6-minute Walk Research Articles

Impact of postoperative femorotibial axis on functional outcomes in unicompartmental knee arthroplasty.

This study aimed to compare the functional outcomes of patients undergoing fixed-bearing medial unicompartmental knee arthroplasty (UKA) classified as either varus or neutral based on their postoperative femorotibial angle (FTA), with the goal of evaluating the impact of FTA on functional results. A total of 38 knees of 35 patients (27 females, 8 males; mean age: 63.6±7.1 years; range, 52 to 75 years) were included in this retrospective study. The data was collected between December 15, 2020, and January 15, 2021. Patients were categorized into two groups based on their postoperative FTA. The neutral group consisted of patients with an FTA range of 5.1° to 7.4°, while the varus group included patients with an FTA range of 0.1° to 4.8°. Knee Outcome Osteoarthritis Score (KOOS), Visual Analog Scale (VAS) scores, sit to stand test results, and six minute walk test data were analyzed. The mean follow-up was 42.0±19.3 months. The postoperative VAS score for the varus group was 0.95±0.99, whereas the neutral group had a VAS score of 2.19±1.83 (p=0.021). The mean KOOS for the varus group was 88.01±7.88, whereas the neutral group had a mean KOOS score of 78.46±13.69 (p=0.006). In patients undergoing UKA, mild varus alignment could yield superior early and midterm functional outcomes compared to a neutral femorotibial angle.

Efficacy of Walking Adaptability Training on Walking Capacity in Ambulatory People With Motor Incomplete Spinal Cord Injury: A Multicenter Pragmatic Randomized Controlled Trial

Background and Objective Balance and walking capacity are often impaired in people with motor incomplete spinal cord injury (iSCI), frequently resulting in reduced functional ambulation and participation. This study aimed to assess the efficacy of walking adaptability training compared to similarly dosed conventional locomotor and strength training for improving walking capacity, functional ambulation, balance confidence, and participation in ambulatory people with iSCI. Methods We conducted a 2-center, parallel-group, pragmatic randomized controlled trial. Forty-one people with iSCI were randomized to 6 weeks of (i) walking adaptability training (11 hours of Gait Real-time Analysis Interactive Lab (GRAIL) training—a treadmill in a virtual reality environment) or (ii) conventional locomotor and strength training (11 hours of treadmill training and lower-body strength exercises). The primary measure of walking capacity was maximal walking speed, measured with an overground 2-minute walk test. Secondary outcome measures included the Spinal Cord Injury Functional Ambulation Profile (SCI-FAP), the Activities-specific Balance Confidence (ABC) scale, and the Utrecht Scale for Evaluation of Rehabilitation-Participation (USER-P). Results No significant difference in maximal walking speed between the walking adaptability (n = 17) and conventional locomotor and strength (n = 18) training groups was found 6 weeks after training at follow-up (−0.05 m/s; 95% CI = −0.12-0.03). In addition, no significant group differences in secondary outcomes were found. However, independent of intervention, significant improvements over time were found for maximal walking speed, SCI-FAP, ABC, and USER-P restrictions scores. Conclusions. Our findings suggest that walking adaptability training may not be superior to conventional locomotor and strength training for improving walking capacity, functional ambulation, balance confidence, or participation in ambulatory people with iSCI. Trial Registration Dutch Trial Register; Effect of GRAIL training in iSCI.

A 12-Week Ballroom Dance Training Improves Physical Fitness Performance More Than Walking Training in Older Women, Regardless of Vitamin B12 or D Adequacy.

This study aimed to compare the effects of Ballroom Dancing (BD) versus Walking Training (WT) on the physical fitness performance in physically independent older women with adequate or inadequate levels of vitamins B12 and D. Forty-three sedentary women aged 68.5 ± 6.5 years, were allocated to the BD (n = 23) or WT (n = 20) groups. They took part in a 12-week intervention, performed 3 times a week, for about 50 minutes with moderate effort intensity. Data were collected through Short Physical Performance Battery (SPPB), 6 minutes Walk Test (6MWT), Hand Grip Test (HGT), Isokinetic tests for lower limbs and blood tests to detect serum levels of vitamins B12 and D. The BD group performed better after the intervention in relation to the WT in the Sit and Stand Test (SST) (BD pre = 3.1 score vs post = 3.8 score; WT pre = 2.8 score vs post = 3.4 score; P = .02) and in the Peak Torque 180° extension (PKTOQ 180° extension) (BD pre = 56.7 Nm vs post = 61.2 Nm, WT pre = 56.7 Nm vs post = 56.1; P < .01). A time effect was observed in all other variables, with the exception of HGT. Both interventions improved physical fitness performance, regardless of the adequacy of vitamins B12 and D, but the older women from BD obtained significant improvements in more variables than the WT.

