Research Academy Research Articles

Phenytoin Induced Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome: A Case Report

Published on:June 2022 Journal of Young Pharmacists, 2022; 14(2):253-255 Case Report | doi:10.5530/jyp.2022.14.48 Authors: Meghna Gosi1, Sujit Kumar Sah1,*, Arya Merin1, Siddartha Ningappa Dhurappanavar1, Ashwini Padubidri Kombettu2 1Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, SS Nagar, Mysuru, Karnataka, INDIA. 2Department of Dermatology, JSS Hospital, JSS Academy of Higher Education and Research, SS Nagar, Mysuru, Karnataka, INDIA. Abstract: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is an idiosyncratic and rare drug reaction that can be severe and life‑threatening if untreated. We present a 34 year old male patient, who developed DRESS syndrome after receiving phenytoin for 8 weeks and presented with rapidly progressive erythematous rash on trunk, face and upper extremities, fever and facial swelling. Abnormal laboratory findings, RegiSCAR score, and Naranjo’s probability scale revealed the association between phenytoin and DRESS syndrome. Phenytoin was withdrawn and adequately managed with systemic corticosteroids, antihistamine, and other symptomatic treatments. DRESS syndrome can be cured completely by early detection and removal of culprit drug along with other adequate symptomatic treatments.Key words: DRESS syndrome, Naranjo probability, Hypersensitivity reaction, Scale, Phenytoin, RegiSCAR score.

An Insight on Patient’s Knowledge, Attitude and Practice of their Psychiatric Illness: An Assessment on Pre and Post Mental Health Education

Published on:June 2022 Journal of Young Pharmacists, 2022; 14(2):207-213 Original Article | doi:10.5530/jyp.2022.14.39 Authors: Samaksha Pasupalate Bheemaraju1, Kishor Manohar Rao2, Madhan Ramesh1,* 1Department of Pharmacy Practice, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, INDIA. 2Department of Psychiatry, JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, Karnataka, INDIA. Abstract: Background: Patient information leaflets (PILs) are as decisive as pharmacotherapy interventions in managing all psychiatric disorders. PILs are globally accepted patient counselling aids to improve their knowledge about the disease and to encourage medication-taking behaviour. To design, validate the PILs and assess the pre and post-Mental Health Education (MHE) of patients with Depression, Bipolar affective disorder, Alcohol dependence Syndrome and Schizophrenia. Materials and Methods: This study was conducted in two phases. In Phase-I, the PILs were developed and validated with the help of healthcare and non-healthcare professionals. Quality information was assessed by using the Ensuring Quality Information for Patients (EQIP) questionnaire and PMOSE/IKIRSCH formula was used to measure the readability and complexity. In phase-II, the impact of pre and post MHE on knowledge, attitude and practice of PILs was evaluated. Chi-square test was performed to assess the difference between pre and post-MHE. Results: A total of 106 participants validated the PILs. The compatibility was low and proficiency level was level-2, which signifies understanding capability in people having high school as educational background. Majority (>90%) of the validator’s response to the PILs were found to be acceptable. This study resulted in a significant improvement (p=0.001) on pre and post- MHE with respect to Knowledge Attitude and Practice questionnaire of Depression, Bipolar affective disorder, Alcohol dependence Syndrome and Schizophrenia respectively. Conclusion: It was found that PILs provided better understanding about the psychiatric disorder and encouraged to adhere to the medications.Keywords: Mental health education,KAP, Patient information leaflet, Psychiatric illness, Ambulatory patients.

0794 Understanding Barriers and Communication Behaviors Impacting Referral to Sleep Surgery: Qualitative Patient Perspectives

