2D Systems Research Articles

Eliminating the channel resistance in two-dimensional systems using viscous charge flow

Driven by the pursuit of high-performance electronic devices and the exploration of quantum phenomena, research into two-dimensional (2D) systems and materials, has unveiled their exceptional properties and potential applications. While extensive efforts have centered on minimizing contact resistance, reducing the intrinsic channel resistance within the conducting material remains a formidable challenge. Research in this direction has focused on investigating superconductivity and ballistic transport. However, the practical applications of these phenomena are usually constrained by the requirement for cryogenic conditions. Charge transport in the hydrodynamic regime emerges as a versatile alternative, offering enhanced resilience to these challenges, and making it a promising avenue for effectively reducing channel resistance in 2D systems. The current perspective delves into charge hydrodynamics, exploring its mechanisms, recent advancements, enduring challenges, and its potential in reducing the channel resistance.

Giant piezoelectricity driven by Thouless pump in conjugated polymers

Piezoelectricity of organic polymers has attracted increasing interest because of several advantages they exhibit over traditional inorganic ceramics. While most organic piezoelectrics rely on the presence of intrinsic local dipoles, a highly nonlocal electronic polarisation can be foreseen in conjugated polymers, characterised by delocalised and highly responsive π-electrons. These 1D systems represent a physical realisation of a Thouless pump, a mechanism of adiabatic charge transport of a topological nature which results, as shown in this work, in anomalously large dynamical effective charges, inversely proportional to the bandgap energy. A structural (ferroelectric) phase transition further contributes to an enhancement of the piezoelectric response reminiscent of that observed in piezoelectric perovskites close to morphotropic phase boundaries. First-principles density functional theory (DFT) calculations performed in two representative conjugated polymers using hybrid functionals, show that state-of-the-art organic piezoelectric are outperformed by piezoelectric conjugated polymers, mostly thanks to strongly anomalous effective charges of carbon, larger than 5e—ordinary values being of the order of 1e—and reaching the giant value of 30e for band gaps of the order of 1 eV.

Optimal design of fast adiabatic topological pumping in modulated lattices

Utilizing synthetic dimensions generated by spatial or temporal modulation, topological pumping enables the exploration of higher-dimensional topological phenomena through lower-dimensional physical systems. In this Letter, we propose a rational design paradigm of fast adiabatic topological pumping based on 1D and 2D time-modulated discrete elastic lattices. First, the realization of topological pumping is ensured by introducing quantitative indicators to drive a transition of the edge or corner state in the lattice spectrum. Meanwhile, with the help of limiting speed for adiabaticity to calculate the modulation time, a mathematical formulation of designing topological pumping with the fastest modulation speed is presented. By applying the proposed design paradigm, topological edge–bulk–edge and corner–bulk–corner energy transport are achieved with 11.2 and 4.0 times of improvement in modulation speed compared to classical pumping systems in the literature. In addition, applying to 1D and 2D space-modulated systems, the optimized modulation schemes can reduce the number of stacks to 5.3% and 26.8% of the classical systems while ensuring highly concentrated energy transport. This design paradigm is expected to be extended to the rational design of fast topological pumping in other physical fields.

Identity and Maturity of iPSC-Derived Oligodendrocytes in 2D and Organoid Systems

Oligodendrocytes originating in the brain and spinal cord as well as in the ventral and dorsal domains of the neural tube are transcriptomically and functionally distinct. These distinctions are also reflected in the ultrastructure of the produced myelin, and the susceptibility to myelin-related disorders, which highlights the significance of the choice of patterning protocols in the differentiation of induced pluripotent stem cells (iPSCs) into oligodendrocytes. Thus, our first goal was to survey the different approaches applied to the generation of iPSC-derived oligodendrocytes in 2D culture and in organoids, as well as reflect on how these approaches pertain to the regional and spatial fate of the generated oligodendrocyte progenitors and myelinating oligodendrocytes. This knowledge is increasingly important to disease modeling and future therapeutic strategies. Our second goal was to recap the recent advances in the development of oligodendrocyte-enriched organoids, as we explore their relevance to a regional specification alongside their duration, complexity, and maturation stages of oligodendrocytes and myelin biology. Finally, we discuss the shortcomings of the existing protocols and potential future explorations.