Assessment of the accessibility of public transport in the Tricity (Poland): analytical use of geographical information systems (GIS) in the context of selected public transport measures

ABSTRACT The Tricity consists of three coastal cities – Gdańsk, Gdynia and Sopot – which also form the core of the Tricity agglomeration. They are among the main development centres of the country. Proper access to public transport for residents is crucial for the sustainable development of the agglomeration. Although the cities are connected by functional links in different areas, the further development of a coherent public transport system is problematic. It is therefore crucial to formulate the question of how these cities can develop the public (collective) transport network? Do residents have access to it and does it meet their needs? Are these measures complementary? A proprietary methodological approach using QGIS and ORS tools was used to conduct the survey. The results of the survey show that 83.5% of Tri-City residents have the nearest train, bus, tram or trolleybus stop within a 5-minute walk of their place of residence. This is followed by 14.39% of residents having a stop within 10 min, 1.47% within 15 min and 0.20% within 20 min. Unfavourable time accessibility applies to 0.45% of residents. The findings of the study may help Tricity local authorities to develop a sustainable public transport policy.

Transtibial osseointegration following unilateral traumatic amputation: An observational study of patients with at least two years follow-up

ImportanceMost patients use a traditional socket prosthesis (TSP) to ambulate independently following transtibial amputation. However, these patients generally require prosthesis repairs more than twice annually and an entirely new prosthesis every two years. Furthermore, transtibial amputation patients have four times the skin ulceration rate of transfemoral patients, prompting more frequent prosthesis refitting and diminished use. Trans-Tibial osseointegration (TTOI) is a promising technique to address the limitations of TSP, but remains understudied with only four cohorts totaling 41 total procedures reported previously. Continued concerns regarding the risk of infection and questions as to functional capacity postoperatively have slowed adoption of TTOI worldwide. ObjectiveThis study reports the changes in mobility, quality of life (QOL), and the safety profile of the largest described cohort of patients with unilateral TTOI following traumatic amputation. DesignRetrospective observational cohort study. The cohort consisted of patients with data outcomes collected before and after osseointegration intervention. SettingA large, tertiary referral, major metropolitan center. ParticipantsTwenty-one skeletally mature adults who had failed socket prosthesis rehabilitation, with at least two years of post-osseointegration follow-up. Main outcomes and measuresMobility was evaluated by K-level, Timed Up and Go (TUG), and Six Minute Walk Test (6MWT). QOL was assessed by survey: daily prosthesis wear hours, prosthesis problem experience, general contentment with prosthesis, and Short Form 36 (SF36). Adverse events included any relevant unplanned surgery such as for infection, fracture, implant loosening, or implant failure. ResultsAll patients demonstrated statistically significant improvement post osseointegration surgery with respect to K-level, TUG, 6MWT, prosthesis wear hours, prosthesis problem experience, general prosthesis contentment score, and SF36 Physical Component Score (p < 0.01 for all). Three patients had four unplanned surgeries: two soft tissue refashionings, and one soft tissue debridement followed eventually by implant removal. No deaths, postoperative systemic complications, more proximal amputations, or periprosthetic fractures occurred. Conclusions and relevanceTTOI is likely to confer mobility and QOL improvements to patients dissatisfied with TSP rehabilitation following unilateral traumatic transtibial amputation. Adverse events are relatively infrequent and not further disabling. Judicious use of TTOI seems reasonable for properly selected patients. Level of evidence2 (Therapeutic investigation, Observational study with dramatic effect).

The relationship between muscle strength and quality with functional performance in women mid- to long-term after Roux-en-Y gastric bypass

