Abnormal Joint Torque Coupling Research Articles

A Method to Quantify Multi-Degree-of-Freedom Lower Limb Isometric Joint Torques in Children with Hemiplegia.

Pediatric hemiplegia, caused by a unilateral brain injury during childhood, can lead to motor deficits such as weakness and abnormal joint torque coupling patterns which may result in a loss of independent joint control. It is hypothesized that these motor impairments are present in the paretic lower extremity, especially at the hip joint where extension may be abnormally coupled with adduction. Previous studies investigating lower extremity isometric joint torques in children with spastic cerebral palsy used tools that limited data collection to one degree of freedom, making it impossible to quantify these coupling patterns. We describe the adaptation of a multi-joint lower extremity isometric torque measurement device to allow for quantification of weakness and abnormal joint torque coupling patterns at the hip in the pediatric population. We also present preliminary data in three children without hemiplegia to highlight how the presence of atypical femoral bony geometry, often observed in childhood hemiplegia, can be accounted for in the Jacobian transformations and affect joint torque measurements at the hip.

Neural Constraints Affect the Ability to Generate Hip Abduction Torques When Combined With Hip Extension or Ankle Plantarflexion in Chronic Hemiparetic Stroke

Stroke lesions interrupt descending corticofugal fibers that provide the volitional control of the upper and lower extremities. Despite the evident manifestation of movement impairments post-stroke during standing and gait, neural constraints in the ability to generate joint torque combinations in the lower extremities are not yet well determined. Twelve chronic hemiparetic participants and 8 age-matched control individuals participated in the present study. In an isometric setup, participants were instructed to combine submaximal hip extension or ankle plantarflexion torques with maximal hip abduction torques. Statistical analyses were run using linear mixed effects models. Results for the protocol combining hip extension and abduction indicate that participants post-stroke have severe limitations in the amount of hip abduction torque they can generate, dependent upon hip extension torque magnitude. These effects are manifested in the paretic extremity by the appearance of hip adduction torques instead of hip abduction at higher levels of hip extension. In the non-paretic extremity, significant reductions of hip abduction were also observed. In contrast, healthy control individuals were capable of combining varied levels of hip extension with maximal hip abduction. When combining ankle plantarflexion and hip abduction, only the paretic extremity showed reductions in the ability to generate hip abduction torques at increased levels of ankle plantarflexion. Our results provide insight into the neural mechanisms controlling the lower extremity post-stroke, supporting previously hypothesized increased reliance on postural brainstem motor pathways. These pathways have a greater dominance in the control of proximal joints (hip) compared to distal joints (ankle) and lead to synergistic activation of musculature due to their diffuse, bilateral connections at multiple spinal cord levels. We measured, for the first time, bilateral constraints in hip extension/abduction coupling in hemiparetic stroke, again in agreement with the expected increased reliance on bilateral brainstem motor pathways. Understanding of these neural constraints in the post-stroke lower extremities is key in the development of more effective rehabilitation interventions that target abnormal joint torque coupling patterns.

A Wrist and Finger Force Sensor Module for Use During Movements of the Upper Limb in Chronic Hemiparetic Stroke

Previous studies using robotic devices that focus on the wrist/fingers following stroke provide an incomplete picture of movement dysfunction because they do not consider the abnormal joint torque coupling that occurs during progressive shoulder abduction loading in the paretic upper limb. This letter introduces a device designed to measure isometric flexion/extension forces generated by the fingers, wrist, and thumb during robot-mediated 3-D dynamic movements of the upper limb. Validation data collected from eight participants with chronic hemiparetic stroke are presented in this paper.

Impairment-Based 3-D Robotic Intervention Improves Upper Extremity Work Area in Chronic Stroke: Targeting Abnormal Joint Torque Coupling With Progressive Shoulder Abduction Loading

The implementation of a robotic system (ACT(3D)) that allowed for a quantitative measurement of abnormal joint torque coupling in chronic stroke survivors and, most importantly, a quantitative means of initiating and progressing an impairment-based intervention, is described. Individuals with chronic moderate to severe stroke (n = 8) participated in this single-group pretest-posttest design study. Subjects were trained over eight weeks by progressively increasing the level of shoulder abduction loading experienced by the participant during reaching repetitions as performance improved. Reaching work area was evaluated pre- and postintervention for ten different shoulder abduction loading levels along with isometric single-joint strength and a qualitative clinical assessment of impairment. There was a significant effect of session (pre versus post) with an increase in reaching work area, despite no change in single-joint strength. This data suggests that specifically targeting the abnormal joint torque coupling impairment through progressive shoulder abduction loading is an effective strategy for improving reaching work area following hemiparetic stroke. Application of robotics, namely, the ACT(3D), allowed for quantitative control of the exercise parameters needed to directly target the synergistic coupling impairment. The targeted reduction of abnormal joint torque coupling is likely the key factor explaining the improvements in reaching range of motion achieved with this intervention.

