50th Anniversary Research Articles

Computer simulations of soft matter. On 60-th anniversary of Jaroslav Ilnytskyi

This special issue Condensed Matter Physics, entitled "Computer Simulations of Soft Matter" is dedicated to Jaroslav Ilnytskyi on the occasion of his 60-th birthday. Prof. J. Ilnytskyi is one of scientific leaders of the Institute for Condensed Matter Physics of the National Academy of Sciences of Ukraine (NASU), who iswell known for his contributions to the theory and computer simulation studies of polymer fluids, liquid crystals, macromolecular and colloid solutions. Versatility of Jaroslav works is due to his excellent background commonly resulting in original ideas, his feeling and ability to choose and apply appropriate methods for the solution of various problems. Finally, Jaroslav works are distinguished by the profound analyses of either theoretical or simulation results with respect to experimental observations frequently complemented by the discussion of possible applications.

Юридическая наука в России: особенности современного состояния и перспективы развития

Introduction. The article describes the discussion at the 20th international scientifictheoretical conference “State and Law: Evolution, Current State, Development Prospects (to the 25th Anniversary of the St. Petersburg University of the Ministry of Internal Affairs of Russia)” (2023) held at St. Petersburg University of the Ministry of Internal Affairs of Russia. 433 researchers took part in the discussion of actual issues of modern legal science. These are scientists and practitioners of Russia, Azerbaijan, Belarus, Moldova, Kyrgyzstan, Tajikistan. The participants presented the views on the peculiarities of the modern stage of development of national legal science - postclassical (post-neoclassical) legal science; the importance of disciplinarity and interdisciplinarity of legal research in the development of theoretical jurisprudence; updating the methodological basis of modern legal science; the dependence of the state of jurisprudence on the transformations of social reality; topical problems of legal understanding and legal regulation. Methods. The main methodological principles of the research were the principles of comprehensive study of legal processes and phenomena, integrity of theory and practice, historicism. The main methodological approaches of the research were defined as the system approach and the value approach. The last one contributed to the identification of the ideas important for the modern stage of development of legal science. The method of integrity made it possible to identify the features of the current state of legal science as a system of interrelated elements of legal knowledge and the reasons determining their change in the course of historiographical analysis. Results.The views of modern scientists on actual issues of modern jurisprudence are characterised: the specifics of the state of post-classical (postnon-classical) legal science (I. L. Chestnov); the features of the methodology of modern theoretical jurisprudence (N. V. Varlamova, M. L. Davydova, V. V. Denisenko, S. A. Kalinin, N. V. Mamchenko); the significance in the development of theoretical jurisprudence of the problem of disciplinarity and interdisciplinarity (S. V. Kodan, I. A. Andreeva, E. N. Tonkov); the dependence of the state of modern theoretical jurisprudence on the instability of social reality (A. V. Skorobogatov, V. G. Zarubin, V. A. Semenov); the place of modern legal science in the disciplinary structure of social and humanitarian sciences (L. V. Denisova); structure of modern theoretical jurisprudence (V. Yu.Belsky, A. L. Zolkin, M. V. Baranova); features of legal understanding and law enforcement (R. I. Baigutlin, L. V. Karnaushenko, E. S. Zaitseva, D. A. Matantsev); organisational and legal determinants of the development of modern legal science (I. A. Goncharov, A. G. Repiev).

An Equity Agenda for the Field of Health Care Quality Improvement.

On the occasion of the 20th anniversary of the publication of To Err Is Human: Building a Safer Health System (IOM, 2000) and Crossing the Quality Chasm: A New Health System for the 21st Century (IOM, 2001), the National Academy of Medicine convened the leaders of seven prominent U.S. health care quality organizations to […]

Charles Todd and the Overland Telegraph Line

Adam Courtenay, an Australian author and journalist completed Mr Todd’s Marvel: How one man telegraphed Australia to the modern world, a recent book on Charles Todd and the Overland Telegraph Line (OTL), in time for it to be published around the 150th anniversary of the completion of the historic project. Although the book concentrates on the immense task and challenges of building the OTL from Port Augusta to Palmerston (now called Darwin), it does provide a focus on the people that participated and, especially, on the special role of Charles Todd. This book review concludes that the book is a useful introduction to the subject, with occasional inclusions of information that might not be well known, and permits the reader easy access to the subject through its narrative style and generous spread of illustrations. However, the book does have limitations. It lacks an index and citations detailed enough to be followed up. For the reader who might wish to pursue particular issues or events, these limitations are frustrating indeed. Overall, it is for the general reader, rather than for those seeking to gain an even deeper understanding of the times, the project, and the major participants and their motivations.

