Balance Ability Research Articles

Effects of Standard Tai Chi on Exercise Capacity and Mental Health in Exercise-Deprived Overweight/Obese Adults and Assessment of Participant Adherence.

To explore the effects of Tai Chi on body mass index (BMI), exercise capacity, and mental health of overweight/obese adults, and investigate factors influencing adherence to enhance adherence of Tai Chi as a sustainable exercise method. A randomized, controlled, exploratory clinical trial was conducted paired with a qualitative study of adherence management. A total of 20 overweight/obese participants were randomly assigned to a standard Tai Chi group (experimental) and a simplified Tai Chi group (control) for an 8-week intervention, 10 patients in each group, with a 12-month follow-up. BMI was calculated and exercise capacity including an isokinetic muscle strength and balance ability test were evaluated. Mental health was assessed using the General Well-Being Schedule (GWB), Pittsburgh Sleep Quality Index (PSQI), and Coping Self Efficacy Scale (CSES) at baseline, 4th week, and 8th week, respectively. The qualitative research included open-interviews with Tai Chi practitioners and semi-structured interviews with subjects. The intervention was conducted in Haidian Park, Beijing, China from October 6, 2022, to January 1, 2023, without dropouts. After an 8-week intervention, the participants in the experimental group exhibited a significant decrease in BMI (P<0.05). Both groups demonstrated significant improvements in exercise capacity (P<0.05). The experimental group exhibited a significant enhancement in the GWB, PSQI and CSES (P<0.05). Only GWB had significant difference in the control group (P<0.05). The experimental group surpassed the control group in GWB and CSES (P<0.05). The adherence rate was 87.5% in the experimental group and 57.9% in the control group after 8 weeks intervention. Analysis on adherence identified 15 themes, the top 3 themes mentioned were as follows: mind-body effects, online and on-site guidance, training schedule (for subjects); mind-body effects, difficulties in practicing, and understanding of Tai Chi (for practitioners). Both interventions were effective in improving exercise capacity. Tai Chi, integrating both physical and mental conditioning, reduced weight, improved exercise capacity and mental happiness, and increased adherence, providing a sustainable exercise program (ChiCTR2200063599).

The effect of family posture control combined with GAME therapy on motor function in children with severe cerebral palsy.

This paper has a purpose to explore the effects of home posture control combined with goal-activity-exercise-environment therapy on motor function in children with severe cerebral palsy (CP). Data of 80 children with severe CP treated from January 2022 to December 2023 were collected. They were divided into experimental group (EG) and control group according to different treatment methods, with 40 people in each group. The controlled group (CG) obtained routine treating means, including occupational therapy, electromyographic biofeedback therapy, and other treatment items. The EG received a combination of home posture control and goal-activity-exercise-environment therapy on the basis of conventional treatment. Meanwhile, parents received professional training to manage their children's posture and received reinforcement training through goal-activity-exercise-environment therapy. The Gross motor function measure-88, Peabody developmental motor scale-fine motor, pediatric balance scale, Fugl-Meyer assessment and other scales were used to evaluate the motor function, balance ability, daily living activity ability, and developmental level of patients. After 3 months of treatment, the Gross motor function measure-88 scores of these 2 groups were 70.96 ± 18.29 and 57.42 ± 21.41, respectively. The Peabody developmental motor scale-fine motor scores were 76.48 ± 14.42 and 59.77 ± 14.89, respectively. The balance ability index, upper limb motor function index, daily living activity ability, and developmental level of the EG were significantly higher than the CG's, and the P-values were all <.05. The combination of home posture control and GAME therapy can significantly improve the motor function and daily living activities of children with severe CP. This helps to maintain the normal growth and development of the child, and has certain clinical value.

High-Definition Trans-Spinal Current Stimulation Improves Balance and Somatosensory Control: A Randomised, Placebo-Controlled Trial.

