Engaging in academic entrepreneurship enhances the potential for academics to generate scientific advancements, capitalize on findings, and create impactful contributions. This study examines how organizational support affects the relationship between entrepreneurial orientation and role integration on academic entrepreneurship performance at state universities in Indonesia. The population includes lecturers from eleven state universities with research results that can be commercialized. A purposive sampling method selected 330 respondents, focusing on science and social sciences lecturers with research at a technological readiness level of 6 to 9, demonstrating pilot stages and commercialization readiness based on national assessments. Data analysis used variance-based structural equation modeling and partial least squares (PLS). The findings indicate that entrepreneurial orientation significantly affects academic entrepreneurship performance (p < 0.05), and role integration significantly affects academic entrepreneurship performance (p < 0.05). Additionally, organizational support moderates the relationship between entrepreneurial orientation and academic entrepreneurship performance (p < 0.05), and organizational support moderates the relationship between role integration and academic entrepreneurship performance (p < 0.05). AcknowledgmentsWe would like to thank the lecturers at eleven state universities in Indonesia who contributed to this investigation. Their assistance allowed the authors to obtain data that met the study criteria and generate accurate and exact data analysis per the research goals.