3D Model Research Articles

Sphaeroptica: A tool for pseudo-3D visualization and 3D measurements on arthropods.

Natural history collections are invaluable reference collections. Digitizing these collections is a transformative process that improves the accessibility, preservation, and exploitation of specimens and associated data in the long term. Arthropods make up the majority of zoological collections. However, arthropods are small, have detailed color textures and share small, complex and shiny structures, which poses a challenge to conventional digitization methods. Sphaeroptica is a multi-images viewer that uses a sphere of oriented images. It allows the visualization of insects including their tiniest features, the positioning of landmarks, and the extraction of 3D coordinates for measuring linear distances or for use in geometric morphometrics analysis. The quantitative comparisons show that the measures obtained with Sphaeroptica are similar to the measurements derived from 3D μCT models with an average difference inferior to 1%, while featuring the high resolution of color stacked pictures with all details like setae, chaetae, scales, and other small and/or complex structures. Shaeroptica was developed for the digitization of small arthropods but it can be used with any sphere of aligned images resulting from the digitization of objects or specimens with complex surface and shining, black, or translucent texture which cannot easily be digitized using structured light scanner or Structure-from-Motion (SfM) photogrammetry.

Real-time data sensing and digital twin model development for pavement material mixing: enhancing workability and optimisation

ABSTRACT An essential aspect of pavement construction sustainability is its low-energy consumption and emissions. The study of pavement materials workability tests holds significant importance in terms of achieving well-mixed conditions with low-energy consumption. The complex components of the material and the uncertain kinematic behaviours of aggregates during mixing make this process challenging. And, few studies of the signal response of pavement materials have been found in the field of civil engineering. For this purpose, an accurate evaluation and monitoring approach for mixing are needed. In this paper, a wireless real-time sensing method is used to monitor the dynamic behaviour of aggregates during mixing. A 3D digital twin model, combining data-sensing techniques and numerical simulation, has been proposed for rapid identification of the mixing material. This model has been validated via a data-fusion algorithm. The application of this model makes a contribution to the data-intensive analysing jobs and decision-making tasks in pavement construction engineering.

Complex left atrial appendage closure using 3D printing system simulation in a patient with mitral prosthetic valve: a case report

Abstract Background Left atrial appendage (LAA) closure (LAAc) has emerged as a safe and effective alternative to oral anticoagulation (OAC) for stroke prevention in patients with atrial fibrillation (AF) and contraindications to OAC. Case Summary A 61-year-old woman with permanent atrial fibrillation (AF) and a history of mitral surgery replacement with mechanical prosthesis was referred to our cardiology department to undergo left atrial appendage (LAA) closure (LAAc). The preoperative computed tomography (CT) revealed that the ostium of the left atrial appendage was close to the mitral prosthesis ring. As a result of the difficult LAA morphology a CT-image based virtual model was created, then a 3D printing model was prepared in our laboratory and procedure simulation was performed with the two different LAA occlusion devices (plug- vs. pacifier like models) to see which one was more suitable for the patient anatomy. Discussion In this case of complex LAAc in a patient with mechanical prosthetic mitral valve with the use of a 3D-printed model has guided prosthesis selection and device sizing reducing procedure time and complications.

Thermal Comfort Simulation-Based Forest Management Scenarios for Forest Healing

Background and objectives: Forest environments provide various healing benefits for humans and have been widely studied. Nevertheless, the field of forest management for forest healing remains relatively understudied. The purpose of this study is to utilize thermal environmental simulation to derive forest management scenarios that are optimized for forest healing. Methods: This study focused on the Seogwipo Experimental Forest on Jeju Island, Korea. Three-dimensional forest models were generated based on field surveys. Thermal environment simulations were conducted using Grasshopper with the Ladybug and Honeybee plug-ins, and the thermal comfort levels of six forest management scenarios were evaluated using the Universal Thermal Climate Index (UTCI). Results: The simulation results showed that, among all the scenarios, only scenario (c), “10% thinning in the buffer zone”, led to an improvement in thermal comfort. Additionally, the study identified discrepancies in thermal comfort between different forest management scenarios. Conclusions: In the management of forests for healing forestry purposes, the distinction of forest zones by use and the application of different forest management scenarios have thermal comfort implications. Thus, the methodology could be employed in forest management for forest healing purposes.

