Plasma Absorption Research Articles

Hollow-type plasma absorption probe for measurement of electron density in low pressure plasmas: A sheath thickness–insensitive technique

Abstract We propose a hollow plasma absorption probe (PAP) designed to improve the accuracy of electron density measurement in low-pressure plasmas regardless of the sheath thickness on the planar probe surface. This improvement is achieved through an artificial hollow space acting as a thick sheath to bring the resonant absorption frequency (f_PAP) from the hollow PAP close to the surface wave resonant frequency (f_SWR), insensitive to variation in sheath thickness. Electromagnetic simulations confirmed the efficiency of the hollow design, showing a minimized discrepancy between f_PAP and f_SWR even with the thin sheath. Optimal configurations with a coaxial core diameter of 5 mm and a hollow depth of 5 mm were found and tested in plasmas ranging from 〖5×10〗^8 cm^(-3) to 〖5×10〗^10 cm^(-3). Comparative experiments employing a planar cutoff probe to directly measure f_pe demonstrated good agreement between the electron density derived from the hollow PAP and from the planar cutoff probe, compared to that from a conventional planar PAP.

Effect of external magnetic field inhomogeneity on the nonlinear absorption of intense laser pulse in inhomogeneous warm plasma

This paper studies the propagation of an intense laser pulse and the collisional absorption in an inhomogeneous warm plasma by taking into account the external magnetic field inhomogeneity and the ponderomotive force. The calculations are carried out and compared for different magnetic field strengths and their various configurations. For this purpose, using the hydrodynamic equations, the electron density and hence the effective dielectric permittivity of the magneto-active warm plasma are derived and the nonlinear wave equation is solved through the numerical method of Runge–Kutta. The results show that increasing the strength of the external magnetic field causes an increase in the absorption coefficient and the linear magnetic field has a higher influence on the absorption coefficient with respect to the wiggler and constant magnetic fields. Moreover, when the electron temperature increases, the amplitude of the laser field and the absorption coefficient are increased and the spatial damping rate of the laser pulse takes a peak in the plasma. The results also indicate that increasing the energy of the laser pulse causes a decrease in the nonlinear absorption, and the laser energy spatial damping is significantly decreased in contrast to the growth of the amplitude of the laser field. A qualitative comparison of the results indicates that if a linear magnetic field is applied in the same direction of the laser propagation, the collisional absorption rate will be larger with respect to the other magnetic fields. Moreover, the difference in the influence of the mentioned magnetic fields on the collisional absorption increases with increasing the electron temperature and normalized cyclotron frequency and decreases with increasing laser intensity.

Electron Bernstein wave aided Hermite cosh-Gaussian laser beam absorption in plasma with static magnetic field

Electron Bernstein wave aided Hermite cosh-Gaussian laser beam absorption in plasma with static magnetic field

Improved Rapid Equilibrium Dialysis-Mass Spectrometry (RED-MS) Method for Measuring Small Molecule-Protein Complex Binding Affinities in Solution.

Rapid equilibrium dialysis (RED) is predominantly used for the characterization of drug absorption, distribution, metabolism, and excretion (ADME) properties in plasma and biological fluids. We describe herein improvements in the use of RED in conjunction with mass spectrometry (RED-MS) to enable robust binding affinity measurements of small molecules for recombinant proteins and complexes from a single dialysis data set. The affinities calculated from RED-MS correlated well with measurements by both surface plasmon resonance (SPR) and affinity selection mass spectrometry (AS-MS). The method was particularly useful for quantifying the binding of small molecules to large protein complexes that were not amendable by common biophysical characterization techniques. Compound pooling and integration with automated liquid handling increased assay throughput and enabled the analysis of hundreds of measurements per week. RED-MS offers a viable option for measuring compound binding in solution and may facilitate small molecule affinity optimization toward difficult-to-drug protein complexes.

