Absorption Of Micronutrients Research Articles

Impact on quality of life caused by vitamin D deficiency in bariatric patients: a literature review

Introduction: Bariatric surgery is a procedure performed to control obesity and its associated morbidities. Surgeries with malabsorptive and mixed techniques cause a deficit in the absorption of micronutrients, including vitamin D. Objective: The objective of this literature review was to investigate studies that verified the impact of vitamin D deficiency on the preand postoperative quality of life of individuals undergoing bariatric surgery. Methods: The search strategy was carried out in the virtual databases PubMed, Scielo, LILACS, Scopus, Web of Science, Embase, and the Virtual Health Library, in addition to gray literature such as Google Scholar, OpenGrey, Ibict/BDTD (Brazilian digital library of theses and dissertations) and ProQuest using the Medical Subject Headings (MeSH) and Health Sciences Descriptors (DeCS) descriptors with Boolean logical operators (AND, OR and NOT. The studies considered potentially eligible were those that presented in the same article the levels of vitamin D in the pre and postoperative period of the individuals, as well as the effect generated on their quality of life from where the data collection and analysis of the main outcomes found were made. Results: The online search resulted in 197 studies located in the virtual bibliographic databases and 115 in the gray literature. After removing the duplicates, 235 articles remained that were read by title and abstract, and 12 articles were chosen for reading the full text, leaving 7 that met the inclusion criteria. In most of the included studies, vitamin D deficiency was higher preoperatively than postoperatively in bariatric individuals. Better levels of 25(OH)D were correlated with reduced body weight, decreased BMI, and improved glycemic profile. Conclusion: Combating obesity remains an important issue in Public Health, with bariatric surgery being a safe way to reduce overweight since vitamin D levels are lower in the postoperative period of bariatric individuals, however, it is suggested to choose the appropriate technique to maintain ideal vitamin indices.

Lyoprotectants for Lactobacillus brevis B144 and their capability to maintain the expression of surface layer protein

Lactobacillus brevis as a probiotic has been reported to facilitate micronutrient absorption such as minerals (zinc, calcium, magnesium) into the intestine through the surface layer protein (Slp). Negatively charged-Slp from the bacteria that adheres on the intestinal mucosa binds to the positively charged-minerals, e.g., calcium, zinc, iron, magnesium and potassium via an ionic interaction. In this study, several sugar-based lyoprotectants (glucose, galactose, and lactose) and skim milk were implemented in the L. brevis B144 InaCC freeze drying. The dried L. brevis B144 InaCC was kept in the refrigerator up to three months and monthly tested for the cell viability. The dried L. brevis B144 InaCC was re-culture and then its Slp was isolated using 8 M guanidine hydrochloride. In general, combinations of skim milk and the sugar-based lyoprotectant provided higher protection than the skim milk alone. Meanwhile, without any lyoprotectant, the L. brevis B144 InaCC lose its ability to grow. In regards to maintain the capability of the Slp expression, the L. brevis B144 InaCC which was protected with the combination of 20% skim milk and 10% galactose showed the highest protein expression level among the other lyoprotectants.

Fecal Myeloperoxidase Levels in Pregnant Women and Risk Factors to Low Birth Weight in A Makassar Slum Settlement: A Sub-Study of The Indonesian Birth Cohort Study

Purpose: Intestinal inflammation can affect the absorption of micronutrients from the bowel, which can lead to maternal malnutrition and adverse pregnancy outcomes. This study aimed to measure fecal myeloperoxidase (MPO) levels as a biomarker of inflammation in pregnant women and explore risk factors for low birth weight in the slum area of the Tallo District, Makassar City. Method: This study used a retrospective cohort study design with a purposive sample of 172 pregnant women. Stool specimens were collected and tested using a human myeloperoxidase enzyme-linked immunosorbent assay kit. Data were collected through interviews using the Kobo Toolbox. Result: The median fecal myeloperoxidase level in pregnant women was 24.2 ng/ml. The correlation with low birth weight was insignificant (r = -0.0037, p = 0.96). Based on bivariate analysis, the risk factors significantly associated with low birth weight were first parity (RR = 2.8 (95% CI: 1.3-6.4), and preterm birth (RR = 3.9 (95% CI: 1.9-8.3), while the multivariate analysis showed that the most significant risk variable for low birth weight was preterm birth (ARR = 4.9 (95% CI: 2.6-9.1). Conclusion: This study found that gestational age at birth was significantly associated with low birth weight in infants. There was no significant association with fecal myeloperoxidase level in the pregnant mother.

