Abia State University Teaching Hospital Research Articles

Effect of methanol stem bark extract of Ochna schweinfurthiana (Ezeata) on liver enzymes in Wistar rats

1 Department of Obstetrics and Gynaecology, Faculty of Clinical Medicine, Chukwuemeka Odumegwu Ojukwu University Teaching Hospital, Amaku, Awka. Anambra State. Nigeria. 2 Department of Physiology, Faculty of Basic Medical Sciences, Chukwuemeka Odumegwu Ojukwu University, Uli campus. Anambra State. Nigeria. 3 Department of General Medicine, Faculty of Clinical Medicine, Royal Bournemouth Hospital (University Hospital Dorset NHS Foundation Trust) Bournemouth, England, BH7 7DW United Kingdom. 4 Department of Gastroenterology, Faculty of Clinical Medicine, Royal Bournemouth Hospital (University Hospital Dorset NHS Foundation Trust) Bournemouth, England, BH7 7DW United Kingdom. 5 Department of Obstetrics and Gynaecology, Faculty of Clinical Medicine, Abia StateUniversity Teaching Hospital, Aba. Abia State. Nigeria.

Evaluation of Heavy Metals in Auto Mechanics in Aba Metropolis, South East, Nigeria Who Were Exposed to Petrol and Petroleum Products

Background: Every day, humans come into contact with heavy metals in the environment. These metals are widespread throughout the world and are known to affect and create specific biological changes that may be detrimental to the body. Auto mechanics are known to come in contact with these hazardous substances during vehicle maintenance and repair activities, which may lead to the release of heavy metals into the body as well as the environment. Aim: To evaluate the levels of heavy metals that auto mechanics are exposed to from petroleum and petroleum products in mechanic workshops in Aba Metropolis. Study Design: A cross sectional study with a total of 204 participants, 123 of whom were auto mechanics and 81 of whom were non auto mechanics (controls), had blood samples taken from them. Place and Duration of Study: The blood samples were taken from auto mechanic working in mechanic workshop spread around four locations of Aba Metropolis during the period of May 2022 to November, 2022. Samples were analyzed at Abia State University Teaching Hospital, Aba, Abia State and Laboratory Department, JAROS Inspection Services Limited, Port Harcourt, Rivers State, Methods: The levels of heavy metals (Pb, Hg, Cd, Cr, and As) in blood were measured using atomic absorption spectrophotometry. The Statistical Analysis System (SAS), STAT 15.1 was used to analyse the data from the study. Results: The serum concentration of heavy metals in reducing order, were Cr > Pb > As > Hg > Cd in the exposed individuals while in the control subjects, the order from the highest concentration was; Cr > Pb >As > Cd > Hg. The blood of auto mechanics had a significantly higher level of Pb and Hg than that of non-auto mechanics (p<0.05). Duration of exposure of the auto mechanics to petrol and its product showed an adverse effect from the results gotten in this study. Conclusion: Heavy metal contamination still poses a threat to health and well-being of the auto mechanics in Aba Metropolis.

Evaluation of the Types and Drug Sensitivity Patterns of Bacterial Isolates from Patients with Eye Discharge at Abia State University Teaching Hospital, Aba, Nigeria

This study aimed to evaluate the types and drug sensitivity patterns of bacterial isolates from patients with eye discharge at the Abia State University Teaching Hospital (ABSUTH), Aba, Nigeria. A total of 100 samples were collected, with the most prevalent bacterial isolates being Staphylococcus aureus (26%) and Coagulase-negative Staphylococci (21%), while no bacterial growth was reported in 42% of samples. In terms of patient demographics, a significant proportion of the patients were females (64%) aged between 61-70 years. In relation to contact lens use, a high percentage (97%) of the bacterial isolates were detected in patients who did not use contact lenses. An occupational distribution analysis revealed that bacterial isolates were more frequent in farmers and traders compared to students and retirees. Antimicrobial sensitivity testing of the bacterial isolates showed varying degrees of resistance, with significant resistance observed against Erythromycin, Ciprofloxacin, and Perfloxacin. In contrast, higher sensitivity was noted towards Chloramphenicol and Gentamycin. The findings underscore the importance of regular microbiological evaluation and sensitivity testing in patients presenting with eye discharges to guide effective antimicrobial therapy. These findings could guide the selection of empiric antibiotics for treating ocular infections in this region and suggest the need for routine microbiological surveillance to monitor and guide antibiotic prescription to mitigate against antibiotic resistance.