I.Ya. TENYUSHEV: TOUCHES TO THE CREATIVE PORTRAIT OF A TEACHER, A JOURNALIST, A SCIENTIST, A WRITER

The article analyzes and summarizes the contribution of a famous Chuvash teacher, journalist, scientist, writer I.Ya. Tenyushev (19.01.1923 – 14.02.2016) to the development of Chuvash journalism. The article is devoted to the 100th birth anniversary of Ivan Yakovlevich Tenyushev, a participant in the Great Patriotic War, a journalist who worked in the media for more than 70 years and 33 years as a teacher at the Chuvash State University, a scientist who studied the history of Chuvash journalism, the founder of the training system for the mass media cadres of Chuvashia and a researcher of the creative heritage of the Chuvash educator I.Ya. Yakovlev. The purpose of the study is to study the formation of I.Ya. Tenyushev as a teacher, a journalist, a scientist and to analyze the creative path of the journalist, the scientist and the teacher during the period of working (1967–1983, 1998–2015) at I.N. Ulianov Chuvash State University. Materials and methods. A retrospective analysis of the historical aspects of the topic was carried out on the basis of personal data, as well as publications of scientific and methodological literature. The main research methods were the analysis and generalization of data contained in these sources, information from scientific and methodological literature. It was for the first time that some historical aspects of the creative path passed by the famous teacher, journalist, scientist, writer, I.Ya. Tenyushev, were studied. Study results. A brief historical overview of I.Ya Tenyushev’s formation as a teacher, a journalist, a scientist is presented and the creative path of the journalist, the scientist and the teacher during the period of working (1967–1983, 1998–2015) at I.N. Ulianov Chuvash State University is analyzed. The practical significance of the study lies in the fact that the results obtained eliminate gaps in the regional history of I.Ya. Tenyushev’s creative path. The prospects of the study lie in the fact that the results obtained can be used in generalization and systematization of information on the history of journalism in Chuvashia. Conclusions. On the basis of a retrospective analysis of the research materials, the stages of I.Ya. Tenyushev’s creative path are theoretically substantiated and differentiated showing him as a teacher, a journalist, a scientist during the period of working (1967–1983, 1998–2015) at I.N. Ulianov Chuvash State University.

Jurisprudence for the Development of Science: Ideas that Should Not Be Forgotten (To the 100th Anniversary of the Institute of Legislation and Comparative Law under the Government of the RF)

The article examines topical issues in regulation and organization of academic activities, which are related to the more than 100-year history of functioning of one of the oldest research institutions in the country – the Institute of Legislation and Comparative Law under the Government of the Russian Federation. In the course of the study of archival materials and available publications by the Institute’s employees, some original and currently relevant proposals and hypotheses were identified. They are concerning the organization of research, the direct implementation of academic activities, as well as relations in the field of science subject to legal regulation (in particular, those related to: the distinction of legislation on the scientific and technical process as an independent part in the system of national law in the 1960s; the impossibility of scheduling scientific discoveries; the need to involve researchers (the object of control) in the management process; the “probabilistic” nature of research and the infeasibility of standardization in research work as is the case with setting norms in industrial production; the incorrectness of identification of administrative management in science with academic advising as a specific phenomenon, etc.). These remain relevant to this day. An attempt has been made to correlate the developments of the team of the particular academic organization with the sociopolitical situation in the corresponding historical period and the dominant scientific positions.

ASSESSMENT OF V.D. DIMITRIEV’S ACTIVITY AND SCIENTIFIC HERITAGE IN MODERN HISTORICAL SCIENCE

The article analyzes the publications of the famous historian V.D. Dimitriev (1924–2013), the main directions of his research, as well as publications about his activities and scientific works. In 2024 the scientific community celebrated the 100th anniversary of his birth, so it is necessary to show some results of studying the activities and scientific heritage of this outstanding personality. The purpose of the article is to review and classify the entire range of publications about V.D. Dimitriev and to analyze some historiographical works on the historian’s scientific works. Materials and methods. When writing the article, the principles of historicism, objectivity and consistency, methods of historical research were used, i.e. historical-comparative, historical-typological, problem-chronological methods, as well as the ones of historiographical analysis. Study results. The largest number of publications about V.D. Dimitriev are biographical articles, mostly anniversary ones. Only some of them contain a historiographical assessment of his scientific heritage (the works of Y.P. Smirnov, I.Ya. Froyanov and others). Three collections were published for the anniversary of the scientist, which give a more detailed description of his works on ethnogenesis of the Chuvash people, the history of Chuvash towns, the history of feudalism in Chuvashia, V.D. Dimitriev’s research of Chuvash historical legends, biographical sketches of representatives of the Chuvash people, the scientist’s research methodology, etc. The scientist’s research was evaluated by leading experts on the problems studied by Vasily Dimitrievich: A.G. Ivanov, G.N. Aiplatov, A. Kappeler, A.I. Nogmanov, G.N. Plechov, E.K. Mineeva, Yu.V. Gusarov, V.P. Ivanov, Yu.P. Smirnov, A.A. Chibis, and others. Dimitriev’s research on the history of Chuvashia during the feudal era and the study of Chuvash historical traditions received the greatest number of responses in the scientific world. Conclusions. Despite a significant number of publications about V.D. Dimitriev, they are unsystematic in nature, that is why there is an urgent need to create a holistic monographic study on the activities and scientific heritage of the scientist. It is necessary to introduce the materials contained in the archive of V.D. Dimitriev into scientific circulation. It is advisable to post small-circulate.