PRELIMINARY RESULTS FOR A TARGETED INTERVENTION FOR IMPROVING REACHING RANGE OF MOTION IN SEVERE HEMIPARETIC STROKE USING THE ARM

Purpose/Hypothesis: Abnormal upper extremity coordination can be expressed in the form of atypical muscle synergies that result in limited and stereotypic movement patterns such that when an individual with hemiparetic stroke attempts to support the arm against gravity there is a strong coupling with elbow flexion. These movement constraints are functionally disabling. While quantification of stroke-related impairments such as abnormal shoulder/elbow torque coupling has been thoroughly described in our laboratory under isometric and dynamic conditions, only recently have striking advances in rehabilitation robotics enabled us to develop a rehabilitation protocol that specifically targets discoordination in a quantifiable and repeatable fashion. We have developed and are employing the Arm Coordination Training 3D Device (ACT3D). This report documents preliminary evidence supporting the efficacy of an impairment-specific dynamic strengthening protocol for a group of individuals with chronic stroke and was taken as part of a larger randomized controlled study. Number of Subjects: Six individuals with stroke were trained to actively support their arm while reaching to various outward targets over a period of eight weeks. Materials/Methods: The intervention was progressed by increasing the level of required active limb support or gravitational loading experienced by the participant during reaching repetitions as performance improved. Functional work area was evaluated pre-and post-intervention for ten different support levels. Pre- and post-intervention clinical assessments were also taken by a blinded physical therapist as secondary outcomes. Results: Consistent with our previous work, there was a significant effect of limb support level such that as subjects were required to support up to and beyond the weight of their limb, there was a concurrent reduction in available work area. Notably, there was a significant effect of session on work area. Following the intervention, work area significantly increased for all limb support levels. There were also related improvements in the clinical assessment battery. Conclusions: This preliminary data suggests that specifically targeting the abnormal joint torque coupling impairment is an effective strategy for improving reaching work area following hemiparetic stroke. Clinical Relevance: Following the completion of this study physical therapists will have new evidence supporting the application of an impairment-targeted intervention for individuals with chronic and severe hemiparetic stroke.

Position-dependent torque coupling and associated muscle activation in the hemiparetic upper extremity

Previous studies have demonstrated abnormal joint torque coupling and associated muscle coactivations of the upper extremity in individuals with unilateral stroke. We investigated the effect of upper limb configuration on the expression of the well-documented patterns of shoulder abduction/elbow flexion and shoulder adduction/elbow extension. Maximal isometric shoulder and elbow torques were measured in stroke subjects in four different arm configurations. Additionally, an isometric combined torque task was completed where subjects were required to maintain various levels of shoulder abduction/adduction torque while attempting to maximize elbow flexion or extension torque. The dominant abduction/elbow flexion pattern was insensitive to changes in limb configuration while the elbow extension component of the adduction/extension pattern changed to elbow flexion at smaller shoulder abduction angles. This effect was not present in control subjects without stroke. The reversal of the torque-coupling pattern could not be explained by mechanical factors such as muscle length changes or muscle strength imbalances across the elbow joint. Potential neural mechanisms underlying the sensitivity of the adduction/elbow extension pattern to different somatosensory input resultant from changes in limb configuration are discussed along with the implications for future research.

Evidence for strength imbalances as a significant contributor to abnormal synergies in hemiparetic subjects.

Abnormal synergies in the paretic shoulder and elbow of hemiparetic subjects were quantified during maximal voluntary contractions (MVCs) in 27 subjects with a history of stroke and 8 age-matched control subjects. A six-axis load cell allowed simultaneous measurement of the primary torque the subject was attempting to maximize and the secondary torques at other joint actions. For example, during MVC of shoulder flexion, shoulder flexion is the primary torque and the secondary torques are internal/external rotation, abduction/adduction, and elbow flexion/extension. In general, the stroke subjects had increased secondary torques compared to controls, resulting in abnormal joint torque coupling within the set consisting of elbow flexion, internal rotation, adduction, shoulder flexion. Unlike previous studies, abnormal secondary torques in several cases were due to strength imbalances, which occur when the strength deficit for a particular joint action is greater than the strength deficit in the opposite joint action. This hypothesis was supported by electromyographic recordings and by the finding that subjects with larger strength imbalances tended to produce larger secondary torques. Possible mechanisms and consequences for rehabilitative treatments are discussed.