1064-nm Laser Research Articles

Investigation of the influence of the processing speed and the linear pulse density of the laser surface texturing process

Fine-tuning laser parameters is necessary to achieve the desired quality of the process of laser surface texturing. This requires a set of experiments to assess the influence of the main process parameters on the quality of the surface of a treated alloy. By varying the laser parameters, different laser-material interactions, such as heating, melting, or evaporation can be observed. This study analyzes the influence of two interrelated processing parameters in laser surface texturing – the speed of beam motion on the surface on the one hand, and, on the other, the linear pulse density. They ultimately have a direct impact on the resulting microstructure, hydrophilicity, and electrochemical properties of austenitic steel (AISI 304). By adjusting the pulse repetition rate of a 1064-nm fiber laser from 500 kHz to 1000 kHz at a constant speed of 100 mm/s, the surface wettability changes from hydrophobicity to hydrophilicity. All surfaces treated with laser scanning speeds varying from 20 mm/s to 200 mm/s at a constant rate of 500 kHz are hydrophobic. As a result, the changed ability to repel liquids alters the corrosion properties of the steel in a 0.5 M H2SO4 solution. The results allow one to distinguish ranges of laser-beam parameters that could be useful in selecting certain properties of the stainless-steel surface layer.

Laser-assisted blepharoplasty: An innovative safe and effective technique.

Blepharoplasty is one of the most popular esthetic procedures with an acceptable risk profile and a relatively quick procedure. The aim was to evaluate the efficacy and safety of a new CO2 and 1540-nm laser-assisted blepharoplasty technique applied to the upper and lower eyelids. A total of 38 patients were enrolled. Photographs were taken before the treatment and at 6-month follow-up. One "blind" observer assessed the performance of this technique by ranking the results in four categories of eyelid esthetic: 1=no or poor results (0%-25%), 2=slight improvement (25%-50%), 3=moderate improvement (50%-75%) and 4=marked improvement (75%-100%). All possible complications were monitored. Thirty-two patients (84 %) achieved marked improvement, four patients (11%) moderate improvement, two patients (5 %) slight improvement, while zero subjects (0%) poor or no improvement. No serious adverse effects were observed. Our results from clinical evaluations suggest that the CO2 and 1540-nm laser assisted blepharoplasty is proved to be a sophisticate intervention efficacious in improving the treatment of patients with various degrees of eyelid and periocular aging and also in reducing downtime.

355 nm ultraviolet laser output based on a PPMgLN crystal.

This paper reports the method of generating a 355nm ultraviolet (UV) quasicontinuous pulse laser by using two periodically poled Mg-doped lithium niobate (PPMgLN) crystals in a single-pass cascade. In the first PPMgLN crystal with a length of 20mm and a first-order-poled period of 6.97µm, the second-harmonic light of a 532nm laser with 780mW is generated from the 1064nm laser with an average power of 2W; After that, in the second PPMgLN crystal with a length of 15mm and a third-order-poled period of 5.30µm, the 532nm laser generated was combined with the 1064nm laser remaining through the first PPMgLN crystal to obtain a 355nm UV laser with a maximum output average power of 20mW, a repetition rate of 40kHz, a pulse width of 49ns, and a peak power of 10W. Compared with existing reports, we have higher peak power and single pulse energy, which is an important application of the PPMgLN crystal. This paper will provide an important case for the realization of a 355nm UV quasicontinuous or a continuous laser.

Solar laser pumping approach for both simultaneous and stable multibeam operation under tracking error condition

A solar laser pumping approach to achieve both simultaneous and stable multibeam solar laser operation under solar tracking error condition is proposed here. By using a heliostat, solar radiation is firstly redirected to a parabolic mirror, secondarily concentrated by an aspheric lens, and finally absorbed by four Nd:YAG rods within a pump cavity using a homogenizer. Zemax® and LASCAD™ analysis demonstrate that four simultaneous and stable 1064-nm continuous-wave solar laser emissions with similar multimode power levels can be achieved even with azimuthal solar tracking errors up to ± 0.5 deg. The variation on the multimode solar laser power of the four rods is significantly reduced from 32.38% and 55.52% without the homogenizer to 0.00% and 0.21% with the homogenizer for ± 0.1 deg and ± 0.2 deg azimuthal solar tracking error, respectively. More importantly, simultaneous and stable TEM00 mode solar laser emissions from the four rods are also numerically attained under solar tracking error condition.

