Abnormal Glycometabolism Research Articles

Levels of serum ferritin and hemoglobin in different stages of abnormal glycometabolism

In healthy control group(group A),impaired fasting glucose group (group B) and diabetes group(group C),serum ferritin levels gradually raised[(170.7±91.8),(255.2±161.9) and (362.8±298.5) μmol/L].Hemoglobin Was elevated in impaired fasting glucose group,while returned to normal or even lower in diabetes group[group A(141.0±9.5),group B(148.2±11.2),group C(132.3±19.2)g/L].There was no difference in high sensitivity C-reactive protein among the groups. Key words: Ferritin; Hemoglobin; Fatty acids,nonesterified; Diabetes mellitus,type 2

Expression of placental glucose transporters in pregnant women with abnormal glycometabolism

Objective To investigate the expression of glucose transporters(GLUTs)in placentas of pregnant women with abnormal glyeometabolism,and to explore its effect on glucose transport between mother and fetus and its relation with the birth weight.Methods Placentas of 41 pregnant women with abnormal glycometabolism(7 cases of DM,10 GDM A1,10 GIGT and 14 GDMA2)and 15 normal pregnant women as control were selected.The expression of GLUT1 and GLUT3was detected by immunohistochemistry.The birth weight was measured at delivery.Results GLUT1 was expressed in the syncytiotrophoblasts and cytotrophoblasts,whereas GLUT3 in some endothelial cells.The expressions of GLUT1 and GLUT3 were significantly different among the five groups(P＜0.01).Positive correlation was shown between the GLUT1 expression and the birth weight(rs=0.532,P＜0.01),but not in GLUT3 expression.Conclusions The expression of GLUT1 and GLUT3 in placentas of pregnancy with abnormal glycometabolism is enhanced,and GLUT1 may play a predominant role in the fetal glucose uptake. Key words: Glucose transport proteins,facilitative; Placenta; Pregnancy complications; Glucose metabolism disorders

Relationship between abnormal glycometabolism and ultra-sensitive C-reactive protein in non-alcoholic fatty liver

Relationship between abnormal glycometabolism and ultra-sensitive C-reactive protein in non-alcoholic fatty liver

Glucose metabolism status and angiographic features of coronary artery in patients undergoing their first coronary angiography: study of 553 cases

To investigate the correlation between glucose metabolism status and coronary artery lesion in the patients undergoing their first coronary angiography (CAG). Oral glucose tolerance test (OGTT) and CAG were performed in 553 patients with suspected or confirmed coronary artery disease (CAD), aged 60.1 +/- 9.7. The anthroposomatologic parameters, blood pressure, HbA1c, and lipid profile of these patients were collected. Their glucose metabolism status was assessed based on the WHO diagnostic criteria of diabetes mellitus 1999 and American Heart Association's grading standards for evaluating coronary artery stenosis and Gensini score were applied to analyze the coronary artery lesion. According to the CAG results the patients were divided into CAD group and non-CAD group and then the glucose metabolic characteristics in both groups were analyzed by comparison based on the glycometabolic status. The patients were also grouped into diabetic and non-diabetic groups and the coronary artery angiographic features in both groups were compared. Among the 533 patients 277 (50.1%) had normal OGTT, 127 (23.0%) were diagnosed as with impaired glucose regulation, 61 (11%) were newly diagnosed as with type 2 diabetes mellitus, and the other 88 patients (15.9%) were already known diabetics. The prevalence of abnormal glycometabolism in the CAD group was 56.4%, significantly higher than that in the non-CAD group (34.5%, P < 0.05). The prevalence of multiple branches involvement in the diabetic group was 63.8%, significantly higher than that of the non-diabetic group (44.1%, P < 0.05), and the Gensini score in the diabetic group was 15 (30.5), significantly higher than that of the [20 (27), P < 0.05]. Abnormal glycometabolism is common in the population undergoing coronary angiography. Both the prevalence of multiple branches involvement and the degree of stenosis of coronary in the diabetics are higher than that in those without diabetes.

Predominance of Small Dense Low-Density Lipoproteins and Abnormal Glucose Regulation in Patients With Acute Coronary Syndrome

Although small dense low-density lipoprotein (sd-LDL) has an established association with diabetic dyslipidemia, previous studies have failed to show an association between sd-LDL and diabetes among coronary heart disease patients. This study investigated the prevalence of sd-LDL and abnormal glucose regulation in acute coronary syndrome (ACS). LDL size at the onset of ACS was measured by nondenatured gradient gel electrophoresis in 314 of 429 consecutive patients. Sd-LDL was prevalent in 54% of the patients, irrespective of the presence of previously known diabetes (50% vs 60% in nondiabetes and diabetes, respectively). Diabetes was present in 122 (28%) of the patients, and 110 patients without diabetes underwent an oral glucose tolerance test. Impaired glucose tolerance (IGT) and newly detected diabetes were found in as many as 44% and 22% of the patients tested, even though their hemoglobinA1c levels were in the normal range (5.3+/-0.5%). The prevalence of sd-LDL was significantly higher in patients with glucose intolerance than in those with normal glucose tolerance (61% vs 42%). IGT and diabetes were far more common than normal glucose regulation in ACS patients, and the abnormal glycometabolism was closely associated with highly atherogenic sd-LDL.