Contemporary Strategies for the Structural Design of Multi-Story Modular Timber Buildings: A Comprehensive Review

Modular timber construction embodies a pioneering and eco-friendly methodology within the building sector. With the notable progress made in manufacturing technologies and the advent of engineered wood products, timber has evolved into a promising substitute for conventional materials such as concrete, masonry, and steel. Beyond its structural attributes, timber brings environmental advantages, including its inherent capacity for carbon sequestration and a reduced carbon footprint compared to conventional materials. Timber’s lightweight nature, coupled with its versatility and efficiency in factory-based production, accelerates modular construction processes, providing a sustainable solution to the growing demands of the building industry. This work thoroughly explores contemporary modular construction using wood as the primary material. The investigation spans various aspects, from the fundamentals of modularity and the classification of modular timber solutions to considerations of layout design, structural systems, and stability at both the building and module levels. Moreover, inter-module joining techniques, MEP (mechanical, electrical, and plumbing) integration, and designs for disassembly are scrutinized. The investigation led to the conclusion that timber modular construction, drawing inspiration from the steel modular concept, consistently utilizes a structural approach based on linear members (timber frame, post-and-beam, etc.), incorporating stability configurations and diverse joint techniques. Despite the emphasis on modularization and prefabrication for adaptability, a significant portion of solutions still concentrate on the on-site linear assembly process of those linear members. Regarding modularity trends, the initial prevalence of 2D and 3D systems has given way to a recent surge in the utilization of post-and-beam structures, congruent with the ascending verticality of buildings. In contrast to avant-garde and bold trends, timber structures typically manifest as rectilinear, symmetric plans, characterized by regular and repetitive extrusions, demonstrating a proclivity for centrally located cores. This work aims to offer valuable insights into the current utilization of modular timber construction while identifying pivotal gaps for exploration. The delineation of these unexplored areas seeks to enable the advancement of modular timber projects and systems, fully leveraging the benefits provided by prefabrication and modularity.

Ferroelectric Polarization‐Mediated Modulation of Optical Properties in 2D van der Waals Architectures

AbstractThe integration of 2D ferroelectric materials with 2D photoelectric materials presents a promising avenue for addressing issues related to controlled doping and device integration in layered semiconductors. The reversible and non‐volatile residual polarization inherent to ferroelectrics can provide stable n‐ or p‐type doping for 2D semiconductors. Despite advances in doping strategies for 2D materials, existing techniques, and post‐doping characterization methodologies exhibit limitations, including the challenge of achieving high‐resolution graphical depictions of doped structures. Here, a WS2/CuInP2S6 heterostructure is demonstarted whereby the residual polarization of ferroelectric CuInP2S6 regions with anti‐parallel directions supplies screening charges of opposite signs to WS2 monolayers. This notably alters the ratio of neutral excitons and negatively charged trions within the recombination luminescence of the direct‐gap semiconductor, thereby offering a viable approach for controllable, non‐volatile modulation in 2D systems. Beyond proposing a feasible strategy for patterned doping and effective regulation in 2D semiconductors through interface engineering, this work enhances the understanding of the interplay between ferroelectrics and semiconductors.

Exfoliation of Ca3Co4O9 to Two-Dimensional Single-Crystalline Misfit Calcium Cobaltates for Energy Storage Applications.