Evaluation of Some Hematological Parameters in Patients with Diabetes Mellitus Attending Abia State University Teaching Hospital Aba Based on Socio-Demographic Characteristics

The evaluation of lipid profile and some hematological parameters in diabetic patients attending Abia State Teaching Hospital Aba, was carried out. Venous blood samples were collected from 150 participants who gave consent. This comprises 100 diabetic patients as test and 50 healthy subjects as control. The plasma glucose and hemoglobin levels were determined using spectrophotometric methods. Data from this study were analyzed using statistical package for the social sciences (SPSS). Result shows that, platelet (395.44±72.11x109/l), prothrombin time (13.63±0.95secs) levels were higher in study population compared with control (176.18±25.26x109/l, 11.85±0.63secs, respectively) (p<0.05 in each case). The hemoglobin (124.83±15.01g/l) was lower in diabetic patients compared with control (131.66±10.45g/l) (p<0.05). From the findings, management of conditions related to cardiovascular disease, artherosclerotic disease, anemia and stress in diabetics may benefit patients if some hematological parameters are included as part of their routine laboratory investigations. Keywords: hematological parameters, coagulation, platelets, cardiovascular disease, diabetes mellitus

Assessment of practice of handwashing as Covid-19 preventive measure among medical students of Abia State University Teaching Hospital, (ABSUTH) Aba, Abia State, Nigeria

Background: Coronavirus disease (Covid-19) is a communicable disease which is causing morbidity and mortality globally. Hand washing, wearing of a facemask and social distancing are preventive measures that have been options available in our country, Nigeria. The practice of hand washing includes cleansing of hands by rubbing both hands together using and alcohol-based hand sanitizer or washing both hands with soap and water to prevent microbial growth. Objective: This study aimed at assessing the practice of hand washing as a covid-19 preventive measure amongst medical students of ABSUTH, Aba. Method: This was a descriptive cross-sectional study carried out among medical students in ABSUTH, Aba, Abia State, A self-administered semi-structured questionnaire was adopted and used to obtain information from the 430 students. Numerical variables were summarized using mean and standard deviation, categorical variables were summarized using frequency and proportions. Association was tested at p-value of 0.05%. Result: There was a non-response rate of 50 (13.8%) as 380 students participated. Mean age of the participants was 24 ± 5.94. Two hundred and eighty-one (73.9%) constituted the majority and was found among the 21 – 25 age range. Female was in majority as 230 (60.5%) of them participated. The level of practice of handwashing was 195 (51.3%). Majority of the students scored above 52% in all the different aspects of handwashing practices and there was statistically significant association between all the hand washing practices and medical students’ participation at a p-value of 0.05%. Conclusion: Medical students showed a good level of practice towards infection and control measures. Social media was major source of information. Some misconceptions were noted regarding minimum duration of handwashing with soap and water and level of practices.

Autopsy Pathology of Invasive Lobular Carcinoma of the Breast: A Case Report

The cause of death can be determined by performing an autopsy. This study reviewed the autopsy pathology performed on a 54 year old woman who died of invasive lobular carcinoma of the breast. The autopsy was performed at Abia State University Teaching Hospital, Aba, Nigeria. She presented with fever and generalized body weakness of one week duration and was being treated for malaria and typhoid fever. Her condition deteriorated in two days of hospitalization despite the treatment given and she later passed away. Autopsy findings revealed that the breasts were symmetrical and the overlying skin was grossly normal. There was no area of ulceration or change in the skin. The nipples were not retracted. Cut sections of both breasts showed diffuse white fibrous tissue in areas and no obvious lymphadenopathy was noted. Histologic sections of the breast tissue showed uniform small bland cells with round nuclei and inconspicuous nucleoli invading a fibrotic fibrocollagenous stroma and adipocytes in single files. There was poor attempt at tubule formation. Histological section of the lungs showed infiltration by malignant epithelial cells similar to ones seen in the breast. There were haemorrhages, congestion and edema in the alveolar interstitium, and some of the alveolar were filled with fibrinous material. Also seen were numerous mixed inflammatory cell infiltrates. The final diagnosis was invasive lobular carcinoma of the breast, with widespread metastasis to the lungs, pleural and peritoneum. The cause of death was ruled as invasive lobular carcinoma of the breast. A thorough autopsy of deaths of women of postmenopausal age was recommended in other to identify associated pathologies. Keywords: Breast cancer, Invasive lobular carcinoma, Invasive ductal carcinoma, Autopsy