Modified throughput ninhydrin method for the qualitative assessment of dietary protein absorption in pig plasma.

Protein maldigestion and malabsorption lead to malnutrition and are a feature of exocrine pancreatic insufficiency (EPI). Although it is the current standard, measurement of nitrogen in stool to assess protease activity is indirect. Up to 80% of hydrolysed proteins appear in blood in the form of peptides, so we developed a method to measure peptide-derived amino acids in plasma as a relevant measure of proteolysis, verified its accuracy, precision, and linearity, and validated it in a porcine model. We modified a ninhydrin method. Large proteins were eliminated from plasma with 10 kDa-cut-off centrifugal filters. Free and total amino acids were measured in permeate before and after its hydrolysis. Peptide-derived amino acids were quantified by subtracting free amino acids from total amino acids. We verified the method in vitro and by comparing results in healthy and EPI pigs. The accuracy of the analysis was close to 100%, with excellent precision (mean relative standard deviation for low, medium, and high amino acid levels = 0.88%) and with stringent linearity (r2 = 0.986, %RE = 5.23). The high-throughput ninhydrin method detected levels of peptide-derived amino acids in vivo with maximal changes seen approximately 2 hours postprandially in young pigs. The AUC and Cmax were significantly higher in healthy compared to EPI pigs (P = .0026 and P = .0037, respectively). The high-throughput ninhydrin method is a sensitive, reliable, and practical method for the estimation of dietary peptide-derived amino acids. This assay endpoint could serve as a direct biomarker of protein digestion and absorption.

Bright compact ultrabroadband source by orthogonal laser-sustained plasma

Laser-sustained plasma (LSP) source featuring high brightness and broadband spectral coverage is found to be powerful in various fields of scientific and industrial applications. However, the fundamental limit of low conversion efficiency constrains the system compactness and widespread applications of such broadband light sources. In this paper, we propose an innovative orthogonal LSP to break through the conversion efficiency limitation. Driven by the elevated conversion efficiency from absorbed laser power to ultraviolet (UV) emission, a compact broadband source (250–1650 nm) with UV spectral radiance exceeding 210 mW/(mm2⋅sr⋅nm)\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$${mW}/({{mm}}^{2}\\,\\cdot\\, {sr}\\,\\cdot\\, {nm})$$\\end{document} is achieved with >100 W pump laser. With the plot of a two-dimensional refractive index model, we report an important conceptual advance that the orthogonal design eliminates the influence of the negative lensing effect on laser power density. Experimental results unambiguously demonstrate that we achieve a bright compact UV-VIS-NIR source with negligible thermal loss and the highest conversion efficiency to our knowledge. Significant enhancement of 4 dB contrast-to-noise ratio (CNR) in spectral single-pixel imaging has been demonstrated using the proposed ultrabroadband source. By establishing the quantitative link between pumping optics design and plasma absorption, this work presents a compact broadband source that combines superior conversion efficiency and unprecedented brightness, which is essential to high-speed inspection and spectroscopy applications.

Average bit-error rate analysis of an inter-satellite optical communication system under the effect of perturbations.

The benefits of higher data transmission rates, extensive communication frequency bandwidths, reduced power consumption, and enhanced anti-interference capabilities make inter-satellite optical communication (ISOC) a promising technology for the future. However, during orbital motion, satellites are subjected to external perturbation forces, which affect the performance of the ISOC system. This paper establishes an ISOC system consisting of two co-orbital satellites orbiting the Earth under the influence of perturbations. For what we believe to be the first time, the probability density function (PDF) of the radial displacement caused by perturbations is introduced. Subsequently, a PDF detailing the inter-satellite pointing errors, while accounting for the effects of perturbations and platform vibrations, is presented. Moreover, pointing errors and plasma absorption are considered in the PDF derivation process for the end-to-end ISOC system. The closed-form expression for the average bit-error rate (BER) of the proposed system is derived using Meijer's G function. Simulation results are provided to validate the theoretical expression. The findings show that key parameters associated with perturbations significantly influence the PDF of inter-satellite pointing errors and the average BER of the proposed ISOC system.