Abstract Introduction Shared decision-making is a process when patients, families, and clinicians work together to make optimal, personalized medical choices in the face of more than one reasonable treatment option. These interactions can influence the joint decision and may have lasting impressions for future healthcare encounters. Considering the American Academy of Sleep Medicine’s recent clinical practice guideline on the referral of adults with obstructive sleep apnea (OSA) for surgical consultation, we aimed to understand patient experiences, in terms of barriers and communication behaviors in the referral process to sleep surgery consultation. Methods We performed a qualitative study consisting of in-depth semi-structured virtual interviews with adult patients (aged ≥18 years) with OSA (apnea-hypopnea index ≥5 events per hour of sleep, scored by AASM-accredited standards) and who were recommended for sleep surgery at a tertiary Sleep Surgery Clinic. Open ended questions focused on patient experiences during healthcare encounters from diagnosis, trials with noninvasive management options and ultimate referral to sleep surgery. The interviews were audio-recorded, transcribed, and analyzed using content analysis to identify themes. Results Ten adult patients with OSA who were evaluated in sleep surgery clinic were approached and enrolled from March through April 2021. Barriers to sleep surgery clinic included delays in OSA diagnosis due to limited OSA awareness and perceived inconvenience of sleep study, providers faulting patient for persistent sleep symptoms, patient-reported lack of urgency by providers in troubleshooting noninvasive management options, scheduling delays and waitlists, and cost. Patients were open to trialing noninvasive treatment options, though opportunities for reevaluation and shared decision-making may address unmet needs, as inadequate improvements led to frustration after multiple encounters. Patients appreciated providers who were empathetic and provided information sharing, in terms of transparent and understandable explanations. Conclusion This study focused on experiences of patients with OSA and barriers faced to reach sleep surgery consultation. Improved communication structure to discuss unresolved concerns and remaining management options, as well as vetted resources, would set the foundation for effective shared decision-making and timely referral for sleep surgery consultation. Support (If Any) Academy of Otolaryngology Head and Neck Surgery Resident Research Centralized Otolaryngology Research Efforts (CORE). NIH T32 DC000018.

Research Academy Chengdu, University of International Business and Economics

Research Academy Chengdu, University of International Business and Economics

Pelaksanaan pemberian bantuan sosial kepada korban bencana kebakaran di Desa Naru Kecamatan Sape Kabupaten Bima NTB

On October 10, 2021, a catastrophic fire hit Naru Village, Sape District, Bima Regency, West Nusa Tenggara. Hundreds of people had to be evacuated because their houses were razed to the ground. The fire devoured 63 houses consisting of 71 families (241 people lost their homes), the survivorswere still forced to live in refugee camps built by the army. This disaster occurred in the midst of the Covid-19 pandemic which has had a negative impact on economic conditions and public health. In order to ease the burden on the victims, the Surya Mandiri Midwifery Academy Bima initiated a community service program consisting of a fundraising campaign, raising funds from the community and collaborating with the Surya Mandiri Bima Midwifery Academy of Research and Community Service. This program is expected to raise awareness about the importance of providing assistance to disaster victims.

P137 Supporting patients to get the best from their osteoporosis treatment; what works for whom, why and in what circumstance: a rapid realist review

Abstract Background/Aims For two decades, clinicians and academics have been writing about the problem of poor adherence in osteoporosis, while people with osteoporosis have identified a need for more follow up and information about medicines. We aimed to understand what works in supporting people with osteoporosis to get the best from their medicines, and specifically, to understand what mechanisms enable components of interventions to support osteoporosis medication optimisation and the underlying contextual conditions that enabled these mechanisms. Methods We conducted a Rapid Realist Review. The scope was informed by a workshop of the Effectiveness Working Group of the Royal Osteoporosis Society Osteoporosis and Bone Research Academy and the approach informed by background syntheses of qualitative literature and the Perceptions and Practicalities Approach as an underpinning conceptual framework. A primary search identified observational or interventional studies which aimed to improve medicines adherence or optimisation. Included studies were assessed for quality and data extracted relating to context, mechanism and outcomes. A supplementary second search was conducted to gain additional insight on included key papers and emerging mechanisms. Extracted data were interrogated by authors independently for patterns of context-mechanism-outcome configurations and further discussed in weekly team meetings. Recommendations for research and clinical practice were co-developed with clinical and lay stakeholders. Results 41 papers were included. We identified five contextual timepoints for the person with osteoporosis (identifying a problem; starting medicine; continuing medicine) and the practitioner and healthcare system (making a diagnosis and giving a treatment recommendation; reviewing medicine) and mechanisms relating to patient informed decision making, treatment burden, supporting routinisation and memory, supporting clinical decision making, targeting support, and approaches which were integrated and sustainable. Interventions which support patient informed decision making, improve patient knowledge and understanding, have potential to influence long-term commitment to treatment, although few studies explicitly addressed patients’ perceptions of illness and treatment as recommended in NICE guidelines. During treatment, targeting additional consultations to those most in need may be a cost and clinically effective approach to enable this. Supporting primary care clinician decision making and integration of primary and secondary care services also appears to be important, in improving rates of treatment initiation and adherence. Supporting patients’ ability to adhere (eg by lowering treatment burden and issuing reminders) may be helpful to address practical difficulties but there is little evidence to support the use of reminders alone. Conclusion For medicines optimisation for people with osteoporosis, we suggest a need for more patient-centred interventions to address patients’ perceptions of illness and treatment, and reduce treatment burden. Specialist services should consider the extent to which they integrate with, and support primary care clinical decision-making, in order to impact long-term clinical outcomes. Specific research recommendations have been co-developed, to address these knowledge gaps. Disclosure Z. Paskins: Grants/research support; NIHR, Versus Arthritis, Royal Osteoporosis Society. O. Babatunde: None. A. Sturrock: None. L. Toh: None. R. Horne: None. I. Maidment: None.

