6th World Research Articles

PD-1/PD-L1 combined with LAG3 is associated with clinical activity of immune checkpoint inhibitors in metastatic primary pulmonary lymphoepithelioma-like carcinoma.

Primary pulmonary lymphoepithelioma-like carcinoma (PLELC) is an Epstein–Barr virus (EBV)-related, rare subtype of non-small-cell lung cancer (NSCLC). Immune checkpoint inhibitors (ICI) show durable responses in advanced NSCLC. However, their effects and predictive biomarkers in PLELC remain poorly understood. We retrospectively analyzed the data of 48 metastatic PLELC patients treated with ICI. Pretreated paraffin-embedded specimens (n = 19) were stained for PD-1, PD-L1, LAG3, TIM3, CD3, CD4, CD8, CD68, FOXP3, and cytokeratin (CK) by multiple immunohistochemistry (mIHC). Next-generation sequencing was performed for 33 PLELC samples. Among patients treated with ICI monotherapy (n = 30), the objective response rate (ORR), disease control rate (DCR), median progression-free survival (mPFS), and overall survival (mOS) were 13.3%, 80.0%, 7.7 months, and 24.9 months, respectively. Patients with PD-L1 ≥1% showed a longer PFS (8.4 vs. 2.1 months, p = 0.015) relative to those with PD-L1 <1%. Among patients treated with ICI combination therapy (n = 18), ORR, DCR, mPFS, and mOS were 27.8%, 100.0%, 10.1 months, and 19.7 months, respectively. Patients with PD-L1 ≥1% showed a significantly superior OS than those with PD-L1 <1% (NA versus 11.7 months, p = 0.001). Among the 19 mIHC patients, those with high PD-1/PD-L1 and LAG3 expression showed a longer PFS (19.0 vs. 3.9 months, p = 0.003). ICI also showed promising efficacy for treating metastatic PLELC. PD-L1 may be both predictive of ICI treatment efficacy and prognostic for survival in PLELC. PD-1/PD-L1 combined with LAG3 may serve as a predictor of ICI treatment effectiveness in PLELC. Larger and prospective trials are warranted to validate both ICI activity and predictive biomarkers in PLELC.This study was partly presented as a poster at the IASLC 20th World Conference on Lung Cancer 2019, 7–10 September 2019, Barcelona, Spain.

14th World Stroke Congress, Singapore, 26-29 October 2022

Free accessAbstractFirst published online October 25, 202214th World Stroke Congress, Singapore, 26-29 October 2022Volume 17, Issue 3_supplhttps://doi.org/10.1177/17474930221125973

Report on the 15th International Conference of the Journal ”Palliative Medicine in Practice” after the 12th World Congress of the European Association for Palliative Care

Report on the 15th International Conference of the Journal ”Palliative Medicine in Practice” after the 12th World Congress of the European Association for Palliative Care

Homeopathy and high dilutions in the context of water structure research: the experience in the 9th World Water Forum - 2022

