3He Particles Research Articles

Effects of preexposure to a subthreshold dose of helium particles on the changes in performance produced by exposure to helium particles

On exploratory class missions, such as a mission to Mars, astronauts will be exposed to doses of particles of high energy and charge and protons up to 30 – 40 cGy. These exposures will most likely occur at random intervals across the estimated 3-yr duration of the mission. As such, the possibility of an interaction between particles must be taken into account: a prior subthreshold exposure to one particle may prevent or minimize the effect of a subsequent exposure (adaptation), or there may be an additive effect such that the prior exposure may sensitize the individual to a subsequent exposure of the same or different radiations. Two identical replications were run in which rats were exposed to a below threshold dose of 4He particles and 2, 24 or 72 h later given either a second below threshold or an above threshold dose of 4He particles and tested for performance on an operant task. The results indicate that preexposure to a subthreshold dose of 4He particles can either sensitize or attenuate the effects of the subsequent dose, depending upon the interval between exposures and the doses. These results suggest that exposure to multiple doses of heavy particles may have implications for astronaut health on exploratory class missions.

Characterization of vacuum ultraviolet-irradiated surface modification of CoO(111) crystal by low-energy atom scattering spectroscopy

The surface of a CoO(111) single crystal was treated with vacuum ultraviolet (VUV) light at a wavelength of 172 nm without heat treatment. We studied the surface structural analysis of CoO(111) before and after VUV light irradiation in air using low-energy atom scattering spectroscopy. The primary beam was 3 keV-4He0, and backscattered 4He particles from Co atoms were detected using a microchannel plate detector. We compared the experimental spectra to simulation results, and the results demonstrated that the rock-salt CoO(111) surface was transformed to a spinel Co3O4(111) surface after VUV light irradiation. We also identified details about the chemical properties and topmost layers of CoO(111) surfaces before and after VUV light irradiation.

Exposure to Low (≤10 cGy) Doses of 4He Particles Leads to Increased Social Withdrawal and Loss of Executive Function Performance.

Astronauts on the planned mission to Mars will be exposed to galactic cosmic radiation (GCR), with proton and He particles accounting (in approximately equal amounts) for ∼75% of the equivalent dose. Exposure to ≤15 cGy of space radiation ions with Z ≥ 15 particles has been shown to impair various executive functions, including attentional set shifting and creative problem-solving in rats. Executive functions also regulate social interactions and mood. Should space radiation exposure alter these executive functions as it does cognitive flexibility, there is the possibility of altered interactions among crew members and team cooperativity during prolonged space exploration. This study characterized the effects of ≤10 cGy 400 MeV/n of 4He particles on cognitive flexibility and social interaction (within freely interacting dyads) in male Wistar rats. Exposure to ≥1 cGy 4He ions induced deficits in the SD and/or CD stages of the attentional set shifting (ATSET) task, as reported after exposure to Z ≥ 15 space radiation ions. Should similar effects occur in astronauts, these data suggest that they would have a reduced ability to identify key events in a new situation and would be more easily distracted by extraneous variables. The irradiated rats were also screened for performance in a task for unconstrained cognitive flexibility (UCFlex), often referred to as creative problem-solving. There was a marked dose-dependent change in UCFlex performance with ∼30% of rats exposed to 10 cGy being unable to solve the problem, while the remaining rats took longer than the sham-irradiated animals to resolve the problem. Importantly, performance in the ATSET test was not indicative of UCFlex performance. From a risk assessment perspective, these findings suggest that a value based on a single behavioral end point may not fully represent the cognitive deficits induced by space radiation, even within the cognitive flexibility domain. Rats that received 5 cGy 4He ion irradiation had a significantly lower level of interaction toward their sham-irradiated partners in a non-anxiogenic (uncaged) dyad interactions study. This is consistent with the social withdrawal previously observed in space radiation-exposed male mice in a three-chamber test. 4He-irradiated rats exhibited a significantly higher incidence and duration of self-grooming, which is even more concerning, given that their dyad partners were able to physically interact with the irradiated rats (i.e., touching/climbing over them). This study has established that exposure of male rats to "light" ions such as He affects multiple executive functions resulting in deficits in both sociability and cognitive flexibility, and possibly affective behavior (reward valuation). Further studies are needed to determine if these space radiation-induced co-morbidities are concomitantly induced within individual rats.