Interaction between the core and the edge for ion cyclotron resonance heating based on artificial absorption plasma model

In numerical simulations of the ion cyclotron range of frequencies (ICRF) wave heating scheme, core solvers usually focus on wave propagation and absorption mechanisms within the core plasma region. However, the realistic scrape-off layer (SOL) plasma is usually simplified, making it difficult to have deeper understanding of wave propagation and absorption within the SOL. In this work, we employ a cold plasma assumption and an artificial absorption mechanism based on the approach of reference (Zhang et al 2022 Nucl. Fusion 62 076032), to study wave propagation and absorption in the realistic SOL plasma of the EAST. During the exponential decay of the total coupled power with respect to the toroidal mode numbers, several fluctuations are observed in the case of low collisional frequencies. The fluctuations may be caused by the cavity modes associated with specific toroidal mode numbers. Due to the presence of cut-off densities, the edge power losses and the total coupled power exhibit different behaviors before and after the cut-off layer is “open”. Furthermore, the simulation results obtained from the kinetic model in reference (Zhang et al 2022 Nucl. Fusion 62 076032) is discussed. This suggests that both the core-edge combined model and the artificial mechanism are capable of simulating wave propagation and absorption.

Carbon nanotubes induced the enhancement of Raman scattering performance in silver thin films

In this study, Ag/CNTs composite films with excellent properties of surface-enhanced Raman scattering (SERS) were fabricated. The SEM images show that the template effect and stress concentration area of carbon nanotubes (CNTs) can not only induce the growth of Ag nanoparticles, but effectively increase the number and intensity of "hot spots". Due to the introduction of CNTs, the plasma absorption peak of Ag/CNTs composite films was observed to be enhanced in the range of visible light. The as-deposited Ag/CNTs samples showed high sensitivity and good temporal stability in the detection of MB probe molecules, with the detection limit of 10−9 mol/L and the enhancement factor of 6 × 105, respectively. In addition, the enhancement contribution of the substrate was further investigated by Finite difference time domain simulation, and the simulation results were consistent with those of the experimental results, which indicate that the synthesized Ag/CNTs thin films have potential application prospect in SERS technology.

Multiaxial filament winding of biopolymer microfibers with a collagen resin binder for orthobiologic medical device biomanufacturing

Multiaxial filament winding is an additive manufacturing technique used extensively in large industrial and military manufacturing yet unexplored for biomedical uses. This study adapts filament winding to biomanufacture scalable, strong, three-dimensional microfiber (3DMF) medical device implants for potential orthopedic applications. Polylactide microfiber filaments were wound through a collagen ‘resin’ bath to create organized, stable orthobiologic implants, which are sized for common ligament (e.g. anterior cruciate ligament) and tendon (e.g. rotator cuff) injuries and can be manufactured at industrial scale using a small footprint, economical, high-output benchtop system. Ethylene oxide or electron beam sterilized 3DMF samples were analyzed by scanning electron microscopy (SEM), underwent ASTM1635-based degradation testing, tensile testing, ISO 10993-based cytocompatibility, and biocompatibility testing, quantified for human platelet-rich plasma (PRP) absorption kinetics, and examined for adhesion of bioceramics and lyophilized collagen after coating. 3DMF implants had consistent fiber size and high alignment by SEM. Negligible mass and strength loss were noted over 4 months in culture. 3DMF implants initially exceeded 1000 N hydrated tensile strength and retained over 70% strength through 4 months in culture, significantly stronger than conventionally produced implants made by fused fiber deposition 3D printing. 3DMF implants absorbed over 3x their weight in PRP within 5 min, were cytocompatible and biocompatible in vivo in rabbits, and could readily bind tricalcium phosphate and calcium carbonate coatings discretely on implant ends for further orthobiologic material functionalization. The additive manufacturing process further enabled engineering implants with suture-shuttling passages for facile arthroscopic surgical delivery. This accessible, facile, economical, and rapid microfiber manufacturing platform presents a new method to engineer high-strength, flexible, low-cost, bio-based implants for orthopedic and extended medical device applications.