Water plays a vital role in adapting natural and human systems in a climate change scenario. Understanding how this fundamental element of life is organized and functioning is essential to gather, disseminate, and advance knowledge about water at the micro and nanostructure level. With developments in the different research areas, the International Panel on Water Structure – IPWS was created during the 8th World Water Forum (WWF) of Brasília in 2018. Just as the Toronto Conference in 1986 was a milestone for the climate agenda to spark a process of the organization by the scientific community of what became the Intergovernmental Panel on Climate Change - IPCC, the 8th World Water Forum held in Brasilia in 2018 became a milestone in the agenda of the micro and nanostructure of water. The IPWS connects leading researchers who develop research on water structure and related fields of knowledge and their most diverse applications from an interdisciplinary perspective. Since 2018, CIRAT – International Center on Water and Transdisciplinarity has been responsible for the executive secretary of the IPWS. In 2020 a partnership between CIRAT and WATER – a Multidisciplinary Research Journal has begun, intending to organize a special edition on Water and Transdisciplinarity to be launched during the 9th WWF, in Dakar, on March 24th, 2022. The whole project was organized by Prof. Leoni Bonamin, from Universidade Paulista, with the support of the Editor-in-Chief of this journal, Prof. Gerald Pollack, from Washington University at Seattle. This special edition aimed to disclose advanced knowledge about water at different structural levels, leading to a new understanding of water in response to the challenges of our century. The focus was on the cross-over of information with technical quality and bold thinking, as shown in Figure 1 below. Homeopathy was included among the themes. It was a multi-step process aiming to offer readers a sample of how frontier science can signal a very different and much more exciting future to the following generations than we usually expect. The objective was to gather scientific quality and allow the authors to propose and discuss hypotheses based on the literature. For this, the manuscripts were initially received, after personal invitations sent to more than 200 researchers in the field, whose contributions were evaluated in a pre-selection based on the scope of WATER. They then went through a thorough two-step peer review process. In the first stage, ad-hoc reviewers were invited to give their opinions. In the second stage, members of the Editorial Board carried out a new detailed analysis of the content to ensure maximum scientific understanding, allowing the authors to be bold in their projects while careful with the methodology. From the Board's organization to the design of the editorial flow and peer review, the entire process was carried out voluntarily by all the actors involved. Thus, the whole editorial process was philanthropic, there were no costs for the authors, and all articles were published as open access. Authors from five countries participated in this project: Brazil, India, Italy, Russia, and the United States. Given the multidisciplinary nature of this special edition, the sequence of articles was organized following a well-defined logic: from the broadest to the most specific topics, culminating in innovative proposals with the possibility of immediate application. For this, different sessions were organized according to the topics: "Opinion Article," "Hypotheses," "Water Structure," "High Dilutions," "Water and Environment," and "New Devices." Four of twelve articles reported results on high dilutions, including its physicochemical properties and the implications on biological systems, such as plants and aquatic animals [1-4]. This initiative inspired all to envision the possibility of offering practical solutions to old problems involving different ways of water management, which could reduce social gaps and improve the quality of life fairly and universally. The Issue will be available online from April 30th, 2022.

Protocol for the Tessa Jowell BRAIN MATRIX Platform Study

IntroductionGliomas are the most common primary tumour of the central nervous system (CNS), with an estimated annual incidence of 6.6 per 100 000 individuals in the USA and around 14...

20th World Wind Energy Conference & Exhibition (WEEC 2022)

This paper represents a preface to the Proceedings of the 20th World Wind Energy Conference & Exhibition (WEEC 2022) held in Rimini, Italy, from the 28th to the 30th of June 2022. Background information, conference resolution and the organizational structure of the meeting, program committee, and acknowledgments of the contributions of the many people who made the conference a success are presented.

OVERVIEW OF ENGLISH LANGUAGE PROFICIENCY INDEX IN EFL-COUNTRIES

The English Proficiency Index (EPI) ranking released by Education First (EF) shows that Indonesian EPI falls under Vietnam in 2016 and commits a decreasing trend since 2011. Besides, other EFL-countries, e.g., Belgium and Argentina, could reach the 11th and 19th world ranking in the same year. These phenomena showed that Indonesian had problems in improving English language proficiency. Therefore, this paper is aimed at; (1) pointing out the factors affecting EPI from social-cultural, legal and educational perspectives, (2) factors affected by EPI, and, (3) recommendations for improving EPI based on the other EFL-countries with high EPI.&#x0D; Keywords: English Language Proficiency Index (EPI), EFL-countries

Abstracts of the 10th World Congress of Perinatal Medicine in Developing Countries, 1–5 June 2022, Punta Cana, Dominican Republic

Abstracts of the 10th World Congress of Perinatal Medicine in Developing Countries, 1–5 June 2022, Punta Cana, Dominican Republic

Fourth World Congress of Sports Physical Therapy Scientific Abstracts

The International Journal of Sports Physical Therapy is pleased to publish abstracts from the 4th World Congress of Sports Physical Therapy, which will take place in Nyborg, Denmark, August 26-27, 2022. The theme of the Congress is “Translating Science into Actioon.” The variety of presentations during this congress are examples of the contemporary sports physical therapy research activities taking place around the world.The abstracts presented in the following pages were selected by the Scientific Committee, which included members from and from the International Federation of Sports Physical Therapy. It should be noted that abstracts have not been reviewed by the Editorial Board, Associate Editors or Editor-in- Chief of the International Journal of Sports Physical Therapy.After careful review by an international team of reviewers, research abstracts will be presented by authors at the World Congress.Each abstract presents only a brief summary of a research project / presentation and does not permit full assessment of the scientific rigor with which the work was conducted. While the abstracts offer only preliminary results that may require further refinement and future validation, they do serve an important role of sharing new research ideas from around the world. This sharing of ideas helps to encourage worldwide dialogue among researchers, clinicians, and educators that will ultimately contribute to the sports physical therapy body of knowledge.Notice: The abstracts below are presented as prepared by the authors. The accuracy and content of each abstract remain the responsibility of the authors.