186 Community Research Academy: Lifting Community Voices for Equity in Health Research and Innovation

OBJECTIVES/GOALS: To engage community partners in full spectrum of translational sciences participants will: 1. Develop community-based research projects. 2. Evaluate pilot awards submitted to the Community Advisory Board for funding. 3. Actively participate in the research cores at the CTSC METHODS/STUDY POPULATION: The Academy workshop curriculum supports an in-depth examination of the translational research process, introduction to the CTSC Community Advisory Board; as well as to community based participatory research; grant evaluation process, and the need for active community involvement in various cores, and clinical trials. Workshops presented by tenured professionals and community leaders with multi-media out of class assignments. Scheduled sessions were 1 hour, and 15 minutes. Exams given post class session with a mean score of 22.8/30 for session 1 and a mean score of 23.80/30 for session 2. RESULTS/ANTICIPATED RESULTS: The Community Research Academy (CRA) has thus far held for two sessions. Of the 45 enrollees, 20 completed the entire program. Of those, ten have joined the CAB board; and three have actively participated in the pilot award review process. One of the CRA graduates will be publishing her photo novella assignment in Health Affairs. One person changed careers,: and several people have taken all the classes for a second time. Many participants originally came from our faith-based connections. Now word of mouth is expanding the program. DISCUSSION/SIGNIFICANCE: Community engagement ensures that the fresh voices of diverse populations are involved in translational science. Their input ultimately leads to creating novel clinical innovations; such community-driven ingenuity which addresses the deeply felt needs of those communities.

Comparison of Stop and Chop and Phaco Chop Nucleotomy Techniques in Phacoemulsification

Department of Ophthalmology, Sri Devaraj Urs Medical College, Sri Devaraj Urs Academy of Higher Education and Research, Tamaka, Kolar

One-year results following PASCAL-based or MitraClip-based mitral valve transcatheter edge-to-edge repair.

AimsMitral valve transcatheter edge‐to‐edge repair (TEER) has been established as a suitable alternative to mitral valve surgery in patients with severe mitral regurgitation (MR) and high surgical risk. The PASCAL system represents a novel device, potentially augmenting the toolkit for TEER. The aim of this study was to assess and compare short and 1 year safety and efficacy of the PASCAL and MitraClip systems for TEER.Methods and resultsProcedural, short, and 1 year outcomes of a 1:2 propensity‐matched cohort including 41 PASCAL and 82 MitraClip cases were investigated. Matching was based on clinical, laboratory, echocardiographic, and functional characteristics. The primary endpoints assessed were procedural success [as defined by the Mitral Valve Academy Research Consortium (MVARC)], residual MR, functional class, and a composite endpoint comprising death, heart failure hospitalization, and mitral valve re‐intervention. We found for the PASCAL and the matched MitraClip cohort no significant differences in MVARC defined technical (90.2% vs. 95.1%, P = 0.44), device (90.2% vs. 89.0%, P = 1.0), or procedural (87.8% vs. 80.5%, P = 0.45) success rates. Accordingly, the overall MR reduction and improvement in New York Heart Association (NYHA) class were comparable (1 year follow‐up: MR ≤ 2 95% vs. 93.6%, P = 1.0; NYHA ≤ 2 57.1% vs. 66.7%, P = 0.59). The composite outcome revealed no statistically significant difference between both devices (1 year follow‐up: 31.7% vs. 37.8%, P = 0.55). Interestingly, we found at both short and 1 year follow‐up a significantly higher rate of patients with none or trace MR in the PASCAL‐treated cohort (short follow‐up: 17.9% vs. 0%, P = 0.0081; 1 year follow‐up: 25% vs. 0%, P = 0.0016). Conversely, the rate of aborted device implantations due to an elevated transmitral gradient was higher in PASCAL interventions (9.8% vs. 1.2%, P = 0.04).ConclusionsTranscatheter edge‐to‐edge repair using the PASCAL or MitraClip device results in favourable and comparable outcomes regarding safety, efficacy, and clinical improvement after 1 year.