BACKGROUND: The reduction of muscle mass and strength commonly observed after bariatric surgery might negatively affect the individual physical function. Muscle quality is also of functional relevance in different populations, but its significance in patients who underwent bariatric surgery has yet to be explored. OBJECTIVE: To examine the association between muscle strength and quality with physical function in women mid- to long-term after Roux-en-Y gastroplasty (RYGB). METHODS: In this cross-sectional study, 133 women (43.7± 9.9 years) who have undergone RYGB at least two years before the study were included. All participants underwent body composition evaluation using DEXA and knee extensors peak moment (PM) using an isokinetic dynamometer. Muscle quality (MQ) was obtained through the ratio between absolute PM and dominant leg fat-free mass. Physical function was measured through the 30-second sit-to-stand (30-STS), 6-minute walking (6-MWT), and timed up-and-go (TUG) tests. RESULTS: Differences between PM tertiles were observed for 30-STS and 6-MWT tests. However, statistical significance disappeared when adjusting for age. Regarding PM relative to body weight, all functional tests were significantly different between tertiles. Comparing functional performance according to MQ tertiles, differences were found for 30-STS and 6-MWT tests, but significance disappeared when adjusting for age. Absolute PM was correlated to the 30-STS performance and 6-MWT, while PM relative to body mass and MQ were correlated with all functional tests. CONCLUSIONS: Muscle strength and quality seem to be associated with physical function in women mid-to-long-term after RYGB, but strength relative to bodyweight outperformed absolute strength and MQ.

Examining the scale effect of nearby residential green space on residents’ BMI: A case study of Guangzhou, China

Green spaces are closely related to the quality of the urban environment and public health. However, studies have rarely paid attention to nearby residential green space which is more closely connected to residents’ daily lives. Does nearby residential green space have a scale effect on the body mass index (BMI) of residents? What type of green space has a more significant effect? Does this effect differ for residents living in central urban areas and suburban areas? To answer these questions, this study first measured three scales of nearby residential green space accessibility of 1398 samples of 18 neighborhoods’ survey data in Guangzhou, China, combined with the application of the TIQS (Travel O-D point Intelligent Query System). And then, multilevel mixed-effects models were developed to examine the scale effect of nearby residential green space accessibility on residents’ BMI. The results show that nearby residential green space has a scale effect on individual BMI and the effect of the 10-minute walking scale is the most significant. Within a 10-minute walking distance from the residence, the larger the green space and the more accessible it is, the lower the individual’s BMI. Parks are the green spaces that are most correlated to residents’ BMI, but their effect is somewhat different between the central urban areas and suburban areas. These findings give us a better understanding of the association between nearby residential green space and public health, as well as providing implications for the improvement of the urban green space system and policy development for healthy cities.

Physical Activity Changes From Before to During the First Wave of the COVID-19 Pandemic Among Community-Dwelling Older Adults in Finland.

This study aimed to compare community-dwelling older adults' physical activity (PA) during the COVID-19 restrictions in 2020 to their PA levels 2years before and investigate associations between earlier physical performance and PA levels over the follow-up. Participants' (n = 809, initial age 75-85years) self-reported PA was assessed at baseline in 2017-2018 and May/June 2020 as total weekly minutes of walking and vigorous PA. Physical performance was assessed at baseline using the maximal handgrip strength and Short Physical Performance Battery tests. During the first wave of the COVID-19 pandemic, a median change in total weekly minutes of walking and vigorous PA among all participants was + 20.0 (interquartile range: -60.0 to 120.0, p < .001)min per week compared with 2years earlier. Higher baseline Short Physical Performance Battery total scores were associated with higher total weekly minutes of walking and vigorous PA over the follow-up in men and women, and better handgrip strength in women.

Feasibility study of rehabilitation for cardiac patients aided by an artificial intelligence web-based programme: a randomised controlled trial (RECAP trial)—a study protocol

IntroductionCardiac rehabilitation (CR) delivered by rehabilitation specialists in a healthcare setting is effective in improving functional capacity and reducing readmission rates after cardiac surgery. It is also associated with a...

471 Using Computer Vision and Wearable Devices to Improve Care of Parkinson’s Disease

OBJECTIVES/GOALS: Inexpensive, accurate home monitoring is the standard-of-care in many diseases like hypertension or diabetes; however, it has yet to be widely used in neurodegenerative diseases. We used wearable activity monitors and computer-vision evaluated assessments to estimate Parkinson’s disease (PD)-related disease burden. METHODS/STUDY POPULATION: We recruited 22 people from the University of Iowa Movement Disorders Clinic. Each person completed a standardized set of 3 fine motor tasks using their hands. We recorded a video of this activity, which was evaluated using MediaPipe - an open-source pose classification program from Alphabet - as well as had an nurse-practitioner evaluate the performance on a validated scale (UPDRS). Participants wore a Fitbit Inspire 3 activity tracker at home for the next two weeks. We quantified disease burden using the Parkinson’s Disease Questionnaire 39 - a validated 39-item survey about the intensity of PD-related impairment. Using data from the videos and activity trackers, we estimated 1) the standardized UPDRS assessment of motor impairment and 2) the total PDQ-39 score. RESULTS/ANTICIPATED RESULTS: We found observationally recorded fastest sustained (at least 5 minutes) walking speed was a strong predictor of PDQ-39, explaining over one third of the variability in the measure. Range of motion in the videos was a significant predictor of UPDRS scores; however, was only weakly related to the overall PDQ-39 score. Further processing of the signals from the video, including wavelets and frequency domain analysis, may provide better predictive capabilities. PDQ-39 subscores (e.g., cognition, social support, mobility) will be the subject of further analysis. DISCUSSION/SIGNIFICANCE: Home monitoring has become the standard in other fields because of the better generalizability of home measurements. Improving the detection and evaluation of PD using home monitoring will lead to more timely and accurately changes in medication and less need for clinic visits - especially off levodopa.

