3He Magnetic Resonance Imaging Research Articles

Hyperpolarised 3He MRI and 81mKr SPECT in chronic obstructive pulmonary disease

During recent years, magnetic resonance imaging (MRI) using hyperpolarised (HP) 3He gas has emerged as a promising new method for the imaging of lung ventilation. However, systematic comparisons with nuclear medicine techniques have not yet been performed. The aim of this study was to compare ventilation imaging methods in 26 patients with chronic obstructive pulmonary disease (COPD) and nine lung healthy volunteers. HP 3He MRI, 81mKr single-photon emission computed tomography (SPECT), high-resolution computed tomography (HRCT) and pulmonary function tests were performed. The three scans were scored visually as percentage of non-ventilated/diseased lung, and a computer-based objective measure of the ventilated volume in HP 3He MRI and 81mKr SPECT and an emphysema index in HRCT were calculated. We found a good correlation between HP 3He MRI and 81mKr SPECT for both visual defect score (r=0.80, p<0.0001) and objective estimate of ventilation (r=0.45, p=0.0157). In addition, both scans were well correlated with reference methods for the diagnosis of emphysema (pulmonary function test and HRCT). The defect scores were largest on 81mKr SPECT (the score on HP 3He MRI was one-third less than that on 81mKr SPECT), but the difference was reduced after normalisation for different breathing depths (HP 3He MRI at total lung capacity; 81mKr SPECT at tidal breathing at functional residual capacity). HP 3He MRI provides detailed ventilation distribution images and defect scores are comparable on HP 3He MRI and 81mKr SPECT. Additionally, new insights into the regional pulmonary microstructure via the apparent diffusion coefficient measurements are provided by HP 3He MRI. HP 3He MRI is a promising new diagnostic tool for the assessment of ventilation distribution.

Hyperpolarized helium MRI assessment of the spatial heterogeneity in lung function with potential relationship to radiation response

Pulmonary toxicity is a major limiting factor in thoracic radiotherapy. Previous studies have shown a regional difference in lung radiation sensitivity (Travis et al 1997, Khan et al 1995). The purpose of this study was to use hyperpolarized helium (3He) magnetic resonance (MR) imaging to examine the spatial heterogeneity of lung function as it may relate to radiation sensitivity. We hypothesize that radiosensitivity differences in the lung can be explained by functional information found in apparent diffusion coefficient (ADC) maps calculated from our 3He MR Images.

Hyperpolarized helium MRI assessment of the spatial heterogeneity in lung function with potential relationship to radiation response

Purpose/Objective: Pulmonary toxicity is a major limiting factor in thoracic radiotherapy. Previous studies have shown a regional difference in lung radiation sensitivity (Travis et al 1997, Khan et al 1995). The purpose of this study was to use hyperpolarized helium (He) magnetic resonance (MR) imaging to examine the spatial heterogeneity of lung function as it may relate to radiation sensitivity. We hypothesize that radiosensitivity differences in the lung can be explained by functional information found in apparent diffusion coefficient (ADC) maps calculated from our 3He MR Images.

3D airway segmentation via hyperpolarized 3He gas MRI by using scale-based fuzzy connectedness

Computerized segmentation of 3D tracheobronchial tree is a necessary first step for subsequent registration and analysis of pulmonary airway and vascular magnetic resonance (MR) images obtained by using hyperpolarized 3Helium gas and Gadolinium. The scientific and clinical implications of acquiring these data on the tracheobronchial tree (for studying ventilation, V) and on the coinciding pulmonary arterioles (for studying perfusion, Q), is the next frontier for static and dynamic pulmonary MRI. In this paper, we report an airway segmentation method from 3He MR images based on the scale-based fuzzy connectedness approach. Incorporated in this method are the pre-processing steps of inhomogeneity correction and intensity standardization. The basic sequential steps in the proposed airway segmentation method are: (1) image acquisition, (2) radio frequency field inhomogeneity correction, (3) standardization of MR image intensity scale, (4) seed specification, (5) scale-based fuzzy connected segmentation of airways, and (6) thresholding and binarization. The majority of these steps are automatically executed; others allow interaction through a graphical interface provided in the 3DVIEWNIX software system, in which the algorithms are implemented. The method achieves an overall precision of about 98% in terms of the extent of overlap in repeated segmentations. Its level of accuracy can be described by a true positive volume fraction of about 98% (considering manual delineation as the surrogate of true delineation), and a false negative and positive volume fraction of about 1%. The total operator and computational time required per study are on the average 2 and 20 min.