Effects of Sleeve Gastrectomy on Thyrotropin Hormone (TSH) and Vitamin D Levels among Obese Patients in Nineveh Governorate

Objectives: This study aimed to assess the impact of bariatric surgery on thyrotropin (TSH), calcium, vitamin D, and lipid profile levels three months post-surgery among patients who underwent the procedure. We also investigated the prevalence of micronutrient deficiencies during the initial three months before and after surgery, along with monitoring the effects of gastric sleeve surgery on body mass index (BMI) reduction.
 Methods: The study involved the analysis of data from a cohort comprising 30 patients of both genders who had undergone sleeve gastrectomy due to obesity, with a preoperative BMI of 40 kg/m² or higher. The research spanned from July 2022 to January 2023, with patients undergoing gastric sleeve surgery at Al-Zahrawi Hospital in Nineveh. These patients were subsequently followed up for a period of three months post-surgery.
 Results: The study findings demonstrated a significant reduction in TSH, vitamin D, calcium, total cholesterol (TC), triglycerides (TG), low-density lipoproteins (LDLc), very low-density lipoproteins (VLDLc) cholesterol, and BMI in patients who underwent gastric sleeve surgery within the three-month follow-up period, in comparison to their pre-surgery levels. Additionally, there was a noteworthy increase in high-density lipoproteins of cholesterol (HDLc) in the serum of these patients post-operation. The results further indicated positive correlations between TSH, vitamin D, cholesterol, LDLc, and the Atherogenic Index. Likewise, positive correlations were observed between vitamin D, TSH, total cholesterol, triglycerides (TG), and LDLc.
 Conclusion: Post-surgery deficiencies in vitamin D, calcium, and TSH levels are attributed to inadequate intake and absorption of micronutrients, highlighting the importance of nutritional supplementation. Sleeve gastrectomy offers a promising avenue for sustained BMI reduction in the long term.

Nutritional Support for Liver Diseases.

The liver is a key organ that is responsible for the metabolism of proteins, fats, and carbohydrates and the absorption and storage of micronutrients. Unfortunately, the prevalence of chronic liver diseases at various stages of advancement in the world population is significant. Due to the physiological function of the liver, its dysfunction can lead to malnutrition and sarcopenia, and the patient's nutritional status is an important prognostic factor. This review discusses key issues related to the diet therapy of patients with chronic liver diseases, as well as those qualified for liver transplantation and in the postoperative period.

Review of Dietary Soy’s Effects on Human Health and Its Constituents

Soy protein is a natural component of soybeans and is known to provide a variety of health advantages. It offers advantages and is a different source of protein for folks who don’t consume meat. The purpose of this review is to familiarize readers with the value of soy beans in both the food and medical industries. Legumes, which also include peanuts, chickpeas, various beans, and pulses, contain soybeans. Soybeans are incredibly flexible because they can be made into meal, flour, and oil. Soy protein has roughly 25g of approved health claims per day, which is known to lower total cholesterol and LDL. Soy has a variety of powerful ingredients, including fiber, isoflavones, phytic acid, saponins, and trypsin inhibitors. Soy has been seen to have several harmful consequences. Numerous studies have raised concerns about the potential negative effects of it because of the allergens present and the antinutrient agents they contain, which prevent micronutrient absorption. It may also result in hypothyroidism because it lacks some essential amino acids, making it a source of incomplete protein. Additionally, it might have hormonal effects on infants later in life.

Evaluation of the Effect of the Vigor of Soybean Seeds Treated with Micronutrients Using X-ray Fluorescence Spectroscopy and Hyperspectral Imaging

Seed treatment with micronutrients is a crucial strategy for providing early seedling supply during development, and is commonly employed in soybean cultivation. However, responses to micronutrient treatment may vary based on seed vigor levels. Therefore, this study aimed to assess the potential of hyperspectral imaging combined with preprocessing and machine learning, compared to X-ray fluorescence spectroscopy, in evaluating the dynamics of micronutrient uptake during the germination of soybean seeds with varying levels of vigor. Two seed lots with differing levels of vigor were utilized for the analysis. The absorption of micronutrients by the seeds was evaluated using X-ray fluorescence spectroscopy (XRF), microprobe X-ray fluorescence spectroscopy (μ-XRF) and hyperspectral imaging (HSI) in two regions of interest (cotyledons and the embryonic axis). Artificial neural network (ANN), decision tree (DT) and partial least squares–discriminant analysis (PLS-DA) classification models, along with the Savitzky–Golay (SG), standard normal variation (SNV) and multiplicative scatter correction (MSC) methods, were employed to determine seed vigor based on the impact of micronutrient treatment. XRF identified higher concentrations of micronutrients in the treated seeds, with zinc being the predominant element. μ-XRF analysis revealed that a significant proportion of the micronutrients remained adhered to the hilum and seed coat, irrespective of seed vigor. The PLS-DA classification model using spectral data exhibited higher accuracy in classifying soybean seeds with high and low vigor, regardless of seed treatment with micronutrients and the analyzed region.

