95% CI 9.4% -34.6% ), and 26.3% (95% CI 9.1% -47.5% ), respectively (P=0.690) . Conclusion: Allo-HSCT is an effective treatment for MDS-EB, with monomeric karyotype, HCI-CI, and grade Ⅱ-Ⅳ acute gastrointestinal GVHD as independent risk factors affecting the patient's OS. The WHO 2022 classification helps distinguish the efficacy of allo-HSCT in different subgroups of patients. Allo-HSCT can improve the poor prognosis of patients with MDS-f, but those with MDS-biTP53 have a higher risk of recurrence post-transplantation.

Correction coil and magnet feeder lessons learned

China has contributed to the manufacturing of the Error Field Correction Coils (CC) and the Magnet Feeders for ITER (International Thermonuclear Experimental Reactor). The manufacturing projects have been carried by ASIPP (Institute of Plasma Physics Chinese Academy of Sciences). In this paper, the lessons learned from these two manufacturing projects will be described with special focus on some key manufacturing processes. These experiences gained from the work carried so far in CC and magnet feeder manufacturing and testing are very valuable not only for the remaining manufacturing tasks of these two projects, but also for similar systems of other Tokamak fusion device.

Assessing the Evidence Base for School-Based Promotion and Prevention Interventions: Introduction to the Series.

Schools are an important component in the mental health system of care for youths. Teachers and other school staff have unique opportunities to promote emotional wellness and prevent mental health conditions. Although numerous programs are available, identifying evidence-based and effective options is a significant challenge. This introduction lays out the rationale and methodology of the Assessing the Evidence Base (AEB) Series, a collection of systematic reviews of school-based mental health promotion and prevention approaches recommended by the National Academies of Sciences, Engineering, and Medicine for students in kindergarten through grade 12. Authors of the current AEB Series used the rating criteria derived from the 2014 AEB Series, which provided systematic reviews of a wide spectrum of interventions for mental and substance use disorders. Like its predecessor, the current series upholds a high standard of scientific rigor while ensuring that the information is easily accessible to various stakeholders in education, behavioral health, and communities. It describes the universal features included in each systematic review, such as a rating of the level of evidence for interventions, intervention program components, identification of interventions that have yielded positive outcomes for students from underserved populations, and a review of cost data. The AEB systematic reviews will serve as an important tool for decision makers involved in managing limited resources for various programs in school-based mental health services by synthesizing large bodies of research for use by leaders in education and behavioral health.

“Everyone Can Master the Correct Use of Mathematical Methods”: The Relevance of L.D. Kudryavtsev’s Ideas for Modern Mathematics Education

The article discusses the ideas, devoted to mathematics education, of Lev D. Kudryavtsev, corresponding member of the USSR Academy of Sciences, professor-mathematician. These ideas are based on more than half a century of practical experience of L. D. Kudryavtsev at the Moscow Institute of Physics and Technology – he presented his vision of the problems of educating students, the unity of mathematics, as well as methods of teaching it in the collection of articles. The thoughts and ideas of L. D. Kudryavtsev are still relevant today, in the age of digital transformation of the education system and of the entire life of society.

A Bibliometric Analysis of the Outdoor Thermal Environment Based on CiteSpace

The outdoor thermal environment (OTE) is closely related to sustainable urban development and human living, and related research has attracted widespread attention. The research hotspots and research frontiers were obtained using CiteSpace to analyze 4473 relevant studies published in English from the Web of Science (WOS) core database from 1998 to 2023. The results show that (1) Hong Kong Polytechnic University, National University of Singapore, Chinese Academy of Sciences, Tsinghua University, and Harbin Institute of Technology are important in OTE research. China has the largest number of publications in the field of OTE, but the United States has the greatest centrality and significant influence. (2) The focus of OTE keyword clustering research is divided into four main categories: thermal environment perception, the thermal environment index, thermal environment quality, and thermal environment optimization. (3) The frontiers of OTE research have changed from focusing on environmental quality, thermal perception, numerical simulation, urban space, and thermal adaptation to thermal mitigation, energy conservation, energy consumption, and optimization strategies. Visualization research in the field of OTE helps to provide references for the direction of future research on improving climate change, human thermal comfort, urban planning, and pre-planning.

