ABO Blood Group Research Articles

Cold autoantibody interference in pretransfusion testing and its resolution: a case report

We report a case of cold autoantibody detected in a 69-year-old gentleman diagnosed with chronic lymphocytic leukemia and cold autoimmune hemolytic anaemia. Pretransfusion testing showed panagglutination in ABO grouping, antibody screening and identification, with positive direct antiglobulin test (DAT) and positive control cells. A cold autoantibody was suspected, however, the test using a prewarm method and washed RBC with warm saline failed to resolve it. Further tests using DTT-treated cells resolved the grouping as AB RhD positive and DAT as positive with anti-C3d only (control negative). Cold autoadsorption was done and repeated antibody screening using cold-autoadsorped plasma was negative, excluding the presence of alloantibody. The cold-agglutinin titer was >1028 having a wide thermal range. Crossmatching using cold autoadsorped plasma with the AB-positive donor blood was compatible and the patient was transfused safely. For such cold autoantibody cases, an extensive immunohematological workup is required to exclude underlying alloantibody for transfusion safety and efficacy. Bangladesh Journal of Medical Science Vol. 23 No. 04 October’24 Page : 1238-1242

An epidemiologic blood group-1

Aim Polycythemia, also known as erythrocytosis, is an abnormal accumulation of red blood cells, packed cell volume, and hemoglobin that can lead to debilitating symptoms and significant mortality. Polycythemia is estimated to affect 22 people per 100,000. The epidemiology of polycythemia in Iraq is limited. This study aimed to investigate the prevalence and incidence of polycythemia in Babylon City, Iraq, from 2018 to 2022 and to identify populations at high risk. Materials and Methods Due to the relative scarcity of epidemiological studies on polycythemia in Iraq, this study was conducted to identify some epidemiological features of polycythemia patients in Babylon province. A study conducted at the Babylon Central Blood Bank included 220 polycythemia patients. This data was obtained by reviewing all patient documents and the registration book from 2018 to 2022. Participants completed a questionnaire with information about their Sex, age, place of residence, smoking habits, and blood group. Statistics were analyzed using SPSS version 23.0 and Prism software. Results were presented in numbers and percentages and analyzed using the Chi-square test. Results Results indicated that polycythemia increased between 2018 and 2020, with the highest numbers in 2018 and decreasing in 2022. There was a higher frequency in the age group of (41-50) years, and it was more common in males with polycythemia (92.72%) who were smokers (79.09%). Most polycythemia patients had the B blood group (38.2%), while the AB blood group had the lowest percentage (5.5%), and most cases were Rh-positive (91.8%). Conclusion this study provided an overview of the epidemiology of polycythemia in Babylon, Iraq. The findings indicate that polycythemia was more prevalent in men of middle age and with blood group B+. Therefore, further research is needed to examine the relevance of the ABO blood group to polycythemia severity and susceptibility. Bangladesh Journal of Medical Science Vol. 23 No. 04 October’24 Page : 1068-1074

ABO blood types and head and neck cancer: a systematic review with meta-analysis of observational studies

ObjectivesThis research aims to explore the correlation between ABO blood groups and neoplasms in the head and neck region, specifically investigating the susceptibility of different blood groups to tumours.DesignSystematic review...

ABO Blood Type and Pretreatment Systemic Inflammatory Response Index Associated with Lymph Node Metastasis in Patients with Breast Cancer.

Lymph node metastasis (LNM) is an important prognostic factor for breast cancer. Inflammatory stimulation can change tumor microenvironment and lead to LNM, but the relationship between LNM and peripheral immunoinflammatory indices has not been clarified in breast cancer. The clinical information of 1918 patients with breast cancer admitted to Meizhou People's Hospital from October 2017 to December 2023 were retrospectively analyzed. The relationship of clinicopathological features (age, body mass index (BMI), ABO blood types, family history of cancer, tumor site, disease stage, LNM, distant metastasis, and molecular subtypes) and peripheral immunoinflammatory indices (pan-immune inflammation value (PIV), systemic immune inflammation index (SII), and system inflammation response index (SIRI)) were analyzed. There were 935 (48.7%) patients had no LNM and 983 (51.3%) had LNM. There were statistically significant differences in the distributions of ABO blood groups (p=0.022) and molecular subtypes (p<0.001) between the two groups. PIV, SII, and SIRI levels in patients with LNM were significantly higher than those without LNM (all p<0.05). The proportions of LNM in patients with high PIV, SII, and SIRI levels were higher than those with low PIV, SII, and SIRI levels, respectively. Logistic regression analysis showed that non-O blood type (non-O blood type vs O blood type, odds ratio (OR): 1.327, 95% confidence interval (CI): 1.056-1.667, p=0.015), luminal B subtype (luminal B vs luminal A, OR: 2.939, 95% CI: 2.147-4.022, p<0.001), HER2+ subtype (HER2+ vs luminal A, OR: 2.044, 95% CI: 1.388-3.009, p<0.001), and high SIRI level (≥0.875 vs <0.875, OR: 1.572, 95% CI: 1.092-2.265, p=0.015) were independently associated with LNM. Non-O blood type, luminal B and HER2+ subtypes, and high SIRI level (≥0.875) have potential role in predicting the status of LNM in breast cancer patients.