History of Agroengineering Science in Saint Petersburg

At the end of the 19th and beginning of the 20th centuries, there was a significant development in the field of domestic agricultural engineering science, which focused on the challenges associated with the creation of agricultural machinery. The integration of new technologies in agriculture necessitated a scientific foundation for these advancements, with a keen consideration for the traditional methods of land cultivation. It is posited that the origins of the scientific team at the Institute of Agroengineering and Environmental Problems of Agricultural Production can be traced back to the establishment of the Bureau of Agricultural Mechanics in Saint Petersburg in 1907. (Research purpose) The paper aims to provide a comprehensive overview of the historical and scientific foundations surrounding the emergence and evolution of agroengineering science in Saint Petersburg; and illustrate the continuity of scientific traditions in addressing production objectives within the realm of «Agroecology». (Materials and methods) The analysis was conducted by drawing upon publications that delve into the inception in Russia agricultural mechanization science, the chronicles of the State Agricultural Museum as well as materials prepared for the 100th anniversary of the Bureau of Agricultural Mechanics’ establishment. (Results and discussion) The paper outlines the primary stages and identifies the scientists who played pivotal roles in the operations of the Bureau during 1907-1917. Commencing its activities in Leningrad in 1930, the Institute was later relocated to Moscow. In Leningrad, branches of both VIM and VIESKH were established, where former members of the Bureau continued their work. Further, after various organizational changes, the Leningrad branches were amalgamated in 1962 to form an independent institution known as NIIMESKH of the North-West. This later evolved into the research and production association «Nechernozemagromash» with the workforce exceeding 1,200 employees. In 2018, the Institute once again became a branch of VIM, with a renewed focus on comprehensive scientific research aimed at ensuring the environmental sustainability of agricultural production. (Conclusions) The most significant outcome stemming from the team’s extensive history is the continuity of knowledge transmission. Presently, operating under the umbrella of the Federal Scientific Agroengineering Center VIM, the team at the Institute of Agroengineering and Environmental Problems of Agricultural Production continues the illustrious traditions of its inaugural predecessor—the Bureau of Agricultural Mechanics. It remains steadfast in its commitment to these traditions in tackling emerging challenges in agricultural science and practice.

Social development of Russian society at the turn of the 30th anniversary of the Constitution: prospects and expectations. In Memory of Ekaterina Ivanovna Kozlova

The article is devoted to the study of the current state of Russian society, its social development at the turn of the 30th anniversary of the Constitution. The author, relying on the judgments of Ekaterina Ivanovna Kozlova devoted to the formation of the current statehood, turns to the assessment of ensuring compliance of constitutional provisions with the social reality of Russian society, the constitutional approaches laid down, the results achieved, the planned prospects and expectations. The modern development of Russian society follows the path of democratization and socialization. The ongoing legal transformations contribute to this. The social development of society is proclaimed the goal of any democratic rule of law state. The social development of Russian society proceeds from the constitutional foundations of the welfare state. The social development of Russian society is carried out through constitutional transformations of social spheres of society aimed at changing the way of life of society, improving well-being, forming socio-economic incentives, increasing social guarantees and updating the modern economy. According to the author, the main directions of social development of Russian society are spiritual and moral (ideological) values, the social potential of the family; economic development.