Review of Dietary Soy's Effects on Human Health and Its Constituents

Soy protein is a natural component of soybeans and is known to provide a variety of health advantages. It offers advantages and is a different source of protein for folks who don’t consume meat. The purpose of this review is to familiarize readers with the value of soy beans in both the food and medical industries. Legumes, which also include peanuts, chickpeas, various beans and pulses, contain soybeans. Soybeans are incredibly flexible because they can be made into meal, flour and oil. Soy protein has roughly 25 g of approved health claims per day, which is known to lower total cholesterol and LDL. Soy has a variety of powerful ingredients, including fiber, isoflavones, phytic acid, saponins and trypsin inhibitors. Soy has been seen to have several harmful consequences. Numerous studies have raised concerns about the potential negative effects of it because of the allergens present and the antinutrient agents they contain, which prevent micronutrient absorption. It may also result in hypothyroidism because it lacks some essential amino acids, making it a source of incomplete protein. Additionally, it might have hormonal effects on infants later in life.

Pine Bark as a Potential Source of Condensed Tannin: Analysis through Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and Energy Dispersive X-ray (EDX)

This study aimed to evaluate the tannin content in the bark of five pine species from a forest harvesting area of the Ixtlán de Juárez community, Oaxaca, México. The species studied were Pinus patula, Pinus ayacahuite, Pinus rudis, Pinus douglasiana, Pinus pseudostrobus. The bark samples were subjected to a drying, grinding, and sieving process. These compounds were extracted using two methods: by constant reflux with ethanol for three hours or in a water bath with distilled water for two hours. The percentage of total extract, Stiasny number, and condensed tannins were quantified. The quantitative number of condensed tannins present in the bark for each of the five species studied ranged from 0.65% to 5.14% for the ethanolic extracts and 0.14% to 1.46% for the aqueous extracts. Analysis by Fourier transform infrared spectroscopy (FTIR) identified polyphenolic compounds and functional groups characteristic of tannins. Analysis by scanning electron microscopy (SEM) and X-ray dispersive spectroscopy (EDX) provided the elemental analysis and chemical composition of the tannin extracts, respectively, finding trace elements of silver, cadmium, phosphorus, iodine, and sulfur, which are minerals present in the soil, meaning that through processes of micronutrient absorption, these can interact with the tannins or polyphenols in the barks of the tree species being studied. The results indicate that the bark of P. patula and P. ayacahuite have a higher concentration of condensed tannins, 5.14% and 4.71%, respectively, in the ethanol extraction, and may be susceptible to exploitation due to the amount of bark generated in forestry activities.

Seed molybdenum concentration and yield of cowpea as influenced by foliar application of sodium molybdate and soil application of simple superphosphate

Cowpea is a legume rich in amino acids and proteins, cultivated worldwide. However, the crop has low grain yield, which is attributed to inadequate management of fertilizers. Therefore research was conducted to evaluate the effect of phosphorus applied via soil and molybdenum via leaves on productivity and seed molybdenum concentration of cowpea. The experiment was carried out in a greenhouse, in a 4 x 4 factorial scheme: Molybdenum doses (Mo) (0, 100, 250 or 500 g ha−1 of sodium molybdate) and doses of phosphorus (0, 50, 100 or 150 kg P2O5 ha−1), in a randomized block design, with four replications. Mo applications were split in the flowering and maturation phase to ensure the best absorption of micronutrients. At the end of maturation, pod length, pod mass, number of grains per pod, 100 grain mass, grain yield, seed molybdenum and concentration were measured. There was a significant interaction between the doses of phosphorus and molybdenum for pod length and number of grains per pod with increments in production and optimal dose estimated at 374.15 g ha−1 of molybdenum and 123.43 kg ha−1 of phosphorus. Phosphate fertilization increases grain yield, pod dry weight and 100-grain weight by 41%, 51% and 20%, respectively, compared to the control treatment. The splitting of molybic fertilization is an effective way to increase the nutrient concentration in the seed, which leads to a reduction in the cost of producing Mo-rich seeds, without causing toxic effects on plants.