Editorial: Is There a Relationship/An Association Between ABO Blood Group System and Cardiac Conduction Disorders?

Abstract Introduction Data from the literature suggest a slight increase in cardiovascular risk for people with non-O blood types. The purpose of the study was to evaluate if there is an association between advanced cardiac conduction disorders and blood groups. Material and methods In this retrospective study, a group of patients with atrio-ventricular conduction disorders or sinus node disease, having an indication for permanent cardiostimulation, was analyzed and compared with a control group consisting of patients who underwent coronary angiography or elective peripheral angiography. The blood group was determined in all patients. Univariate and multivariate statistical methods were used. Results Six hundred forty patients, mean age 72±11y, 55.3% men, were included: 320 patients with advanced atrio-ventricular conduction disorders or sinus node dysfunction in the study group and 320 patients in the control group. Blood type A had the highest prevalence (46.8%), followed by blood types O (28.95%), B (16.74%) and AB (7.51%). In the group with heart rhythm disorders, patients with blood type A had an increased risk of atrio-ventricular block (OR 1.38, p= 0.02), but not with sinus node disease (OR 1.02, p= 0.98). Blood type O had a protective role both for atrio-ventricular block and for sinus node dysfunction (OR 0.65, p= 0.01). Conclusion Blood type A proved to be an independent predictor for atrio-ventricular conduction disorders in patients with severe heart rhythm disorders with indication for permanent cardiostimulation.

Analysis of RhC Antigen Weak Expression Combined with Mimicking Autoanti-Ce and Homologous Anti-Jkb Causing Mismatch

To investigate the reasons for the weak expression of RHCE gene in a patient whose mimicking anti-Ce combined with anti-Jkb caused cross-matching non-combination. ABO, Rh, and Kidd blood group antigens were identified by test tube method and capillary centrifugation. Antibody screening and antibody specificity identification were performed using saline, polybrene and antiglobulin in tri-media association with multispectral cells. RHCE gene sequencing and haploid analysis were performed by multiplex PCR technique and RHCE protein modeling was performed using Swiss-Model. The serum of the patient contained anti-Ce mimicking autoantibodies along with anti-Jkb antibodies. c.48G>C, c.150C>T, c.178C>A, c.201A>G, c.203A>G, and c.307C>T mutations were detected in the RHCE triple-molecule sequencing. A 109 bp insertion sequence was found in intron 2, with fragment loss from intron 5-8. The Rh-group genotype was DCe/DCe , and phenotype was CCDee. Genotyping techniques can assist in deducing the molecular mechanisms of some weakly expressed RhC, c, E, and e in patients' sera to aid in the identification of difficult antibodies and thus ensure the safety of patients' blood transfusion.

Increased expression of ABO blood group antigens secretion phenotype with O blood group and age advances.

To ascertain the prevalence of ABH antigen secretors and non-secretors among Yemenis. In addition to explore the factors that may affect the expression of the secretion phenotype. This cross-sectional study was carried out between May and September 2022 on 215 healthy Yemeni individuals at the International Malaysian University, Ibb, Yemen. The participants were tested for blood group antigen on their blood samples using standard test tube method using the suitable ABH antisera. Saliva was collected and tested for secretion using hemagglutination inhibition test with suitable A, B, and H antisera. Before collecting the blood samples, informed consent was obtained from each participant and complete data and history questionnaire were collected by the research team. In general, 78.1% of Yemini participants were found to be secretor (80% men and 73.3% females). This percentage increased within O blood group (95%) and decreased within AB blood group (54%) individuals. Both O and AB blood groups showed statistically significant association with secretor trait. Also, it was noticed that age advance increases the expression of Se gene. In addition, the secretor state increased among Rh-negative people. The frequency of ABH secretors was 78.1% among Ibb province population in Yemen. Blood group O revealed the greatest frequency (95%), whereas blood group AB showed the lowest secretor frequency (54%). The secretor phenotype was highly expressed gradually with advance age then decline.