Abstract 1291: ASPIRE: Advocates and Scientists Partner in Research Education

Abstract UNC Lineberger Comprehensive Cancer Center (LCCC) has a robust and growing cancer patient advocacy community. UNC Lineberger is the flagship publicly funded comprehensive cancer center in North Carolina. We are constantly looking for ways to educate patient and community advocates on recent advances in cancer biology research and clinical trials. Our advocates are also valuable partners for our basic and clinical researchers that may be early in their career. We developed and implemented an inaugural research education program for new advocates. We model this program partly on the highly successful and popular AACR Scientist Survivor Program that recently celebrated it’s 25th anniversary. Some of the UNC LCCC advocates participate in the SSP and were motivated to develop our own local program. We will showcase our pilot 2024 ASPIRE education program that brings together cancer patient and community advocates and cancer researchers to learn from each other. The basic itinerary of the ASPIRE program is: 1.Three separate one-hour online presentations by UNC Lineberger researchers with a patient advocate moderator. The topics covered are: Cancer 101 : cancer biology, diagnosis, staging, treatment. Clinical Trials 101: clinical trials, phases, patient protection, progress with for example accrual of representative populations. Research 101: bench research, bioinformatic, AI, how research works and how it may lead to new treatments. To showcase a tissue donation program being developed by UNC Patient Advocates that will benefit researchers. 2.The lecture series is followed by a breakfast roundtable discussion for all the participants to discuss their experiences. There will be short presentations and discussions in small groups of researchers and cancer patient advocates. We will summarize our ASPIRE pilot experience, how our participation in the SSP program motivated this local program, and how we plan to incorporate feedback from participants to inform future programs. We hope this will lead to more informed patient advocates that can then be even more powerful in research advocacy. Citation Format: Laurie Betts, Jennifer Potter, Veronica Carlisle, Patricia A. Spears. ASPIRE: Advocates and Scientists Partner in Research Education [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 1291.

Public authority and the will of the people: to the 100th anniversary of the birth of E. I. Kozlova

The article deals with the main issues of power and the will of the people, associated with the activities of public authorities. Consideration of these issues is based on the works of Professor E. I. Kozlova. It is noted that the content of a democratic state should be based on the values of the society of a particular state, without establishing the primacy of a single standard of a liberal state. Building a democratic state may be associated with the solution of the following tasks: achieving a balance of interests of the whole society and the minority; creating conditions for a broad discussion of issues of state and public importance; providing access to information about the activities of public authorities; historical succession of state building. It is noted that these tasks are solved in law through the introduction of public discussion of bills; fixing traditional values in constitutional law and sectoral legislation and ensuring their protection (protection of the feelings of believers, a ban on the rehabilitation of Nazism, a ban on same-sex marriages). At the same time, it is proposed: to introduce criteria and grounds for mandatory public discussions for public authorities; legislative consolidation of the publication of transcripts of meetings of public authorities that do not contain state secrets. In the development of the theory of democracy E. I. Kozlova, the author notes that the list of forms of realization of national sovereignty cannot be closed, it is constantly updated and developed by the peoples themselves, in accordance with their will.

About the Settlement of the City of Ufa-II: To the 70th Anniversary of Scientific Research

Purpose. The settlement of Ufa-II is a reference monument of the early Middle Ages of the Southern Urals. The work introduces the latest materials from the site into academic discourse.Results. The obtained materials complement the picture of the development of the immediate surroundings of the Ufa-II settlement. The thickness of the cultural layer in the study area was more than 1 m, which suggests that the site had been in operation for quite a long time. Data on the archaeozoological collection and the results of a morphological and chemical-analytical study of the soil cover are presented. The osteological material is highly fragmented, it bears traces of cuts and appears to be kitchen remains. The species composition is represented by 4 domestic animal species. The cultural layer in its chemical composition is characterized by an increased content of gross phosphorus, and the content of humus, total nitrogen, mobile forms of phosphorus and potassium corresponds to background natural soils. The total thickness of the cultural layer of the monument in this profile is an average of 110 cm. The overlying layers were formed at a later time.Conclusion. The studies made it possible to establish the presence and thickness of the cultural layer. The obtained materials indicate that in the early Middle Ages, the area around the citadel of the settlement was actively developed by the tribes of the Bakhmutin and Turbaslin archaeological culture in the period of the 5th – 7th / 8th centuries.

Bibliophile, Bibliologist, Researcher of the Book Art (on the 60th Anniversary of Mikhail Vadimovich Seslavinsky)

The article is devoted to scientific, exhibition and collecting activities of Mikhail Vadimovich Seslavinsky, candidate of historical sciences, full member of the Russian Academy of Arts, leader of the modern Russian bibliophile community, Chairman of the Council of the National Union of Bibliophiles. His scientific and popular science works in the field of book history, bibliography, art of the book, history and modern state of Russian bibliophilia are analyzed (in total — more than 40 book publications, including major monographic works, about 300 articles, reports, notes, publications of documents, as well as interviews with figures of the book and bibliophile world). The scholar has made a significant contribution to the study of the history of bookbinding, Russian children’s books, the work of Russian artists-emigrants in France, the book heritage of poets and artists of the Silver Age (O.E. Mandelstam, M.I. Tsvetaeva, A.A. Akhmatova, A.N. Benois) and many other topics. He also proposed original approaches to the definition of book rarities that came out from under the printing press in the twentieth century.Large-scale exhibition projects prepared on the basis of his personal bibliophile collection were considered. The role of M.V. Seslavinsky as the creator and head of the National Union of Bibliophiles, chairman of the editorial board of the journal “About Books” was noted.