To investigate and compare the effects of three different high-definition (HD) non-invasive current stimulation (NICS) protocols on the spinal cord on support balance and somatosensory abilities in healthy young people. Fifty-eight students were enrolled in this crossover study. All participants underwent application of (i) 1.5 mA anodal high-definition trans spinal direct current stimulation (HD-tsDCS), (ii) 1.5 mA cathodal HD-tsDCS, (iii) 1.5 mA high-definition trans spinal alternating current stimulation (HD-tsACS), and (iv) sham HD-tsDCS/ACS over the eighth thoracic vertebra in a randomised order. Balance (Y Balance test), deep sensitivity (Tuning Fork Test), and superficial sensitivity (Monofilament Test) of the lower limbs were tested immediately before and after each intervention. Balance ability improved significantly following anodal HD-tsDCS and HD-tsACS compared with that following sham HD-tsDCS/ACS. Similarly, deep sensitivity increased significantly with anodal HD-tsDCS and HD-tsACS compared to that with sham HD-tsDCS/ACS and cathodal HD-tsDCS. Furthermore, superficial sensitivity improved significantly following anodal HD-tsDCS compared with that after HD-tsACS and cathodal HD-tsDCS. Our data show that HD-tsNICS effectively modulates the balance and somatosensory control of the lower limbs. Several diseases are associated with illness-induced changes in the spinal network in parallel with sensorimotor disabilities. Non-invasive spinal modulation may be a favourable alternative to conventional brain applications in rehabilitation. Future studies should therefore investigate these promising approaches among cohorts of patients with disabilities.

Machine learning’s effectiveness in evaluating movement in one-legged standing test for predicting high autistic trait

IntroductionResearch supporting the presence of diverse motor impairments, including impaired balance coordination, in children with autism spectrum disorder (ASD) is increasing. The one-legged standing test (OLST) is a popular test of balance. Since machine learning is a powerful technique for learning predictive models from movement data, it can objectively evaluate the processes involved in OLST. This study assesses machine learning’s effectiveness in evaluating movement in OLST for predicting high autistic trait.MethodsIn this study, 64 boys and 62 girls participated. The participants were instructed to stand on one leg on a pressure sensor while facing the experimenter. The data collected in the experiment were time-series data pertaining to pressure distribution on the sole of the foot and full-body images. A model to identify the participants belonging to High autistic trait group and Low autistic trait group was developed using a support vector machine (SVM) algorithm with 16 explanatory variables. Further, classification models were built for the conventional, proposed, and combined explanatory variable categories. The probabilities of High autistic trait group were calculated using the SVM model.ResultsFor proposed and combined variables, the accuracy, sensitivity, and specificity scores were 1.000. The variables shoulder, hip, and trunk are important since they explain the balance status of children with high autistic trait. Further, the total Social Responsiveness Scale score positively correlated with the probability of High autistic trait group in each category of explanatory variables.DiscussionResults indicate the effectiveness of evaluating movement in OLST by using movies and machine learning for predicting high autistic trait. In addition, they emphasize the significance of specifically focusing on shoulder and waist movements, which facilitate the efficient predicting high autistic trait. Finally, studies incorporating a broader range of balance cues are necessary to comprehensively determine the effectiveness of utilizing balance ability in predicting high autistic trait.

Assessment of body balance status in bikers: a study using R

Road traffic injuries are one of the most important and serious causes of unnatural death in India. Two-wheelers, especially motorcycle accidents contribute significantly in this regard. In order to avoid accidents and consequent losses, emphasis should be given on safe riding. Besides the condition of the vehicle, the road surface, willingness to adhere to safety regulations, body balance is a key factor in safe riding two-wheelers in order to avoid meeting with accidents of different consequences. In this backdrop, the study was aimed to assess whether there is any differences in body balances between the Bengalee adult male motorcyclists and similar individuals who do not know how to ride a motorcycle. 41 consenting individuals, among which 25 motorcylcists and 16 indivuals who do not know to ride motorcycle, were participated in the study. Anthropometric measurements were carried out using standard procedures and tools. Body balances tests like timed up and go and single limb step test along with visuo-tactile reaction time test were performed. Statistical package R 4.3.0 was used for statistical analysis. Student’s t test was performed. The study showed significant (P&lt;0.05) differences in body balance parameters between the two groups of individuals. Which leads to the conclusion that motorcyclists shown better body balancing ability than their counter group.