High risk of long-term recurrence after a first episode of venous thromboembolism during pregnancy or postpartum: the REcurrence after a PrEgnAncy related Thrombosis (REPEAT) Study

IntroductionLong term-recurrence risk following a pregnancy associated venous thromboembolism (VTE) is sparsely assessed. ObjectiveTo determine the rate of recurrence after a pregnancy associated VTE, and identify associated risk factors. MethodFive hundred and eighty-seven women with a history of first VTE occurring during pregnancy or until 3 months after delivery were referred to La Timone Hospital, Marseille, France. Women were consecutively included between 2000 and 2015. VTE characteristics and biological parameters were collected at inclusion. During the 2016-2019 period, patients were recontacted to gather information on post-inclusion VTE. A weighted Cox model, adapted to the study’s ambispective design, was used to analyse pre- and post-inclusion VTE recurrences. ResultsAfter quality controls, 583 women were analyzed. Incidence of recurrent VTE was 2.4% person-years. Cumulative risk of VTE recurrence was 38% (n=221), with a median follow-up of 31 years (95%CI [27-35]); 6%, 13%, 17%, 30% at 2, 5, 10 and 30 years respectively. Pulmonary embolism (PE) at first event was associated with a 2-fold increased risk of PE at recurrence compared with isolated deep venous thrombosis (DVT, Hazard Ratio (HR)=2.63, 95%CI [1.44-4.82]). Risk factors significantly associated with recurrence were: interrupted pregnancies (HR=1.85, 95%CI [1.18-2.90]; lower limb DVT (HR=2.95, 95%CI [1.16-7.49] and AB blood group (HR=1.71, 95%CI [1.06-2.77]). ConclusionAlthough the recurrence risk is low within the first 10 years after a pregnancy associated VTE, 1/3 patients experienced a new event over a 30-year period. Interrupted pregnancies, lower limb DVT, and AB blood group were associated with higher risk of recurrence.

Frequency of ABO, Rh and Kell Blood Group among Blood Donors in Brazzaville, Republic of the Congo

Introduction: Blood group antigens play an essential role in transfusion safety and in avoiding the risk of alloimmunization. The ABO, Rh and Kell blood group systems are the most clinically important. The aim of this study was to determine the frequency of ABO, Rh and Kell blood groups among blood donors in Brazzaville, Republic of Congo. Methods: This was a cross-sectional study conducted among blood donors in Brazzaville, republic of Congo, from June 2021 to November 2022. The blood samples were tested for ABO, Rh and Kell antigens by standard tube agglutination method. The statistical analysis was done using SPSS version 21.0. Results: A total of 350 participants were included, of which 258(73.7%) of donors were males and 92 (26.3%) females. The antigen frequencies of ABO and Rh(D) blood group system showed that O was the most prevalent blood group 46.8% followed by A (28.9%), B (16.9%), and AB (7.4%). The Rh-positive donors were more prevalent (94.86%) as oppose to the Rh-negative (5.14%). The most common Rh phenotype is the Dccee (64.86%) while the rarest phenotype is the dCcee (0.86%). The prevalence of K and k antigen was 0.9% and 99.1%, respectively. Conclusion: This study determined the phenotypic variability of ABO and Rh blood group antigens with low prevalence of Kell antigen. The extensive phenotypic status of Rh and Kell systems in blood donors is important for the efficient management of blood banks and transfusion services.