Endovascular laser treatment. Comparison of lasers and fibers of different generations: study of temperatures and tissue damage produced on a porcine liver model

The current international guidelines identify tumescent ablative techniques such as laser thermal ablation (EVLA) and radiofrequency (RFA) to be the gold standard in varicose vein surgery.New-generation lasers have been introduced, which have high wavelengths (1940 and 2000 nm) and therefore with a greater affinity for water than the old generation (980- and 1470-nm lasers). The purpose of the study was to evaluate the biological effect and the temperatures produced during the use of lasers with different wavelengths (980, 1470, and 1940 nm) and with optical fibers with different emission (radial diverging at 60° and radial with cylindrical mono-ring) on in vitro model. Porcine liver was used as an in vitro model. The laser control units used had 3 different wavelengths: 980, 1470, and 1940 nm. The optical fibers used were 2: the Corona 360 fiber (mono-ring radial fiber) and the infinite fiber (cylindrical mono-ring fiber). The laser operating parameters used included the delivery of 6 W in continuous wave (CW) mode with a standard 10 s/cm pull-back. Eleven measurements were made for each fiber and for each laser, for a total of 66 measurements. We performed measurements of the maximum transverse diameter produced with laser irradiation to evaluate the biological effectiveness of the treatment. During laser irradiation, we performed measurements of both of the temperatures reached on the external surface of the porcine tissue, near the tip of the laser catheter, and the temperatures reached inside the irradiated tissue by using a digital laser infrared thermometer with apposite probe. The calculation of the statistical significance (p-value) was obtained with the ANOVA method with two between factors.The comparison study of the maximum transverse diameter (DTM) of the lesion produced on the target tissue demonstrated the absence of statistically significant differences between the 1470-nm laser and the 1940-nm laser regardless of the type of fiber used. It was not possible to perform measurements of the maximum transverse diameter produced with the 980-nm laser as this produced no visible effect on the model. The comparison study of the temperatures developed during and immediately after the treatment instead showed higher maximum surface temperatures (TSM) and a higher thermal increase (IT) regardless of the type of fiber used in a statistically significant way (respectively, p 0.002 and 0.012) when using the 980-nm laser versus the 1940-nm laser. Comparing instead the 980-nm laser with 1470 nm, there were no differences in TI recorded during the procedure but a significantly higher VTI (p 0.029). The experiment conducted with the new generation laser, compared with those of the first and second generation, shows how this works overall at lower temperatures with the same effectiveness.

Efficacy and Safety of Picosecond Laser in the Treatment of Melasma: A Network Meta-analysis.

The role of lasers in the treatment of melasma and acquired hyperpigmentation disease of the skin has been suggested by clinicians. However, there is no consensus on the most efficient and safe treatment method. To systematically evaluate the efficacy and safety of picosecond laser in the treatment of melasma. PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, Chinese scientific journal database, and Wanfang database were searched. The data for therapeutic efficacy, melasma area and severity score, and incidence rate of adverse reactions were extracted from the included studies. A total of 20 studies involving 1,182 patients were included in this network meta-analysis. Combined therapy with carbamic acid and 1064-nm picosecond laser was the best measure. Melasma area and severity index score of patients after low-power fractional CO2 laser treatment was higher than that of patients after the treatment with 1064-nm picosecond laser. Aminomethyl cyclic acid combined with 1064-nm picosecond laser may have the highest effective rate after treatment. Low-power fractional CO2 laser provided the lowest melasma area and severity index score after treatment, and the incidence rate of adverse reactions after treatment, was highest when intense pulsed light was used.

Improvement of Faraday Rotation and Its Application in Preconditioned Single-Wire Z-Pinch Plasma

Magnetic field measurement in Z-pinch plasma has drawn considerable interest because it is a key problem in the research of dynamic behaviors and the coupling of magnetic field and plasma. In this study, the measurement sensitivity of the rotation angle in Z-pinch plasma was improved by considering the second polarization effect caused by optical elements. The magnetic field distribution of preconditioned single-wire Z-pinch plasma was determined by this method. The Faraday rotation of the 1064-nm probe laser was measured by the beam-splitting polarization method when the plasma acted as a Faraday medium. A second polarization effect on the rotation angle was realized by taking the different transmittances and reflectivities of the <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$p$</tex-math> </inline-formula> and <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$s$</tex-math> </inline-formula> components of the beam splitters into account. This configuration doubled the sensitivity of the Faraday rotation measurement. The diagnostic errors produced by the techniques and data processing were quantified. The early stage of the preconditioned imploding plasma was monitored, and the distributions of areal electron density, Faraday rotation, and magnetic field were measured. The experimental results demonstrated that the current distribution can be divided into three parts by two dense shells. The majority of the current was distributed outside the dense shell which existed inside the coronal plasma. In addition, only a small amount of current was distributed in the wire core.

