Abnormal Morphological Changes Research Articles

Short-term administration of parenteral glucose-lipid mixtures improves protein kinetics in portacaval shunted rats

The efficacy of various total parenteral nutrition regimens administered for 72 h in supporting the rat after portacaval anastomosis was evaluated. All animals that received amino acid-containing formulas had significantly improved nitrogen balance (p < 0.05), albumin synthetic rates (p < 0.05), and serum albumin concentration (p < 0.05) compared with animals receiving dextrose only. Rats that received the mixed-fuel system containing amino acids, dextrose, and lipid had significantly improved leucine flux and whole body protein synthesis (p < 0.05) compared with animals that received dextrose only, or amino acids and dextrose. Diets composed of dextrose only, amino acids and dextrose, or amino acids and dextrose with the addition of currently available long-chain triglyceride lipid emulsion induced abnormal morphologic changes in the liver. No hepatic morphologic changes were evident in rats that received an isocaloric mixedfuel regimen containing medium- and long-chain triglycerides. The results suggest that mixed-fuel systems containing amino acids and dextrose with lipids are superior to formulas containing dextrose only, or dextrose with amino acids. The improved liver morphology observed in animals given the lipid emulsion system containing medium- and long-chain triglycerides suggests that medium-chain triglycerides may provide an additional benefit in supporting the patient with liver dysfunction.

Safracins, new antitumor antibiotics. III. Biological activity.

Safracins A and B have antibacterial activity against Gram-positive and Gram-negative bacteria in vitro but no therapeutic activity in mice infected with Staphylococcus aureus. Safracins A and B induce abnormal morphological changes in Echerichia coli cells. Tests with transplantable mice tumors demonstrate that safracins A and B inhibit the growth of P388 leukemia and IMC carcinoma.

The surface morphology of the infundibular muscle in patients with tetralogy of fallot.

The surface morphology of the infundibular muscles obtained from open heart surgery was investigated in 10 patients with tetralogy of Fallot. Various degrees of abnormal surface morphological changes were observed from the endocardium to the myocardium. In the endocardium striking proliferation of the endothelial cells was usually accompanied by focal loss of the endothelium with fibrotic change. Based on the characteristic alterations of the surface morphology 4 different groups of myocardial cells could be identified: normal myocytes, defective myocytes, sclerotic myocytes, and necrotic myocytes. Because intact surface morphology is responsible for integrated cellular function these pathological findings observed on the surface morphology of the endocardium and myocardium can provide a valuable reference to further understanding of functional disorders of the infundibular muscle in patients with tetralogy of Fallot.

Cytotoxicity and dermonecrosis of sea nettle ( Chrysaora quinquecirrha) venom

Abnormal morphological changes were observed in CHO K-1 cells previously exposed to either crude or DE-52 fractionated sea nettle ( Chrysaora quinquecirrha) venom. At high doses the venom inhibited the growth of cultured cells and interfered with intracellular uridine and thymidine incorporation. Low doses of venom induced mitogenic activity in CHO K-1 cells. Partially purified venom agglutinated trypsinized rabbit erythrocytes in the presence of calcium. The venom's dermonecrotic activity and its cytotoxic and hemagglutinating activities were eluted together from a DEAE cellulose column.

Diagnosis and management of folate deficiency in low birthweight infants.

Significant folate deficiency in 14 out of 37 preterm infants of birthweights 2.0 kg or less was found to be reliably and most conveniently diagnosed by abnormal morphological changes in peripheral blood and confirmed by the response to folic acid. Deficiency appeared to be more common in light-for-dates infants including the smaller of twins. Neither the clinical status nor the levels of haemoglobin or erythrocyte folate was a reliable guide to the presence of megaloblastic erythropoiesis in the very young preterm infant. 100-200 microgram folic acid a day, orally or IM, may be required to ensure an optimal haematological response, and this would be appropriate for therapeutic trial if the diagnosis is in doubt. This amount would also replenish tissue folate stores; larger doses are likely to exceed the requirements of small infants.

Teratogenic Potential in Rats Fed the Nuclear Polyhedrosis Virus ofHeliothis

Abnormal changes in physical condition, behavior, and internal morphology were not observed when female rats were fed polyhedral inclusion bodies (PIB) of the Heliothis nuclcopolyhedrosis virus. Dams were fed 1 × 108 PIB per kilogram of rat per day during the 5th to 14th day of gestation. Administration of PIB to pregnant dams did not affect number or weight of fetuses, resorption sites, or relationship between corpora lutea and implantation site. Teratologies, attributed to virus, were not encountered after detailed skeletal and visceral examinations of fetuses born of virus-fed, pregnant dams.