SYstem for Microwave PLasma Experiments (SYMPLE) for Investigation of Microwave Absorption in Over-Dense Plasma

SYstem for Microwave PLasma Experiments (SYMPLE) for Investigation of Microwave Absorption in Over-Dense Plasma

Oxytetracycline dose reduction in salmon farming: Assessing a micro encapsulated novel formulation in an in vivo model

Oxytetracycline (OTC) is used in Chilean salmonid farming for bacterial pathogens treatment, mainly orally administered. Oral bioavailability of OTC in salmonids is low, so a high percentage of the dose is excreted by fishes. To increase OTC oral absorption, Zn-alginate microparticles were developed by spray drying, with a yield of 59.09%. An in vivo study was performed using Oncorhynchus mykiss (Rainbow trout) to compare OTC Zn-alginate micro-particles oral absorption in plasma and muscle matrices. Seven sampling points for plasma and four for muscle were considered. OTC was quantified in both matrices by UPLC-MS/MS. Results indicated a statistically significant difference between plasma concentrations of the OTC microparticles with respect to the commercial OTC formulation, reflecting a higher absorption of the microencapsulated drug, reaching maximum concentration 4 h earlier than the commercial formulation. In addition, the microparticles showed a release of OTC that remained constant for 12 h. In muscle, OTC microparticles reached twice the maximum concentration than the commercial formulation at 8 h. In conclusion, OTC microparticles improve the oral absorption of the molecule, which could allow drug delivery optimization and dose reduction in bacterial pathogens treatment in salmon production, consequently, decrease contamination of the environment with OTC residues.

Turbulence-enhanced THz generation by multiple chaotically-distributed femtosecond filaments in air

Remote generation of electromagnetic waves in the terahertz (THz) by the volume of air medium gains increasing scientific interest due to the demand for this spectral range in solving various practical problems including those belonging to the nonlinear atmospheric optics. During self-focusing and filamentation of high-power femtosecond laser pulses in air, the source of THz radiation is the plasma of laser filaments. One of the main challenges of THz generation by a laser filament is increasing the value of optical energy conversion to the long-wavelength band. In this paper, we present the results of our studies on DC-biased THz generation during single-color filamentation in air of focused femtosecond Ti:Sapphire-laser pulses (800 nm, pulse energy up to 40 mJ). The distinctive feature of our study is that a femtosecond optical pulse propagates through a spatially-localized heated air layer containing randomly inhomogeneous refractive index perturbations, which mimics strong air turbulence. For the first time to our knowledge, we show, that the turbulent air layer formed at the beginning of the optical path allows increasing the yield of THz radiation up to 1.5 times due to the formation of multiple chaotically-arranged filaments resulting from random perturbations of the optical beam energy profile that reduces the subsequent THz (re)absorption in the filament plasma.

An expert panel on the adequacy of safety data and physiological roles of dietary bovine osteopontin in infancy.