Compact and highly stable electro-optic Q-switched laser at 1064 nm based on a composite YAG/Nd:YAG crystal

We report a compact and highly stable 1064-nm electro-optic Q-switched laser operating at the repetition rate of 1 kHz. A composite Nd:YAG crystal was used as the gain media and the cavity length was 105 mm. Under the average pump power of 11 W, the output power achieved 2.404 W with the pulse width of 4.558 ns, corresponding to the maximum peak power of 0.527 MW and the optical-to-optical conversion efficiency of 21.85%. The slope efficiency reached 42.69%. The beam quality in the horizontal (Mx2) and vertical (My2) directions were 1.81 and 1.58, respectively. The pulse timing jitter was less than 1 ns, and the average power fluctuation measured within 30 min was 0.83% (RMS). It is believed that such a compact and highly stable pulsed laser with high repetition rate, high peak power, and good beam quality has great potential in the fields of lidar, etc.

Solar-pumped 1061-/1064-nm dual-wavelength Nd:YAG monolithic laser

Solar-pumped lasers have promising potential in space technology. The first solar-pumped 1061-/1064-nm dual-wavelength Nd:YAG monolithic laser is proposed. The resonant cavity of the laser is formed by coating the dielectric film directly on both ends of the laser medium, and the thin film coated on the output end is specially designed to adjust the transmittance at 1061 and 1064 nm, thus balancing the threshold pump power and realizing a dual-wavelength output. Through theoretical analyses and simulations, a solar-pumped 1061-/1064-nm dual-wavelength laser with improved output power of 81.3 mW was achieved, corresponding to the slope efficiency of 0.13% and the optical-to-optical efficiency of 0.085%, which provides a possible solution for dual-channel space laser communication.

Ultrasound-guided SoracteLite™ transperineal laser ablation (TPLA) of the prostate for the treatment of symptomatic benign prostatic hyperplasia (BPH): a prospective single-center experience

PurposeTo evaluate the efficacy and safety of ultrasound-guided transperineal laser ablation (TPLA) in patients with symptomatic BPH.Materials and methodsFrom January 2020 to January 2022, 63 prospectively enrolled patients underwent TPLA with a 1064-nm continuous-wave diode laser (EchoLaser, Elesta SpA). Primary endpoints were the change in IPSS, QoL, Qmax, PVR and prostate volume at 3 and 12 months.ResultsAt 3 months, IPSS improved from 20.8 ± 7.4 to 11.0 ± 6.6 (p < 0.001), QoL from 4.7 ± 1.4 to 1.5 ± 1.2 (p < 0.001) and Qmax from 8.6 ± 3.5 mL/s to 13.2 ± 5.7 mL/s (p = 0.083). PVR decreased from 124.8 ± 115.4 mL to 43.6 ± 53.6 mL (p < 0.001), and prostate volume decreased from 63.6 ± 29.7 mL to 45.6 ± 21.8 mL (p = 0.003). At 12 months, IPSS improved from 20.8 ± 7.4 to 8.4 ± 5.9 (p < 0.001), QoL from 4.7 ± 1.4 to 1.2 ± 0.8 (p < 0.001), and Qmax from 8.6 ± 3.5 mL/s to 16.2 ± 4.3 mL/s (p = 0.014). PVR decreased from 124.8 ± 115.4 mL to 40.6 ± 53.6 mL (p = 0.003), and prostate volume decreased from 63.6 ± 29.7 mL to 42.8 ± 14.2 mL (p = 0.071). Transient complications consisted of two patients with prostatic abscess (Clavien-Dindo grade IIIa) and one patient with orchitis (Clavien-Dindo grade II).ConclusionsTPLA for symptomatic BPH provides clinical benefits at 3 and 12 months, and the treatment is well tolerated.

Stimulated vibrational-rotational Raman scattering of hydrogen pumped at a 1064-nm laser.

