Event Abstract Back to Event Lead toxicity and the hypothalamic-pituitary-testicular axis Nadia A. Hamadouche1* 1 Universite Es Senia, Laboratoire de Biochimie Appliquee, Departement de Biologie Faculte des Sciences , Algeria Environmental exposure to toxic lead occurs in a number of industries with potential adverse effects on the reproductive capacity of exposed men. Clinical and animal studies indicate that abnormalities of spermatogenesis result from toxic lead exposure. The experiment were performed on 30 adult male rats divided in three equal groups and were orally given 250 mg/l and 500 mg/l of lead acetate diluted in mineral water by force feeding for 90 days and the other group was used as control. This study was designed to associated blood lead concentration and reproductive disorders. The results revealed a significant decrease in the weight of the testes, epididymides and pituitary. This reduction in weight of sex glands and pituitary was accompanied by an alteration of the normal histological structure. The results showed a significant (p < 0,001) reduce of epididymal and testicular sperm counts including daily sperm production. Moreover, lead obviously affected sperm density and sperm viability and a significant increase of sperm abnormalities in rats treated compared with the controls. We have observed a significant difference for circulating testosterone, LH and FSH following lead poisoning. Therefore, lead exposure resulted in oxidative stress and this was well extrapolated from the increase in lipid peroxidation products (LPP). The results indicate that there was a significant (p < 0,001) increase of (LPP) in exposed rats than their corresponding control both in pituitary testis, and epididymides. Results clearly show that lead has a deleterious impact on the reproductive system witch impairs hypothalamic-pituitary axis functions. Keywords: Fertility, hypothalamic-pituitary axis, Lead acetate, Peroxidation, Sperm cells Conference: 3rd Mediterranean Conference of Neuroscience , Alexandria, Egypt, 13 Dec - 16 Dec, 2009. Presentation Type: Poster Presentation Topic: Imaging & Neuroendocrinology Citation: Hamadouche NA (2009). Lead toxicity and the hypothalamic-pituitary-testicular axis. Front. Neurosci. Conference Abstract: 3rd Mediterranean Conference of Neuroscience . doi: 10.3389/conf.neuro.01.2009.16.162 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 26 Nov 2009; Published Online: 26 Nov 2009. * Correspondence: Nadia A Hamadouche, Universite Es Senia, Laboratoire de Biochimie Appliquee, Departement de Biologie Faculte des Sciences, Oran, Algeria, naithamadouche@live.fr Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Nadia A Hamadouche Google Nadia A Hamadouche Google Scholar Nadia A Hamadouche PubMed Nadia A Hamadouche Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.
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