Abnormal Location Research Articles

Alterations of Astrocytic Aquaporin 4 expression and distribution in Down Syndrome with Alzheimer’s Disease onset

AbstractBackgroundAstrocytic Aquaporin 4 (AQP4) is a water channel that is typically expressed in astrocytic endfeet, associated with the blood brain barrier (BBB). This association is thought to facilitate the removal of waste products (e.g. beta amyloid (Aβ)) via the ‘glymphatic system’. With Aβ plaque deposition in Alzheimer’s Disease (AD), AQP4 becomes dysregulated observed as a shift in distribution from astrocytic endfeet to astrocytic processes, resulting in inefficient Aβ removal. Here, AQP4 expression and distribution within astrocytes was characterized via immunohistochemistry in human brain tissue from people with Down Syndrome without AD (DS) and with AD (DSAD). We hypothesized that AQP4 protein level would be higher and distributed along astrocytic processes as opposed to the BBB in DSAD relative to DS.MethodAQP4 was evaluated by immunohistochemistry and quantified using QuPath (% loads, positive pixel count) for both frontal (FC) and occipital cortex (OC) in the following groups: DS (n = 17, age range = 0‐51) and DSAD (n = 20, age range = 46‐70). In addition, AQP4 distribution was classified by a blinded observer who annotated distinct AQP4 positive astrocytic morphologies, listed as follows: In WM, ‘Star,’ ‘Webbed,’ and ‘Stippled,’ and in GM, ‘Bushy,’ ‘Branched,’ ‘Globular,’ ‘Endfoot/Vascular Associated.’ResultWe show that AQP4 protein staining was higher in GM DS with AD neuropathology than in DS without AD neuropathology for both FC and OC (FC p = 0.0007; OC p = 0.0034). In addition, we observed a shift from ‘star’ shaped distribution within DS astrocytes to more ‘webbed’ and ‘stippled’ shapes in DSAD; this was not observed in OC. We found a shift in GM morphologies from ‘bushy’ morphology of AQP4 immunostaining in DS to more ‘Branched and Globular’ shapes in DSAD in OC whereas there is a shift from a ‘Bushy’ morphology in DS to more ‘Endfoot/Vascular Associated’ morphologies in the DSAD FC.ConclusionAQP4 expression is higher in DSAD than DS and appears to show a spectrum of astrocyte morphologies with distinct patterns based upon spatial location (FC/OC and GM/WM). Taken together, AQP4 dysfunction and shift to abnormal spatial location may reduce Aβ clearance through the glymphatic system, leading to enhanced plaque formation in DSAD.

Mini Percutaneous Nephrolithotomy in Ectopic Lumber Kidney: A Case Report

The chance of the development of hydronephrosis and the formation of stones is more in the ectopic kidney. Treatment of stones in ectopic kidneys is challenging for urologists due to abnormal location and rotation of the kidney and unfavourable local anatomy. We herein report a case of stone in a lumber kidney successfully managed by mini percutaneous nephrolithotomy (PCNL) in a prone position. A 55-year-old male presented with right lower abdominal pain. His CT scan of the KUB reveals the right kidney is in an ectopic location and has a hyperdense structure measuring about 15 mm in length, seen in the right renal pelvis with mild dilatation of the pelvicalyceal system. The patient underwent right-sided prone mini PCNL under the subarachnoid block (SAB), and complete stone clearance was achieved. There was no adverse event during or after surgery or post-operative blood transfusion. Bangladesh J. Urol. 2022; 25(2): 122-125

Difficulties of Cochlear implantation in malformations of the inner ear

According to various authors, 20% of children with sensorineural hearing loss or deafness, anomalies in the structure of the temporal bones are determined according to the results of computed tomography. Cochlear implantation in the presence of cochleovestibular malformations is associated with a number of difficulties. These include the peculiarities of cochleostomy and placing of the electrode inside the cochlea, the risk of damage to the facial nerve due to its abnormal location, intraoperative liquorrhea, which can lead to the development of bacterial meningitis in the postoperative period, as well as the risk of penetration of the electrode into the internal auditory canal. In this research, we present our method of performing cochlear implantation in case of a malformation in the development of the inner ear (common cavity). The method expands the possibilities of cochlear implantation for e auditory perception in patients with this pathology.

