Hand dysfunction has been reported to be present in myelomeningocele children, yet the type, extent, and cause of such dysfunction have remained unclear. This study was undertaken to discover whether motor dysfunction was present in the upper limbs of children with the diagnosis spina bifida myelomeningocele with lesions below the spinal level T4. Tests of manual muscle strength and grip strength indicated that spina bifida children have inferior motor function when compared with a control group of individually matched normal children. When the spina bifida group was divided on the basis of presence or absence of hydrocephalus it was apparent that the hydrocephalic children had poorer muscle power. The non-hydrocephalic children, however, did not have normal motor function. Thus the level of the lesion, and the presence of hydrocephalus, could not be identified as the prime cause of hand dysfunction discovered in the sample studied.