A ∼2.1-µm laser is within an atmospheric transmission window and can be used in remote sensing. In this work, a 1064-nm laser was used as the pump source, pressurized hydrogen was used as the Raman active medium, and a dual-wavelength ∼2.1-µm Raman laser was generated. The 2147-nm laser was generated by a combination processes of stimulated vibrational Raman scattering and stimulated rotational Raman scattering, while a 2132-nm laser was generated by stimulated S-branch vibrational Raman scattering. Optimizing experimental conditions yielded a maximum pulse energy of 76.1mJ, a peak power of ∼9.2M W, and a photon conversion efficiency of 29.8%.

Progressive Lipodystrophy: topical laser treatment with Endolift® procedure using Eufoton® LASEmaR®1500 1470-nm wavelength

Lipodystrophies are a group of rare disorders of diverse aetiology characterised by variable body fat loss. The loss of body fat may affect nearly the entire body (generalised), only certain body regions (partial) or small areas under the skin (localised). Body fat loss can result from underlying genetic defects, autoimmune mechanisms, or drugs. Progressive lipodystrophy is a chronic, inflammatory, degenerative disease of the connective tissue. It leads to the blockage of the circulation and lymphatic drainage, followed by an accumulation of toxins, which promote hyperplasia of the fat cells. As a consequence, connective tissue rigidity promotes skin dimpling or orange skin. This study was designed to evaluate the efficiency of Endolift®, a novel minimally invasive outpatient laser procedure, for the treatment of Progressive Lipodystrophy. 30 women showing cellulite, in the range of 20 to 55 y-o, were enrolled for this study. Patients have undergone a single treatment under tumescent anaesthesia. Treatment was performed using the Endolift® procedure, consisting of the device Eufoton® LASEmaR® 1500. In addition, a 1470-nm wavelength laser was utilised, lead by micro-optical fibres of different calibres directly inside the skin. This treatment aims to destroy and remove degenerative connective tissue and promote neocollagenesis. Optimal results were obtained by 23 patients, 5 had good results, and 2 reported moderate results. No side effect was recorded. Adipocytolysis was performed on 6 patients and we removed 50 to 350 ml of fat. Even after 3 years, 80% of patients maintain significant results. These data show that Endolift® laser treatment represents one of the most effective treatments for removing Progressive Lipodystrophy.

Prospective comparison study of a 550 picosecond 755 nm laser vs a 50 ns 755 nm laser in the treatment of nevus of Ota

Since the introduction of selective photothermolysis, Q-switched nanosecond lasers have been used for the treatment of dermal pigmented lesions. Over the past several years, picosecond lasers have been introduced to the cosmetic community. We recently performed a study comparing a 550 picosecond 755nm laser versus a 50ns 755nm laser, with the purpose of evaluating the clinical efficacy and complications of each laser when treating nevus of Ota. Ten Asian patients with nevus of Ota were enrolled in the study. Each lesion was split into 2 parts, and patients were treated with a 755nm picosecond laser (PSL) and a 755nm nanosecond laser (NSL). The clinical endpoint for fluence choice was immediate whitening (PSL: 2.33 ~ 3.36J/cm2, NSL: 5.5 ~ 7J/cm2) of the treated area. The pulse duration was fixed at 550 picoseconds (PSL) and 50ns (NSL). The spot size of each laser was 2.5-3mm. Laser treatments were performed until excellent clinical improvement was observed. Patients were examined 1week after the first treatment, at each follow-up visit, and 6months after the last laser treatment. The average number of treatment sessions to achieve excellent clinical improvement was 4.2 treatments using PSL and 5.4 treatments using NSL. One case of hyperpigmentation and one case of hypopigmentation were observed in the NSL treatment group. There were no complications in the PSL treatment group. The 755nm 550 picosecond laser is significantly more effective than the 755nm 50ns laser in the treatment of nevus of Ota. The PSL treatment group also had minimum side effects.

Early acne scar intervention with 1064nm picosecond laser in patients receiving oral isotretinoin: a randomized split-face controlled pilot study.

