This study aims to analyze 21st century skills in tailoring courses to support independent learning in the Department of Fashion Education FT-UNM. This type of research is qualitative research using data collection methods in the form of interviews with lecturers and students, and observation of the RPS used. The results showed the application of 21st century skills which include Critical Thinking, Creativity, Collaboration & Communication in learning tailoring courses. Research shows that 21st century skills are related to one another in tailoring course learning, so that each of the 21st century skills known as Skills 4C cannot be achieved if separated. This research shows the need to apply 4c skills in learning, so that it can be material for learning other practical courses to compile a plan for the application of 4c skills in learning.