The pioneering neuroscientist Bruce McEwen died on January 2, 2020 at the age of 81 following a brief illness. He was the Alfred E. Mirsky Professor and head of the Harold and Margaret Millikin Hatch Laboratory of Neuroendocrinology at The Rockefeller University. Born in Fort Collins, Colorado, Bruce grew up in Ann Arbor, Michigan, in an academic household; his father George was a Professor of English in the University of Michigan’s Engineering School. After graduating from Oberlin College, Bruce started graduate study at The Rockefeller University in 1959 and, after a postdoctorate in Sweden and a brief appointment at the University of Minnesota, served on The Rockefeller University’s faculty for 54 years until his death. He and his wife, the neuroimmunologist Karen Bulloch, collaborated in research and writing. Bruce remained active scientifically until the very end, with a paper published on the day of his death. His friend and coauthor on that paper, Huda Akil, and his brother, Craig McEwen, remember him. Bruce McEwen with Kobe and Buber on the coast of Maine. Image courtesy of Karen Bulloch McEwen (The Rockefeller University, New York, NY). Bruce has been a major force in neuroscience. He conducted groundbreaking research and inspired many of us to think differently about how we create science and how we use it for the greater good. The central theme of his research—the brain biology of stress—lends itself to every level of exploration, from the molecular and cellular, to the neural and behavioral, to the societal and global, and Bruce explored them all. In a seminal 1968 Nature paper (1), Bruce demonstrated for the first time the binding of glucocorticoids in the brain, specifically in the hippocampus. This was very surprising as the hippocampus had been thought to be primarily relevant to memory. That discovery led to the … [↵][1]1To whom correspondence may be addressed. Email: akil{at}umich.edu. [1]: #xref-corresp-1-1