Abnormal Node Location Algorithm in Multi-source Heterogeneous Network Based on Association Rules

Abstract It is difficult to mine association rules between multi-source heterogeneous network nodes, which leads to the high false detection rate, node location error, and location overhead of multi-source heterogeneous network abnormal nodes. Therefore, this article proposes a new abnormal node location algorithm in multi-source heterogeneous network based on association rules. The algorithm of sliding windows multiple value pattern tree is used to extract the association of multi-source heterogeneous network data and realize the mining of association rules between multi-source heterogeneous network nodes. The association rule mining results are preprocessed, and the multi-source heterogeneous network abnormal node location model is built using the multidimensional scaling algorithm and the low rank matrix decomposition model. The model is solved to obtain the multi-source heterogeneous network abnormal node location results. The experimental results show that the false detection rate of abnormal nodes in the proposed algorithm is always below 4.6 %, the maximum node location error is only 2.1 mm, and the average location overhead is 55.1 ms, which can achieve the goal of fast and accurate location of abnormal nodes in multi-source heterogeneous networks.

A report of an unusual case of cartilaginous choristoma of the tongue and review

AbstractBackgroundChoristomas consist of the proliferation of normal cells or tissue in an abnormal location. Oral choristomas are considered very rare.AimsThe present study aims to report a case of dorsal tongue surface cartilaginous choristoma, with emphasis on its clinical and histopathological features.Case ReportA 72‐year‐old woman attended a dental office with a chief complaint of a persistent tongue lesion. The patient reported that the lesion grew slowly for about 3 months, with no trauma history in the region. An intraoral examination revealed a nodular lesion on the dorsal tongue surface, normal mucosa coloration, firm consistency and sessile implantation, measuring approximately 1.5 cm in diameter. Based on the clinical examination, a diagnosis hypothesis of a granular cell tumour was considered, and an excisional biopsy was performed for confirmation. Given the microscopic findings, the histopathological diagnosis confirmed a cartilaginous choristoma. The patient has been under follow‐up for 12 months, with no signs of relapse.ConclusionThis case highlights the importance of clinical and histopathological findings for the correct diagnosis and treatment of oral choristoma.

Incomplete Partition Type II Cochlear Malformations: Delineating the Three-Dimensional Structure from Digitized Human Histopathological Specimens.

There are clinically relevant differences in scalae anatomy and spiral ganglion neuron (SGN) quantity between incomplete partition type II (IP-II) and normal cochleae. IP-II is a commonly implanted cochlear malformation. Detailed knowledge of intracochlear three-dimensional (3D) morphology may assist with cochlear implant (CI) electrode selection/design and enable optimization of audiologic programming based on SGN maps. IP-II (n = 11) human temporal bone histological specimens were identified from the National Institute on Deafness and Other Communication Disorders National Temporal Bone Registry and digitized. The cochlear duct, scalae, and surgically relevant anatomy were reconstructed in 3D. A machine learning algorithm was applied to map the location and number of SGNs. 3D scalae morphology of the basal turn was normal. Scala tympani (ST) remained isolated for 540 degrees before fusing with scala vestibuli. Mean ST volume reduced below 1 mm 2 after the first 340 degrees. Scala media was a distinct endolymphatic compartment throughout; mean ± standard deviation cochlear duct length was 28 ± 3 mm. SGNs were reduced compared with age-matched norms (mean, 48%; range, 5-90%). In some cases, SGNs failed to ascend Rosenthal's canal, remaining in an abnormal basalward modiolar location. Two forms of IP-II were seen: type A and type B. A majority (98-100%) of SGNs were located in the basal modiolus in type B IP-II, compared with 76 to 85% in type A. Hallmark features of IP-II cochleae include the following: 1) fusion of the ST and scala vestibuli at a mean of 540 degrees, 2) highly variable and overall reduced SGN quantity compared with normative controls, and 3) abnormal SGN distribution with cell bodies failing to ascend Rosenthal's canal.

Malignant Right Coronary Artery Causing Positional Angina

Abstract Malignant Right Coronary Artery (RCA), with an incidence of 0.03%–0.17% in patients undergoing angiography is a rare form of congenital coronary artery anomaly. These patients may be asymptomatic and undetected having a risk of sudden cardiac death or symptomatic and posing a diagnostic and management dilemma. Routine coronary angiography may at times be unable to pick up the lesion due to abnormal location of right coronary ostia. The management has to be individualized based on patient symptoms and other parameters and comorbidities. Here, we present a case of malignant RCA managed by coronary artery bypass grafting.