Evaluation of Some Thyriod Hormones in Diabetics Attending Abia State University Teaching Hospital

The evaluation triiodothyronine, thyroxine, thyrotropin, c-reactive protein, interleukin-6 and tumor necrosis factorα in diabetic patients attending Abia State Teaching Hospital Aba, was carried out. Venous blood samples were collected from 150 participants who gave consent. This comprises 100 diabetic patients as test and 50 healthy subjects as control. The serum Triiodothyronine, thyroxine, thyrotropin was determined using Fincare™ quantitative assay method. Data from this study were analyzed using statistical package for the social sciences (SPSS). Result shows that thyroxine (8.97±1.28µg/dl), thyrotropin(2.08±0.85µiu/ml) respectively) (p<0.05 in each case). The serum triiodothyronine (0.89±0.38ng/ml), was lower in diabetic patients, compared with control (1.04±0.33ng/l) (p<0.05). From the findings, management of conditions related to cardiovascular disease, atherosclerotic disease, anemia and stress in diabetics may benefit patients if thyroid hormones are included as part of their routine laboratory investigations. Keywords: thyroid hormones, cardiovascular disease, diabetes mellitus, atherosclerotic disease

Autopsy Pathology of Diabetic Nephropathy with Hypertensive Cardiovascular Disease and Anemic Heart Failure

An autopsy was performed at Abia State University Teaching Hospital, Aba, Nigeria on a 58 year old woman who was known to be diabetic and hypertensive. Results of autopsy findings showed that the external description was cachectic, severely pale, cyanosed and jaundiced. The thorax, abdominal and pelvic organs were in their normal anatomic position. The trachea mucosa was hyperemic. The bronchi contained frothy fluid. The parietal pleural was shiny and smooth. The heart was enlarged and flabby. The parietal pericardium was smooth and shiny and not attached to the visceral pericardium. The tongue was pale, furred and have prominent papillae. The esophageal mucosa was hyperaemic. The cut sections of the liver showed a nutmeg appearance. The thymus was vestigial. The cut surfaces were cream colored and solid. The thyroid was grossly normal in size. The cut surfaces were brownish and showed colloid in areas. Both kidneys were grossly normal. The cut sections showed loss of corticomedullary differentiation. There were bilateral multicystic swellings on both ovaries. The cranium was intact with no fracture in the skull. The cerebral vessels showed few fatty streaks but no aneurysmal dilatation. Histologic section of the kidney showed numerous glomeruli with varying degree of sclerosis, and capillary basement membrane thickening. The cause of death was anemic heart failure, metastatic serous cystadenocarcinoma, and diabetic nephropathy with hypertensive cardiovascular disease. Thorough autopsies on all deaths of heart failure to study other associated pathologies was recommended. Keywords: Autopsy, Anemic Heart Failure, Hypertensive Cardiovascular Disease, Diabetic Nephropathy, Histology

Autopsy Pathology of Hypertensive Cardiovascular Disease: Case Reports

An Autopsy is performed on a dead body primarily to determine the cause of death. Two autopsies of death from hypertensive cardiovascular disease were performed at Abia State University Teaching Hospital, Aba, Nigeria. The first autopsy was on a 51 year old man diagnosed about 12 years before his death with hypertension. Autopsy report after his death revealed pan-valvular dilatation, benign nephrosclerosis, chronic pyelonephritis, hepatomegaly with chronic passive congestion of the liver, splenomegaly, pleural effusion, pulmonary edema, ascites and moderate cerebral edema. The cause of death was ruled as congestive cardiac failure and hypertensive cardiovascular disease. The second autopsy was on a 60 year old woman who died after a 5 day history of headache and a day history of loss of consciousness. Autopsy report after her death revealed massive intracerebral and intraventricular haemorrhage, pontine haemorrhage, laryngotracheobronchitis, pulmonary edema, and congested liver and spleen. The cause of death was ruled as hypertensive cardiovascular disease with massive intracranial haemorrhage. A thorough autopsy of deaths from hypertensive cardiovascular disease to reveal other associated pathologies was recommended. Keywords: Autopsy, Hypertensive cardiovascular disease, Intracranial haemorrhage, Congestive cardiac failure, Hypertension