Transiently worse postural effects after vestibulo-ocular reflex gain-down adaptation in healthy adults.

Suffering an acute asymmetry in vestibular function (i.e., vestibular neuritis) causes increased sway. Non-causal studies report associations between lateral semicircular canal function and balance ability, but direct links remain controversial. We investigate the immediate effect on body sway after unilateral vestibulo-ocular reflex (VOR) gain down adaptation simulating acute peripheral vestibular hypofunction. Eighteen healthy adults, mean age 27.4 (± 12.4), stood wearing an inertial measurement device with their eyes closed on foam before and after incremental VOR gain down adaptation to simulate mild unilateral vestibular neuritis. Active head impulse VOR gain was measured before and after the adaptation to ensure VOR gain adaptation. Percentage change for VOR gain was determined. Sway area was compared before and after VOR adaptation. VOR gain decreased unilaterally exceeding meaningful change values. Sway area was significantly greater immediately after VOR gain down adaptation, but quickly returned to baseline. In a subset of subjects VOR gain was re-assessed and found to remain adapted despite sway normalization. These results indicate that oculomotor adaptation targeting the lateral semicircular canal VOR pathway has an immediate, albeit transient increase in body sway. Rapid return of body sway to baseline levels suggests dynamic sensory reweighting between vestibular and somatosensory inputs to resolve the undesirable increased body sway.

Positive effects of lower extremity constraint-induced movement therapy on balance, leg strength and dual-task ability in stroke patients: a longitudinal cohort study.

To investigate whether high-intensity lower extremity constraint-induced movement therapy can improve balance, leg strength, and dual-task ability. A longitudinal cohort study in a real-world outpatient clinic. 147 community-dwelling participants in the subacute and chronic poststroke phases. Participants received lower extremity constraint-induced movement therapy for 6 hours/day during 2 consecutive weeks, including balance, strength, and functional training. The Berg Balance Scale (BBS), Single-Leg-Stance (SLS) bilaterally, one Repetition Maximum (1RM) in a leg press, symmetry of leg strength (Diff-1RM), Timed Up and Go (TUG), and the TUG Manual test were assessed before, after, and 3 months after lower extremity constraint-induced movement therapy. Compared with preintervention data, statistically significant improvements after lower extremity constraint-induced movement therapy (p < 0.001) were demonstrated for balance with an absolute value in BBS at 1.9 points (effect size 0.38) and SLS at 2.4 s (effect size 0.24), and for leg strength at 10.2 kg (effect size 0.54) for the affected leg. Diff 1RM decreased significantly at 5.8 kg (effect size 0.39) and improvements on dual-task ability at 2.7 s were significant (effect size 0.14). The effects persisted at the 3-month follow-up. High-intensity lower extremity constraint-induced movement therapy may be a feasible treatment option for middle-aged stroke patients to affect balance, leg strength, and dual-task ability positively in an out-patient clinical setting.

Effects of 8 weeks of rhythmic physical activity on gross motor movements in 4-5-year-olds: A randomized controlled trial