Scientific Advances in Biostimulation Reported in the 5th Biostimulant World Congress

Biostimulants are agronomic products that have become highly important in agriculture, as they are formulated with substances capable of stimulating physiological and biochemical processes in plants that help them adapt to different detrimental environmental conditions such as drought, salinity, high temperatures, nutritional deficiencies, etc. in such a way that the crops, under these conditions, maintain a good agronomic yield and quality of harvest. Every two years, the International Congress on Biostimulants is held with the aim of publicizing the most innovative and recent advances in every relevant type of product: new active ingredients, modes of action, cultivation protocols, test platforms and phenotyping, use of analytical omics tools, etc. In December 2021, the 5th World Congress on Biostimulants was held in Miami (Florida, USA). This publication summarizes the most relevant results that were presented at this congress, in which biostimulants formulated with algae extracts and amino acids stood out in a number of presentations. The various studies presented were carried out on diverse crops such as apple, blackberry, carrot, celery, cherry, corn, grape (table and wine), olive, pear, pepper, potato, rapeseed, spinach, sunflower, soybean, tomato, and wheat. The future lines of the new generation of biostimulants were also marked.

Pediatric-Type Indolent B-Cell Lymphomas With Overlapping Clinical, Pathologic, and Genetic Features.

Pediatric-type follicular lymphoma (PTFL) and pediatric nodal marginal zone lymphoma (PNMZL) are rare pediatric-type indolent B-cell lymphomas (PedIBCL) that differ clinicopathologically from their adult counterparts. Accurate diagnosis is important to avoid overtreatment but is often challenging. The mutational landscape of PTFL is known and may aid diagnosis, but the genetic features of PNMZL are not well understood. We analyzed 21 cases of PedIBCL according to their clinicopathologic findings and classified them into PTFL (n=11), PNMZL (n=2), and “mixed type” tumors (n=8) showing ambiguous histology. We also analyzed 2 cases of adult B-cell lymphomas showing features of PedIBCL. Targeted sequencing of 121 lymphoma-related genes was performed. The median age of PedIBCL patients was 16 years (range: 3 to 47), and all but 1 PTFL patient were male. All patients presented with limited-stage disease, and only 1 relapsed. There were no significant differences in clinical features among the 3 PedIBCL groups. The most frequently mutated genes were MAP2K1, TNFRSF14, KMT2C, IRF8, and NOTCH2. The genetic features of all groups were similar to the established mutational landscape of PTFL. The 2 adult B-cell lymphomas cases also had MAP2K1, TNFRSF14, and IRF8 mutations, but the clinical features were not typical of PedIBCL. In summary, this study demonstrated that PTFL and PNMZL are similar diseases with overlapping clinical, pathologic, and genetic features; mixed type tumors can also occur. Atypical adult cases with similar histologic features were also observed. Therefore, the disease spectrum of PedIBCL may be much broader than is currently believed.

Whole Exome Sequencing of Patients With Heritable and Idiopathic Pulmonary Arterial Hypertension in Central Taiwan.