Features of pregnancy course in patients with thrombophilia and abnormal placenta location

Aim: to identify inherited and acquired thrombophilia as well as features of pregnancy course in women with abnormal placenta location.Materials and Methods. Within the framework of a prospective controlled cohort non-randomized, interventional study there was analyzed pregnancy course in 135 women with abnormal placenta location: group I – 42 patients with abnormal placenta location in history; group II – 61 women with placenta previa detected during ongoing pregnancy; group III – 32 patients with placenta previa detected both in ongoing and previous pregnancy. The control group consisted of 120 pregnant women with normal placenta location without a previous complicated obstetric history. All patients underwent clinical examination of pregnancy course assessing fetus intrauterine growth retardation (IUGR) and fetal biophysical profile; inherited and acquired thrombophilia were identified – analyzing circulating antiphospholipid antibodies (APAs) by ELISA, inherited thrombophilia by polymerase chain reaction to identify mutations in genes encoding 5,10methylenetetrahydrofolate reductase (MTHFR), G20210A mutations in prothrombin gene, V Leiden mutation, polymorphismin fibrinogen and plasminogen activator inhibitor 1 (PAI-1) genes.Results. Inherited thrombophilia was detected in 101 (74.81 %) pregnant woman with abnormal placenta location: group I – in 31 (73.8 %) patients, group II and group III – in 44 (72.1 %) and 26 (81.3 %) patients, respectively. Inherited forms of thrombophilia were detected in 29 (24.2 %) women from control group. Multigenic forms of thrombophilia peaked in group III (14/43.8 %), followed by group I (16/38.1 %) and group II (23/37.7 %). In the control group, multigenic thrombophilia was detected in 16 (13.3 %) women. Selective inherited thrombophilia and АРАs circulation were detected in 30 (22.22 %) women with abnormal placenta location: group I – in 8 (19.0 %) patients, group II – in 13 (21.3 %), and group III – in 9 (28.1 %) cases. In the control group, there were only 8 (6.7 %) such patients. Patients with IUGR signs were identified in all study groups: 4 (9.52 %) in group I, 6 (9.84 %) in group II, 6 (18.75 %) in group III as well as in control group in 6 (6.67 %) women.Conclusion. Pregnancy management in patients with thrombophilia and placental abnormalities should be accompanied by an proper fetal assessment (biophysical profile) and, in some cases, anticoagulant or antiplatelet therapy. However, insufficient number of cases requires to conduct further investigations to assess a relation between thrombophilia, placenta previa and a risk of obstetric complications particularly IUGR.

Intramyocardial choristoma-a rare entity: first-ever case report and literature review

We report the first-ever case of ‘Intramyocardial choristoma’ documented in English-language literature. A 71-year-old woman, during her preoperative echocardiogram assessment, noted to have a large left ventricle (LV) mass with severe mitral regurgitation (MR). The patient was asymptomatic, with CT scan reported a large dense calcified LV mass. She underwent mitral valve replacement with LV mass resection operation. The mass was completely excised. Histopathological examinations show intramyocardial choristoma, with the lesion shows cardiac muscle with areas of calcification and mature bone tissue, with clear margins. Discharged well post operatively. Commonest clinical scenarios for intracardiac masses are myxomas, infective endocarditis with vegetation and thrombus. Primary cardiac tumours are very rare. Choristoma are rare benign tumour, with histologically normal tissues in an abnormal location, with a very rare recurrence rate. Transthoracic echocardiogram is reliable for the evaluation of the intracardiac masses, but the use of contrast echocardiogram gives additional benefit in analysing the characteristics of the intracardiac mass. For complex lesion, such as intramural component, extension into the inflow or outflow and into pericardial/extracardiac, MRI have added benefits. The treatment of choice is complete surgical resection. Follow up surveillance scans are recommended, as there is a very low risk of recurrence with uncertain prognosis. A multidisciplinary team approach is highly recommended in managing the patient pre-operative, intra-operative and post-operatively. Post operatively, regular follow up with imaging is recommended.