ObjectiveRhythmic physical activity holds promise for positively influencing the gross motor development of 4-5-year-old children, yet empirical research in this domain remains limited. This study aimed to investigate the effects of rhythmic physical activity on the gross motor development in children aged 4–5 years. MethodsFifty children aged 4–5 years were recruited and randomly assigned to either the intervention or control group. Both groups participated in a 10-week intervention program facilitated by a professional trainer, with support from numerous dedicated volunteers from reputable sports universities. This program comprised a one-week baseline assessment followed by 8 weeks of rhythmic physical activity training conducted three times per week. Gross motor performance was assessed using the PGMQ scale before and one week after the intervention. ResultsFollowing the 8-week intervention, the intervention group demonstrated significant enhancements in displacement ability, with notable improvements observed in. Specifically, the scores for running, sliding lateral transfer, leaping step, two-footed back-and-forth jump, and total displacement ability showed significant increases (P < 0.05). Moreover, the total scores for running, standing long jump, sliding lateral transfer, leaping step, two-footed back-and-forth jump, and displacement ability exhibited significant differences between the intervention and control groups (P < 0.05). Regarding manipulative ability, the intervention group showed significant increases in scores for over-the-shoulder throwing, two-handed catching, and kicking (P < 0.05). Moreover, there were significant differences between groups in the scores for two-handed catching and kicking (P < 0.05). Concerning balance ability, the intervention group exhibited significant improvements in scores for single-leg stand, double-leg stand, and total balance ability (P < 0.05). No significant differences were observed in any of the indices within the control group (P > 0.05). The two-way repeated measures ANOVA of intervention × time revealed significant differences in scores for running, sliding lateral movement, leaping step, jumping back and forth with both feet, leading ability, kicking, manipulation ability, single-leg stand, double-leg stand, balance ability, and gross motor scores (P < 0.05). ConclusionsThis study underscores the beneficial impact of engaging in eight weeks of rhythmic physical activity on the gross motor development of 4-5-year-olds. Furthermore, the improvements in gross motor development achieved through rhythmic physical activity may surpass those obtained through general physical activity.

Neck muscle vibration and prism adaptation fail to improve balance disturbances after stroke: A multicentre randomised controlled study

BackgroundPilot studies suggest potential effects of neck muscle vibration (NMV) and prism adaptation (PA) on postural balance disturbances related to spatial cognition. ObjectivesTo evaluate the effect of 10 sessions of NMV and/or PA on ML deviation. We used the mediolateral centre of pressure position (ML deviation) as a biomarker for spatial cognition perturbation, hypothesising that PA and NMV would improve ML deviation, with a potential synergistic impact when used together. MethodsWe conducted a multicentre, single-blind, randomised controlled study. Participants within 9 months of a right-hemisphere supratentorial stroke and with less than 40% body weight supported on the paretic side in standing were randomised into 4 groups (PA, NMV, PA+NMV, or control). Primary outcomeML deviation at Day 14. Secondary outcomes: force platform data, balance abilities, autonomy, and ML deviation, measured just after the first session (Day 1), at Day 90, and Day 180. A generalised linear mixed model (GLMM) assessed intervention effects on these outcomes, adjusting for initial ML deviation and incorporating other relevant factors. Results89 participants were randomised and data from 80 participants, mean (SD) age 59.2 (10.2) years, mean time since stroke 94 (61) days were analysed. At Day 14, a weak time x group interaction (P = .001, omega-squared = 0.08) was found, with no significant between-group differences in ML deviation (P = .12) or in secondary outcomes (P = .08). Between-group differences were found on Day 1 (P = .03), Day 90 (P = .001) and Day 180 (P < .0001) regardless of age and stroke-related data. On Day 1, ML deviation improved in both the PA and NMV groups (P = .03 and P = .01). In contrast, ML deviation deteriorated in the NMV+PA group on Day 90 and Day 180 (P = .01 and P = .01). ConclusionsThe study found no evidence of any beneficial effects of repeated unimodal or combined sessions of NMV and/or PA on ML deviation after stroke. Trial registrationClinicalTrials.gov identifier NCT01677091

Balance Ability And Brain Activation Characteristic In Adolescents With Typically Developing

Balance Ability And Brain Activation Characteristic In Adolescents With Typically Developing

Effect Of Different Joint Mobilization On Balance Ability Of Patients With Functional Ankle Instability

Effect Of Different Joint Mobilization On Balance Ability Of Patients With Functional Ankle Instability

Knee muscle strength, body composition, and balance performance of youth soccer players