Abia State University Teaching Hospital, Aba 2022/23 Admission List Batch 1st and 2nd is Out ☎️[08135160398]-☎️08135160398DR OGBOLU.Candidates Nigeria must posses the Senior Secondary School Certificate or its equivalent with five credits to include English Language and either Physics, Chemistry, Biology/Health Science at not more than 2 sittings.

Abia State University Teaching Hospital, Aba 2022/23 Admission List Batch 1st and 2nd is Out ☎️[08135160398]-☎️08135160398DR OGBOLU.Candidates Nigeria must posses the Senior Secondary School Certificate or its equivalent with five credits to include English Language and either Physics, Chemistry, Biology/Health Science at not more than 2 sittings.

School of Nursing (SON), Abia State University Teaching Hospital (ABSUTH), Aba 2022/2023 form is out call 09078816209 .The management has announced the Screening Form 2022/2023 academic session is out contact the school helpline on +234_907_881_62_09 or (+234)9078816209. Candidates who has met requirements for ssce and that of the school can apply by contacting Dr. Mrs Grace on 090-788-162-09. ALSO POST

School of Nursing (SON), Abia State University Teaching Hospital (ABSUTH), Aba 2022/2023 form is out call 09078816209 .The management has announced the Screening Form 2022/2023 academic session is out contact the school helpline on +234_907_881_62_09 or (+234)9078816209. Candidates who has met requirements for ssce and that of the school can apply by contacting Dr. Mrs Grace on 090-788-162-09. ALSO POST

2022/2023 School of Nursing, Abia State University Teaching Hospital (ABSUTH), Aba Application/Admission Nursing Form out Call (0810-847-0382)-(08108470382)-(0810-847-0382) Dr mrs Mercy for more details on how to apply and register online.The Management of the school hereby inform the general public on the sales of the general Nursing Admission form into the School of Nursing.And also the sales of two (2) years

2022/2023 School of Nursing, Abia State University Teaching Hospital (ABSUTH), Aba Application/Admission Nursing Form out Call (0810-847-0382)-(08108470382)-(0810-847-0382) Dr mrs Mercy for more details on how to apply and register online.The Management of the school hereby inform the general public on the sales of the general Nursing Admission form into the School of Nursing.And also the sales of two (2) years

School of Nursing, Abia State University Teaching Hospital (ABSUTH), Aba Application/Admission Nursing 2022/2023 Form out Call (0810-847-0382)-(08108470382)-(0810-847-0382) Dr mrs Mercy for more details on how to apply and register online.The Management of the school hereby inform the general public on the sales of the general Nursing Admission form into the School of Nursing.And also the sales of two (2) years

School of Nursing, Abia State University Teaching Hospital (ABSUTH), Aba Application/Admission Nursing 2022/2023 Form out Call (0810-847-0382)-(08108470382)-(0810-847-0382) Dr mrs Mercy for more details on how to apply and register online.The Management of the school hereby inform the general public on the sales of the general Nursing Admission form into the School of Nursing.And also the sales of two (2) years

School of Post Basic Midwifery, Abia State University Teaching Hospital (ABSUTH), Aba Application/Admission Nursing 2022/2023 Form out Call (0810-847-0382)-(08108470382)-(0810-847-0382) Dr mrs Mercy for more details on how to apply and register online.The Management of the school hereby inform the general public on the sales of the general Nursing Admission form into the School of Nursing.And also the sales of two

School of Post Basic Midwifery, Abia State University Teaching Hospital (ABSUTH), Aba Application/Admission Nursing 2022/2023 Form out Call (0810-847-0382)-(08108470382)-(0810-847-0382) Dr mrs Mercy for more details on how to apply and register online.The Management of the school hereby inform the general public on the sales of the general Nursing Admission form into the School of Nursing.And also the sales of two