Human milk, due to its unique composition, is the optimal standard for infant nutrition. Osteopontin (OPN) is abundant in human milk but not bovine milk. The addition of bovine milk osteopontin (bmOPN) to formula may replicate OPN's concentration and function in human milk. To address safety concerns, we convened an expert panel to assess the adequacy of safety data and physiological roles of dietary bmOPN in infancy. The exposure of breastfed infants to human milk OPN (hmOPN) has been well-characterized and decreases markedly over the first 6 months of lactation. Dietary bmOPN is resistant to gastric and intestinal digestion, absorbed and cleared from circulation within 8-24 h, and represents a small portion (<5%) of total plasma OPN. Label studies on hmOPN suggest that after 3 h, intact or digested OPN is absorbed into carcass (62%), small intestine (23%), stomach (5%), and small intestinal perfusate (4%), with <2% each found in the cecum, liver, brain, heart, and spleen. Although the results are heterogenous with respect to bmOPN's physiologic impact, no adverse impacts have been reported across growth, gastrointestinal, immune, or brain-related outcomes. Recombinant bovine and human forms demonstrate similar absorption in plasma as bmOPN, as well as effects on cognition and immunity. The panel recommended prioritization of trials measuring a comprehensive set of clinically relevant outcomes on immunity and cognition to confirm the safety of bmOPN over that of further research on its absorption, distribution, metabolism, and excretion. This review offers expert consensus on the adequacy of data available to assess the safety of bmOPN for use in infant formula, aiding evidence-based decisions on the formulation of infant formula.

Electrostatic wave assisted super-gaussian laser beam absorption in collisional plasma embedded with static magnetic field

Electrostatic wave assisted super-gaussian laser beam absorption in collisional plasma embedded with static magnetic field

Measurement of 2p-3d absorption in a hot molybdenum plasma

We present measurements of the 2p-3d transition opacity of a hot molybdenum–scandium sample with nearly half-vacant molybdenum M-shell configurations. A plastic-tamped molybdenum–scandium foil sample is radiatively heated to high temperature in a compact D-shaped gold Hohlraum driven by ∼30 kJ laser energy at the SG-100 kJ laser facility. X rays transmitted through the molybdenum and scandium plasmas are diffracted by crystals and finally recorded by image plates. The electron temperatures in the sample in particular spatial and temporal zones are determined by the K-shell absorption of the scandium plasma. A combination of the IRAD3D view factor code and the MULTI hydrodynamic code is used to simulate the spatial distribution and temporal behavior of the sample temperature and density. The inferred temperature in the molybdenum plasma reaches a average of 138 ± 11 eV. A detailed configuration-accounting calculation of the n = 2–3 transition absorption of the molybdenum plasma is compared with experimental measurements and quite good agreement is found. The present measurements provide an opportunity to test opacity models for complicated M-shell configurations.

Plasma wave propagation conditions analysis using the warm multi-fluid model

Although an accurate description of wave propagation and absorption in plasmas requires complicated full-wave solutions or kinetic simulations, local dispersion analysis can still be helpful to capture the main physics of wave properties. Plasma wave propagation conditions or accessibility informs whether a wave can propagate to a region, which usually depends on the wave frequency, wave vector, the local plasma density, and magnetic field. We demonstrate a warm multi-fluid eigenvalue model and a matrix approach to rapidly calculate plasma wave accessibility diagrams, where thermal effects are also included via an isotropic pressure term. All cold plasma waves, from high-frequency electron cyclotron waves, intermediate-frequency lower hybrid waves, to low-frequency ion cyclotron waves, are presented. By comparing with the kinetic model, it is interesting to find that the warm multi-fluid model, though incapable of reproducing the Bernstein modes, can provide a quick way to determine whether thermal effects are important.

Predicting Drug-Drug Interactions Involving Rifampicin Using a Semi-mechanistic Hepatic Compartmental Model.