Study on the effect of variable laser power on residual stress distribution in laser directed energy deposition of Ti6Al4V

In the laser directed energy deposition (LDED) process, cyclic thermal stress loading induces significant temperature variations on the surface and subsurface of the workpiece during repeated heating, leading to the formation of residual tensile stress during cooling. This adversely affects the mechanical properties of the parts, causing deformation and defects. In this study, a heat transfer model and a three-dimensional stress model were established based on finite element analysis. A variable laser power (VLP) deposition strategy was proposed to dynamically simulate the temperature and stress fields of Ti6Al4V titanium alloy under different deposition strategies. The model was validated by collecting substrate temperature variations using thermocouples and measuring residual stress with an X-ray diffractometer (XRD). Experimental results showed that the temperature error between the simulation and the experiment ranged from 6.25 % to 10.12 %, with an average stress simulation error of 6.92 %. Among the four strategies, the samples using the VLP strategy showed a reduction in the average substrate temperature by 12.68 % to 15.08 % compared to the other three strategies. The maximum principal stress in the layer was reduced by 7.8 % to 32.14 %, and the residual stress distribution was more uniform in all directions. The microstructure of the deposition layer further indicated that the VLP strategy improves residual stress distribution and leading to better deposition quality.

Research on Safety Separation Distance in Paired Approach Based on Monte Carlo Simulation

Faced with the increasing number of flights, efficient and orderly operations have become a critical issue for busy airports. The closely spaced parallel runway paired approach technology has been proven to be an effective solution for increasing runway capacity and operational efficiency. This research focuses on determining the safety separation between paired aircraft, particularly the collision safety limit. This study refines the kinematic modeling process by constructing a three-dimensional kinematic model and advancing the starting point of paired approach, making the simulation process more aligned with reality. Subsequently, the Monte Carlo simulation method is applied, integrating the kinematic model and considering collision risks to simulate the entire paired approach process. Multiple scenarios are created, and simulation experiments are conducted to determine the safety separation between the two paired aircraft. Finally, by adjusting parameter settings and taking the example of the two closely spaced parallel runways at Chongqing Jiangbei International Airport, the correlation between various influencing factors and the safety separation is analyzed. Different scenarios are simulated 100,000 times each, and the results show that the speed difference between the two paired aircraft has the most significant impact on the safety separation, followed by the paired approach mode and runway centerline spacing. The wake turbulence category matching has a minimal effect on the safety separation. The results provide a theoretical basis for airports with closely spaced parallel runways to further reduce the separation between paired aircraft, thereby enhancing airport capacity and runway operational efficiency.

Automation of conceptual design and modification of aircraft type unmanned aerial vehicles using multidisciplinary optimization and evolutionary algorithms. Part 1: Methods and models

This paper proposes a method for selecting rational parameters for large-size aircraft-type unmanned aerial vehicles at the initial design stages using an optimization algorithm of differential evolution and numerical mathematical modeling of aerodynamic problems. The method assumes implementation of weight and aerodynamic balance in the main flight modes, it can consider aircraft-type unmanned aerial vehicles with one or two lifting surfaces, applies parallel calculations, and automatically generates a three-dimensional geometric model of the aircraft appearance based on the optimization results. A method for accelerating by more than three times the process of solving the problem of optimizing aircraft takeoff weight parameters by introducing the target function into the set of design variables is proposed and demonstrated. The results of assessing the reliability of the mathematical models used for aerodynamics and the correct calculation of the target function are presented, taking into account various constraints. A comprehensive check of the operability and effectiveness of the method were considered by solving demonstration problems by optimizing more than ten main design parameters of the appearance of two existing heavy-class unmanned aerial vehicles with known characteristics from open sources. Examples of using the optimization results to modify prototypes are provided.

Novel "Phenyl-Pyrazoline-Oxadiazole" Ternary Substructure Derivatives: Synthesis, Insecticidal Activities, and Structure-Activity Relationship Study.