Potential Relationship between ABO Blood Group and COVID-19 Susceptibility

Numerous research have looked into the potential relationship between blood group systems and the severity of COVID-19, with varying degrees of success. However, depending on how common the Rh and ABO blood types are in a given community, their correlations with COVID-19 may also vary. Thus, in order to explore this relationship more thoroughly and give population-based data to the global scientific community, we carried out this study on Iraqi people. Methodology: Every patient who arrived at Al-Shatra General Hospital in the province of Thi-Qar between December 2022 and June 2023 had their data examined. One hundred participants, ranging in age from eighty to eighty, made up the study. Their hospital medical records were used to determine their ABO, Rh type, and COVID-19 positive. Result: The total number of patients was 100, and males constituted 56% of this population. Among the 100 patients, 19% were diagnosed with diabetes mellitus while 34% had hypertension. From the findings, it was noted that A+, B+, and O+ blood types had more occurrences of COVID-19 positive cases. Interestingly, the percentage of individuals testing positive for COVID-19 was higher at 58% among those with hypertension and lower at 42% among those with diabetes mellitus. Conclusions: The relationship between blood types and COVID-19 infection is a multifaceted dynamic that encompasses various factors, including comorbidities, age, sex, and the distribution of blood groups within a population. It has been observed that individuals with hypertension are more prone to experiencing elevated rates of COVID-19.

DIAGNÓSTICO E MONITORAMENTO DA ERITROBLASTOSE FETAL: UMA REVISÃO DA LITERATURA

The text addresses fetal erythroblastosis, a serious condition resulting from blood incompatibility between mother and fetus, generally due to the Rh factor. Initially, the discovery of the ABO and Rh blood systems is discussed, highlighting the importance of the latter for understanding the disease. Objective: to understand the pathophysiological mechanisms of fetal erythroblastosis, focusing on Rh incompatibility, thereby analyzing the impacts of fetal erythroblastosis on health of the fetus and newborn.Methods: The work is a bibliographical review where topics such as pathophysiology, diagnosis and prevention of the disease studied were researched.Conclusion: Diagnosis is essential, being done through prenatal exams, such as the Coombs test, which detects the presence of maternal antibodies against fetal antigens. Treatment includes administration of anti-Rh immunoglobulin to prevent the mother’s sensitization to the baby’s Rh factor. Prevention also involves the administration of this immunoglobulin during pregnancy and after birth, if necessary, to avoid future complications and ensure the baby’s safety.

Neonatal Jaundice Risk Factors and Multidirectional Intensive Phototherapy Management at Azadi Teaching Hospital in Kirkuk City

Background: A common illness in infants, neonatal jaundice is caused by high bilirubin levels in the first few days of life, which results in yellowing of the skin and eyes. Aim: This study aims to explore neonatal jaundice risk factors and assess the efficacy of multidirectional intensive phototherapy management at Azadi Teaching Hospital in Kirkuk City. Patients and Methods: In this retrospective cross-sectional study spanning from April 1st, 2021, to October 1st, 2021, a total of 497 newborns were examined. Jaundiced neonates underwent intensive phototherapy utilizing the Bilisphere 360 system, which featured a chamber with 16 cylindrical, blue TL 20W/52 fluorescent tubes. The newborns were positioned on a gauze hammock suspended at the chamber's center, illuminated on all sides. Results: A study found that neonatal jaundice affects 50.70% of studied neonates, primarily in the 16-21-day age group, with males accounting for 57.95% of the sample. 94.84% of neonates experience jaundice due to ABO blood group incompatibility and 88.10% due to Rh incompatibility. Additionally, 77.78% of term deliveries are associated with jaundice. Infants with jaundice have higher Thyroid Stimulating Hormone (TSB) and Thyroid Stimulating Hormone (TSH) levels and a younger mean age compared to non-jaundiced infants. Bilisphere 360 proves significantly more effective in the critical 12 to 48 hours after admission, with a mean total bilirubin of 10.71 ± 1.01 mg/dl compared to 14.65 ± 1.71 mg/dl for Neonatal Exchange Transfusions (P-Value: 0.001). Factors like blood group incompatibility, labor duration, and birth weight influence TSB levels in jaundiced neonates. The Bilisphere 360 method is found to be more effective in managing neonatal jaundice than Neonatal Exchange Transfusions in reducing total bilirubin levels.

The Association Between Maternal ABO Blood Group and the Occurrence of Spontaneous Preterm Birth: A Retrospective Population-Based Cohort Study.