An evaluation of pulmonary atelectasis and its re-expansion: hyperpolarized 3He MRI in the Yorkshire pig 1

Rationale and Objectives. Atelectasis, the collapse of small airways, is a significant clinical problem. We use hyperpolarized (HP) 3He magnetic resonance imaging (MRI), or HP 3He MRI, to describe atelectasis in the normal Yorkshire pig, the pig with atelectasis, and the pig with re-expansion of atelectasis. We compare HP 3He MRI findings with depictions of atelectasis by proton MRI. Materials and Methods. During end-expiration in the anesthetized and paralyzed Yorkshire pig (n = 6), HP 3He gas produced by the optical pumping spin-exchange method, was delivered via an endotracheal tube. For two separate groups, atelectasis was either induced by Fogarty-catheter occlusion balloon inflation (n = 3), or lateral chest wall administration of sodium hydroxide (NaOH) (n = 3). MRI was performed at time zero, at 5, 9, 13, 15, and 19 minutes after atelectasis production, 30 minutes after balloon deflation, and 10 and 30 minutes after recruitment of atelectatic areas with increased tidal volumes and added positive end-expiratory pressure. High-resolution, cross-sectional MR images were procured, and comparison was made with the traditional proton MRI. Results. Atelectatic areas by HP 3He MRI were easily distinguishable in both subject groups, and correlated with those located by proton MR. HP 3He MR images showed absence of ventilation, whereas proton MR images depicted dense, white areas. Re-expansion of atelectasis was well delineated by HP 3He MRI. Conclusion. HP 3He MRI may overcome many of the shortcomings of other well-established radiographic methods. HP 3He MRI is a novel, informative method for describing atelectasis and its re-expansion.

Hyperpolarized helium-3 gas magnetic resonance imaging of the lung.

3He magnetic resonance imaging (MRI) is capable of producing new and regional information on normal and abnormal lung ventilation. The basis of 3He MRI involves "optical pumping" to hyperpolarize the 3He nuclei by photon angular momentum transfer. The hyperpolarized gas is administered via inhalation. 3He is an inert, nontoxic noble gas and absorbed in less than 0.1%. Imaging consists of a four-step protocol. 1) Gas density 3He MRI with high spatial resolution displays the distribution of a 3He bolus in a 10-second breath-hold. An almost homogeneous distribution is regarded as normal. Patients with lung diseases show multiple ventilation defects. 3He MRI has been shown to be more sensitive than proton MRI, computed tomography, nuclear medicine or pulmonary function testing for detection of ventilation defects. 2) Dynamic imaging 3He MRI with high temporal resolution shows the dynamic distribution of ventilation during continuous breathing after inhalation of a single breath of 3He gas. Homogeneous and fast distribution is regarded as normal, whereas patients show irregular and delayed patterns with redistribution and air trapping. 3) Diffusion-weighted 3He MRI provides a new measure for pulmonary microstructure because the apparent diffusion coefficient (ADC) reflects lung structure. Normal ADC values are less than 0.25 cm2/s and are increased in fibrosis and emphysema (0.3-0.9 cm2/s). 4) Oxygen-sensitive 3He MRI allows for regional and temporal analysis of intrapulmonary Pao2, which reflects regional pulmonary perfusion, ventilation-perfusion ratio, and oxygen uptake. In patients, an inhomogeneous Po2 distribution indicates alterations of ventilation-perfusion matching. Based on increased experience, 3He MRI can be regarded as a highly promising tool for functional analysis of ventilation. The clinical significance of the increase in sensitivity and sensitivity associated with 3He MRI is yet to be determined.