In recent years, isoxazole insecticides or parasiticides targeting the γ-aminobutyric acid receptor, such as fluralaner or fluxametamide, featured a novel chemical structure and exhibited potent insecticidal activity with no-cross resistance. Thus, many research institutes have tried to modify the structures of these agents to find a new insecticide. Previously, the majority of researchers stuck to the "phenyl-isoxazole-phenyl" structure, making modifications only to other components. In this study, the "phenyl-isoxazole-phenyl" ternary motif was modified for the first time based on bioisosterism theory. A series of new derivatives carrying pyrazoline and 1,3,4-oxadiazole moieties were designed and synthesized to investigate their insecticidal activities against the diamondback moth (Plutella xylostella) and fall armyworm (Spodoptera frugiperda). Preliminary bioassay data showed that some of the target compounds exhibited good insecticidal activities against P. xylostella and S. frugiperda. Especially, compound A21 showed insecticidal activity against P. xylostella (LC50 = 1.2 μg/mL) better than commercial insecticide ethiprole (LC50 = 2.9 μg/mL) but worse than parasiticide fluralaner (LC50 = 0.5 μg/mL). Similarly, compound A21 exhibited insecticidal activity to S. frugiperda (LC50 = 13.2 μg/mL) better than commercial insecticide fipronil (LC50 = 78.8 μg/mL) but worse than fluralaner (LC50 = 0.7 μg/mL). Compound A21 could serve as a potential lead compound to control P. xylostella and S. frugiperda. The three-dimensional quantitative structure-activity relationship model revealed that the further introduction of an electron-donating group in the 2- or 3-site may increase the insecticidal activity of A21. Molecular dynamics simulations showed that the hydrogen bond of A21 and receptor was important for the binding receptor. This study has identified a new substructure called "phenyl-pyrroline-oxadiazole" instead of the previously known "phenyl-isoxazole-phenyl" substructure, offering a useful guide for the design of novel insecticide molecules.

Exploring the black box of human reproduction: endometrial organoids and assembloids - generation, implantation modeling, and future clinical perspectives

One of the critical processes in human reproduction that is still poorly understood is implantation. The implantation of an early human embryo is considered a significant limitation of successful pregnancy. Therefore, researchers are trying to develop an ideal model of endometrium in vitro that can mimic the endometrial micro-environment in vivo as much as possible. The ultimate goal of endometrial modeling is to study the molecular interactions at the embryo-maternal interface and to use this model as an in vitro diagnostic tool for infertility. Significant progress has been made over the years in generating such models. The first experiments of endometrial modeling involved animal models, which are undoubtedly valuable, but at the same time, their dissimilarities with human tissue represent a significant obstacle to further research. This fact led researchers to develop basic monolayer coculture systems using uterine cells obtained from biopsies and, later on, complex and multilayer coculture models. With successful tissue engineering methods and various cultivation systems, it is possible to form endometrial two-dimensional (2D) models to three-dimensional (3D) organoids and novel assembloids that can recapitulate many aspects of endometrial tissue architecture and cell composition. These organoids have already helped to provide new insight into the embryo-endometrium interplay. The main aim of this paper is a comprehensive review of past and current approaches to endometrial model generation, their feasibility, and potential clinical application for infertility treatment.

On new genera and species of crack-leg spiders (Araneae, Udubidae) from Madagascar

Two new genera, Tabiboka gen. nov. and Zorascar gen. nov., are described to accommodate five new Udubidae species from Madagascar: Tabiboka milleri gen. et sp. nov. (type species; ♂♀), T. milloti gen. et sp. nov. (♂♀), T. polotowae gen. et sp. nov. (♂♀), Zorascar pasunepipe gen. et sp. nov. (type species; ♂♀) and Z. pasunepomme gen. et sp. nov. (♀). In addition, two new species of Zorodictyna Strand, 1907 are described: Zorodictyna almae sp. nov. (♂♀) and Z. silvadavilae sp. nov. (♂♀). Uduba inhonesta Simon, 1906 is declared to be a junior synonym of Zorodictyna oswaldi (Lenz, 1891). The descriptions of the new species are complemented with a phylogenetic analysis to tentatively place them into an existing phylogenetic framework. Phylogenetic analyses based on COI and 16S rRNA genes and morphological data show that they are separate species and confirm their familial and supraspecific placement within the Udubidae. The new species are further described using high quality colored photographs, drawings, SEM and (for Zorascar gen. nov. ssp.) by the use of X-Ray micro-computed tomography to recreate virtual 3D models without destroying the original specimens. A dichotomous key to identify Malagasy Ububidae is provided. Whereas many undescribed Udubidae remain in Madagascar, the phylogenetic and generic arrangement that we present here succinctly summarizes the higher classification of Madagascar Udubidae.