BackgroundMuscle strength and balance abilities have been related to game performance injury prevention. This study aimed to (1) assess knee muscle strength performance based on intra- and inter-limb asymmetries, (2) investigate the relationships between knee muscle strength, body composition, and balance, and (3) analyze the variance in the overall stability index (OSI) explained by knee muscle strength indicators after controlling for age and body composition.MethodsThe sample included 104 young male soccer players (16.0 ± 1.6 years). Body composition, knee muscle strength, and balance ability were assessed. A paired samples t-test was used to examine differences between the preferred leg (PL) and the non-preferred leg (NPL). Pearson correlations and hierarchical multiple regression were conducted to explore the relationships between strength, body composition, and balance.ResultsNo significant inter-limb asymmetries were detected for the knee flexors (KF) and knee extensors (KE) performance. The hamstrings-to-quadriceps ratio does not suggest the existence of intra-limb asymmetries (p = 0.06). Significant and negative correlations were found between KF (r = -0.38, p ≤ 0.01) and KE (r = -0.58, p ≤ 0.01) for the PL. Concerning the NPL, KE also revealed a significant and negative relationship with balance (r = -0.30, p ≤ 0.01). Significant and positive relationships were found between bodyweight, fat-free mass, and balance. After controlling for age and body composition, knee muscle strength could explain between 13% and 30% of the variance observed in the OSI (NPL and PL, respectively).ConclusionsThe results underline knee muscle strength as an important predictor of balance. Thus, training programs targeting knee muscle strength development should be considered during the season periodization by coaches and their staff throughout the players’ developmental stages.

The effect of classical music on balance, emotional state, and perceived effort in precompetitive artistic gymnasts and trampoline athletes

PurposeIn artistic gymnastics (AG) and trampoline (TR ), athletes must be able to combine strength, flexibility, and artistry. The purpose of the study was to examine the effect of classical music on balance, emotional state, and perceived effort in precompetitive AG and TR athletes after a 6-week intervention training program.MethodsThe sample consisted of 36 athletes (20 AG and 16 TR athletes) who were randomly divided into two equal groups: experimental (with music) and control (without music). Balance ability was assessed with the Balance Error Scoring System (static balance) and the Y-balance test (dynamic balance). Before and after the intervention, participants completed the RPE-FS questionnaire which included a perceived fatigue scale (PFS) and an emotion scale (ES) to assess perceived fatigue (PF) and emotional state. The total sample followed a 6-week intervention training program, twice per week. TR athletes performed all exercises on a TR , whereas AG athletes performed their exercises on the floor. During the 6 weeks, the athletes completed the questionnaire before and after each training session.ResultsThe results showed a statistically significant improvement in static and dynamic balance in female athletes of both sports (&lt;i&gt;p&lt;/i&gt; &lt; 0.05), with the percentage of improvement in AG athletes being comparatively higher than that of TR athletes. There were also significant differences in individual measures of emotional state and perceived fatigue in the examined sample.ConclusionsClassical music differentiates the rate of performance improvement in precompetitive young female athletes in these two sports.

Effectiveness of STEM Learning Model and Project-Based Learning to Enhance Critical Thinking Skills in Senior High School

STEM and Project-Based Learning (PjBL) learning models have been applied to support 21st century learning. However, no empirical evidence has been found to reveal the combined effectiveness of the two models. This study aims to determine the effectiveness of STEM, Project-Based Learning (PjBL), and lecture learning models in improving critical thinking skills. The research was conducted at SMA Negeri 8 Ternate City, North Maluku Province, involving 64 students divided into three classes studying Indonesian natural resource management. A concurrent embedded strategy combining quantitative and qualitative data collection was used. Initial test data indicated reliability at 0.76, with normality tests for the STEM model at 0.08, the PjBL model at 0.13, and lecture learning at 0.14, all showing normally distributed data. The homogeneity test showed homogeneous data with a value of 1.097. The balance test using one-way ANOVA indicated balanced initial abilities (Fhitung 2.52 Ftabel 3.14). Results demonstrated that by applying the STEM and PjBL learning models, students achieved proficiency in critical thinking skills. Final test data, including normality tests, one-way unequal ANOVA, and post-ANOVA tests, showed significant improvement in critical thinking skills. The STEM model and PjBL model were both effective with no significant differences between them, while both differed significantly from the lecture learning model. The results suggest that both STEM and PjBL models are effective in enhancing critical thinking skills. To address the shortcomings of traditional lecture methods, educators should consider integrating STEM and PjBL approaches into their teaching practices.

Delayed Cortical Responses During Reactive Balance After Stroke Associated With Slower Kinetics and Clinical Balance Dysfunction.