Layered materials have become indispensable in the development of two-dimensional (2D) systems, offering extensive specific surface area and exceptional electrical, electrochemical, and optical properties critical for diverse applications in energy storage, catalysis, sensing, and optoelectronics. While mono- and biatomic layered materials have demonstrated remarkable characteristics in lower dimensions, the quest for complexity in materials has opened new avenues for tailoring properties to specific requirements. Within this context, misfit-layered compounds (MLCs) stand out as promising candidates. In this study, we present a successful synthesis of few-layered misfit CaCoO2-CoO2 2D nanosheets in bulk quantities from bulk calcium cobalt oxide (CCO-B or CCO). These newly synthesized 2D exfoliated misfit nanosheets demonstrate remarkable 7-fold electrochemical energy storage properties, surpassing their parent bulk CCO, as cathode materials in aqueous Zn-ion batteries. This work addresses the longstanding challenge of exfoliating bulk MLCs to nanostructured, lower dimensional MLCs, opening doors for utilization in advanced energy storage systems and beyond.

Process development for the production of mesenchymal stromal cell-derived extracellular vesicles in conventional 2D systems

BackgroundIn recent years, the importance of extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) has increased significantly. For their widespread use, a standardized EV manufacturing is needed which often includes conventional, static 2D systems. For these system critical process parameters need to be determined. MethodsWe studied the impact of process parameters on MSC proliferation, MSC-derived particle production including EVs, EV- and MSC-specific marker expression, and particle functionality in a HaCaT cell migration assay. ResultsWe found that cell culture growth surface and media affected MSCs and their secretory behavior. Interestingly, the materials that promoted MSC proliferation did not necessarily result in the most functional MSC-derived particles. In addition, we found that MSCs seeded at 4 × 103 cells cm−2 produced particles with improved functional properties compared to higher seeding densities. MSCs in a highly proliferative state did not produce the most particles, although these particles were significantly more effective in promoting HaCaT cell migration. The same correlation was found when investigating the cultivation temperature. A physiological temperature of 37°C was not optimal for particle yield, although it resulted in the most functional particles. We observed a proliferation-associated particle production and found potential correlations between particle production and glucose consumption, enabling the estimation of final particle yields. ConclusionsOur findings suggest that parameters, which must be defined prior to each individual cultivation and do not require complex and expensive equipment, can significantly increase MSC-derived particle production including EVs. Integrating these parameters into a standardized EV process development paves the way for robust and efficient EV manufacturing for early clinical phases.

High-κ Wide-Gap Layered Dielectric for Two-Dimensional van der Waals Heterostructures.

van der Waals heterostructures of two-dimensional materials have unveiled frontiers in condensed matter physics, unlocking unexplored possibilities in electronic and photonic device applications. However, the investigation of wide-gap, high-κ layered dielectrics for devices based on van der Waals structures has been relatively limited. In this work, we demonstrate an easily reproducible synthesis method for the rare-earth oxyhalide LaOBr, and we exfoliate it as a 2D layered material with a measured static dielectric constant of 9 and a wide bandgap of 5.3 eV. Furthermore, our research demonstrates that LaOBr can be used as a high-κ dielectric in van der Waals field-effect transistors with high performance and low interface defect concentrations. Additionally, it proves to be an attractive choice for electrical gating in excitonic devices based on 2D materials. Our work demonstrates the versatile realization and functionality of 2D systems with wide-gap and high-κ van der Waals dielectric environments.

Mechanical Properties of Small Quasi-Square Graphene Nanoflakes

The rise of straintronics—the possibility of fine-tuning the electronic properties of nanosystems by applying strain to them—has enhanced the interest in characterizing the mechanical properties of these systems when they are subjected to tensile (or compressive), shear and torsion strains. Four parameters are customarily used to describe the mechanical behavior of a macroscopic solid within the elastic regime: Young’s and shear moduli, the torsion constant and Poisson’s ratio. There are some relations among these quantities valid for elastic continuous isotropic systems that are being used for 2D nanocrystals without taking into account the non-continuous anisotropic nature of these systems. We present in this work computational results on the mechanical properties of six small quasi-square (aspect ratio between 0.9 and 1.1) graphene nanocrystals using the PM7 semiempirical method. We use the results obtained to test the validity of two relations derived for macroscopic homogeneous isotropic systems and sometimes applied to 2D systems. We show they are not suitable for these nanostructures and pinpoint the origin of some discrepancies in the elastic properties and effective thicknesses reported in the literature. In an attempt to recover one of these formulas, we introduce an effective torsional thickness for graphene analogous to the effective bending thickness found in the literature. Our results could be useful for fitting interatomic potentials in molecular mechanics or molecular dynamics models for finite carbon nanostructures, especially near their edges and for twisted systems.