Silk Fibroin 3D Microparticle Scaffolds with Bioactive Ceramics: Chemical, Mechanical, and Osteoregenerative Characteristics

Adv. Eng. Mater. 2020, 22, 2000458 DOI: 10.1002/adem.202000458 In the initially published version of this article the affiliation for N. A. Parekh was wrong. The correct statement is as follows: N. A. Parekh Academy of Scientific and Innovative Research (AcSIR) Ghaziabad 201002, India The authors apologize for any inconvenience caused.

The past masters: the impact of the Evolution of Management Thought on history

PurposeThe purpose of this article is to commemorate the 50th anniversary of Evolution of Management Thought (EMT), a critically acclaimed text in management and organizational studies for its value in historicizing the practice of management.Design/methodology/approachThe authors asked Daniel Wren and Arthur Bedeian in their own words to their contribution. In addition, the authors offer commentary and critique of 16 leading management historians who share their reflections on the intellectual significance of Wren and Bedeian, and the punctuation of EMT as a canonical text in the field of management history.FindingsThe legacy of Wren and Bedeian can be felt across the academy of historical research on business and organizations. Their work has separately made significant contributions to management studies but together they have forged a fruitful partnership that has given rise to multiple generations of scholars and scholarship that continue to shape the field to this day.Originality/valueThe contribution of the authors in this article is to mark the significant milestone of EMT’s five-decade success by hearing from the authors themselves about their longstanding success as well as giving space to critique about the past, present and future of our collective historical scholarship shaped by Wren and Bedeian’s legacy.

Quantification of Microsomal Triglyceride Transfer Protein in Non Alcoholic Fatty Liver Disease Patients: A Cross-sectional Study

Introduction: Non Alcoholic Fatty Liver Disease (NAFLD) is one of the common liver disease characterised by fat accumulation in hepatocytes. NAFLD is a broad spectrum of simple steatosis, Non Alcoholic Steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma. Triglycerides (TG) are exported in the form of Very Low Density Lipoprotein (VLDL). VLDL are formed by incorporation of TG into apo-B by Microsomal Triglyceride transfer Protein (MTP). Therefore, MTP is a key protein for lipid transport. Estimation of MTP protein levels and its correlation with simple steatosis and steatohepatitis can be helpful in understanding its role in NAFLD progression. Aim: To estimate the serum levels of MTP in simple steatosis and steatohepatitis and also to check its correlation with TG and VLDL in NAFLD patients with and without co-morbidities. Materials and Methods: The present cross-sectional study was carried out in Department of Cell Biology and Molecular Genetics, Sri Devaraj Urs Academy of Higher Education and Research, Kolar, Karnataka, India, between November 2019 to January 2021. Study participants included 60 NAFLD subjects which were divided into simple steatosis (group 1, n=10) and steatohepatitis (group 2, n=50). These subjects were further subdivided into cases with co-morbidities and cases without co-morbidities. Serum levels of MTP, high sensitivity C Reactive Protein (hsCRP), Fasting Blood Sugar (FBS), liver enzymes, lipid profile were assessed. Statistical analysis was done by using unpaired Student’s t-test and Pearson’s correlation. Results: The mean age was 46.5 years in steatosis group and 48.85 years in steatohepatitis group. In steatosis group, there were 5 (50%) males and 5 (50%) females, whereas in steatohepatitis group 32 (64%) were females and 18 (36%) were males. The serum levels of MTP were significantly decreased in simple steatosis cases with co-morbidities as compared to cases without co-morbidities (p=0.006). A significant negative correlation was observed between MTP v/s TG and MTP v/s VLDL (r=-0.665, p=0.036) in simple steatosis cases with and without co-morbidities. Same trend was observed in steatohepatitis cases but the correlation was insignificant (r=-0.08, p=0.563). Conclusion: The serum levels of MTP decreases as the NAFLD progresses. A significant decrease in serum levels of MTP was also observed in cases with co-morbidities as compared to cases without co-morbidities. Serum levels of MTP showed negative correlation with TG and VLDL in simple steatosis cases.

