A3 Coupling Reaction Research Articles

Copper‐catalyzed one‐pot synthesis of propargylamines via CH activation in PEG

AbstractAn efficient and convenient three‐component A3 coupling reaction of aldehyde, amine and alkyne via CH activation with CuI alone as the catalyst in PEG is developed, providing a wide range of propargylamines with yields ranging from moderate to excellent. Additionally, the catalyst system was recovered and reused several times without evident loss in activity. Copyright © 2010 John Wiley & Sons, Ltd.

Recyclable Merrifield resin‐supported organocatalysts containing pyrrolidine unit through A3‐coupling reaction linkage for asymmetric Michael addition

Merrifield resin-supported pyrrolidine-based chiral organocatalysts A-D through A(3)-coupling reaction linkage have been developed and found to be highly effective catalysts for the Michael addition reaction of ketones with nitrostyrenes. The reactions generated the corresponding products in good yields (up to 92%), excellent enantioselectivities (up to 98% ee), and high diastereoselectivities (up to 99:1 dr). In addition, the catalysts can be reused at least five times without a significant loss of catalytic activity and stereoselectivity.

A³ Coupling Reaction with Ni-MOF- Supported Silver Nanoparticles

A^³ Coupling Reaction with Ni-MOF- Supported Silver Nanoparticles

Silver Nanoparticles Supported by Novel Nickel Metal-Organic Frameworks: An Efficient Heterogeneous Catalyst for an A³ Coupling Reaction

A novel heterogeneous catalyst of silver nanoparticles was prepared by using a nickel metal-organic framework (Ni-MOF) as a template. The catalyst has a very high catalytic activity and a strict structural selectivity towards linear aliphatic aldehydes in an A 3 coupling reaction. The catalyst could be recovered by simple phase separation and reused for many times without obvious loss of activity.

Copper-Nanoparticle-Catalyzed A3 Coupling via C-H Activation

Recyclable metal nanoparticles provide an efficient, economic, and novel route for the synthesis of propargylamines via three-component A3 coupling reaction of aromatic aldehyde, amine and alkyne. This method provides a wide range of substrate applicability. This protocol avoids the use of heavy metal, co-catalyst and gives propargylamines in quantitative yield.

The first Au-nanoparticles catalyzed green synthesis of propargylamines via a three-component coupling reaction of aldehyde, alkyne and amine

Recyclable Au-nanoparticles provide an efficient, economic, novel route for multi component A3 coupling reaction of aldehyde, amine and alkyne. This method provides the wide range of substrate applicability. This protocol avoids the use of heavy metals, co-catalyst and gives the propargylamine in excellent yields.

XPS Investigation of A3 Coupling Reaction in Room Temperature Ionic Liquids

We herein report a new analytical application of XPS to the identification of organic molecules in room temperature ionic liquid for the first time. An organic compound, propargylamine (1), produced in 1-butyl-3-methylimidazolium hexafluorophosphate ([bmim][<TEX>$PF_6$</TEX>]), which is one of the room temperature ionic liquids (RTILs), via <TEX>$A^3$</TEX> coupling reaction, is characterized by means of x-ray photoelectron spectroscopy (XPS) rather than using conventional organic compound analysis techniques. There are four non-equivalent carbons in RTILs and 1 each. The ratios of normalized integrated areas of the deconvoluted binding energy of core electron of carbon (C1s) peaks are well matched to the number of carbons in those compounds. The binding energies of C1s of the featured carbons in 1, C4 (sp carbons in acetylene group) and C5 (<TEX>$sp^2$</TEX> carbons in benzene ring), are assigned 286.2 and 285.4 eV, respectively. These results will be able to provide an important tool and a new strategy for the analysis of organic molecules