Tuberous sclerosis is an autosomal dominant neurocutaneous disorder with an incidence of approximately 7/100 000. Inheritance is autosomal dominant, but up to 70% of cases are new mutations. Tuberous sclerosis is mainly characterized by a triad of epilepsy, learning difficulties and skin lesions including angiofibromas, hypopigmented macules, connective tissue naevi and periungual fibromas. Angiofibromas are a common presentation of tuberous sclerosis. They cause considerable cosmetic and hygienic morbidity for patients. Treatments of angiofibromas have included curettage, cryosurgery, chemical peeling, dermabrasion, shave excision, lasers and 13-cis retinoic acid. Traditional methods of treating angiofibromas are not entirely successful as they frequently lead to scarring and pigmentary changes. We report the successful use of radiofrequency dessication and coagulation in treating multiple angiofibromas of four patients. The technique is easy to use and very cost effective. Key words: tuberous sclerosis, angiofibroma, ambulatory surgical procedures. Cite this article : Ulas Guvenc, Anil Gunsel Bahali, Umit Tursen, Tamer Irfan Kaya, Guliz Ikizoglu, Erdinc Terzi. Treatment of facial angiofibromas of tuberous sclerosis with radiofrequency dessication and coagulation. RoJCED 2017;3(4):182-185 https://doi.org/10.26574/rojced.2017.4.3.182