3D multi-robot olfaction in naturally ventilated indoor environments: Locating a time-varying source at unknown heights

Source localization is significant for mitigating indoor air pollution and safeguarding the well-being and safety of occupants. While most study focuses on mechanical ventilation and static sources, this study explores the less-explored domain of locating time-varying sources in naturally ventilated spaces. We have developed an innovative 3D localization system that adjusts to varying heights, significantly enhancing capabilities beyond traditional fixed-height 2D systems. To ensure consistency in experimental conditions, we conducted comparative analyses of 2D and 3D methods, using a swinging fan to simulate natural ventilation. Our findings reveal a substantial disparity in performance: the 2D method had a success rate below 46.7% in cases of height mismatches, while our 3D methods consistently achieved success rates above 66.7%, demonstrating their superior effectiveness in complex environments. Furthermore, we validated the 3D strategies in real naturally ventilated settings, confirming their wider applicability. This research extends the scope of indoor source localization and offers valuable insights and strategies for more effective pollution control.

Abstract 5722: Preclinical activity of CDK4/6 inhibitor alone or in sequential combination with chemotherapy using breast cancer cell line-derived organoid culture

Abstract Breast cancer ranks as the most prevalent cancer globally, with lung and colorectal cancers following closely. Dysregulation of the cyclinD:CDK4/6:Rb axis has been shown to be a common feature in a number of human malignancies, including breast cancer. Targeting this pathway has emerged as a promising strategy for breast cancer treatment. Currently, the U.S. Food and Drug Administration has approved three CDK4/6 inhibitors for advanced hormone receptor-positive, HER2-negative breast cancer, when used in combination with endocrine therapy. However, there are still many breast cancer cases that do not qualify for these criteria and, therefore, do not benefit from CDK4/6 inhibitors prompting investigations into their potential synergy between CDK4/6 inhibitors with chemotherapy. Efforts are currently being made to test the application of these drugs in combination with chemotherapy. Previous studies have demonstrated a synergetic effect of combining CDK4/6 inhibitors and other therapies to treat breast and prostate cancers. While many studies administer these drugs concurrently, our hypothesis proposes a sequential combination approach. This method involves arresting cell cycle at the G0G1 phase using CDK 4/6 inhibitors and then releasing the drug when the cells are more vulnerable to chemotherapy treatment. Such an approach has the potential to expand the application of CDK4/6 inhibitors beyond ER+/HER2- breast cancer. The primary objective of this study is to evaluate the effectiveness of CDK4/6 inhibitors, both alone and in sequential combination with chemotherapy, across a range of breast cancer subtypes. Breast cancer cell lines (MDA-MB-231, HCC70 and T47D) were used in the study. For each cell line, a total of 3x105 cells were seeded in a 6-well plate, and after an overnight incubation, the media was changed with or without a CDK4/6 inhibitor (abemaciclib) and cultured for up to 72 hours. We monitored the drug's efficacy through flow cytometry and cell counting. Abemaciclib suppressed cell proliferation and cell cycle in G0G1 phase in the treated cells compared with the control. The results were similar in both receptor-positive and triple-negative breast cancer cell lines. The effect of abemaciclib was dose-dependent, and reversible at least 48 hours after drug withdrawal, suggesting an opportune time for administering chemotherapy. Future research will delve into investigating the efficacy of sequential treatment with chemotherapy after CDK 4/6 inhibitor withdrawal, utilizing 2D and 3D culture systems. Citation Format: Moses Kamita, Haythem Ali, Evelyn Jiagge, Jessica Bensenhaver, Eleanor Walker. Preclinical activity of CDK4/6 inhibitor alone or in sequential combination with chemotherapy using breast cancer cell line-derived organoid culture [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 5722.