Slowed balance and mobility after stroke have been well-characterized. Yet the effects of unilateral cortical lesions on whole-body neuromechanical control is poorly understood, despite increased reliance on cortical resources for balance and mobility with aging. Objective. We tested whether individuals post stroke show impaired cortical responses evoked during reactive balance, and the effect of asymmetrical interlimb contributions to balance recovery and the evoked cortical response. Using electroencephalography, we assessed cortical N1 responses evoked over fronto-midline regions (Cz) during backward support-surface perturbations loading both legs and posterior-lateral directions that preferentially load the paretic or nonparetic leg in individuals' post-stroke and age-matched controls. We tested relationships between cortical responses and clinical balance/mobility function, as well as to center of pressure (CoP) rate of rise (RoR) during balance recovery. Cortical N1 responses were smaller and delayed after stroke (P < .047), regardless of perturbation condition. In contrast to controls, slower cortical response latencies associated with lower clinical function in stroke (Mini Balance Evaluation Systems Test: r = -.61, P = .007; Timed-Up-and-Go: r = .53, P = .024; walking speed: r = -.46, P = .055). Paretic-loaded balance recovery revealed slower CoP RoR (P = .012) that was associated with delayed cortical response latencies (r = -.70, P = .003); these relationships were not present during bilateral and nonparetic-loaded conditions, nor in the older adults control group. Individuals after stroke may be limited in their balance ability by the slowed speed of their cortical responses to destabilization. In particular, paretic leg loading may reveal cortical response impairments that reflect reduced paretic motor capacity.

Plantar Pressure Characteristics with Foot Postures and Balance Abilities in Indigenous Taiwanese: A Preliminary Exploration.

BACKGROUND Although Indigenous Taiwanese are generally known for having excellent athleticism and balance abilities, the correlation between foot characteristics and balance abilities has rarely been discussed. This study aimed to explore the characteristics of plantar pressure profiles associated with foot posture and balance abilities among Indigenous Taiwanese. MATERIAL AND METHODS We recruited 165 Indigenous college students and 183 healthy age-matched students. Bipedal static plantar pressure distributions (PPDs) with arch index (AI) and centers of gravity balance were examined using the JC Mat. Foot posture was determined by estimating the rearfoot postural alignment. RESULTS Indigenous Taiwanese in the study generally had low-arched feet with increased plantar loads at the medial (left: 1.21±0.43%; right: 1.20±0.46%) and lateral longitudinal arches (left: 24.51±5.26%; right: 24.45±6.64) (P<0.01) and the medial metatarsals (left: 21.78±3.81%; right: 22.19±3.91) (P<0.01). Footprint images illustrated pronounced cuboid and navicular collapses. Performances of balance abilities (left: 49.53±4.38%; right: 50.47±4.38) (P<0.01) and rearfoot postural angles (left: 1.37±1.25°; right: 1.32±1.17°) (P<0.05) were better than those of controls. CONCLUSIONS The feet in Indigenous Taiwanese had low arches and higher plantar loads at the medial and lateral longitudinal arches and medial metatarsals, while their centers of gravity were symmetrical and rearfoot posture was normal. These results may facilitate further studies on the relationship between foot characteristics, potential athleticism, and musculoskeletal injuries in Indigenous Taiwanese.

Relationship between Attention Concentration and Ability of Endurance and Dynamic Balance among the Female students at (9-12) Age Group

Relationship between Attention Concentration and Ability of Endurance and Dynamic Balance among the Female students at (9-12) Age Group

Treatment of neurologic pathology and inflammation in Machado-Joseph disease through in vivo self-assembled siRNA.