Clinical usefulness of digital twin guided virtual amiodarone test in patients with atrial fibrillation ablation

It would be clinically valuable if the efficacy of antiarrhythmic drugs could be simulated in advance. We developed a digital twin to predict amiodarone efficacy in high-risk atrial fibrillation (AF) patients post-ablation. Virtual left atrium models were created from computed tomography and electroanatomical maps to simulate AF and evaluate its response to varying amiodarone concentrations. As the amiodarone concentration increased in the virtual setting, action potential duration lengthened, peak upstroke velocities decreased, and virtual AF termination became more frequent. Patients were classified into effective (those with virtually terminated AF at therapeutic doses) and ineffective groups. The one-year clinical outcomes after AF ablation showed significantly better results in the effective group compared to the ineffective group, with AF recurrence rates of 20.8% vs. 45.1% (log-rank p = 0.031, adjusted hazard ratio, 0.37 [0.14-0.98]; p = 0.046). This study highlights the potential of a digital twin-guided approach in predicting amiodarone’s effectiveness and improving personalized AF management. Clinical Trial Registration Name: The Evaluation for Prognostic Factors After Catheter Ablation of Atrial Fibrillation: Cohort Study, Registration number: NCT02138695. The date of registration: 2014-05. URL: https://www.clinicaltrials.gov; Unique identifier: NCT02138695.

Analysis of G+20 Horizontally Connected Buildings with and Without Fluid Viscous Dampers

As urban populations continue to grow globally, the demand for new cities and high-rise structures is increasing due to limited land resources and expanding social and commercial activities. To address these challenges, this study investigates the seismic performance of G+20 horizontally connected buildings, focusing on the effects of fluid viscous dampers (FVDs) on structural response. A 3D model of two G+20 buildings, one with and one without FVDs, was developed using ETABS software, and seismic analysis was conducted for a Zone V seismic region in India. The study evaluates key performance parameters, including storey displacement, storey drift, and storey shear, to assess the effectiveness of the dampers. Results showed that adding FVDs significantly reduced overall building displacement, particularly in the X-direction at the top storey, with a reduction of approximately 40%. The Y-direction saw a more modest 5% reduction, attributed to geometric and stiffness irregularities. Additionally, storey drifts in the X-direction were higher than in the Y-direction but were significantly reduced after installing dampers. The findings highlight the importance of FVDs in improving the seismic resilience of horizontally connected high-rise buildings and offer valuable insights for future structural design in earthquake prone areas.

Target-specified reference-based deep learning network for joint image deblurring and resolution enhancement in surgical zoom lens camera calibration

Background and objectiveFor the augmented reality of surgical navigation, which overlays a 3D model of the surgical target on an image, accurate camera calibration is imperative. However, when the checkerboard images for calibration are captured using a surgical microscope having high magnification, blur owing to the narrow depth of focus and blocking artifacts caused by limited resolution around the fine edges occur. These artifacts strongly affect the localization of corner points of the checkerboard in these images, resulting in inaccurate calibration, which leads to a large displacement in augmented reality. To solve this problem, in this study, we proposed a novel target-specific deep learning network that simultaneously enhances both the blur and spatial resolution of an image for surgical zoom lens camera calibration. MethodsAs a scheme of an end-to-end convolutional deep neural network, the proposed network is specifically intended for the checkerboard image enhancement used in camera calibration. Through the symmetric architecture of the network, which consists of encoding and decoding layers, the distinctive spatial features of the encoding layers are transferred and merged with the output of the decoding layers. Additionally, by integrating a multi-frame framework including subpixel motion estimation and ideal reference image with the symmetric architecture, joint image deblurring and enhanced resolution were efficiently achieved. ResultsFrom experimental comparisons, we verified the capability of the proposed method to improve the subjective and objective performances of surgical microscope calibration. Furthermore, we confirmed that the augmented reality overlap ratio, which quantitatively indicates augmented reality accuracy, from calibration with the enhanced image of the proposed method is higher than that of the previous methods. ConclusionsThese findings suggest that the proposed network provides sharp high-resolution images from blurry low-resolution inputs. Furthermore, we demonstrate superior performance in camera calibration by using surgical microscopic images, thus showing its potential applications in the field of practical surgical navigation.