Comparison between PHITS and GEANT4 Simulations of the Heavy Ion Beams at the BEVALAC at LBNL and the Booster Accelerator at BNL

Heavy charged particles have been discussed for clinical use due to their superior dose-depth distribution compared to conventional radiation such as X-rays. In addition, high-charge and energy (HZE) ions in galactic cosmic rays (GCR) present important health risks for crewed space missions to the Earth's moon or Mars. Experiments at heavy ion accelerators are used in radiobiology studies; however, numerical simulations of track segment or Bragg peak irradiations are complicated by the details of the beam-line and dosimetry systems. The goal of the present work is in support of biophysics modeling of historical radiobiology data at Lawrence Berkeley National Laboratory (LBNL) and more recent results from the Brookhaven National Lab (BNL) facility (NASA Space Radiation Lab (NSRL)). In this work, the Spread-Out Bragg Peak (SOBP) of 4He, 12C, and 20Ne particles, and a Bragg curve of 56Fe ion have been simulated numerically in the geometries of LBNL and BNL using the Monte-Carlo based PHITS and GEANT4 simulation toolkits. The dose contributions of primary particles and secondary particles, including neutrons and photons, in the target material are computed and discussed as well. Comparisons suggest more contributions of secondaries in GEANT4 simulations compared to PHITS simulations, and less statistical fluctuation and better prediction of neutrons in PHITS simulations. Neutrons and gamma-rays are estimated to make minor contributions to absorbed doses for these beams.

Measuring the Impact of Nuclear Interaction in Particle Therapy and in Radio Protection in Space: the FOOT Experiment

In Charged Particle Therapy (PT) proton or 12C beams are used to treat deep-seated solid tumors exploiting the advantageous characteristics of charged particles energy deposition in matter. For such projectiles, the maximum of the dose is released at the end of the beam range, in the Bragg peak region, where the tumour is located. However, the nuclear interactions of the beam nuclei with the patient tissues can induce the fragmentation of projectiles and/or target nuclei and needs to be carefully taken into account when planning the treatment. In proton treatments, the target fragmentation produces low energy, short range fragments along all the beam path, that deposit a non-negligible dose especially in the first crossed tissues. On the other hand, in treatments performed using 12C, or other (4He or 16O) ions of interest, the main concern is related to the production of long range fragments that can release their dose in the healthy tissues beyond the Bragg peak. Understanding nuclear fragmentation processes is of interest also for radiation protection in human space flight applications, in view of deep space missions. In particular 4He and high-energy charged particles, mainly 12C, 16O, 28Si and 56Fe, provide the main source of absorbed dose in astronauts outside the atmosphere. The nuclear fragmentation properties of the materials used to build the spacecrafts need to be known with high accuracy in order to optimise the shielding against the space radiation. The study of the impact of these processes, which is of interest both for PT and space radioprotection applications, suffers at present from the limited experimental precision achieved on the relevant nuclear cross sections that compromise the reliability of the available computational models. The FOOT (FragmentatiOn Of Target) collaboration, composed of researchers from France, Germany, Italy and Japan, designed an experiment to study these nuclear processes and measure the corresponding fragmentation cross sections. In this work we discuss the physics motivations of FOOT, describing in detail the present detector design and the expected performances, coming from the optimization studies based on accurate FLUKA MC simulations and preliminary beam test results. The measurements planned will be also presented.

Study of the 4He(4He,4He)4He* inelastic scattering at the MAGNEX facility

The 4He(4He,4He)4He* inelastic scattering was revisited in a new coincidence measurement at the MAGNEX facility of Istituto Nazionale di Fisica Nucleare – Laboratori Nazionali del Sud. The 4He + 4He → 4He + 4He* → 4He + 3H + 1H and 4He + 4He → 4He + 4He* → 4He + 3He + n reactions were measured simultaneously by detecting the 4He particles at the MAGNEX magnetic spectrometer in coincidence with the 3H and 3He at the OSCAR silicon telescope. The main concept of the experiment is described and the data reduction strategy is reported.

Semi-empirical systematic of [formula omitted] reaction cross section at 14,6 MeV

A new semi-empirical formula for the calculation of (n,3He) reaction cross section at an energy of 14.6 MeV is suggested, It contains four free parameters to fit few experimental data, we propose additional parameter to formula proposed by Broeders and Konobeyev (2007) that increase the contribution of pre-equilibrium 3He particle emission. The exciton model in closed form and coalescence model are used to describe the pre-equilibrium 3He particle emission in reaction induced by neutron. Compared to earlier works the proposed systematics is more close to experimental data and performs statistical parameters Σ and χ2.