Machado-Joseph disease, also known as Spinocerebellar ataxia type 3 (MJD/SCA3), is a fatal autosomal dominant hereditary ataxia characterized by cerebellar ataxia resulting from the abnormal expansion of CAG repeats in exon 10 of the ATXN3 gene. Presently, there is no effective treatment for SCA3. Small interfering RNAs (siRNAs) are emerging as potential therapeutic strategies to specifically target the disease-causing mutant ATXN3 (mATXN3) protein. However, the delivery efficiency of siRNAs remains a major obstacle for clinical application, particularly in brain disorders. This study aimed to develop a synthetic biology strategy to reprogram the host liver as a tissue chassis to induce and deliver in vivo self-assembled siRNAs (IVSA-siRNAs) to target the ATXN3 gene. A synthetic construct directed by a cytomegalovirus promoter was designed to encode a neuron-targeting rabies virus glycoprotein tag and mATXN3-siRNA. After intravenous injection, the synthetic construct was taken up by mouse livers, which were then reprogrammed to enable the self-assembly, production, and secretion of small extracellular vesicles (sEVs) encapsulating mATXN3-siRNA. The sEV-encapsulated mATXN3-siRNA was further transported through the endogenous circulating system of sEVs, crossing the blood-brain barrier and reaching the cerebellar cortex and spinal cerebellar tract, where they silenced the ATXN3 gene. Treatment with the synthetic construct for 8 or 12 weeks led to significant improvements in motor balance ability and reduction of cerebellar atrophy in YACMJD84.2 transgenic mice. The number of Purkinje cells in the cerebellar cortex was significantly increased, and the loss of myelin basic protein was reduced. Moreover, the quantity of neurotoxic nuclear inclusion bodies and the expression of glial fibrillary acidic protein, which promotes neuroinflammation in activated astrocytes, were decreased significantly. The synthetic construct facilitated the generation and delivery of IVSA-siRNA to the cerebellar cortex and spinal cerebellar tract, thereby inhibiting the expression of mATXN3 protein. This treatment successfully addressed motor impairments, alleviated neuropathological phenotypes, and mitigated neuroinflammation in YACMJD84.2 transgenic mice. Our strategy effectively overcomes the primary challenges associated with siRNA therapy for cerebellar ataxia, offering a promising avenue for future clinical treatments.

Correlation between Cranio-Vertebral Angle and Muscle Activity According to Body Movements in Forward Head Posture

The purpose of this study is to determine the correlation between FHP and how it may affect muscle activity during raising the arm and loss of body balance, 40 young people participated. All subjects will have their cranio-vertebral angle (CVA) and muscle activity of the serratus anterior (SA), upper trapezius (UT), and lower trapezius (LT), static balance index, and central pressure excursion index (CPEI) measured. Muscle activity was measured using TeleMyo 2400(Noraxon U.S.A., Inc., Scottsdale, AZ, USA), and static balance indicators and CPEI were measured using the MatscanVersaTek system (Tekscan Inc., MA). Spearman correlation analysis was used to determine the correlation between variables. CVA and SA, UT, and LT all showed significant correlation, positive correlation with SA(r=0.429/p=0.006) and LT(r=0.377/p=0.017), and negative correlation with UT(r=-0.473/p=0.007) (Table 2). CVA showed a moderate level of negative correlation with AREA(r=0.-0.420 /p=0.007) and L-R distance(r=-0.508 /p=0.000) among balance indicators, and did not show a significant correlation with CPEI (Table 3). In people with more severe FHP, SA, and LT muscle activity tended to be lower, UT muscle activity tended to be higher, and static balance ability was lower. According to the results of this study, FHP can have a negative effect on various factors of the body, such as arm movement and static balance, suggesting that establishing correct posture is necessary to prevent secondary physical problems.

Implementasi Permainan Tradisional Batok Kelapa Untuk Meningkatkan Kemampuan Koordinasi Gerak dan Keseimbangan Tubuh

This research aims to improve the movement coordination and body balance abilities of class 1C students at SDN Pakis 1 Surabaya through the implementation of the traditional coconut shell game. This Classroom Action Research (PTK) was carried out in two cycles, each consisting of planning, action implementation, observation, and reflection stages. The results showed a significant improvement in students' motor skills. At pre-cycle, only 25% of students achieved the expected skills. After implementing the coconut shell game, the percentage of students who completed it increased to 42.86% in the first cycle and 82.14% in the second cycle. This increase indicates that the traditional coconut shell game is an effective method in developing students' movement coordination and body balance skills and providing a fun and active learning experience.