Multiscale X-ray phase-contrast CT uncovers adaptive changes and compensatory mechanisms of circulatory pathways during acute liver injury

Intrahepatic circulation is essential for the repair of acute liver injury (ALI); however, very limited information is available concerning changes in the circulatory pathways during ALI. Therefore, multi-scale X-ray phase-contrast CT combined with three-dimensional (3D) visualization is used to quantitatively analyze the intrahepatic circulation pathway (including the hepatic vein, portal vein and hepatic sinusoid) in the mouse model via the intraperitoneal injection of carbon tetrachloride (CCl4) from acute injury to recovery. The results demonstrate that the liver still preserves some vessel-like channels accessed to the central vein when the injury causes the severe collapse of the hepatic sinusoids that cannot be observed in two-dimensional pathologic slices. Moreover, angiogenesis is observed in the terminal branches of the hepatic vein and portal vein. Additionally, we extend the two-dimensional primary lobule to a 3D model and find that the sinusoids in zone III have the most severe injury. The sinusoids in different zones also show changes in parameters such as density and mean diameter during the ALI. In conclusion, phase-contrast CT can reveal the intact vascular system within the liver lobes, thus providing critical information for studying the mechanisms involved in the evolution of circulatory structures from damage to repair.

The Use of 3D Model Printing for Acute Planning in Oral and Maxillofacial Traumatology

Introduction Due to the complex anatomy of craniomaxillofacial structures, facial reconstruction following high-impact traumas is extremely challenging. Therefore, this study aimed to evaluate the use of biomodels in the surgical planning of complex fractures and the sequelae in the oromaxillofacial region. Materials and Methods This is a cross-sectional, exploratory, descriptive, and quantitative documentary study. It was conducted at the “Dom Luiz Gonzaga Fernandes” Emergency and Trauma Hospital, in the hinterland of the state of Paraíba, in Brazil, based on cases recorded between November 2021 and November 2022. The research instrument utilized was a self-developed questionnaire. Results No statistically significant correlation was observed between the biomodel acquisition time and the length of hospitalization, with a Spearman's correlation coefficient of r = -0.079. Although the need for adjustment of osteosynthesis material was 50% in cases where acrylonitrile butadiene styrene (ABS) models were used, with p (1) = 0.464, in order to be significantly more faithful, it would require a study with a higher sample size. The average length of surgery, in minutes, was 91.25 ± 28.00. The average cost of the materials used to manufacture the biomodels, in Brazilian reais (R$), was R$122.00 ± R$89.09. Conclusion The use of biomodels in the surgical planning of complex fractures and oromaxillofacial sequelae did not increase the length of hospitalization. The material used for the prototype manufacture suggests a potential influence on its faithfulness. The length of surgery was shorter in interventions that utilized biomodels in the planning phase. It was also noted that the average cost of manufacture varies according to the type of material chosen and the quantity required.

Full-Thickness Perfused Skin-on-a-Chip with In Vivo-Like Drug Response for Drug and Cosmetics Testing

In this study, we present a novel 3D perfused skin-on-a-chip model fabricated using micro-precision 3D printing, which offers a streamlined and reproducible approach for incorporating perfusion. Perfused skin models are well-regarded for their advantages, such as improved nutrient supply, enhanced barrier function, and prolonged tissue viability. However, current models often require complex setups, such as self-assembled endothelial cells or sacrificial rods, which are prone to variability and time-consuming. Our model uses projection micro-stereolithography 3D printing to create precise microcapillary-like channels using a biocompatible resin, overcoming the drug-absorbing properties of PDMS. A customized chip holder allows for the simultaneous culture of six perfused chips, enabling high-throughput testing. The engineered skin-on-a-chip features distinct dermis and epidermis layers, confirmed via H&E staining and immunostaining. To evaluate drug screening capabilities, inflammation was induced using TNF-α and treated with dexamethasone, with cytokine levels compared to 2D cultures and human skin biopsies. Our 3D model exhibited drug response trends similar to human skin, while showing reduced cytotoxicity over time compared to biopsies. This perfused skin-on-a-chip provides a reliable, physiologically relevant alternative for drug and cosmetics screening, simplifying perfusion setup while preserving key benefits.

Does Hand-Predominance Have a Predominant Influence on Craniofacial Asymmetric and Anthropometric Analysis in Preadolescences?