To develop a semi-mechanistic hepatic compartmental model to predict the effects of rifampicin, a known inducer of CYP3A4 enzyme, on the metabolism of five drugs, in the hope of informing dose adjustments to avoid potential drug-drug interactions. A search was conducted for DDI studies on the interactions between rifampicin and CYP substrates that met specific criteria, including the availability of plasma concentration-time profiles, physical and absorption parameters, pharmacokinetic parameters, and the use of healthy subjects at therapeutic doses. The semi-mechanistic model utilized in this study was improved from its predecessors, incorporating additional parameters such as population data (specifically for Chinese and Caucasians), virtual individuals, gender distribution, age range, dosing time points, and coefficients of variation. Optimal parameters were identified for our semi-mechanistic model by validating it with clinical data, resulting in a maximum difference of approximately 2-fold between simulated and observed values. PK data of healthy subjects were used for most CYP3A4 substrates, except for gilteritinib, which showed no significant difference between patients and healthy subjects. Dose adjustment of gilteritinib co-administered with rifampicin required a 3-fold increase of the initial dose, while other substrates were further tuned to achieve the desired drug exposure. The pharmacokinetic parameters AUCR and CmaxR of drugs metabolized by CYP3A4, when influenced by Rifampicin, were predicted by the semi-mechanistic model to be approximately twice the empirically observed values, which suggests that the semi-mechanistic model was able to reasonably simulate the effect. The doses of four drugs adjusted via simulation to reduce rifampicin interaction.

Polyethyleneimine-immobilized CoCl2 nanoparticles: Synthesis, characterization, application as a new efficient and reusable nanocomposite catalyst for one-step transesterification reaction

Polyethyleneimine-supported cobalt (II) chloride as a novel polymeric nanocomposite acidic catalyst for the one-stage transesterification reaction of ethyl acetate with various alcohols is reported. The catalyst was characterized by Fourier transform infrared spectroscopy, X-ray powder diffraction, transmission electron microscopy, scanning electron microscopy, dynamic light scattering technique, and thermal gravimetric analysis. Furthermore, inductively coupled plasma and atomic absorption spectroscopy were used to determine the quantity of Cobalt nanoparticles in the catalyst. By adding the catalyst (0.10 g, 0.20 mol%) and n-hexane/chloroform (5.0 cm3) as solvent under reflux conditions, the studies demonstrated successful transesterification reactions with excellent yields (80–98%) and short reaction times (0.50–1.30 h) using various substrates on the scale of 1.0 mmol. Seven consecutive reactions could be performed on the catalyst without significantly decreasing its activity. The most noteworthy aspects of this process are its low cost, safety, and environmental friendliness due to the catalyst’s non-toxicity, straightforward operation, and effective outcomes.

Cost-effective layered double hydroxides/conductive polymer nanocomposites for electrochemical detection of wastewater pollutants

There is an urgent need to develop multifunctional cost-effective nanomaterials and nanocomposites that can be used in numerous applications while showing high efficiency and cheaper implementation compared to conventional techniques and/or materials. In this work, zinc/iron layered double hydroxide (LDH) and polyaniline (PANI) were synthesized as a model LDH/conductive polymer nanocomposite, which is a promising family of cheap multifunctional materials. This electrochemical properties of this nanocomposite was investigated for detection of heavy metal (HM) ions in water streams, using lead as a model HM. In the present work, zinc/iron LDH and PANI was assigned as carbon paste electrode modifier. The composite was fully characterized using various characterization techniques including X-ray diffraction (XRD), scanning electron microscope (SEM), and Fourier transform InfraRed (FTIR). The electrochemical redox reactions of lead (II) ions at the modified electrode interface were investigated using cyclic voltammetry (CV), differential pulse voltammetry (DPV), Accordingly, a linear relation of Pb2+ ions was achieved in the concentration range 1–80 µM with limit of detection (LOD) was 167.8 nM and limit of quantification (LOQ) was 559.4 nM. Furthermore, the cost of using such material for lead removal using a typical adsorption study was compared to using conventional inductively coupled plasma (ICP) or atomic absorption spectrometry (AAS) equipment for tracking HM removal during the adsorption process. Cost analysis revealed that the final overall cost of the modified carbon paste electrode is estimated as 1.25 USD. This cost represents less than 0.1% of the total cost required to conduct the same adsorption study using a typical ICP or AAS equipment. This composite can pave the road towards portable measurements for onsite detection of wastewater pollutants using cheap disposable-electrodes as compared to massive expensive off site equipment such as ICP and AAS.