Early acne scar intervention is important. Oral isotretinoin is widely used in patients with moderate to severe acne. Picosecond laser has shown a promising effect on scar clearance. However, there is a lack of reports on the efficacy and safety of early acne scar management by using 1064-nm picosecond laser in patients receiving low-dose oral isotretinoin. Twenty-four patients with atrophic acne scars of Fitzpatrick skin type III to V were enrolled. All patients were receiving low-dose oral isotretinoin (0.12-0.22mg/kg/day) during the treatment. The face of the participants was randomly assigned to receive 2 sessions of fractional picosecond 1064nm Nd: YAG laser (FxPico) treatment and 2 follow-ups, with an interval of 1month (month 0-3). Clinical efficacy and safety were assessed by photographs, ECCA grading scale, the number of scar lesions melanin and erythema indexes (MI and EI), TEWL, DLQI, and patient satisfaction and the adverse events were recorded on every visit. FxPico significantly decreased the ECCA score and showed higher improvement in the ECCA score. FxPico treated side achieved a significant reduction in all acne scar types, while only boxcar scars and rolling scars showed higher improvement. TEWL but not MI or EI were significantly improved. DLQI and patient satisfaction were higher with the FxPico-treated side than control side. No adverse effects were observed and all the side effects observed were temporary and tolerable. Early intervention by FxPico on patients receiving low-dose oral isotretinoin is a safe and effective modality to improve atrophic acne scars.

Evaluation of the safety and efficacy of a fractional picosecond 1064nm laser for post-acne erythema in adult Chinese patients.

To evaluate the efficacy and safety of fractional 1064nm picosecond Nd:YAG laser (FPNYL) in the treatment of post-acne erythema (PAE) of adult Chinese. A total of 22 patients received 1 session of treatment and were followed up at the eighth week. Primary outcomes were measured by the Clinician erythema assessment scale (CEAS). Secondary outcomes included a global aesthetic improvement scale (GAIS) and patients' assessment of satisfaction on a five-point scale. Pain scores and adverse effects were also evaluated. Twenty-two patients with Fitzpatrick skin types III and IV were enrolled in the study and completed all treatments and follow-up visits. The mean CEAS scores fell from 2.74±0.80 to 1.95±0.75 (p<0.05). The mean GAIS of PAE improvement was 2.46±0.68. Erythema percentile scores by VISIA increased from 32.63±7.0 to 45.75±11.45 (t=5.442, p=0). The patient satisfaction score was 1.86±1.17. The pain scores were 3.27±1.17 for the FPNYL treatment (varied from 2 to 6). There were moderate erythema and oedema, which last for 3.84±0.78 days. There were overall 68.18% (15/22) patients who felt pruritus in different degrees and 27.27% patients who encountered acne eruptions (white head type). No scar, hyperpigmentation or hypopigmentation was found. Treatment with fractional 1064nm picosecond Nd:YAG laser is effective and safe for PAE of Chinese patients.

Light-Assisted Drying for the Thermal Stabilization of Nucleic Acid Nanoparticles and Other Biologics.

Cold-chain storage can be challenging and expensive for the transportation and storage of biologics, especially in low-resource settings. Nucleic acid nanoparticles (NANPs) are an example of new biological products that require refrigerated storage. Light-assisted drying (LAD) is a new processing technique to prepare biologics for anhydrous storage in a trehalose amorphous solid matrix at ambient temperatures. Small volume samples (10μL) containing NANPs are irradiated with a 1064nm laser to speed the evaporation of water and create an amorphous trehalose preservation matrix. In previous studies, samples were stored for 1month at 4°C or 20°C without degradation. A FLIR SC655 mid-IR camera is used to record the temperature of samples during processing. The trehalose matrix was characterized using polarized light imaging to determine if crystallization occurred during processing or storage. Damage to LAD-processed NANPs was assessed after processing and storage using gel electrophoresis.

Aiming to personalized laser therapy for nevus of Ota: melanin distribution dependent parameter optimization.

Aiming to the personalized laser therapy of nevus of Ota (NO), a local thermal non-equilibrium model was employed to optimize laser wavelength, pulse duration, and energy density under different melanin depth and volume fraction. According to our simulation, the optimal pulse duration is between 15 and 150ns to limit heat transfer inside the hyperplastic melanin, and 50ns is recommended to decrease the energy absorption by normal melanin in epidermis. Correlations of the minimum and the maximum energy densities are proposed with respect to melanin depth and volume fraction for the 755-nm and 1064-nm lasers. For the same NO type, the therapy window of the 755-nm laser is larger than that of 1064-nm. For NO with shallow depth or low volume fraction, the 755-nm laser is recommended to make the treatment more stable owing to its lager therapy window. For deeper depth or higher volume fraction, the 1064-nm laser is recommended to avoid thermal damage of epidermis. Through comparison with clinical data, the optimized laser parameters are proved practicable since high cure rate can be achieved when energy density falls into the range of predicted therapy window. With developing of non-invasive measurement technology of melanin content and distribution, personalized treatment of NO maybe possible in the near future.