There is limited and inconsistent evidence that imply a relationship between ABO blood types and rate of preterm birth (PTB). We aim to examine the association between maternal ABO blood group and PTB rate. A retrospective-study conducted at a university teaching institution on data collected between 2013 and 2019. Women who delivered a viable neonate at ≥ 24 weeks without major malformations were included. Indicated PTBs were excluded. PTB and early PTB were defined as deliveries that occurred < 37 and < 34 weeks respectively. PTB was further divided into 3 subgroups according to etiology: membranes rupture, intact membranes, and placental abruption regardless of membranes' status. The primary outcome was spontaneous PTB rate. Of 19,301 women included, PTB and early PTB rates were 7.3% (1,418/19,301) and 2.3% (440/19,301) respectively. Rates of PTB in blood groups A, B, O, and AB, were 7.3%, 6.9%, 7.5%, and 7.5% respectively (p = 0.68). There was no significant difference according to etiology. Rates of early PTB were also comparable (p = 0.63). After adjustment for demographic and obstetric variables, blood type was associated with increased placental abruption rate among women who had early PTB (p = 0.038). Placental abruption rate was significantly higher in group A (22.5%) compared to group B (14.1%), (adjusted p = 0.04) and group O (14.0%), (adjusted p = 0.01). The rate in group AB was 17.1%, (adjusted p = 0.85). In conclusion, no association was found between a particular blood group and PTB rate. Women with group A, admitted in early PTB, had an increased risk that the underlying etiology was placental abruption.

Rapid parallel blood typing on centrifugal microfluidic platform by microcolumn gel immunoassay

Microcolumn gel immunoassay (MGIA) has the ability to meet the requirements of clinical diagnosis due to its reliable sensitivity and accuracy. However, traditional MGIA exhibits limitations including inadequate portability, low throughput, and extended analysis time. To address these challenges, we combined MGIA with microfluidic technology, demonstrating a centrifugal microfluidic-based microcolumn gel immunoassay (μMGIA) platform for blood typing of clinical samples. Experimental results indicate that the μMGIA platform can simultaneously detect six blood group antigens in five clinical blood samples within 2 min. Notably, it offers comprehensive detection of ABO blood group antigens and Rh blood group antigens with 100 % accuracy, outperforming the traditional slide method. The integration of microfluidic technology with MGIA circumvents the constraints of traditional methods, providing a new avenue for blood typing and immunoanalysis of clinical samples.

Examination of the relationship between ABO/Rh blood groups and dietary compliance in children with coeliac disease: A single‐centre experience

AimCoeliac disease (CD) is an autoimmune enteropathy that develops upon ingestion of food containing gluten. The established link between ABO blood groups and numerous infectious and non‐infectious illnesses prompted this investigation into blood group distribution and its relationship with dietary compliance among children diagnosed with CD.MethodsIn this retrospective study, patients with CD who were followed for ≥1 year at the paediatric gastroenterology outpatient clinic of our hospital were evaluated. History, physical examination and coeliac serology results were reviewed for each patient. Patients were divided into two groups based on self‐reported compliance to a gluten‐free diet: diet‐adherent and non‐diet‐adherent. Patient and control groups were examined in terms of ABO blood groups.ResultsA total of 177 patients with CD were included in the study. A control group of 211 age‐ and sex‐matched children without any chronic disease who had undergone blood group testing for various reasons was included for comparison. A total of 65% (n = 115) of the patients were girls, and 35% (n = 62) were boys. No significant relationship was found between CD diagnosis and ABO blood groups among patients (P = 0.559). Furthermore, the dietary compliance status of the patients was not associated with any specific blood group (P = 0.951).ConclusionNo notable difference was found between patients with CD with or without gluten‐free diet compliance in terms of the distribution of ABO blood groups and Rhesus (Rh) factor. Therefore, it can be inferred that all blood groups and subgroups carry an equal risk for CD.

Correlation between ABO blood group and clinical characteristics of patients with lupus nephritis

Correlation between ABO blood group and clinical characteristics of patients with lupus nephritis

Survival benefit of liver transplantation utilizing marginal donor organ according to ABO blood type.

The current liver transplantation (LT) allocation policy focuses on the Model for End-Stage Liver Disease (MELD) scores, often overlooking factors like blood type and survival benefits. Understanding blood types' impact on survival benefits is crucial for optimizing the MELD 3.0 classification. This study used the United Network for Organ Sharing national registry database (2003-2020) to identify LT characteristics per ABO blood type and to determine the optimal MELD 3.0 scores for each blood type, based on survival benefits. The study included LT candidates aged 18 years or older listed for LT (total N=150,815; A:56,546, AB:5,841, B:18,500, O:69,928). Among these, 87,409 individuals (58.0%) underwent LT (A:32,156, AB:4,362, B:11,786, O:39,105). Higher transplantation rates were observed in AB and B groups, with lower median MELD 3.0 scores at transplantation (AB:21, B:24 vs. A/O:26, p<0.01) and shorter waiting times (AB:101 days, B:172 days vs. A:211 days, O:201 days, p<0.01). A preference for Donation after Cardiac Death (DCD) was seen in A and O recipients. Survival benefit analysis indicated that B blood type required higher MELD 3.0 scores for transplantation than A and O (Donation after Brain Death transplantation: ≥15 in B vs. ≥11 in A/O; DCD transplantation: ≥21 in B vs. ≥11 in A, ≥15 in O). The study suggests revising the allocation policy to consider blood type for improved post-LT survival. This calls for personalized LT policies, recommending higher MELD 3.0 thresholds, particularly for individuals with type B blood.