Metabolic Biomarkers of Red Beetroot Juice Intake at Rest and after Physical Exercise.

Red beetroot is known to be a health-promoting food. However, little attention is placed on intestinal bioactive compound absorption. The aim of the study was to assess the urinary red beetroot juice (RBJ) intake biomarkers and possible differences in RBJ's micronutrient absorption at rest or after physical exercise. This is a three-armed, single-blind study, involving seven healthy volunteers which were randomly divided into three groups and alternatively assigned to three experimental sessions: RBJ intake at rest, RBJ intake with physical activity, and placebo intake with physical activity. For each session, urine samples were collected before and 120, 180, and 240 min after the intake of RBJ or placebo. The same sampling times were employed for the experimental session at rest. The RBJ metabolic composition was also characterized to identify the urinary biomarkers derived from the intake. 4-methylpyridine-2-carboxylic acid, dopamine-3-O-sulfate, glutamine, and 3-hydroxyisobutyrate were identified as RBJ intake biomarkers. Physical activity significantly increased only the dopamine-3-O-sulfate excretion 120 min after RBJ intake. Urinary dopamine-3-O-sulfate is related to RBJ dopamine content, while 4-methylpyridine-2-carboxylic acid is a betanin or betalamic acid catabolite. The different excretions of these metabolites following physical activity suggest a possible effect on the RBJ uptake depending on different transport processes through the mucosa, namely diffusion-mediated transport for dopamine and saturable transcellular transport for betalamic acid derivatives. These results open new perspectives in improving the absorption of natural bioactive molecules through physical activity.

Effect of Long-Term Proton Pump Inhibitor Use on Blood Vitamins and Minerals: A Primary Care Setting Study.

Long-term proton pump inhibitor (PPI) use is frequently encountered in primary care. Its effect on micronutrient absorption is known, as vitamin B12, calcium or vitamin D insufficiency may occur in such patients. We recruited patients using a PPI (pantoprazole) for >12 months. The control group was represented by subjects attending the general practitioner not taking any PPI in the last 12 months. We excluded subjects using nutritional supplements or with diseases interfering with micronutrient blood levels. All subjects underwent blood sampling with full blood count, iron, ferritin, vitamin D, calcium, sodium, potassium, phosphate, zinc and folate. We recruited 66 subjects: 30 in the PPI group and 36 in the control group. Long-term pantoprazole users had lower red blood cell count but similar hemoglobin. We did not find any significant difference in blood iron, ferritin, vitamin B12 and folate. Vitamin D deficit was observed more frequently in the PPI group (100%) than in controls (30%, p < 0.001), with blood levels lower in pantoprazole consumers. No differences in calcium, sodium and magnesium were observed. Pantoprazole users had lower phosphate levels than controls. Finally, a non-significant trend for zinc deficiency was found in PPI users. Our study confirms that chronic PPI users may encounter alterations in some micronutrients involved in bone mineral homeostasis. The effect on zinc levels deserves further investigation.

The Influence of Alcohol Consumption on Intestinal Nutrient Absorption: A Comprehensive Review.

Chronic alcohol use has been attributed to the development of malnutrition. This is in part due to the inhibitory effect of ethanol on the absorption of vital nutrients, including glucose, amino acids, lipids, water, vitamins, and minerals within the small intestine. Recent advances in research, along with new cutting-edge technologies, have advanced our understanding of the mechanism of ethanol's effect on intestinal nutrient absorption at the brush border membrane (BBM) of the small intestine. However, further studies are needed to delineate how ethanol consumption could have an impact on altered nutrient absorption under various disease conditions. Current research has elucidated the relationship of alcohol consumption on glucose, glutamine, vitamins B1 (thiamine), B2 (riboflavin), B9 (folate), C (ascorbic acid), selenium, iron, and zinc absorption within the small intestine. We conducted systematic computerized searches in PubMed using the following keywords: (1) "Alcohol effects on nutrient transport"; (2) "Alcohol mediated malabsorption of nutrients"; (3) "Alcohol effects on small intestinal nutrient transport"; and (4) "Alcohol mediated malabsorption of nutrients in small intestine". We included the relevant studies in this review. The main objective of this review is to marshal and analyze previously published research articles and discuss, in-depth, the understanding of ethanol's effect in modulating absorption of vital macro and micronutrients in health and disease conditions. This could ultimately provide great insights in the development of new therapeutic strategies to combat malnutrition associated with alcohol consumption.