Diagnostic Dilemma due to Atypical Presentation of Sublingual Thyroid Ectopia: A Case Report

Thyroid tissue may be found in an abnormal location along the thyroglossal duct tract or other sites due to abnormal embryologic development and migration. Thyroid ectopia is an uncommon but well-documented clinical entity. In the event of any neck swelling, it should be kept as a differential diagnosis. Thyroid scintigraphy plays a very important role in diagnosing ectopic thyroid, with the complementary primary role of high-resolution neck ultrasonography (HRUS). Reported case of an 18-year-old male referred to INMAS for evaluation of a slowly enlarging submental swelling with no history of dysphagia or dyspnea was biochemically hypothyroid. Patient had a history of submental swelling that was misdiagnosed as an abscess, creating a diagnostic dilemma, as he was found to have glandular tuberculosis after surgical drainage of the lesion. Bangladesh J. Nuclear Med. 25(2): 125-127, 2022

Generation of Centromere-Associated Protein-E <em>CENP-E<sup>-/-</sup></em> Knockout Cell Lines using the CRISPR/Cas9 System

The CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 system has emerged as a powerful tool for precise and efficient gene editing in a variety of organisms. Centromere-associated protein-E (CENP-E) is a plus-end-directed kinesin required for kinetochore-microtubule capture, chromosome alignment, and spindle assembly checkpoint. Although cellular functions of the CENP-E proteins have been well studied, it has been difficult to study the direct functions of CENP-E proteins using traditional protocols because CENP-E ablation usually leads to spindle assembly checkpoint activation, cell cycle arrest, and cell death. In this study, we have completely knocked out the CENP-E gene in human HeLa cells and successfully generated the CENP-E-/- HeLa cells using the CRISPR/Cas9 system. Three optimized phenotype-based screening strategies were established, including cell colony screening, chromosome alignment phenotypes, and the fluorescent intensities of CENP-E proteins, which effectively improve the screening efficiency and experimental success rate of the CENP-E knockout cells. Importantly, CENP-E deletion results in chromosome misalignment, the abnormal location of the BUB1 mitotic checkpoint serine/threonine kinase B (BubR1) proteins, and mitotic defects. Furthermore, we have utilized the CENP-E knockout HeLa cell model to develop an identification method for CENP-E-specific inhibitors. In this study, a useful approach to validate the specificity and toxicity of CENP-E inhibitors has been established. Moreover, this paper presents the protocols of CENP-E gene editing using the CRISPR/Cas9 system, which could be a powerful tool to investigate the mechanisms of CENP-E in cell division. Moreover, the CENP-E knockout cell line would contribute to the discovery and validation of CENP-E inhibitors, which have important implications for antitumor drug development, studies of cell division mechanisms in cell biology, and clinical applications.

Placenta previa in in vitro fertilization and unassisted pregnancies–is there a difference in perinatal outcomes and placental histology?

Introduction In-vitro-fertilization (IVF) is an independent risk factor for placenta previa (PP). Our aim was to study this link by comparing the clinical characteristics and placental histology of pregnancies complicated by PP in IVF versus unassisted pregnancies. Methods A retrospective-cohort study of deliveries with PP between 2008 and 2021. Placental histology, obstetric and neonatal outcomes were compared between IVF and unassisted pregnancies. Included, were singleton deliveries complicated by PP at gestational weeks (GA) >24. Results A total of 182 pregnancies were included − 23 IVF pregnancies (IVF group) and 159 unassisted pregnancies (Control group). The control group was characterized by higher gravidity (p = .007) and parity (p < .001) and a trend of more past cesarean deliveries, whereas the IVF group- by a higher rate of nulliparity (p < .001) and diabetes mellitus (p = .04). The control group was characterized by a higher rate of placental weight below the 10th percentile (47.8 versus 13.9%, p = .001) and by a trend of a lower overall placental weight. No differences were noted in maternal and fetal vascular lesions. Discussion While PP in non-assisted pregnancies is probably associated with previous CDs, in IVF it is more “sporadic,” and may complicate any index pregnancy. A lower placental weight was more prevalent in the control group, supporting the concept that pregnancies complicated by PP following IVF can be attributed to initial abnormal location of placentation, rather than an underlying pathological uterine segment of implantation. Nevertheless, IVF and unassisted pregnancies entail similar perinatal outcomes in cases of PP.