Six Minute Walk Test changes during outpatient rehabilitation in individuals Post-COVID with and without moderately severe to severe depression symptoms

Six Minute Walk Test changes during outpatient rehabilitation in individuals Post-COVID with and without moderately severe to severe depression symptoms

The Use of Mobility-Focused Outcome Measures for Young Adults With Cancer Undergoing Chemotherapy

Background: Young adults living with cancer face many unique challenges during treatment and throughout survivorship. Chemotherapy is a standard anticancer treatment that has been known to lead to negative side effects on health including loss of muscle mass, strength, and physical function (ie, physical mobility). This scoping review aimed to explore what, how, and when mobility-focused outcome measures are being used during chemotherapy treatments for young adults living with cancer to examine changes in physical mobility. Methods: Five databases were searched. To be included in this review, studies must have included young adults (age 18-40) living with cancer, who were receiving chemotherapy treatment and used any form of physical mobility measurement during treatment. Duplicates were removed, and all screening and data extraction were performed by 2 or more independent reviewers. Results: A total of 1734 studies were screened, and four studies were included in this review. Three studies included a self-reported activity log. All studies assessed physical mobility using types of performance-based outcome measures such as accelerometers, muscle strength tests, cycle ergometer testing, or the 6- minute walk test. Assessments were conducted in person by study personnel in 2 studies. Outcomes were assessed throughout the chemotherapy cycle, including preadministration, over the first 7 days, weekly, and months into treatment. Conclusion: Although a scarcity of available literature exists, this review highlights the potential for screening and monitoring changes in mobility for young adults with cancer. Clinical application of the measures highlighted in this review shows promise in guiding appropriate interventions and informing changes in treatment dosage. Future research should build upon existing work to address the limited availability of mobility measures validated in this population.

Effect of low intensity aerobic cycle ergometer on maximal walking speed and cadence of myasthenia gravis patients

Background and objectives. MG is associated with muscle weakness which induces fatigue. This condi­tion interferes with patients’ ability to pursue activities of daily living and could cause many complications such as decrement in walking and depression. Though rehabilitation has been proved to reduce symptoms, the optimal dosage of the rehabilitation program is still debatable due to lack of high-quality evidence. The aim of this study was to analyze the effect of aerobic cycle ergometer on maximal walking speed, cadence and fatigue of MG patients. Materials and methods. This randomized control group study was conducted to 20 Myasthenia Gravis patients with MGFA classification I until IIb. 10 meter walking test was used to assess maximal walking speed, 1 minute walking test was used to assess cadence, while Fatigue Severity Scale was used to measure fatigue. Measurement was done before and after 8 weeks of exercise. Paired t-test is used to analyze within group variables, and independent t test to evaluate between-group analysis. Results. There was improvement on maximal walking speed, cadence and fatigue at intervention group with large effect size (CI 95%, p = 0,05), even though the results didn’t differ statistically between groups. Conclusion. There is improvement of maximal walking speed, cadence and fatigue of Myasthenia Gravis patients after exercising using low intensity aerobic cycle ergometer.