Synthesis of enriched boron nitride nanocrystals: A potential element for biomedical applications

The shortcomings in Boron neutron capture therapy (BNCT) and Hyperthermia for killing the tumor cell desired for the synthesis of a new kind of material suitable to be first used in BNCT and later on enable the conditions for Hyperthermia to destroy the tumor cell. The desire led to the synthesis of large band gap semiconductor nano-size Boron-10 enriched crystals of hexagonal boron nitride (10BNNCs). The contents of 10BNNCs are analyzed with the help of x-ray photoelectron spectroscopy (XPS) and counter checked with Raman and XRD. The 10B-contents in 10BNNCs produce 7Li and 4He nuclei. A Part of the 7Li and 4He particles released in the cell is allowed to kill the tumor (via BNCT) whereas the rest produce electron-hole pairs in the semiconductor layer of 10BNNCs suggested to work in Hyperthermia with an externally applied field.

Kinetic inductance neutron detector operated at near critical temperature

We previously succeeded in constructing and demonstrating the capability of a neutron imaging system based on a superconducting current-biased kinetic inductance detector (CB-KID). In the present work, we systematically studied the characteristics of the superconducting neutron detector to improve the spatial resolution and detection efficiency. We found that the number of neutron detection events with CB-KID remarkably increased when the detector temperature increased from 4 K to the critical temperature T c. We observed systematic changes of neutron signals as a function of the detector temperature from 4 K to T c. We evaluated the detection efficiency of the CB-KID detector, and compared with PHITS Monte Carlo simulations, which modeled the sequential physical processes for the 10B(n,α)7Li reaction, the transport dynamics, and the energy deposition by particles including neutrons, 4He particles, 7Li particles, photons, and electrons.

Cross section measurements of 151Eu(3He,5n) reaction: new opportunities for medical alpha emitter 149Tb production

Method for production of alpha emitter 149Tb by irradiation of 151Eu with 70 MeV 3He nuclei is proposed. For the first time, the cross sections for the formation of isotopes 149,150,151,152Tb were measured experimentally using a stack foil technique in the 3He particles energy range 70 → 12 MeV. The thick target yield of 149Tb is 39 MBq/μAh, or 230 MBq/μA 149Tb at saturation. The optimal energy range from the point of view of radioisotopic purity is 70 → 40 MeV. At these conditions about 150 MBq/μA 149Tb can be produced in 8 hours irradiation, which is sufficient for therapeutic applications. The main impurities are 150Tb (~100% in activity) and 151Tb (~30% in activity). The proposed method surpasses its counterparts by the high content of the target isotope in the natural mixture and the simplicity of the radiochemical separation of 149Tb from the bulk target material.

Effects of exposure to 12C and 4He particles on cognitive performance of intact and ovariectomized female rats

Exposure to the types of radiation encountered outside the magnetic field of the earth can disrupt cognitive performance. Exploratory class missions to other planets will include both male and female astronauts. Because estrogen can function as a neuroprotectant, it is possible that female astronauts may be less affected by exposure to space radiation than male astronauts. To evaluate the effectiveness of estrogen to protect against the disruption of cognitive performance by exposure to space radiation intact and ovariectomized female rats with estradiol or vehicle implants were tested on novel object performance and operant responding on an ascending fixed-ratio reinforcement schedule following exposure to 12C (290 MeV/n) or 4He (300 MeV/n) particles. The results indicated that exposure to carbon or helium particles did not disrupt cognitive performance in the intact rats. Estradiol implants in the ovariectomized subjects exacerbated the disruptive effects of space radiation on operant performance. Although estrogen does not appear to function as a neuroprotectant following exposure to space radiation, the present data suggest that intact females may be less responsive to the deleterious effects of exposure to space radiation on cognitive performance, possibly due to the effects of estrogen on cognitive performance.

Matsubara Green's function of 3He atoms floating on a 4He film adsorbed on graphite: A worm algorithm Monte Carlo study with a fictitious potential