The CRM1‐mediated nuclear export effectuates the role conversion of tumour suppressor gene BATF2 in colorectal cancer

The CRM1‐mediated nuclear export effectuates the role conversion of tumour suppressor gene BATF2 in colorectal cancer

The role of radiological research methods in the diagnosis of rare forms of interstitial lung diseases in newborns

Introduction. Interstitial lung diseases in newborns associated with diffuse pulmonary developmental disorders are a difficult to detect, as they are rare, formed at the early stages of embryonic development, clinically manifested in the first hours of life as severe respiratory distress syndrome in newborns. The aim. To demonstrate the role of radiation research methods and the difficulties of differential diagnosis of rare forms of interstitial lung diseases associated with diffuse impaired lung development. Materials and methods. Clinical cases of congenital alveolar dysplasia and alveolar-capillary dysplasia with an abnormal location of the pulmonary veins are described in detail, the radiological data, confirmed by the histological data, are presented. Results. Specific changes in the lungs in ILD of newborns associated with a diffuse disorder of lung development, according to X-ray data in the first day of life, are not determined, however, a progressive negative trend has been noted. The lungs computed tomography allows a detailed diagnosis of structural changes in the lung parenchyma, their severity and prevalence. Issues of differential diagnosis of diffuse disorders of lung development in newborns are discussed; the obtained results correlate with the published data. Conclusions. Histological examination is the “gold standard” in the diagnosis of interstitial lung diseases associated with diffuse lung developmental disorders in newborns, but is most often performed at autopsy. The role of radiological methods in the algorithmic approach of diagnostics is increasing due to the accumulated data, the improvement in the quality of detection and recognition of rare variants of interstitial lung diseases in newborns according to CT of the chest organs.

A Case of Primary EAC Cholesteatoma Extending into Antrum with Normal Middle Ear

Introduction A cholesteatoma is a three-dimensional sac lined by keratinized squamous epithelium containing desquamated keratinized epithelial cell which secretes enzymes that have the tendency to expand and erode the bony structure underlying it and cause intracranial and extracranial complications. This cystic mass is in an abnormal location such as the middle ear, the petrous apex, or the external auditory canal (EAC). It is mostly found in the middle ear and rarely in the EAC. Here we have reported a rare case of unilateral primary EAC cholesteatoma with mild hearing loss in a middle-aged male. Case Report We have reported a case of a 34-year-old male with complaints of right-sided ear discharge and right-sided decreased hearing for the last 5 to 6 years. On examination, right ear EAC was found to be dry, and a sac was observed in posterior wall extending to mastoid present with clear attic, and intact retracted tympanic membrane that was then followed by radiological evaluation to establish the diagnosis of EAC cholesteatoma. This was surgically treated and ear was cleared of all disease. Patient’s symptoms improved postoperatively. Conclusion Primary EAC cholesteatoma with disease-free middle ear is a rare finding and there is very less definitive literature available on the pathogenesis of the same.

Identification of Maternity Mothers with Uterine Inertia at the Kendari City Regional General Hospital

Uterine inertia is a uterine abnormality in which there is insufficient strength to open the cervix or push the fetus out. The causes of uterine inertia are his abnormalities, emotional factors and strength, misdirected labor, abnormal location of the CPD, disturbances in the formation of the uterus during the embryonic period, wrong administration of oxytocin and sedative drugs, excessive stretching of the uterus in multiple pregnancies or hydramnios, and postmature pregnancy. The effects of uterine inertia are prolonged labor, exhaustion, dehydration, and intrapartum infections. To Identify Maternity Mothers With Inertia Uteri at the General Hospital of Kendari City. This type of research implemented in June 2022 at General Hospital Kendari city. the study population was all women with maternal inertia in General Hospital kendari city with a total of 37 ceses. the sampling technique is total sampling.the type of data is quantitative data the data source of research is secondary data. The mother's age, 27 cases occurred at the age of 20-35 years and a few cases occurred at the age of &gt; 35 because of 8 cases. for maternal parity, there was a lot of parity I as many as 14 cases and a few cases in &gt; IV parity of 5 cases. for maternal education, it mostly occurred in SMP as many as 15 cases and a little occurred in DIII / SI as many as 3 cases. for maternal occupation, it occurred mostly in IRT as many as 26 cases and a little occurred in self-employed as many as 3 cases

Identifying Anomalies of Systemic Venous Drainage: Systemic Venous Anomalies; Atrial Morphology.

