Α-oxocarboxylic Acid Research Articles

ChemInform Abstract: SOME REMARKS CONCERNING THE PUBLICATION “A NOVEL SYNTHESIS OF 3‐SUBSTITUTED PYRUVIC ACIDS; A NEW ROUTE TO α,β‐DIAMINO ACIDS” BY M. M. KIDWAI, N. H. KHAN AND M. ALI

Abstract Recently N. H. Khan and cowcrkers published an unprecedented C-C-bond formation by heating 4-arylidene-2-phenyl-2-oxazolin-5-ones with anhydrous formic acid (‘fornic acid process’)1. We repeated this reaction with 4-benzylidene-2-phenyl-2-oxazolin-5-one (1) and formic acid (98–100%, Merck, p.A.) several times, however, we were unable to obtain any α-oxocarboxylic acid 2 as has been claimed by the authors. After 30 min of reflux mainly starting material and some hydrolysis product 3 could be isolated, whereas prolonged heating (3-5h) qave 2-benzcylaminocinnamic acid (3), m.p. 232°C in high yield. We were unable to defect any CO evolution.

Some Remarks Concerning the Publication ‘A Novel Synthesis of 3-Substituted Pyruvic Acids; A New Route to’, β-Diamino Acids' by M. M. Kidwai, N. H. Khan and M. Ali

Abstract Recently N. H. Khan and cowcrkers published an unprecedented C-C-bond formation by heating 4-arylidene-2-phenyl-2-oxazolin-5-ones with anhydrous formic acid (‘fornic acid process’)1. We repeated this reaction with 4-benzylidene-2-phenyl-2-oxazolin-5-one (1) and formic acid (98–100%, Merck, p.A.) several times, however, we were unable to obtain any α-oxocarboxylic acid 2 as has been claimed by the authors. After 30 min of reflux mainly starting material and some hydrolysis product 3 could be isolated, whereas prolonged heating (3-5h) qave 2-benzcylaminocinnamic acid (3), m.p. 232°C in high yield. We were unable to defect any CO evolution.

SYNTHESES AND ANTIVIRAL EFFECTS OF 3-AMINO-6-ALKYL-AS-TRIAZIN-5-OL DERIVATIVES.

The thirteen compounds of amidinohydrazone of α-oxocarboxylic acid and 3-amino-6-alkyl-as-triazin-5-ol were synthesized and tested as to their antiviral activity. Only amidinohydrazone of 2-oxovaleric acid was found effective on common cold virus. Also, it was revealed that the possible existence of the tautomers of 3-amino-6-alkyl-as-triazin-5-ol in the ground state should be in form of keto and imino.