Accumulation Capacity of Nickel and Zinc in Yerba Mate Cultivated in Soils with Contrasting Parent Materials.

Yerba mate (Ilex paraguariensis St. Hill.) has shown a relatively high capacity for micronutrient absorption and could be a candidate for biofortification and combating a lack of micronutrients. To further evaluate the accumulation capacity of Ni and Zn, yerba mate clonal seedlings were grown in containers under five rates of Ni or Zn (0, 0.5, 2, 10, and 40mgkg-1) with three soils originating from different parent material (basalt, rhyodacite, and sandstone). After 10months, plants were harvested, divided into component parts (leaves, branches, and roots), and evaluated for 12 elements. The use of Zn and Ni enhanced seedling growth under rhyodacite- and sandstone-derived soils at the first application rate. Application of Zn and Ni resulted in linear increases based on Mehlich I extractions; recovery of Ni was smaller than Zn. Root Ni concentration increased from approximately 20 to 1000mgkg-1 in rhyodacite-derived soil and from 20 to 400mgkg-1 in basalt- and sandstone-derived soils; respective increases in leaf tissue were ~ 3 to 15mgkg-1 and 3 to 10mgkg-1. For Zn, the maximum obtained values were close to 2000, 1000, and 800mgkg-1 for roots, leaves, and branches for rhyodacite-derived soils, respectively. Corresponding values for basalt- and sandstone-derived soils were 500, 400, and 300mgkg-1, respectively. Although yerba mate is not a hyperaccumulator, this species has a relatively high capacity to accumulate Ni and Zn in young tissue with the highest accumulation occurring in roots. Yerba mate showed high potential to be used in biofortification programs for Zn.

Enhancing micronutrient absorption through simultaneous fortification and phytic acid degradation.

Phytic acid (PA), an endogenous antinutrient in cereals and legumes, hinders mineral absorption by forming less bioavailable, stable PA-mineral complexes. For individual micronutrients, the PA-to-mineral molar ratio below the critical level ensures better bioavailability and is achieved by adding minerals or removing PA from cereals and pulses. Although several PA reduction and fortification strategies are available, the inability to completely eradicate or degrade PA using available techniques always subdues fortification's impact by hindering fortified micronutrient absorption. The bioavailability of micronutrients could be increased through simultaneous PA degradation and fortification. Following primary PA reduction of the raw material, the fortification step should also incorporate additional essential control stages to further PA inactivation, improving micronutrient absorption. In this review, the chemistry of PA interaction with metal ions, associated controlling parameters, and its impact on PA reduction during fortification is also evaluated, and further suggestions were made for the fortification's success.

Soil-transmitted helminths infection in pregnant women with anemia: a systematic review

Background: Soil-transmitted helminths are widespread and grow well in countries with tropical and subtropical climates. It is one of the predispositions to anemia for pregnant women during pregnancy. This condition has long-term adverse effects on mothers and their children, causing the need for serious discussion and treatment. Methods: This systematic review uses pre-existing research by collecting data from valid sources such as Pubmed, Google Scholar, and NCBI, using the inclusion and exclusion criteria that have been determined. Results: Based on the vast amount of research that has previously been conducted, it was found that there is a close relationship involving the soil-transmitted helminth infection and various types of worms infecting pregnant women, which causes anemia. Pregnant women need nutrients and increased blood volume during pregnancy. However, the infection interferes with the absorption of micronutrients in the gastrointestinal tract, resulting in impaired nutrient transport between the woman and her unborn child. Conclusion: Soil-transmitted helminth infection is a predisposing factor for anemia in pregnant women and has long-term adverse effects for both mother and child.

Genetic Aspects of Micronutrients Important for Inflammatory Bowel Disease.

Inflammatory bowel disease (IBD), Crohn’s disease (CD) and ulcerative colitis (UC) are complex diseases whose etiology is associated with genetic and environmental risk factors, among which are diet and gut microbiota. To date, IBD is an incurable disease and the main goal of its treatment is to reduce symptoms, prevent complications, and improve nutritional status and the quality of life. Patients with IBD usually suffer from nutritional deficiency with imbalances of specific micronutrient levels that contribute to the further deterioration of the disease. Therefore, along with medications usually used for IBD treatment, therapeutic strategies also include the supplementation of micronutrients such as vitamin D, folic acid, iron, and zinc. Micronutrient supplementation tailored according to individual needs could help patients to maintain overall health, avoid the triggering of symptoms, and support remission. The identification of individuals’ genotypes associated with the absorption, transport and metabolism of micronutrients can modify future clinical practice in IBD and enable individualized treatment. This review discusses the personalized approach with respect to genetics related to micronutrients commonly used in inflammatory bowel disease treatment.