β-crosslaps in knee osteoarthritis – assessment and rehabilitation

Abstract: The bone turnover is important for the progression of osteoarthritis. The C-terminal telopeptide of type I collagen, β-CrossLaps (β-CTx) is considered as the first-choice bone resorption markers. Today, the biochemical markers have been associated with pain and disease severity in knee osteoarthritis (KOA) patients. We studied the association between β-CTx and functional status in KOA patients, pre- and postrehabilitation program. The primary goals of our study are both to establish the correlation between the serum level of β-CTx and other parameters of clinical and functional status in KOA patients and to compare the CTX-I values before and after rehabilitation program. We respected the actual international management recommendations for KOA. A total of 130 patients were randomly allocated into two distinct groups: Study Group (SG = 90 patients) performed 10 sessions of complete rehabilitation program (magnetodiaflux, transcutaneous nerve stimulation, ultrasound and low intensity laser treatment, kinetic measures), and Control Group (CG = 40 patients) performed 10 sessions of kinetic program. Both programs were performed daily, 5 days/week, 2 weeks. Evaluation of patients was carried out in two stages - initial (T1) and after 3 months (T2). Comparing the initial values with the final ones for β-CTx, we noticed a high significant difference between initial and final values only in SG patients. For the both T1 and T2 moments, there was no a statistically significant difference between β-CTx values from the two groups. Analyzing the differences between the values of clinical parameters (Six Minutes Walking Test, Timed Up-and-Go test, walk cadence and Symmetry index in walk) obtained between the patients from the two groups, we noticed that, for the T2 moment, there was a statistically significant difference between studied parameters, except walk cadence. In the assessment of global KOA patient status (clinical and functional status in accordance with bone-cartilage interface dynamics), β-CTx has significant value and could be used for monitoring the individualized rehabilitation program.

Spatial equity of urban parks from the perspective of recreational opportunities and recreational environment quality: A case study in Singapore

Spatial equity in urban park recreational services can significantly contribute to sustainable urban planning. However, there are shortcomings in research comparing the spatial equity of different categories of parks and urban parks overall from the perspective of recreational opportunities and recreational environment quality available to residents across various neighborhoods. In this paper, emphasizing park access within a 10-minute walk, we proposed an evaluation system at the neighborhood level for regional parks, community parks, and urban parks overall (regional and community parks combined) from this under-researched perspective. Taking Singapore as a case study, the feasibility of this evaluation system has been verified. We applied Lorenz curve, Gini coefficient, locational entropy, and spatial autocorrelation analysis to compare the differences of horizontal spatial equity and spatial distribution patterns of different categories of parks and urban parks overall from the perspective of recreational opportunities and recreational environment quality. Results showed that the horizontal spatial inequity of recreational opportunities is higher than that of recreational environment quality with respect to regional parks, community parks, and urban parks overall. Compared with regional parks, community parks have a greater effect on improving the horizontal spatial equity of recreational opportunities and recreational environment quality of urban parks overall. Park recreational opportunities and recreational environment quality available to residents in each neighborhood have significant spatial accumulation patterns. The evaluation system and its application enable a more comprehensive assessment of the spatial distribution of neighborhood-level park recreational opportunities and recreational environment quality.

Clinical Study of Preoperative Prehabilitation Synchronized Neoadjuvant Chemotherapy for Gastric Cancer Patients

Background. To investigate the effectiveness of prehabilitation in improving physical and nutritional status in patients undergoing gastric cancer resection. Methods. A total of 136 locally advanced gastric cancer patients who planned to undergo neoadjuvant chemotherapy (NAC) plus transabdominal radical surgery were involved. All participants were divided into the prehabilitation group and the control group using the odd-even method, with 68 cases in each group. Intervention consisted of preoperative exercise and nutrition optimization. Participants were adults awaiting elective gastric resection for cancer. The primary outcomes were changes in functional ability and nutritional status, as measured by relative changes in 6 minute walking distance (6MWD) and scores on the albumin and prealbumin. Preoperative (end of the prehabilitation period) and postoperative (from 4 to 6 weeks after surgery) data were compared between the two groups. Results. All 136 patients were randomized in this study. Compared with the control group, the prehabilitation group exhibited improved functional capacity both before surgery (6MWD change) and after surgery. Furthermore, it demonstrated significantly higher levels of albumin and prealbumin before and after surgery than the control group. Conclusion. Prehabilitation in gastric cancer patients can improve preoperative functional capacity and nutritional status. Maintaining a patient’s physical function and nutritional status may have a significant impact on the continuity of cancer care.