Abstract 1878: CTPS1: An unexplored vulnerability in breast and ovarian cancer

Abstract Breast and ovarian cancer represent the most common cancer types in women worldwide and are among the top fatal cancers. Despite the use of cytotoxic chemotherapy and targeted agents, recurrence is frequent and survival rates for patients with advanced metastatic disease are dismal. These realities highlight the need to identify novel biomarkers and therapeutic vulnerabilities in such tumors and to develop alternative treatment strategies. We took an unbiased approach to tackle this problem in which we leveraged publically available (DepMap) and in-house generated genome-wide CRISPR screens conducted in over 1000 cancer cell lines. We initially focused on the identification of essential genes that were unique to triple-negative breast cancer (TNBC) cells and whose expression levels were associated with worse patient outcomes. This interrogation revealed six genes (CTPS1, RHOA, PRKRA, RAD9A, HUS1, and RAD1) meeting these initial criteria. The essentiality of these genes was validated using gene-specific siRNAs in a panel of TNBC cells and knockdown of CTPS1 was shown to elicit the most inhibitory effect. CTPS1 depletion resulted in a rapid S-phase cell cycle arrest followed by apoptosis, not only in TNBC cells but also in highly aggressive ovarian cancer cells which share many molecular features with TNBC. CTPS1 converts uridine triphosphate to cytidine triphosphate, forming an essential nucleic acid required for multiple cellular processes. CTPS1 mRNA expression was substantially elevated in tumor vs. normal tissue, for both breast and ovarian cancer. Using over 40 breast and ovarian cancer cell lines, RT-PCR analyses confirmed increased expression of CTPS1 in TNBC and most ovarian cancer cell lines compared to other disease sub-types and “normal” cell line/tissue controls. Interestingly, chemoresistant and PARP inhibitor-resistant models exhibited the highest levels of CTPS1 among all cells analyzed. We subsequently identified and acquired STP938, a first-in-class highly selective CTPS1 inhibitor being developed by Step-Pharma. STP938 was found to elicit potent anti-cancer effects at nM concentrations across many cell line and patient-derived models, in both 2D and 3D culture systems. RNAseq analysis in aggressive cell line models following STP938 treatment or CTPS1 knockdown revealed significant regulation of genes related to DNA replication and the cell cycle pathways suggesting that combinatorial/sequential treatments of STP938 with replication stress/DNA damage response related drugs may be synergistic. STP938 is currently being developed for the treatment of lymphoma, and our findings support the repurposing of STP938 for breast and ovarian cancer, an avenue that we are currently developing. Citation Format: Xiyin Wang, Michael Emch, Lauren Voll, Rebecca Russell, Esther Rodman, Nicole Pearson, Xiaonan Hou, Scott Kaufmann, Saravut Weroha, Philip Beer, John Hawse. CTPS1: An unexplored vulnerability in breast and ovarian cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 1878.

Spin-controlled topological phase transition in non-Euclidean space

Modulation of topological phase transition has been pursued by researchers in both condensed matter and optics research fields, and has been realized in Euclidean systems, such as topological photonic crystals, topological metamaterials, and coupled resonator arrays. However, the spin-controlled topological phase transition in non-Euclidean space has not yet been explored. Here, we propose a non-Euclidean configuration based on Möbius rings, and we demonstrate the spin-controlled transition between the topological edge state and the bulk state. The Möbius ring, which is designed to have an 8π period, has a square cross section at the twist beginning and the length/width evolves adiabatically along the loop, accompanied by conversion from transverse electric to transverse magnetic modes resulting from the spin-locked effect. The 8π period Möbius rings are used to construct Su–Schrieffer–Heeger configuration, and the configuration can support the topological edge states excited by circularly polarized light, and meanwhile a transition from the topological edge state to the bulk state can be realized by controlling circular polarization. In addition, the spin-controlled topological phase transition in non-Euclidean space is feasible for both Hermitian and non-Hermitian cases in 2D systems. This work provides a new degree of polarization to control topological photonic states based on the spin of Möbius rings and opens a way to tune the topological phase in non-Euclidean space.Graphical abstract

