Integrating anatomical structures with appropriate clinical examples can enhance the understanding of basic medical sciences and speed up the learning process. We have integrated illustrations of normal tissues with illustrations of diseased to highlight the differences between normal and abnormal tissues, and to demonstrate the processes in which normal change into abnormal tissues. Examples include: (1) Connective tissue cells in normal tissue compared to the cells in the tissue during an allergic reaction. (2) Normal and abnormal endothelium in atherosclerosis in blood vessels. (3) Normal stratified columnar cells of the conjunctiva of the eye are compared to cells with inflammatory granulations of the conjunctiva. (4) A normal optic nerve papilla is compared with an optic nerve papilla that exhibits papilledema. (5) Comparison of normal dentinal tissue and abnormal dentin tissue in a case of dentinogenesis imperfecta. Clinical correlations with well‐designed illustrations benefit students in learning clinical concepts, enhance the student's understanding of basic medical sciences, and help the students acquire clinical skills. This learning process paves the road for medical students as well as dental students to develop critical thinking skills while they are still in their early years of medical education, thus guiding them in their future study.Grant Funding Source: University of Mississippi Medical center