Pattern of Complications Following Prostrate Biopsies: A Five Year Review in Abia State University Teaching Hospital Aba, South Eastern Nigeria

Prostate Cancer is the most common cancer among Nigeria men. Prostrate Biopsy remains the single most important investigation for establishment of prostate cancer diagnosis. Even though simple to perform and basically an outpatient procedure, often times, complications occur, some of which may be mild and self-limiting, while others may require hospitalization and other severe measures to deal with. The aim of this study is to analyze the rate and types of complications following biopsies done at Abia State University Teaching Hospital, Aba. Between January 2016 and December 2020 involving 198 men, 198 biopsies were done, out of which complications occurred in 55 cases (27.78%). Hemorrhage was the commonest cause with 28 cases (14.18%) followed closely by perianal pain with 11 cases (5.58%). Other complications seen included: vasovagal attack with 5 cases (2.28%), acute urinary retention with 4 cases (2.028%), lower urinary tract symptoms (luts) with 4 cases (2.028%) and sepsis with 3 cases (1.518%). Hemorrhagic complications were the most common complications found in Abia State University Teaching Hospital Aba.

Awareness Assessment of Treatment Target Goals for Persons Living with Type 2 Diabetes Mellitus Accessing Care in a Tertiary Health Facility, Southeast Nigeria

Background: Diabetes clinic visits by persons living with type 2 diabetes mellitus (PLWDM) afford the healthcare professionals (HCPs) opportunities to assess their achievements of the recommended treatment targets for glycated hemoglobin (HbA1C), lipid profile, blood pressure (BP), and body mass index (BMI). Meeting these targets significantly affect treatment outcome in diabetes mellitus (DM). Awareness of the treatment targets by PLWDM attending the diabetes clinic of Abia State University Teaching Hospital (ABSUTH), Aba, Southeast Nigeria, is not known. This study, therefore, set out to bridge this gap in knowledge. Methodology: This was a cross-sectional study in which consenting PLWDM attending the diabetes clinic of ABSUTH, Aba, were consecutively recruited. Interviewer-administered questionnaire was filled for each subject to assess their knowledge and awareness of the treatment target goals for HbA1C, BP, lipid profile, and BMI. Data obtained were analyzed using Statistical Package for Social Sciences version 23.0 software. Results: A total of 165 persons living with DM, 60 (36.4%) males and 105 (63.6%) females, participated in the study. Majority of them (89.1%) were ignorant of HbA1C and its implications while awareness of their treatment target goals for HbA1C, BP, lipid profile, and BMI was very low at 1.8%, 16.4%, 1.8%, and 0%, respectively, despite their formal educational levels. Conclusion/Recommendation: Awareness of treatment target goals for HBA1C, BP, lipid profile, and BMI was very low among PLWDM in Aba, southeast Nigeria. It is strongly recommended that the HCPs step up their games in diabetes education programs.

Review of the Pattern of Prostate Cancer Aggressiveness Using the Gleason Scoring System among Men Attending Abia State University Teaching Hospital Aba, South Eastern, Nigeria

Prostate cancer is the most common cancer among African – American men and the second most common cause of death in the western world. It is the most common cancer among Nigerian men with increasing incidence, morbidity and mortality. The morbidity and mortality depend on the tumor aggressiveness. The three most important prognostic parameters for this disease include Tumor pathologic stage Tumor histologic differentiation (gleason score) Level of prostate specific antigen (PSA) These factors are needed in stratifying patients into risk groups. The gleason grading system , both in needle biopsy and radical prostatectomy specimens remains one of the most significant factors in the clinical decision making process. Key Challenges of the biopsy based determination of prostate cancer aggressiveness include Tumor heterogeneity Biopsy sampling error and variations in biopsy interpretations The resulting uncertainty in risk assessment leads to significant over treatment with associated cost and morbidity.