Distribution of Ventilation in Lung Transplant Recipients: Evaluation by Dynamic 3He-MRI With Lung Motion Correction

The ability of motion corrected dynamic 3He-magnetic resonance imaging (MRI) to discriminate distributional patterns of inhaled hyperpolarized 3He between different groups of lung transplant recipients was evaluated. An ultrafast low-angle shot 2D sequence (temporal resolution 128 ms) was used for ventilation 3He-MRI of 11 single and 6 double lung transplant recipients. After digital motion correction, signal kinetics were evaluated in a tracheal and 7 pulmonary regions of interest. Results from grafts and native lungs as well as from normal and rejected grafts were compared with each other and to reference values from healthy subjects. In emphysema patients, median alveolar rise time, a parameter for increase of alveolar signal, was 0.28 seconds for the graft and 0.48 seconds for the native lung, in fibrosis patients its median was 0.46 seconds for the graft and 0.21 seconds for the native lung. In double lung recipients, alveolar rise time was 0.29 seconds in normal and clinically rejected grafts. Dynamic ventilation 3He-MRI discriminated normal lung grafts from diseased native lungs in single lung recipients. Graft rejection in double lung recipients could not be discriminated.

3He MR Imaging of Porcine Paranasal Sinuses

Rationale and Objectives The aim of this study was to test the effectiveness of laser-hyperpolarized helium 3 ( 3He) as a contrast agent for magnetic resonance (MR) imaging of porcine paranasal sinuses. Materials and Methods Imaging experiments were conducted on the heads of four 50-kg Yorkshire pigs after open sinus surgery was performed. Paranasal sinus MR images were obtained with laser-polarized 3He gas produced through the spin-exchange method. The gas was delivered into the sinuses through two 14-gauge plastic catheters inserted in the nostrils. The 3He MR images were then compared with spatially correlated proton MR images. Results The porcine paranasal sinuses were adequately depicted by MR imaging with hyperpolarized 3He. The signal intensity of the paranasal sinuses on the 3He MR images was related to the size of the opening joining the sinuses to the nasal cavity and was clearly time dependent. Conclusion Hyperpolarized 3He MR imaging may be particularly useful for identifying the anatomic configuration of the paranasal sinuses, as well as for assessing sinus aeration. Further study of the time-dependence of 3He signal intensity may help increase understanding of gas exchange in the sinuses.

Distal airways in humans: dynamic hyperpolarized 3He MR imaging--feasibility.

Dynamic hyperpolarized helium 3 (3He) magnetic resonance (MR) imaging of the human airways is achieved by using a fast gradient-echo pulse sequence during inhalation. The resulting dynamic images show differential contrast enhancement of both distal airways and the lung periphery, unlike static hyperpolarized 3He MR images on which only the lung periphery is seen. With this technique, up to seventh-generation airway branching can be visualized.

Elucidation of structure-function relationships in the lung: contributions from hyperpolarized 3helium MRI.

Magnetic resonance imaging (MRI) using hyperpolarized 3helium (He) gas as the source of signal provides new physiological insights into the structure-function relationships of the lung. Traditionally, lung morphology has been visualized by chest radiography and computed tomography, whereas lung function was assessed by using nuclear medicine. As all these techniques rely on ionizing radiation, MRI has some inherent advantages. 3He MRI is based on 'optical pumping' of the 3He gas which increases the nuclear spin polarization by four to five orders of magnitude translating into a massive gain in signal. Hyperpolarized 3He gas is administered as an inhaled 'contrast agent' and allows for selective visualization of airways and airspaces. Straightforward gas density images demonstrate the homogeneity of ventilation with high spatial resolution. In patients with lung diseases 3He MRI has shown a high sensitivity to depict ventilation defects. As 3He has some more exciting properties, a comprehensive four-step functional imaging protocol has been established. The dynamic distribution of ventilation during continuous breathing can be visualized after inhalation of a single breath of 3He gas using magnetic resonance (MR) sequences with high temporal resolution. Diffusion weighted 3He MRI provides a new measure for pulmonary microstructure because the degree of restriction of the Brownian motion of the 3He atoms reflects lung structure. Since the decay of 3He hyperpolarization is dependent on the ambient oxygen concentration, regional and temporal analysis of intrapulmonary pO2 becomes feasible. Thus, pulmonary perfusion, ventilation /perfusion ratio and oxygen uptake can be indirectly assessed. Further research will determine the significance of the functional information with regard to physiology and patient management.