A hybrid method to solve a fractional-order Newell–Whitehead–Segel equation

This paper solves fractional differential equations using the Shehu transform in combination with the q-homotopy analysis transform method (q-HATM). As the Shehu transform is only applicable to linear equations, q-HATM is an efficient technique for approximating solutions to nonlinear differential equations. In nonlinear systems that explain the emergence of stripes in 2D systems, the Newell–Whitehead–Segel equation plays a significant role. The findings indicate that the outcomes derived from the tables yield superior results compared to the existing LTDM in the literature. Maple is utilized to depict three-dimensional surfaces and find numerical values that are displayed in a table.

Scaling laws for lattice distortions: Application to high entropy alloys.

Lattice distortions are intrinsic features of all solid solution alloys associated with varying atomic radii; this phenomenon facilitates the formation of single-phase solid solutions. Using high-entropy alloys (HEAs), as an example, we investigate the influence of variations in inter-atomic separations for stabilizing and controlling their structural, mechanical, and thermodynamic properties. This is done through a combination of statistical mechanics analysis and molecular dynamics simulations on simplified 2D systems, as well as a 3D crystals with harmonic and anharmonic inter-atomic bonds with varying natural inter-atomic separations. We demonstrate that the impact of this inter-atomic length disorder (representing static lattice distortion) and temperature fluctuations (representing dynamic lattice distortion) on fundamental and universal thermodynamic, structural, and elastic characteristics are similar and can be unified through effective temperature; i.e. a scaling law for HEAs that establishes a relationship between these factors. This scaling law reveals that different HEAs (i.e. varying degrees of local lattice distortions) collapse onto a single curve when plotted against the effective temperature. We demonstrate that lattice distortion significantly enhances the stability of solid solution alloys (relative to phase separation or ordering by effectively increasing the temperature of the system; this stabilization effect is particularly pronounced in HEAs).

Field-scale numerical investigation of a hybrid gas production method from the oceanic hydrate accumulation at site NGHP-02-09 in the Krishna-Godavari Basin, and the associated geomechanical responses

The objectives of this study are to investigate (a) the technical feasibility of gas production from a gas hydrate accumulation at Site NGHP-02-09 in the Krishna-Godavari Basin, India Ocean using a hybrid production method involving a combination of depressurization and thermal stimulation, as well as (b) the associated geomechanical system response when considering both a simplified and a full geomechanical model. This is an extension of the earlier numerical study of Moridis et al. (2019a) of the site using cylindrical (single-well) 2D systems, which indicated (a) the main source of the produced gas to be CH4 dissolved in the water rather than CH4 from hydrate dissociation because of the presence of a high-permeability water-bearing zone that short-circuits the depressurization process and (b) the possibility of adverse geomechanical issues caused by significant displacements that could not be adequately investigated and resolved by the one-way coupling scheme invoked in that study. The proposed hybrid production plan involves two vertical wells in a 3D Cartesian domain: an injection well of warm ocean (saline) water and a production well at an appropriate distance, with the expectation that the hydrate dissociation caused by the depressurization at the production well can be augmented by the thermal effect of the injected warm water (as well as by its salinity), thus mitigating the effects of the high-permeability water zone. The results of this study that uses high-resolution 3D grids indicate that (a) the hybrid production scheme does not appear to offer any advantage over the simple single-well depressurization method of the earlier study, (b) the majority of the produced gas originates from CH4 exsolution from the water rather from hydrate dissociation, and (c) consideration of full geomechanics leads to generally slightly higher dissociation and fluid production because of the evolution of lower porosities and permeabilities, but also to the disappearance of the gas phase after 62 days of production, after which time CH4 from hydrate dissociation is fully dissolved in the water before production. Thus, the hybrid scheme investigated here appears ineffectual in enhancing hydrate dissociation and gas production, and the hydrate deposits at the Site NGHP-02-09 do not appear to be a promising production target under the conditions in this study, in agreement with the earlier conclusion of Moridis et al. (2019a).