So as to produce totally anomalous systemic venous connection, all of the systemic venous tributaries, along with the coronary sinus, should be connected with the morphologically left atrium. Previous descriptions of this rare constellation of anomalous connections of the systemic venous tributaries of the heart have been compromised by the inclusion of individuals having isomeric atrial appendages. In these settings, most frequently, the totally, or almost totally, anomalous systemic venous connections are associated with a sinus venosus defect. It is the anomalous pulmonary venous connections that then create a venovenous bridge, which permits the systemic venous tributaries to drain into the morphologically left atrium, even though they may be predominantly connected to the right atrium. More rarely, it is feasible for the primary atrial septum to develop so as to leave the systemic venous sinus in direct connection with the body of the morphologically left, rather than the morphologically right, atrium. We report a series of patients potentially falling into the category of anomalous systemic venous connections. The findings show a spectrum from partially to totally anomalous connections, with some better interpreted on the basis of anomalous drainage. Included in our cases, nonetheless, is an autopsied example of totally anomalous systemic venous connection produced by an abnormal location of the primary atrial septum. We discuss the potential morphogenesis for this finding. We emphasize the distinction that needs to be made between anomalous systemic venous connections and anomalous systemic venous drainage.

Body Stalk Anomaly Complicated by Ectopia Cordis: First-Trimester Diagnosis of Two Cases Using 2- and 3-Dimensional Sonography

Body stalk anomaly is a severe defect of the abdominal wall, characterized by the evisceration of abdominal organs and, in more severe cases, thoracic organs as well. The most serious condition in a body stalk anomaly may be complicated by ectopia cordis, an abnormal location of the heart outside the thorax. The aim of this scientific work is to describe our experience with the prenatal diagnosis of ectopia cordis as part of the first-trimester sonographic screening for aneuploidy. We report two cases of body stalk anomalies complicated by ectopia cordis. The first case was identified during a first ultrasound examination at 9 weeks of gestation. The second was identified during an ultrasound examination at 13 weeks of gestation. Both of these cases were diagnosed using high-quality 2- and 3-dimensional ultrasonographic images obtained by the Realistic Vue and Crystal Vue techniques. The chorionic villus sampling showed that the fetal karyotype and CGH-array were both normal. In our clinical case reports, the patients, immediately after the diagnosis of a body stalk anomaly complicated by ectopia cordis, opted for the termination of pregnancies. Performing an early diagnosis of a body stalk anomaly that is complicated by ectopia cordis is desirable, considering their poor prognoses. Most of the reported cases in the literature suggest that an early diagnosis can be made between 10 and 14 weeks of gestation. A combination of 2- and 3-dimensional sonography could allow an early diagnosis of body stalk anomalies complicated by ectopia cordis, particularly using new ultrasonographic techniques, the Realistic Vue and the Crystal Vue.

Laparoscopic-Assisted Total Resection and Endorectal Pull-Through Technique for Congenital Megarectum with Anorectal Malformation

Background/PurposeCongenital megarectum (CMR) is sometimes associated with anorectal malformations (ARM), although there is no established therapeutic strategy. This study aims to clarify the clinical features of ARM with CMR, and to demonstrate the effectiveness of a surgical treatment, namely laparoscopic-assisted total resection and endorectal pull-through technique. MethodsWe conducted a review of the clinical records of the patients with ARM with CMR treated at our institution between January 2003 and December 2020. ResultsSeven of 33 cases of ARM (21.2%) were diagnosed with CMR, four males and three females. The types of ARM were ‘intermediate’ in four, and ‘low’ in three patients. Five of the seven patients (71.4%) required resection of megarectum for intractable constipation and underwent laparoscopic-assisted total resection and endorectal pull-through technique. Bowel function was improved after resection in all five cases. All five specimens showed hypertrophy of the circular fibers, and three of them showed abnormal location of ganglion cells within the circular muscle fibers. ConclusionsCMR often causes intractable constipation and requires resection of the dilated rectum. Laparoscopic-assisted total resection and endorectal pull-through technique for ARM with CMR considered to be an effective, minimally invasive treatment for intractable constipation. Level of evidence for clinical research papersLevel Ⅳ. Type of studyTreatment study.

Research on Power Grid Short-term Load Forecasting Method Based on Data Mining

Because the abnormal location of the power grid load is mismarked, the average relative error increases in the process of forecasting. This paper proposes to study and analyze the method of short-term load forecasting based on data mining. It preprocesses the load characteristic clustering and related data, marks the abnormal position of a power grid within a calibrated mining range according to the load fluctuation state, and defines the short-term load forecasting range. It also constructs a data mining power load forecasting model through the acquired real-time forecasting data and information, designs layered and staged load forecasting links, and corrects and calculates by adopting data mining. The prediction residual error is obtained. The stage prediction standard is further determined, and the prediction processing is realized. The final test results show that the data mining short-term load forecasting test group designed in this paper has a small fluctuation range, indicating that the prediction error has been greatly controlled in the practical application process. The prediction error is small, the accuracy is improved, and it has practical application value.