Role of Micronutrients Foliar Nutrition in Vegetable Production: A Review

Vegetables are potential source of vitamins, minerals and dietary fibers. Proper plant nutrition is essential for successful production of vegetable crops. Integrated supply of micronutrients with macronutrients in adequate amount is an important approach to sustain the soil health and crop productivity besides maintaining the nutritional quality of vegetables. Micronutrients (Fe, Zn, B, Cu, Mn, Cl, Mo, Ni) are required by plants in small or trace quantities. They are essentially as important as macronutrients for better growth, yield and quality of plants. Deficiencies of micronutrients may induce several physiological disorders in plants and drastically affect growth, metabolism and reproductive phase in plants. The successful tasks carried out by various micronutrients include plant metabolism, nutritional management, chlorophyll production, reproductive growth, flower retention, fruit and seed development, etc. Judicious use of micronutrients is essential for vegetable cultivation to get maximum yield of high quality produce. Foliar nutrition is the one of the most efficient method of applying micronutrients. Spraying of nutrient solutions on the foliage of growing plants is known as foliar nutrition. Foliar nutrition of micronutrients at right concentration and at right growth stage is important for better results. Micronutrients applied by foliar application are more effective than those applied through soil application because soil application requires longer time for micronutrient absorption and assimilation. Foliar application of micronutrients plays a dynamic role and has been found beneficial for improving growth, yield and quality attributes of vegetable crops. In general, this review shows an immense potential of foliar nutrition of micronutrients in vegetable production. The main aim of this study is to know and explore the benefits of micronutrients through foliar nutrition for improving the production potential of different vegetable crops.

Alleviating hidden hunger: an infallible bridge to improved health and nutrition

Micronutrient deficiencies, a synonym of hidden hunger,1 is a form of malnutrition that occurs due to low intake and absorption of micronutrients and vitamins, such as iron, iodine, zinc, and vitamin A. Such deficiencies affect sustained good health, including physical and cognitive bodily functions. The impairments caused by micronutrient deficiencies might be initially unnoticeable but can advance to significant implications and sometimes irreparable losses. Children, adolescents, and pregnant women are at a greater risk, as the demands during these stages of life are higher.

Бактеріальні ендофіти пшениці та їхня роль у покращенні мікроелементного складу зерна

In sustainable agriculture, there is a tendency for an increased use of microbiological preparations, especially plant growth promoting bacteria (PGPB), that can supplement the phenotypic plasticity and adaptability of plants, stimulate their growth and development, increase resistance to stress. The endophytic PGPB could be a promising element of technologies for the improvement of mineral nutrition and promotion of growth and yield of wheat (Triticum spp.). They are transferred to the plant by a horizontal, from the environment (rhizosphere, phyllosphere), or a vertical, from the seeds (from generation to generation), way. The growth-promoting effect of endophytes is mediated by the synthesis and secretion of phytohormones and secondary metabolites as well as their ability to absorb N2, suppress the development of bacterial and/or fungal phytopathogens; improve mineral nutrition. The review elucidates current data on the presence of bacterial endophytes in various organs of wheat plants and their characterization as potential PGPB. Data on the most common genera of bacterial endophytes of wheat (Bacillus, Micrococcus, Staphylococcus, Pseudomonas, Pantoea, Kosakonia, etc.) are presented, and their influence on plants is described, in particular, the effect on the absorption of micronutrients important for plants and humans such as iron (Fe) and zinc (Zn), resistance to stress factors and growth. The varietal differences in the wheat endophytic microbiome are noted. An increased micronutrient absorption and assimilation assisted by the bacterial endophytes are associated with the changes in endogenous auxins and ethylene, the release of organic acids, siderophores, indirect activation of metal transporters, etc. The mechanisms underlying plant growth stimulation are complex due to interactions between a microorganism and the whole plant microbiome and their changes during the plant ontogenesis. The analysis of the published data confirms the need for further studies of the species composition and mechanisms of interaction of endophytic PGPB to develop new strategies for improving mineral nutrition of wheat and trace element biofortification of grain. It is a feasible and promising technology of the future to overcome the problems of hidden hunger and provide quality food products to the world population with available resources and a reduced negative impact on the environment.