We evaluated the impact of monitoring indication, early electroencephalography (EEG), and clinical features on seizure risk in all neonates undergoing continuous EEG (cEEG) monitoring following a standardized monitoring protocol. All cEEGs from unique neonates 34-48weeks postmenstrual age monitored from 1/2011-10/2017 (n=291) were included. We evaluated the impact of cEEG monitoring indication (acute neonatal encephalopathy [ANE], suspicious clinical events [SCEs], or other high-risk conditions [OHRs]), age, medication status, and early EEG abnormalities (including the presence of epileptiform discharges and abnormal background continuity, amplitude, asymmetry, asynchrony, excessive sharp transients, and burst suppression) on time to first seizure and overall seizure risk using Kaplan-Meier survival curves and multivariable Cox proportional hazards models. Seizures occurred in 28% of high-risk neonates. Discontinuation of monitoring after 24hours of seizure-freedom would have missed 8.5% of neonates with seizures. Overall seizure risk was lower in neonates monitored for ANE compared to OHR (P=.004) and trended lower compared to SCE (P=.097). The time course of seizure presentation varied by group, where the probability of future seizure was less than 1% after 17hours of seizure-free monitoring in the SCE group, but required 42hours in the OHR group, and 73hours in the ANE group. The presence of early epileptiform discharges increased seizure risk in each group (ANE: adjusted hazard ratio [aHR] 4.32, 95% confidence interval [CI] 1.23-15.13, P=.022; SCE: aHR 10.95, 95% CI 4.77-25.14, P<1e-07; OHR: aHR 56.90, 95% CI 10.32-313.72, P<1e-05). Neonates who undergo cEEG are at high risk for seizures, and risk varies by monitoring indication and early EEG findings. Seizures are captured in nearly all neonates undergoing monitoring for SCE within 24hours of cEEG monitoring. Neonates monitored for OHR and ANE can present with delayed seizures and require longer durations of monitoring. Early epileptiform discharges are the best early EEG feature to predict seizure risk.