Objective. – To determine the in-hospital prognosis and late outcome of cardiogenic shock complicating acute myocardial infarction treated by early (<24 hours) percutaneous coronary intervention (PCI). Methods. – Retrospective monocentric study of a consecutive cohort of patients undergoing early PCI (< 24 heures) for cardiogenic shock complicating acute myocardial infarction from 1994 to 2004. Results. – The cohort included 175 patients (mean age =65 ±14 years, 68% male). A successful PCI was obtained in 69% of patients. The in-hospital mortality was 43%. Independent risk factors associated with an increased mortality were: absence of TIMI three flow ( P <0.0001), absence of smoking ( P <0.009) and the need for mechanical ventilation ( P <0.002). Nor stent use or anti GP IIb/IIIa infusions were predictors of a better outcome. At hospital discharge, mean left ventricular ejection fraction (LVEF) was 38 ±12%. Kaplan-Meier estimate of survival was 63% for in-hospital survivors (maximum follow-up =9 years). Independent predictors of an impaired long-term outcome were: a LVEF <0.3 ( P <0,028) and 3-vessel disease on coronary angiography ( P <0,004). Conclusion. – In-hospital mortality of patients suffering cardiogenic shock complicating acute myocardial infarction and treated by PCI remains high despite PCI improvement. The long-term survival appears, however, to be better than that of patients with coronary artery disease and low LVEF.