Neurobehavioural and Neurochemical Changes in Arsenic Induced Cerebellar Toxicity in Male Sprague-Dawley Rats: An Experimental Study

Introduction: Sodium arsenite, an inorganic arsenic, is naturally present at high level (>50 μg/L) in ground water. Drinking ground water is the biggest threat to public health. Though, there are numerous reports on arsenic neurotoxicity, the arsenic effect on cerebellar neurotoxicity remains vague especially its chronic effect on its neurobehavioural and neurochemical alterations. Aim: To evaluate the neurobehavioural and neurochemical alterations caused by sodium arsenite in cerebellum of rats. Materials and Methods: This experimental study was conducted in the Central Animal House at Sri Devaraj Urs Academy of Higher Education and Research (SDUAHER) from November 2019 to February 2020 for a period of 90 days. Total 16 male spraguedawley rats were randomised into two equal groups. Group I: Control, received normal saline. Group II: Sodium arsenite, Doses of 50 Parts per Millions (PPM) for 90 days through oral gavage. Rats were subjected to Open Field Test (OFT) for locomotor and exploratory behaviour and Beam Walking Test (BWT) for motor coordination and balance. Following behavioural tests, rats were anaesthetised. Blood was drawn from a retro-orbital puncture. Brains were dissected and cerebellum was separated. Concentration of Malondialdehyde (MDA), Nitric Oxide (NO) and activity of Glutathione Peroxidase (GPx) were assessed spectrophotometrically in serum and cerebellum of rats. Mean±SD was used for normally distributed data and groups were compared using independent t-test, whereas for non normally distributed data, Median (25th-75th Percentile) was used and Mann-Whitney U-test was used to compare between two groups. Results: Arsenic-treated rats showed a significant increase in arsenic concentration in serum and cerebellum (5.5±1.6 ng/mL, 2.76±0.56 µg/g, respectively) compared to control (1.14±0.43 ng/mL, 0.65±0.29 µg/g, respectively). There was a significant decrease in locomotor and exploratory behaviour and impairment in motor coordination and balance in arsenic treated rats with a p-value <0.001 in comparison with control rats. The arsenic treated rats had significantly enhanced concentration of MDA and NO level and reduced activity of GPx in serum {16.84 (13.84-18.87), 33.79 (30.05-37.17) nmol/mL, and 6.89 (5.24- 8.5) mmoles of Reduced glutathione (GSH) oxidised/min/mL, respectively} compared to control {8.81 (8.36-9.48), 17.66 (15.33-21.29) nmol/mL, and 15.16 (12.77-16.59) mmoles of GSH oxidised/min/mL, respectively} and also found increased concentration of MDA and NO level and reduced activity of GPx in tissue {7.98 (7.14-8.92), 24.67 (21.4-28-22) nmol/mg of protein and 2.66 (1.19-3.86) mmoles of GSH oxidised/min/ mg protein, respectively} compared to control {3.02 (2.35-3.61), 13.93 (11.0-16.16) nmol/mg of protein and 7.63 (7.08-9.19) mmoles of GSH oxidised/min/mg protein, respectively}. Conclusion: The oral administration of sodium arsenite at the doses of 50 PPM for 90 days showed interesting alterations in neurobehavioural and neurochemical parameters related to cerebellum of rats.