3D visualization systems improve operator efficiency during difficult laparoscopic cholecystectomy: a retrospective blinded review of surgical videos.

3D visualization systems in laparoscopic surgery have been proposed to improve manual task handling compared to 2D, however, few studies have compared the intra-operative efficacy in laparoscopic cholecystectomy (LC). The aim of this study is to determine if there is a benefit in intra-operative efficiency when using a 3D visualization system in difficult LC compared to traditional 2D visualization systems. Retrospective analysis of 'difficult' LCs (Grades 3 or 4) was completed. The assessor was blinded as all cases were recorded and viewed in 2D only. Variables collected included time to complete steps, missed hook diathermy attempts, failed grasp attempts, missed clip attempts and preparation steps for intra-operative cholangiogram (IOC). Multiple linear regression was undertaken for time variables, Poisson regression or negative binomial regression was completed for continuous variables. Fifty-two operative videos of 'difficult' LC were reviewed. 3D systems were associated with reduced operative times, although this was not statistically significant (CI: -2.93-14.93, P-value = 0.183). Dissection of the anterior fold to achieve the critical view of safety was significantly faster by 3.55 min (CI: 1.215-9.206, P-value = 0.002), and with considerably fewer errors when using 3D systems. Fewer IOC preparation errors were observed with a 3D system compared with a 2D system. 3D systems appear to enhance operator efficiency, allowing faster completion of critical steps with fewer errors. This pilot study underscores the utility of video annotation for intra-operative assessment and suggests that, in larger multi-centre studies, 3D systems may demonstrate superior intra-operative efficiency over 2D systems during a 'difficult' LC.

Polar iodate BiO(IO3): A two-dimensional ultrawide-bandgap semiconductor with high carrier mobility and robust piezoelectricity

Ultrawide-bandgap (UWBG) semiconductors, surpassing GaN with a bandgap of 3.4 eV, offer distinct advantages in high-temperature, high-frequency, and radiation-resistant applications. Specifically, two-dimensional (2D) UWBG materials play a crucial role in the miniaturization of practical devices. Here, employing first-principles calculations, we explore the properties of the polar iodate BiO(IO3) in its 2D monolayer configuration, boasting a bandgap of 3.61 eV. Our calculations confirm the feasibility of deriving 2D BiO(IO3) monolayer from its bulk counterpart while retaining structural stability at room temperature. The UWBG BiO(IO3) monolayer exhibits remarkable ultraviolet absorption, mechanical flexibility, and favorable electronic transport behavior. Notably, the estimated electron mobility reaches an impressive 1353.13 cm2 V−1 s−1. Importantly, the 2D structure of BiO(IO3) displays robust in-plane piezoelectricity without the odd–even effect commonly observed in other 2D piezoelectric materials. The piezoelectric coefficients d21 and d22 of monolayer reach high values of 13.87 and 16.66 pm V−1, respectively, surpassing or closely approaching those of most well-studied 2D systems. The direct stacking configuration enables 2D BiO(IO3) materials to maintain robust piezoelectricity at different thicknesses. Charge injection simulations validate the electromechanical conversion process, aligning well with its piezoelectric properties. This suggests the promising application potential of 2D BiO(IO3) in devices such as micro-electro-mechanical systems.

Stability Analysis of GNSS Stations Affected by Samos Earthquake

An earthquake cycle can cause meters of displacement on the surface and at Global Navigation Satellite System (GNSS) stations. This study focuses on the identification of GNSS stations that have significant displacement because of a Mw 7.0 earthquake near Samos Island on 30 October 2020. The S-transformation method is used to examine 3D, 2D and 1D coordinate systems along with threshold and statistical test approaches. The highest coseismic offset among the 21 GNSS stations is displayed by SAMO, and CESM, MNTS, IZMI and IKAR also experience significant displacement. Significantly displaced stations are successfully identified in both 3D and 2D analyses. In the up component, SAMO is the only unstable station. The coordinate S-transformation method can be used in detecting unstable points in a GNSS network and provide valuable information about the effects of an earthquake on GNSS stations.