Alanine Absorption Research Articles

The Absorption of Glycine and Alanine and Their Peptides by Lactobacillus casei

The Absorption of Glycine and Alanine and Their Peptides by Lactobacillus casei

Influence of Cortisone on Rate of Absorption and Formation of Liver Glycogen by Alanine.

Summary1. The rates of absorption of D(-), L (+), and DL-alanine from the gastrointestinal tract of white rats were found to be 85, 110, and 112 mg/100 g of body weight/ hour, respectively. All 3 were approximately equal in their ability to form liver glycogen, maximum values were obtained 6 hours after administration. Cortisone administration had no effect upon the rate of alanine absorption. 2. When DL-alanine was fed to rats at the same time as 5 or 2.5 mg of cortisone was injected no increase in liver glycogen was obtained over the sum of the amounts formed when each of the substances was given separately. When DL-alanine and cortisone was administered so that the peak of glycogen formation for each compound was reached at the same time then there was a significant increase in glycogen formation over the sum of the independent actions of the 2 compounds.

The Absorption of Glycine and d, 1-Alanine.

The rate of intestinal absorption of glycine and alanine has been studied with the method described in a previous publication.1 Groups of 10 rats were killed 1, 2 and 3 hours after feeding a 15 per cent solution of the amino acid by stomach tube. The average absorption coefficients (i. e., the amount absorbed per 100 gm. of body weight per hr.) for glycine were as follows: 1 hr., 0.048 gm.; 2 hours, 0.050 gm.; 3 hours, 0.046 gm. The values obtained for d, 1-alanine were: 1 hour, 0.044 gm.; 2 hours, 0.044 gm.; 3 hours, 0.047 gm. If these values are plotted against time, it will be found that they fall on a straight line. Since the rate of absorption of different hexoses and pentoses was also found to follow a straight line,1 the same considerations that were made with respect to the sugars, apply to the amino acids. The rate of absorption is, within wide limits, independent of the absolute amount and the concentration of amino acid present in the intestine. If this were not the case, the rate of absorption...