A system consisting of 3He atoms floating on the surface of a 4He film adsorbed to a graphite substrate is simulated using the state-of-the-art worm algorithm path integral Monte Carlo technique. The 4He–4He interactions are described by the usual HFDHE2 potential of Aziz et al. [J. Chem. Phys. 70, 4330 (1979)], whereas the 3He–3He interactions are modelled by a fictitious potential (FP) introduced to see what new features can be obtained. We are, so to speak, imagining and predicting the future experimental design of such synthetic potentials based on the fact that before the advent of the Feshbach resonance technique the manipulations of interatomic interactions was unthinkable. This work particularly examines the finite-temperature Matsubara Green's function (MGF) of the above system, and to the best of knowledge this has not been done before. It is found that the MGF displays strong signals arising from particle-hole (p–h) excitations in the 3He as well as the 4He layers. The main goal of this work is then to shed light on the role played by the 3He atoms in defining the strength of these excitations that are explained to occur as a result of 4He particle promotions to the 3He layer and the zero-point motion of 3He atoms. It is argued, that the scattering of the 4He atoms with the 3He particles is the major driving force for strong p–h excitations signalled by the MGF. For some reason, the statistical potential is able to yield values for the numerically obtained zero-point kinetic energy that is close to the one from ideal gas theory. In the absence of 3He atoms, no strong p–h excitations are detected. Our efforts are aimed at a rejuvination of this subject by an examination of the MGF, as the literature on this topic is rare. A value-added feature of this work is the use of the above mentioned FP for a qualitative description of the 3He–3He interactions since we are only interested in a qualitative study. The spatial positions of 3He and 4He atoms are displayed in a set of figures, with emphasis on a “fake” 3He clusterization. Numerical results for the energies are presented which are comparable to those reported by Krotscheck [Phys. Rev. B 32, 5713 (1985)] and Gasparini et al. [Phys. Rev. B 29, 4921 (1984)]. It should be noted, that the present simulations have been heavy-computational and required extensive CPU times.

Effects of head-only or whole-body exposure to very low doses of 4He (1000 MeV/n) particles on neuronal function and cognitive performance

On exploratory class missions, astronauts will be exposed to a range of heavy particles which vary in linear energy transfer (LET). Previous research has shown a direct relationship between particle LET and cognitive performance such that, as particle LET decreases the dose needed to affect cognitive performance also decreases. Because a significant portion of the total dose experienced by astronauts may be expected to come from exposure to low LET 4He particles, it would be important to establish the threshold dose of 4He particles that can produce changes in cognitive performance. The results indicated that changes in neuronal function and cognitive performance could be observed following both head-only and whole-body exposures to 4He particles at doses as low as 0.01–0.025 cGy. These results, therefore, suggest the possibility that astronauts on exploratory class missions may be at a greater risk for HZE-induced deficits than previously anticipated.

Production routes of 107,109Cd radioisotopes via charged particle induced nuclear reactions

Activation cross sections of application related 107Cd and 109Cd via proton, deuteron, alpha particle induced reactions on palladium, 3He and alpha particle induced nuclear reactions on silver and deuteron induced reactions on cadmium and indium were measured by using the stacked foil irradiation technique and gamma-ray spectrometry. The cross sections were compared with the earlier experimental data and theoretical predictions. Integral yields were deduced on the basis of experimental data. Different production routes for both radioisotopes are compared.

Performance test of the MAIKo active target

A new active target named MAIKo (Mu-PIC based Active target for Inverse Kinematics∘) has been developed at Kyoto University and Research Center for Nuclear Physics (RCNP), Osaka University. MAIKo is suited for missing-mass spectroscopy of unstable nuclei at forward scattering angles in inverse kinematics. MAIKo consists of a time projection chamber (TPC), which incorporates a micro-pixel chamber (μ-PIC) as the electron multiplication and collection system. In MAIKo, the medium gas also plays the role of a reaction target, thus allowing detection of low-energy recoil particles with high position resolution. The MAIKo TPC was commissioned with He(93%)+iso-C4H10(7%) and He(93%)+CO2(7%) mixture gasses at 430 hPa. The gas gain and the angular resolution of MAIKo were evaluated with an alpha source and a 4He beam at 56 MeV. The TPC was stably operated up to 1000-kcps beam intensity. A tracking algorithm using the Hough transform method has been developed to analyze scattering events. An angular resolution of 1.3°was achieved for scattered 4He particles.

The Sawtooth Oscillation Effect on Fast-Ion Energy Spectra in ITER Plasma and Neutral Particle Analyzer Measurements

ITER plasma with parameters close to those with the inductive scenario is considered. The distribution functions of fast ions of deuterium D and tritium T are calculated while taking into account the elastic nuclear collisions with alpha particles 4He using the code FPP-3D. The D and T energy spectra detected by the neutral-particle analyzer (NPA) are determined. The plasma mixing effect on these spectra during sawtooth oscillations is studied. It is shown that the NPA makes it possible to detect sawtooth plasma oscillations in ITER and determine the percentage composition of the D‒T mixture in it both with the presence of instabilities and without them. A conclusion is drawn on the prospects of using NPA data in automatic controllers of thermonuclear fuel isotopic composition control and plasma oscillation regulation in ITER.