INNOVATION DEVELOPMENT TRENDS IN INTERNATIONAL TOURISM: CONTENT AND BIBLIOMETRIC ANALYSIS

Objective. The objective of the article is to determine the current trends in the development of innovations in international tourism through the systematization of scientific and analytical literature and bibliometric analysis of the term "innovations in tourism". Methods. To achieve the goal, such research methods as literature review, content and quantitative bibliometric analysis are applied. The review of reports of international organizations is used to identify, collect and analyze data on modern trends in the development of innovations in international tourism, as well as their critical assessment. The content analysis is carried out to determine the components of the ecosystem of innovation and entrepreneurship in international tourism, to determine the innovative spheres (systems) of international tourism. Quantitative bibliometric analysis of scientific research on tourism innovations is carried out using data visualization tools of the Scopus (Elsevier) scientometric database. The time interval of the research is 22 years (2000-2022) according to the search query – “Tourism Innovation”. Results. Quantitative bibliometric analysis of documents for the search query “Tourism Innovation” for the period 2010-2022 in the scientometric database Scopus (Elsevier) is carried out using data visualization tools. The analysis is carried out according to three parameters: 1) the number of documents for the studied period; 2) the country of origin of the authors; 3) sectoral distribution of documents. The content of the most cited publications on the subject under investigation is analyzed. The provisions of the UNWTO Innovation, Education, Digital Transformation and Investment Strategy are elaborated, as well as the organization's practical activities for its implementation are studied. This makes it possible to single out the elements of the ecosystem of innovation and entrepreneurship in international tourism and to determine the functions and roles of ecosystem participants in the promotion and formation of innovation development trends. A critical analysis of the World Tourism Innovation and Development Report (2021-2022) published by the WTA and the Center for Tourism Research of the Chinese Academy of Social Sciences is processed and carried out that allows to conclude that the international tourism industry is on the path to recovery after COVID-19, based on six innovative areas: technological innovation, organizational innovation, product innovation, marketing innovation, institutional innovation, innovation in public services, each with specific ranges (capabilities) of use and emerging future trends.

Ten years of NIHR research training: who got an award? A retrospective cohort study

ObjectiveIn 2017, the National Institute for Health Research (NIHR) academy produced a strategic review of training, which reported the variation in application characteristics associated with success rates. It was noted...

Comparative analysis of metric and nonmetric aspects of foramen ovale of South Indian population with various regions globally and its approach through zygomatic route

Context: The foramen ovale is an obliquely placed, oval-shaped opening at the base of the skull in the greater wing of sphenoid. As the foramen transmits mandibular nerve, accessory meningeal artery, lesser petrosal nerve, and emissary veins, it knowledge of its variations is of supreme interest for surgeons. Aims: The aim of this study is to study the metric and nonmetric variations, of the foramen ovale of 40 dry adult human dried skulls. Settings and Design: The study was conducted in the dissection hall of Chettinad Academy of Research and Education. The study undertaken here is an observational study. Subjects and Methods: Human skulls were studied for location, patency, and various morphometric parameters bilaterally. The materials used were thin copper wire and a digital Vernier caliper of precision 0.01 mm. Statistical Analysis Used: Metric and nonmetric data were analyzed using the SPSS software. Results: The shape of foramen ovale was D shaped in most of the skulls (35%) followed by almond (21%), elongated oval (15%), and oval shape (11%). The presence of bony variations like spur was seen in 27.5% foramina, bony septa in 3.75%, and duplication in 21.25% foramina. The mean length and width of foramen ovale were 6.51 ± 1.24 mm and 3.66 ± 0.82 mm on right and 6.59 ± 1.33 mm and 3.75 ± 0.68 mm on the left, respectively. The mean area of foramen ovale was 19.08 ± 5.71 mm2 and 17.88 ± 5.85 mm2 on the right and the left, respectively. Conclusions: A sound knowledge on the morphometric variations of the foramen ovale helps the operating surgeon to avoid damage to the adjacent structures.