Fabrication of black silicon using picosecond laser irradiation assisted by Se dopant film

Black silicon with micro-nano structures were fabricated by irradiating silicon with 1064nm laser pulses of 8.7-ps duration, 4.5 μJ per single pulse, 100mm/s scanning speed in vacuum, and doping the black silicon by irradiating the silicon coated with Si-Se bilayer film. SEM images show that the surface micron-scale grooves covered with nano-scale particles pattern was produced on Si for both the sample with no film and with Se film, but the surface structure are smoother and more uniform in the presence of Se film. EDS graph demonstrated the presence of Selenium in the black silicon micro-nano structures. Furthermore, Raman spectra results indicate that the micro-nano structured black silicon is still crystal phase.

Preliminary experience with a 1470 nm diode ring laser with echosclerotherapy in lower limb varicose veins

Objective：To study the effect of endovenous laser ablation (EVLA) of lower limb varicose veins using a 1470 nm diode ring laser with ultrasound-guided foam sclerotherapy (UGFS), also known as echosclerotherapy. Methods：From January 2020 to December 2022, 236 patients with primary lower limb varicose veins were enrolled in the study. All patients were treated with 1470 nm diode ring laser with echosclerotherapy in our center. Under tumescent anesthesia, venipuncture of the great saphenous vein (GSV) trunk was performed, followed by 1470 nm laser therapy (80-100J/10W). Before the procedure, 1% polidocanol foam was injected into the insufficient collateral veins extending from the main trunk of the GSV. During the 3days after surgery, self-adhesive elastic bandage was used for compression therapy. After 3 days of surgery, grade II compression stockings was used for 1 month. All patients underwent a follow-up duplex Doppler ultrasound 1, 30 days after the procedure. Hospital stay time, postoperative pain, GSV occlusion rate, recurrence rateand complications, such as ecchymosis, edema, paresthesia and endovenous heat-induced thrombosis (EHIT). Results: Four patients were lost to follow up. The average hospitalization time was 2.8 days, the average admission time after operation was 1-2 days. The average operating time was 45.79 ± 8.57min. At the one month follow up all treated GSV remained occluded. There were 2 patients were treated with echosclerotherapy in outpatient because of new reflux in the treated collateral veins. Seventy-five percent of patients did not have any pain after the treatment and ninety-one point eight percent of ones did not take any analgesic tablets at any time after the procedure. No severe complications such as deep venous thrombosis could be detected. And there was no patient developed EHIT after treatment. Minor complications were ecchymosis at 15.1%, edema at 44.8%, and paresthesia around ankle at 0, respectively. All patients expressed satisfaction with the operative curative effects and cosmetic effects. Conclusion: EVLA with 1470-nm diode ring laser with echosclerotherapy in lower limb varicose veins is comfortable with less incision, hospitalization procedure and is a safe and efficient treatment option.

Phosphotungstate Acid Doped Polyanilines Nanorods for in situ NIR-II Photothermal Therapy of Orthotopic Hepatocellular Carcinoma in Rabbit.

Second near-infrared photothermal therapy (NIR-II PTT) has become a promising strategy for treating cancer in terms of safety and potency. However, the application of NIR-II PTT was limited in the treatment of deep-buried solid tumors due to the low dose of NIR-II absorption nanomaterials and the inadequate laser energy in the deep tumor. Herein, the authors report the engineering of NIR-II absorbing polyaniline nanorods, termed HPW@PANI Nanorods, for in situ NIR-II PTT based on optical fibers transmission of laser power and transarterial infusion for the treatment of orthotopic hepatocellular carcinoma in the rabbit. HPW@PANI Nanorods were prepared via chemical oxidant polymerization of aniline under phosphotungstic acid, which exhibited effective NIR-II absorption for hyperthermia ablation cells. HPW@PANI Nanorods were fast and efficiently deposited into primary orthotopic transplantation VX2 tumor in rabbits via transarterial infusion. Furthermore, an optical fiber was interventionally inserted into the primary VX2 tumor to transmit 1064nm laser energy for in situ NIR-II PTT, which could ablate primary tumor, inhibit distant tumor, and suppress peritoneal metastasis. This study provides new insights into the application of in situ NIR-II PTT based on optical fibers transmission of laser power and transarterial injection of NIR-II absorption nanomaterials to treat deep-buried tumors.