BackgroundGenetic variants could be identified in subjects with idiopathic and heritable pulmonary arterial hypertension (PAH). The 6th World Symposium on Pulmonary Hypertension (WSPH) provided a list of genes with evidence of association with PAH. However, reports using whole exome sequencing (WES) from southeastern Asian PAH cohorts were scarce.MethodsSubjects with idiopathic and heritable PAH (N = 45) from two medical centers in central Taiwan were screened for PAH related gene variants. The genomic DNA was prepared from peripheral blood lymphocytes. We performed WES for all patients enrolled in this study. All identified gene variants were validated by polymerase-chain reaction and Sanger sequencing. The clinical and hemodynamic data were compared between bone morphogenetic protein receptor type-2 (BMPR2) gene variants carriers vs. non-carriers.ResultsEight patients (8/45 = 17.8%) was identified carrying BMPR2 gene variants and 8 patients (8/45 = 17.8%) had other WSPH-listed PAH-related gene variants (1 with ACVRL1, 1 with ENG, 1 with SMAD9, 1 with SMAD1, 1 with ATP13A3 and 3 with AQP1). In addition, a total of 14 non-WSPH-listed PAH-related genetic variant sites (ABCC8, NOTCH1, NOTCH2, NOTCH3, JAG1, BMP10, GGCX, FBLN2, ABCA3 and PTGIS) were found in this PAH cohort. Subjects carrying BMPR2 gene variant (N = 8) were younger at diagnosis of PAH (30 ± 11 vs 49 ± 13 years, p = 0.001) than the non-carrier group (N = 37). BMPR2 variant carriers had a trend toward having higher mean pulmonary arterial pressure (PAP) (61 ± 19 vs. 51 ± 13 mmHg, p = 0.076) than the non-carriers upon initial diagnosis. Pulmonary vascular resistance, right atrial pressure, cardiac output, as well as functional class were similar between BMPR2 variant carriers and non-carriers at initial diagnosis.ConclusionsWe identified 17.8% of patients with BMPR2 gene variants and 17.8% subjects with other 6th WSPH-listed PAH-related gene variants in a Taiwanese idiopathic and heritable PAH cohort. PAH patients carrying BMPR2 variants presented at a younger age with a trend toward having higher mean PAP at initial diagnosis.

World Conference on Sampling and Blending WCSB10, June 2022: broadest scientific coverage ever, excited in-person attendees and a 1000-year historical closure

Sampling and Vikings seems to be the next unexpected connection within Kim Esbensen’s Sampling Column. Kim has been exploring an area of Southern Norway from where the founder of the Theory of Sampling, Pierre Gy, believed his ancestors originated. You will have to read the column to find the “smoking axe”! Oh, and there is an interesting report on the 10th World Conference on Sampling and Blending.

Matters of Life: Human Scapes and Scopes - IASA 10th World Congress 2022

Matters of Life: Human Scapes and Scopes - Call for Contributions to the 10th World Congress 2022 of the International American Studies Association organized in the Guru Gobind Singh Indraprastha University, India, 22nd to 24th November, 2022, and post-conference workshop Matters of Life: Human Shades and Scapes to be held between 25th and 27th November, 2022 in Udaipur, Rajasthan.

A Community-Led Approach as a Guide to Overcome Challenges for Therapy Research in Congenital Disorders of Glycosylation.

Congenital Disorders of Glycosylation (CDG) are a large family of rare genetic diseases for which effective therapies are almost nonexistent. To better understand the reasons behind this, to analyze ongoing therapy research and development (R&D) for CDG, and to provide future guidance, a community-led mixed methods approach was organized during the 4th World Conference on CDG for Families and Professionals. In the quantitative phase, electronic surveys pointed to the prioritization of six therapeutic R&D tools, namely biobanks, registries, biomarkers, disease models, natural history studies, and clinical trials. Subsequently, in the qualitative phase, the challenges and solutions associated with these research tools were explored through community-driven think tanks. The multiple challenges and solutions identified administrative/regulatory, communication, financial, technical, and biological issues, which are directly related to three fundamental aspects of therapy R&D, namely data, sample, and patient management. An interdependence was traced between the prioritized tools, with diagnosis and therapies acting as bidirectional triggers that fuel these interrelationships. In conclusion, this study’s pioneering and adaptable community-led methodology identified several CDG therapy R&D gaps, many common to other rare diseases, without easy solutions. However, the strong proactive attitude towards research, based on inclusive and international partnerships and involving all members of the CDG community, sets the direction for better future therapy R&D.

Abstracts from the 12th World Research Congress of the European Association for Palliative Care

Abstracts from the 12th World Research Congress of the European Association for Palliative Care

Healing the World: Report from the 6th World Union of Wound Healing Societies Congress.

Advances in Skin & Wound Care: May 2022 - Volume 35 - Issue 5 - p 249-251 doi: 10.1097/01.ASW.0000827032.84970.f9

IAB Presidential Address: Bioethics, justice, and lessons from a global pandemic.