METHODOLOGICAL CHALLENGES OF RESEARCH ON PROBLEMS OF SOCIALIZATION OF PERSONALITY IN THE CONTEXT OF THE RUSSIAN-UKRAINIAN WAR

Relevance. Despite being traditional and important for psychological and sociological sciences, the problem of socialization remains vulnerable to criticism due to the apologetic nature of its theoretical and methodological foundations. Within the limits of traditional approaches, the success or failure of the process and results of socialization are considered, in fact, in the interests of the officially recognized state ideology with a corresponding set of ideals and values. This may be acceptable for countries with established democratic regimes, but it generates many insidious questions in the conditions of confrontation between societies with different civilizational reference points. This is the situation we have today in the context of the russian-Ukrainian war. Methodology is based on the discursive approach, which does not deprive the researcher of the right to evaluate socialization from his or her ideological position, but excludes the extrapolation of these evaluations to the psychological (procedural) content of socialization. According to this approach, the discourses in which socialization takes place, rather than its psychological content itself, can be evaluated from a moral or ideological perspective. This allows for a more realistic evaluation of the socialization experience of different societies, different countries and peoples, for comparison, etc. People’s participation in the reproduction and development of discourse can be traced by the results of monitoring all-Ukrainian representative surveys conducted by the Institute of Social and Political Psychology of the National Academy of Sciences of Ukraine since the early 1990s. Results. During this time, the territorial-state discourse has gradually formed as a leading one in Ukrainian society. Its value imperative is the attitude of state independence. About 80% of citizens believe that although there are many obstacles in the way of our statehood, Ukraine should still be independent.

„The Black Box" by George Stocking

Three years before his death on July 13, 2013, George William Stocking, widely regarded as the discipline's "greatest historian of anthropology," wrote an autobiography and memoir entitled Glimpses into My Own Black Box: An Exercise in Self-Deconstruction(2010). The book was published as part of the famous History of Anthropology (HOA) edition, which Stocking started at The University of Wisconsin Press (1983) and edited for two decades. This paper is based on the understanding of the American theoretician of autobiography, William Howarth, who posited that autobiography in literary (and scientific) writing is akin to what self-portrait is in painting. In the introductory chapter of the work, biographical data are presented that bring the character and work of George William Stocking closer to the domestic, Serbian readership (his second marriage to the sociologist Carol Bowman; their stays in Yugoslavia). This is followed by a description of the two main phases in Stocking's life and work: the formative period in his intellectual development and the mature age, known as the "Chicago years", spent in the Departments of History and Anthropology. Bearing in mind the main elements of the autobiographical strategy – character/self-portrait, technique (rhetoric and writing style), and the theme presented by the author's work-text – Stocking's book thematizes the life story, professional and scientific history (history of anthropology) from the position of both a witness and the one of the creators of written histories of the discipline and biographies of its practitioners and theorists. His writing technique is characterized by self-reflection and scientifically argued discussions on anthropological, historical and political topics and problems. Despite the significant influence his writing and edition of the HOA has had in anthropology, social sciences and humanities, the autobiographer problematizes his relationship to the two disciplines that shaped him as a scientist, highlighting his ambivalent position within them. In spite of the objective indicators of professional success, such as prestigious recognitions, awards, a secure position at the University and the Academy of Arts and Sciences, and a comfortable civic life filled with trips, conferences and guest appearances at important American and British scientific research institutions, the subjective experience of "double non-belonging" or rather, liminality, is the leitmotif that colors his self-portrait and the meaning of the text as a whole. The main features of the work, such as its discursive style of narration and description, striving for objectivity and honesty (self-disclosure and „self-deconstruction“), anxiety regarding one's own place, role and importance in science, as well as, at times, a resigned or elegiac tone, especially at the end of the book, i.e. towards the end of his life, provide the basis to include Stocking's strategy in a hybrid type with elements of those two categories that Howarth calls "rhetorical" and "poetic" confession.