The measurement of fatigability severity in individuals with multiple sclerosis and healthy controls

BackgroundMultiple Sclerosis (MS) is a chronic disease that substantially diminishes one's ability to undertake daily living activities. Fatigue has been reported by at least 80 % of persons with MS (PwMS). Yet, little is known concerning the quantification of fatigability using prolonged walking tests. ObjectivesTo compare fatigability severity measures using the 10-minute walk test for PwMS against age- and gender-matched healthy controls (HCs). MethodsParticipants included 53 ambulatory PwMS and 49 HCs. Perceived fatigability was measured by dividing a participant's change in self-reported tiredness by the number of meters walked. Performance fatigability was calculated by dividing the change in walking speed (at 2.5 and 10 min) by the total distance walked in meters. ResultsThere was a significant difference in perceived fatigability between PwMS and HCs (mean difference: 2.73 ± 0.83; p = 0.001) and in performance fatigability (mean difference: 0.24 ± 0.11; p = 0.01). Moreover, there were significant differences in speed and distance at all time points (p ≤ 0.05) between PwMS and HCs. ConclusionsPwMS have significant walking deficits as reflected by greater fatigability in both perceived and performance measures. These methods can enhance therapeutic strategies that improve the walking performances of PwMS.

Normative values in healthy adults for the 6-minute and 2-minute walk tests in Belgium and Vietnam: implications for clinical practice.

To establish reference values for the 6-minute walk test (6MWT) and 2-minute walk test (2MWT) distances, to investigate the correlation between these 2 tests, and to establish prediction equations for these distances in healthy populations of Belgium and Vietnam. Cross-sectional study. The 6MWT and 2MWT were administered to a convenience sample of 239 Belgian and 303 Vietnamese participants between the ages of 18 and 80 years. The mean (standard deviation; SD) 2MWT distances were 215 (32.8) m for Belgian participants and 156 (25.5) m for Vietnamese participants. The mean (SD) 6MWT distances were 625 (90.7) m for Belgian participants and 449 (70.4) m for Vietnamese participants. The Pearson correlation coefficient between the 2 tests was 0.901 (p < 0.001) for Belgian participants and 0.871 (p < 0.001) for Vietnamese participants. Age and sex were the 2 most important predictors of walking distance, followed by body mass index for Belgium and height for Vietnam. The adjusted R² ranged from 0.31 to 0.49 across 4 predictive equations. These results can be used to determine the presence of walking performance deficits and to guide future studies. The 2MWT is suggested as a useful and convenient alternative to the 6MWT for assessing walking performance in clinical practice.

Body Awareness in COPD and Its Relation with Patients’ Clinic States

The detection of impairments in body awareness can provide important data for the clinical assessment and treatment planning of patients with COPD. In this study, we aimed to evaluate body awareness in patients with COPD, and to examine its relationship with patients’ clinics. A total of 114 subjects were divided into two groups: the COPD group (n:56) and the control group (n:58). Disease severity (COPD Assessment Test), functional capacity (6 Minute Walk Test), dyspnea (Modified Borg Scale), body awareness (Body Awareness Questionnaire), depression (Beck Depression Inventory) and anxiety (Beck Anxiety Inventory) levels of the groups were evaluated. Compared to the control group, the COPD group had lower levels of body awareness and higher levels of anxiety and depression (p

Mechanical loading of bone-anchored implants during functional performance tests in service members with transfemoral limb loss.

For individuals with limb loss, bone-anchored implants create a direct structural and functional connection to a terminal prosthesis. Here, we characterized the mechanical loads distal to the abutment during several functional performance tests in Service members with transfemoral (TF) limb loss, to expand on prior work evaluating more steady-state ambulation on level ground or slopes/stairs. Two males with unilateral TF limb loss and two males with bilateral TF limb loss participated after two-stage osseointegration (24 and 12 months, respectively). Tri-directional forces and moments were wirelessly recorded through a sensor, fit distal to the abutment, during six functional tests: Timed Up and Go (TUG), Four Square Step Test (FSST), Six Minute Walk Test (6MWT), Edgren Side-Step Test (SST), T-Test (TTEST), and Illinois Agility Test (IAT). Additionally, participants performed a straight-line gait evaluation on a 15 m level walkway at a self-selected speed (0.93-1.24 m/s). Peak values for each component of force and moment were extracted from all six functional tests; percent differences compared each peak with respect to the corresponding mean peak in straight-line walking. Peak mechanical loads were largest during non-steady state components of the functional tests (e.g., side-stepping during SST or TTEST, standing up from the ground during IAT). Relative to walking, peak forces during functional tests were larger by up to 143% (anterior-posterior), 181% (medial-lateral), and 110% (axial); peak moments were larger by up to 108% (flexion-extension), 50% (ab/adduction), and 211% (internal/external rotation). A more comprehensive understanding of the mechanical loads applied to bone-anchored implants during a variety of activities is critical to maximize implant survivability and long-term outcomes, particularly for Service members who are generally young at time of injury and return to active lifestyles.