BioethicsVolume 36, Issue 5 p. 482-485 SPECIAL ISSUE: IAB 15TH WORLD CONGRESS IAB Presidential Address: Bioethics, justice, and lessons from a global pandemic Vardit Ravitsky, Corresponding Author Vardit Ravitsky vardit.ravitsky@umontreal.ca orcid.org/0000-0002-7080-8801 Department of Social and Preventive Medicine, School of Public Health, University of Montreal, Montreal, C.P. 6128, Succ. Centre-Ville, Quebec, Canada Correspondence Vardit Ravitsky, Department of Social and Preventive Medicine, School of Public Health, University of Montreal. C.P. 6128, succ. Centre-ville, Montréal, Québec, Canada H3C 3J7. Email: vardit.ravitsky@umontreal.caSearch for more papers by this author Vardit Ravitsky, Corresponding Author Vardit Ravitsky vardit.ravitsky@umontreal.ca orcid.org/0000-0002-7080-8801 Department of Social and Preventive Medicine, School of Public Health, University of Montreal, Montreal, C.P. 6128, Succ. Centre-Ville, Quebec, Canada Correspondence Vardit Ravitsky, Department of Social and Preventive Medicine, School of Public Health, University of Montreal. C.P. 6128, succ. Centre-ville, Montréal, Québec, Canada H3C 3J7. Email: vardit.ravitsky@umontreal.caSearch for more papers by this author First published: 30 April 2022 https://doi.org/10.1111/bioe.13037Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume36, Issue5Special Issue: IAB 15th World CongressJune 2022Pages 482-485 RelatedInformation

Message from the Editor in Chief

Dear reader,&#x0D; We are elated to present to you Volume 9, Number 1, 2022 issue of the Selected Papers of the 14th World Conference on Educational Sciences (WCES-2022), which was held online from the 3rd to the 5th of February 2022, in Paris, France. This issue aimed to present the papers that were selected from the myriad number of submissions made in the conference, related to educational breakthroughs and sciences, amidst the recovery from the COVID-19 pandemic.&#x0D; After review, 7 papers were selected. These papers were authored by researchers from Kazakhstan, Turkey, Iran, Cyprus, Slovenia, and Germany. The selected papers include the following: Scientific concept development in early childhood through the lens of “over-development”; The need for academic writing: An online in-service training for academicians; The impact of higher education students’ personality traits on susceptibility to specific gamification elements; Popularization of physical activity in rural schools of Kazakhstan's Aktobe region; Linked List Implementation “Online learning”; Comparison of BA and MA students' attitudes toward virtual education; Atelier experiences in interior architecture education: Zero waste approaches.&#x0D; Dear reader, this issue would not have been possible without the massive input from our researchers, editorial board, and publishing team. We would therefore like to extend our gratitude to all who contributed to making this publication a success.&#x0D; Dear reader, enjoy reading!!&#x0D; &#x0D; Best Regards&#x0D; Assoc. Prof. Dr. Jesus Garcia Laborda, University of Alcala, Spain&#x0D; (Editor in chief)

Narrative review of progress in pathological diagnosis of breast cancer.

Breast cancer (BC) contains a spectrum of diseases with distinctive presentations, morphology, biology, and clinical phenotypes. BC varies significantly in its biological behaviour and response to treatment. Combination of the traditional histopathological with the molecular types of BC allows more accurate prediction of its biological and clinical heterogeneity. We aim to provide a review of the latest advances in breast pathological detection and related biomarkers. We reviewed English publications in PubMed related to progress in pathological diagnosis of breast cancer from 2000 to 2022. This review outlines the latest advances in breast pathological detection and related biomarkers, include histological types, human epidermal growth factor receptor 2 (HER2), estrogen receptor (ER), Ki67, tumor infiltrating lymphocytes. The histological types and molecular pathological markers of BC are closely related to its treatment and prognosis. The 5th edition World Health Organization (WHO) classification of Breast tumours more emphasis on the clinical significance of histological types. The consensus on the testing of biomarkers for BC has also become more precise, not only suggesting that the primary and metastases of BC be detected for the expressions of ER, PR, and HER2, but also introducing the concept of ER and HER2 low-expressions. In addition, the Ki67 proliferation index plays an important role in the expected therapeutic effect. With the gradual rise of immunotherapy, treatments based on programmed death protein-1/programmed death protein-ligand 1 (PD-1/PD-L1) immune checkpoint inhibitors have achieved some results in clinical efficacy for BC, while studies related to tumor infiltrating lymphocytes (TILs) are gradually gaining more attention. With the deep and continued research of BC, these discoveries will demonstrate significant clinical application value in the future.