In Silico Based Bioinformatics Project During the COVID-19 Lockdown Period: An Alternative to Wet Lab Study

Abstract: In the weeks and months following the COVID outbreak, millions of students around the world are forced to switch over from traditional classroom learning to online learning. This unprecedented move had tremendous impact on the mode of learning project based courses. In particular, the field of biological science project based courses which require the students and faculty to work in the laboratory was impacted. 5 students and a faculty from Kalasalingam Academy of Research and Education used modern in silico tools, databases and software to study a biological problem related to antibiotic resistance in a bacterium called Enterobacter hormaechei subsp. hoffmannii OIPHN069. The students used freely available modern bioinformatics tools, databases and software such as NCBI, PROTPARAM, SOPMA, BLAST, CLUSTAL O M E G A , C D D , S W I S S - M O D E L s e r v e r, PATCHDOCK, PYMOL and CARD to carry out the research work. This method of doing the project has resulted in the phase I completion of the project course successfully. This methodology of usage of freely available tools, databases and software will help students worldwide to pursue the project based biology courses successfully. The significance of this study is the capability of students in completion of the biology project with the usage of only computer and internet and not to depend upon expensive wet lab study. Keywords: bioinformatics, in silico, project, computer, COVID

Mother's Integral Research Academy (MIRA): An Experiment in the Path of Transformative Quality Education

Mother's Integral Research Academy (MIRA): An Experiment in the Path of Transformative Quality Education

Digital health interventions for osteoporosis and post-fragility fracture care.

The growing burden from osteoporosis and fragility fractures highlights a need to improve osteoporosis management across healthcare systems. Sub-optimal management of osteoporosis is an area suitable for digital health interventions. While fracture liaison services (FLSs) are proven to greatly improve care for people with osteoporosis, such services might benefit from technologies that enhance automation. The term ‘Digital Health’ covers a variety of different tools including clinical decision support systems, electronic medical record tools, patient decision aids, patient apps, education tools, and novel artificial intelligence (AI) algorithms. Within the scope of this review are AI solutions that use algorithms within health system registries to target interventions. Clinician-targeted, patient-targeted, or system-targeted digital health interventions could be used to improve management and prevent fragility fractures. This review was commissioned by The Royal Osteoporosis Society and Bone Research Academy during the production of the 2020 Research Roadmap (https://theros.org.uk), with the intention of identifying gaps where targeted research funding could lead to improved patient health. We explore potential uses of digital technology in the general management of osteoporosis. Evidence suggests that digital technologies can support multidisciplinary teams to provide the best possible patient care based on current evidence and to support patients in self-management. However, robust randomised controlled studies are still needed to assess the effectiveness and cost-effectiveness of these technologies.

Preface

Great honor to have your supports to 2021 2nd International Conference on Modeling, Big Data Analytics and Simulation (MBDAS2021) and participation in this academic discussion mainly direct at modelling and simulation, simulation optimization, mathematical modeling, time series analysis, complex system modeling and simulation, big data analytics and metrics, big data quality and provenance control, intelligent computing, quantum computing and related areas.Due to the severe impact of Covid-19 and the travel restrictions, most of the authors can’t attend the conference physically. The organizing committee of MBDAS2021 actively response to the call for epidemic prevention and control and adopt virtual form to conduct this academic conference. MBDAS2021 is rescheduled to be held via Tencent Meeting, November 15, 2021. The conference staff send a formal email notification to all the authors and participants before the meeting, try our best to co-ordinate the meeting and possibly make sure that all the details are in place. We set test room for our experts and authors to have a test on their video, audio and screen sharing, etc. in order to avoid the network meeting uncertainty. This virtual mainly conduct in the forms of Keynote Speech, Oral presentations, Posters, Free discussion.It is great honor to invite five senior experts at here to share their keynote speeches to us. The first expert is Prof. Hui-Ming Wee from College of Electrical Engineering & Computer Science, Chung Yuan Christian University, Taiwan. The second expert is Prof. Christophe Claramunt from Naval Academy Research Institute & Arts & Métiers Institute of Technology, France. The third expert is Prof. Cheng Siong Chin from Newcastle University in Singapore, Singapore. The fourth expert is Prof. Stefano Zedda from Department of Business and Economics, University of Cagliari, Italy. The fifth expert is Prof. T. Velmurugan from Dwaraka Doss Goverdhan Doss Vaishnav College, India. They each make keynote speech for 50 minutes. And then the authors make 10mins oral presentations separately. All of them has contribute to a huge success of MBDAS2021 online conference.List of MBDAS2021 Organization Committees, Keynote Speakers, Technical Program Committees are avilable in this pdf.