A 5 Year Review of Prostate Biopsies Taken from Men Attending Abia State University Teaching Hospital Aba, South Eastern Nigeria

Prostate cancer is the most common cancer among African-American men. It is the second most common cause of cancer death in the Western world. Prostate cancer is rarely diagnosed before the age of 50 years, but the incidence and mortality from the disease increases exponentially thereafter. This increased incidence has been attributed mainly to the introduction of screening techniques, especially (the estimation of serum prostate-specific antigen) PSA. There is a great variation in the geographic epidemiology of the disease, and environmental factors appear to be significant contributors to this difference. However, African-American men have higher incidence and mortality than white men. Within the African continent prostate cancer ranks in the top 10 and usually the top 5 for male cancers. Male relatives of prostate cancer patients have an increased risk of developing the disease. Heredity, however, appears to play a prominent role having a small percentage of prostate cancer cases (mostly early-onset disease) with the majority of patients falling in the category of sporadic cancer. Occupation and lifestyle is significant, especially when there is association between high dietary intake of animal fat. Heavy metal exposure (cadmium in particular) plays a role. The most consistent factor is hormone concentration and metabolism. Testosterone levels have been shown to be higher in African-American men than white men.

Glomerular Filtration Rate Decline and increased Serum Creatinine Concentration in Abia State University Teaching Hospital Aba

Glomerular filtration Rate (GFR) is essentially the most reliable index of kidney function in health. A decrease in GFR is a pointer to decline in Kidney function and persistent or progressive GFR decline is a specific diagnostic criterion for chronic kidney disease (CKD). In defining CKD, we consider GFR of less than 60ml/min/1.73m 2 for three months or more. Markers of Kidney function test assess the normal function of kidneys. These markers may be biochemical or even radioactive. They assist in measuring GFR, as well as the concentrating and diluting property (tubular function) of kidneys. One of such biochemical markers is Serum Creatinine. An increase or decrease in the serum level of these biomarkers can be of help in determining the efficiency of kidney function. Endogenously produced creatinine is an accepted biomarker of kidney function. It is produced from the metabolism of skeletal muscle creatine. It is released into the plasma in a stable rate in normal subjects, and freely filtered at the glomerulus. However, creatinine is secreted into the urine in the proximal tubule which can occasionally overestimate GFR by 10- 20 %.A number of GFR estimating equations have been developed to overcome some of the limitations of estimating GFR from serum creatinine. The CG equation (Cockcroft Gault) was developed in 1973 and is used widely. A new equation Modification of diet in renal disease (MDRD) study equation was developed in 1999 and has since been validated in a number of populations. The MDRD equation was used in estimating GFR in this study.

Inflammatory Markers in Workers Occupationally Exposed to Petrol and Petroleum Products

Place and Duration of Study: Sample: Abia State University Teaching Hospital, Aba, Abia State and Laboratory Department, JAROS Inspection Services Limited, Port Harcourt, Rivers State, between April 2018 and June 2018.
 Methodology: A total of 204 samples comprising of 123 auto-mechanics and 81 non -auto-mechanics were assayed. Detailed information of the bio-data of the subjects including age, gender, medical history, health information and lifestyle were obtained from each participant. Blood samples were collected from for the analysis of inflammation markers, IL-6, TNF-α and CRP were determined using standard methods and techniques. The effect of age and duration of exposure on the inflammation parameters were considered. Statistical Analysis System (SAS), STAT 15.1, developed by SAS Institute, North Carolina State University, USA was used for statistical analysis. Data were presented as Mean ± SEM, comparison of means of groups that are more than two was done using Analysis of Variance (ANOVA), and the Tukey test of multiple comparison was used to test for variance within and across groups.
 Results: There was significant increase in the means of IL-6, TNF-α and CRP in the exposed subjects (p <0.05) compared with the control subjects There was no significant difference (p >0.05) in the means of IL-6, TNF-α and C-reactive protein (CRP) between the age groups of the exposed and the control subjects. Similarly, there was no significant difference between the groups, based on duration of exposure. This suggests that the toxic effect does not depend on the age or duration of exposure but on other factors for the automechanics in Aba. 
 Conclusion: This study shows that the exposure of automechanics may significantly increase the serum IL-6 TNF-α and Hs-CRP levels. Increase in the serum levels of the inflammation markers is predictive of the danger of future pathology in automechanics compared with non automechanics in Aba metropolis. Age and duration did not influence significant variation in the automechanics.