Background: Although the human body generally exhibits bilateral symmetry, achieving perfect symmetry is exceedingly uncommon. During preadolescent development, a face that approximates symmetry is considered both aesthetically and functionally ideal. This study aimed to investigate the relationship between craniofacial traits and hand predominance, using three-dimensional (3D) stereophotogrammetry to discern whether facial soft-tissue characteristics are correlated with hand preference. Materials and Methods: The study involved children aged 9 and 10 years who were free from any diagnosed craniofacial anomalies. Three-dimensional stereophotogrammetry was conducted to analyze their facial morphology, and 37 distinct anatomical landmarks were manually identified using a MATLAB-developed program. Results: A total of 188 Taiwanese children participated in the study. All participants were healthy, with a mean age of 9.79 years. Among them, 93.1% (175) were right-hand predominant, and 6.9% (13) were left-hand predominant. There were no significant differences in linear parameters or facial asymmetry between right-hand-predominant and left-hand-predominant participants (p > 0.05). However, a consistent trend toward right laterality, especially in the right lateral frontal region of the cranium, was observed, as illustrated by heat maps of the average three-dimensional model. Conclusions: The study found no association between facial morphology and hand predominance. A normal asymmetry with a rightward tendency was noted in children aged 9 to 10 years, which was particularly notable in the lateral frontal region of the head.

Experimental method for internal deformation measurement of 3D solids with embedded cracks based on 3D printing and digital speckle techniques

Quantification of the internal deformation of fractured solids such as rock masses under external loads, especially the deformation around internal fractures, is crucial for understanding and predicting the failure of fractured solids. However, it is very difficult to achieve the goal using conventional experimental methods. In this study, we proposed a novel internal deformation measurement method based on three-dimensional (3D) printing and digital speckle techniques. The 3D printing technology was applied to fabricate a 3D transparent model with an embedded elliptical crack and to set a speckle pattern on the internal section of the transparent model. The digital image correlation (DIC) method was used to determine the internal deformation field of the 3D fractured model. The measured displacements and strains of the internal sections in the fractured model were compared with the numerical simulation results. The comparison indicates that the proposed experimental method can well determine the deformation inside the 3D model. This built-in speckle method can realize real-time observation of the internal deformation of a 3D solid model in a non-contact and non-destructive manner.

Improving Real-Scene 3D Model Quality of Unmanned Aerial Vehicle Oblique-Photogrammetry with a Ground Camera

In UAV (unmanned aerial vehicle) oblique photogrammetry, the occlusion of ground objects, particularly at their base, often results in low-quality real-scene 3D models. To address this issue, we propose a method to enhance model quality by integrating ground-based camera images. This innovative image acquisition method allows the rephotographing of areas in the 3D model that exhibit poor quality. Three critical parameters for reshooting are the reshooting distance and the front- and side-overlap ratios of reshooting images. The proposed method for improving 3D model quality focuses on point accuracy, dimensional accuracy, texture details, and the triangular mesh structure. Validated by a case study involving a complex building, this method demonstrates that integrating ground camera photos significantly improves the overall quality of the 3D model. The findings show that optimal settings for reshooting include a distance (in meter units) of 1.5–1.6 times the camera’s focal length (in millimeter units), a front overlap ratio of 30%, and a side overlap ratio of 20%. Furthermore, we conclude that an overlap rate of 20–30% in reshooting is a usable value.

Magnetotelluric evidence for the deep causes of different eruptive styles of Changbaishan Tianchi and Longgang volcanoes

Longgang Volcano (LGV) and Changbaishan Tianchi Volcano (CTV) share a common magmatic source at mantle depths. However, the two volcanoes have produced completely different types of eruptions. By performing 3D inversion of an MT dataset that completely covers the LGV and CTV, we have obtained high-resolution electrical resistivity images. The results reveal that the two volcanoes have distinct magmatic plumbing systems, and this is likely the reason for their different eruptive styles. Results from 3D modeling do not show a magma chamber in the shallow crust beneath LGV, interpreted as the rapid rise of the magma from the mantle is responsible for producing a series of densely distributed volcanic cones in the LGV field. In contrast, there is a magma chamber in the upper crust beneath the CTV, where the fractional crystallization and mixing of magma has occurred. This magma chamber has facilitated multiple centralized eruptions, and thereby has led to the formation of the large CTV volcanic cone. These results indicate that differences in their crustal structures may have controlled the different eruptive activities of the LGV and CTV in CVS, Northeast China.