Age as a factor in the responsiveness of the organism to the disruption of cognitive performance by exposure to HZE particles differing in linear energy transfer

Exposure to particles of high energy and charge (HZE particles) can produce decrements in cognitive performance. A series of experiments exposing rats to different HZE particles was run to evaluate whether the performance decrement was dependent on the age of the subject at the time of irradiation. Fischer 344 rats that were 2-, 11- and 15/16-months of age were exposed to 16O, 48Ti, or 4He particles at the NASA Space Radiation Laboratory at Brookhaven National Laboratory. As previously observed following exposure to 56Fe particles, exposure to the higher LET 48Ti particles produced a disruption of cognitive performance at a lower dose in the older subjects compared to the dose needed to disrupt performance in the younger subjects. There were no age related changes in the dose needed to produce a disruption of cognitive performance following exposure to lower LET 16O or 4He particles. The threshold for the rats exposed to either 16O or 4He particles was similar at all ages. Because the 11- and 15-month old rats are more representative of the age of astronauts (45–55 years old) the present results indicate that particle LET may be a critical factor in estimating the risk of developing a cognitive deficit following exposure to space radiation on exploratory class missions.

Note: Coincidence measurements of 3He and neutrons from a compact D-D neutron generator.

Tagging of neutrons (2.45 MeV) with their associated 3He particles from deuterium-deuterium (D-D) fusion reactions has been demonstrated in a compact neutron generator setup enabled by a high brightness, microwave-driven ion source with a high fraction of deuterons. Energy spectra with well separated peaks of the D-D fusion reaction products, 3He, tritons, and protons, were measured with a silicon PIN diode. The neutrons were detected using a liquid scintillator detector with pulse shape discrimination. By correlating the 3He detection events with the neutron detection in time, we demonstrated the tagging of emitted neutrons with 3He particles detected with a Si PIN diode detector mounted inside the neutron generator vacuum vessel.

Isovector excitations in 100Nb and their decays by neutron emission studied via the [formula omitted] reaction at 115 MeV/u

Spin–isospin excitations in Nb100 were studied via the Mo100(t,He3) charge-exchange reaction at 115 MeV/u with the goal to constrain theoretical models used to describe the isovector spin response of nuclei. The experiment was performed with a secondary beam of tritons, and 3He particles were analyzed in the S800 magnetic spectrometer. Decay by neutron emission from excited states in Nb100 was observed by using plastic and liquid scintillator arrays. Differential cross sections were analyzed and monopole excitations were revealed by using a multipole decomposition analysis. The Gamow–Teller transition strength observed at low excitation energies, which is important for estimating the electron-capture rate in astrophysical scenarios, was strongly fragmented and reduced compared to single-particle and spherical mean-field models. The consideration of deformation in the theoretical estimates was found to be important to better describe the fragmentation and strengths. A strong excitation of the isovector spin giant monopole resonance was observed, and well reproduced by the mean-field models. Its presence makes the extraction of Gamow–Teller strengths at high excitation energies difficult. The branches for statistical and direct decay by neutron emission were identified in the spectra. The upper limit for the branching ratio by direct decay (integrated over all observed excitations) was determined to be 20±6%. Even though the statistical uncertainties in the neutron-coincident data were too large to perform detailed studies of the decay by neutron emission from individual states and resonances, the experiment demonstrates the feasibility of the method.

Track structure model of microscopic energy deposition by protons and heavy ions in segments of neuronal cell dendrites represented by cylinders or spheres

Changes to cognition, including memory, following radiation exposure are a concern for cosmic ray exposures to astronauts and in Hadron therapy with proton and heavy ion beams. The purpose of the present work is to develop computational methods to evaluate microscopic energy deposition (ED) in volumes representative of neuron cell structures, including segments of dendrites and spines, using a stochastic track structure model. A challenge for biophysical models of neuronal damage is the large sizes (> 100µm) and variability in volumes of possible dendritic segments and pre-synaptic elements (spines and filopodia). We consider cylindrical and spherical microscopic volumes of varying geometric parameters and aspect ratios from 0.5 to 5 irradiated by protons, and 3He and 12C particles at energies corresponding to a distance of 1cm to the Bragg peak, which represent particles of interest in Hadron therapy as well as space radiation exposure. We investigate the optimal axis length of dendritic segments to evaluate microscopic ED and hit probabilities along the dendritic branches at a given macroscopic dose. Because of large computation times to analyze ED in volumes of varying sizes, we developed an analytical method to find the mean primary dose in spheres that can guide numerical methods to find the primary dose distribution for cylinders. Considering cylindrical segments of varying aspect ratio at constant volume, we assess the chord length distribution, mean number of hits and ED profiles by primary particles and secondary electrons (δ-rays). For biophysical modeling applications, segments on dendritic branches are proposed to have equal diameters and axes lengths along the varying diameter of a dendritic branch.