Prognostic value of ABO blood groups in upfront operated pancreatic ductal adenocarcinomas

PurposePancreatic ductal adenocarcinoma (PDAC) has been shown to have a lower incidence in patients with blood group O. It is currently uncertain if patients with group O have a better prognosis after pancreatectomy. This study assessed the overall survival (OS) and disease-free survival (DFS) of PDAC patients who underwent upfront pancreatoduodenectomy based on ABO blood groups.MethodsA cross-sectional study was performed including patients from two university centers. All consecutive head PDAC patients who underwent upfront pancreatoduodenectomy from 2000 to 2016 were included. OS and DFS were compared between blood groups A, B, AB, and O using Kaplan-Meier curves and log-rank tests.ResultsA total of 438 patients were included (215 women, median age 67). Pre- and intraoperative details were comparable between all subgroups. Median OS did not differ between the four blood groups (A: 23 months, 95% CI 18–28; B: 32, 95% CI 20–44; AB: 37, 95% CI 18–56 and O: 26, 95% CI 20–32, p = 0.192). Median DFS were also similar (A: 19 months, 95% CI 15–23; B: 26, 95% CI 19–33; AB: 35, 95% CI 15–55 and O: 22, 95% CI 15–29, p = 0.441). There was no OS difference between O and non-O groups (median: 26 months, 95% CI 20–33 vs. 25 months, 95% CI 20–30, p = 0.773). On multivariable analysis blood groups were not prognostic of OS. Only lymph node involvement, tumor differentiation, and adjuvant chemotherapy were independent prognostic factors.ConclusionOS and DFS were similar between all four blood groups after pancreatoduodenectomy. Independent predictors of OS were associated with tumor characteristics and adjuvant treatment.

Distribution of ABO and D antigen expression in Yogyakarta, Java Island: a pioneer large-scale study in Indonesia

ObjectiveHere, we sought to report ABO and D antigen distribution in blood donors from Yogyakarta, Java Island, Indonesia. Phenotype data (ABO/D) from donors who donated blood between January 1, 2018, and December 31, 2023, at the Yogyakarta Blood Donor Unit were extracted from the blood donor registry, and phenotype frequency was calculated subsequently.ResultsIn the 245,307 blood donors collected over six years, ABO phenotype frequency: O (frequency: 38.5%) > B (29.4%) > A (24.1%) > AB (8.0%). The D-positive phenotype was far more common (99.5%) than the D-negative phenotype (0.5%). The phenotypic pattern globally is similar to previous reports in Southeast Asia. The D antigen distribution is similar to world distribution as the most common blood group. For the first time in Indonesia, this distribution of ABO and D phenotype is reported in a large-scale study. This work is a pioneer in the coordinated optimization of transfusion guidelines at the national level.

Association between ABO blood groups and hematological myeloid neoplasms in adolescents and adults.

Prior research suggests a potential link between ABO blood types and susceptibility to various malignancies. The correlation between ABO blood types and hematological myeloid neoplasms, however, remains inadequately explored. This study investigates the association between ABO blood groups and the incidence of hematological myeloid neoplasms in adolescents and adults. In this retrospective clinical study, 1,022 adolescent and adult cases of myeloid neoplasms diagnosed at our institution were initially considered. After excluding conditions potentially linked to ABO blood types from prior studies, 792 eligible cases were analyzed. These cases were categorized based on disease subtypes and compared with a control group for blood type distribution. Our findings reveal a significantly higher prevalence of blood type A in patients with myeloid neoplasms compared to the control group, except for chronic myelocytic leukemia and myeloproliferative neoplasms. Conversely, the prevalence of blood type AB in myeloid neoplasms was notably lower than in the control group. The study suggests a potential association between ABO blood types and the risk of developing hematological myeloid neoplasms in adolescents and adults. Further research is warranted to elucidate the underlying mechanisms of this relationship.