Bibliophile, Bibliologist, Researcher of the Book Art (on the 60th Anniversary of Mikhail Vadimovich Seslavinsky)

The article is devoted to scientific, exhibition and collecting activities of Mikhail Vadimovich Seslavinsky, candidate of historical sciences, full member of the Russian Academy of Arts, leader of the modern Russian bibliophile community, Chairman of the Council of the National Union of Bibliophiles. His scientific and popular science works in the field of book history, bibliography, art of the book, history and modern state of Russian bibliophilia are analyzed (in total — more than 40 book publications, including major monographic works, about 300 articles, reports, notes, publications of documents, as well as interviews with figures of the book and bibliophile world). The scholar has made a significant contribution to the study of the history of bookbinding, Russian children’s books, the work of Russian artists-emigrants in France, the book heritage of poets and artists of the Silver Age (O.E. Mandelstam, M.I. Tsvetaeva, A.A. Akhmatova, A.N. Benois) and many other topics. He also proposed original approaches to the definition of book rarities that came out from under the printing press in the twentieth century.Large-scale exhibition projects prepared on the basis of his personal bibliophile collection were considered. The role of M.V. Seslavinsky as the creator and head of the National Union of Bibliophiles, chairman of the editorial board of the journal “About Books” was noted.

Abstract 7315: Collaboration between NIDCR and NCI promotes innovative research in head and neck cancers

Abstract The Oral and Salivary Cancer Biology Program at National Institute of Dental and Craniofacial Research (NIDCR) supports research activities that improve early detection and treatment of cancers of the oral cavity, pharynx, and salivary glands. We promote basic science research on the regulatory pathways and transformation process of pre-cancerous lesions to primary and metastatic tumors, as well as translational science activities to develop novel technologies and therapeutics for the diagnosis, prognosis, and treatment of cancers. NIDCR and National Cancer Institute (NCI) have established long-term collaborations to promote and co-manage awards funded through The Immuno-Oncology Translational Network (IOTN) of the Cancer Moonshot program, Specialized Programs of Research Excellence (SPOREs), and Early Detection Research Network (EDRN) program. NIDCR and NCI have co-developed Notice of Special Interest (NOSI) and Request for Application (RFA) on Advancing Head and Neck Cancer Early Detection Research (AHEAD), which co-funded seven research projects to discover and develop molecular signatures of early detection and diagnosis of HPV positive and negative head and neck cancer (HNC). To further strengthen NIDCR and NCI collaboration, we jointly organized the symposium to promote HNC early detection and biomarker identification at the American Head and Neck Society (AHNS) 11th International Conference on Head and Neck Cancer in July 2023. In addition, NIDCR has organized a symposium to promote HNC research at the 2024 annual meeting of American Association for Dental, Oral, and Craniofacial Research (AADOCR) to celebrate the 75th anniversary of NIDCR. This AADOCR symposium will feature the collaboration between NIDCR with NCI in the Cancer Moonshot program focusing on immunoprevention and immunotherapy, HNC early detection and biomarker research in AHEAD and EDRN, and investigation of HPV positive and negative HNC and clinical translational research under SPORE. At this 2024 AACR annual meeting, NIDCR and NCI program directors will present the collaborations and funding opportunities between NIDCR and NCI, focusing on early cancer detections and biomarker discovery and validation. Collaboration between NIDCR with NCI provides a unique opportunity to promote basic, translational, and clinical research in advancing HNC early detection to benefit cancer patients. Citation Format: Zhong Chen, Wendy Wang. Collaboration between NIDCR and NCI promotes innovative research in head and neck cancers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 7315.

Self-understanding, envisioning the future, and prevention: An appreciation and a reflection on the occasion of the 100th anniversary.

On the 100th birthday of the Global Alliance for Behavioral Health and Social Justice, it is appropriate to reflect on the evolution of thought on depression prevention research, as seen through a historical perspective, to note how the field has grown and how it can address the issues of today. This article is a personal reflection on one practitioner's evolution of thought on resilience and preventive intervention, starting with interviewing civil rights workers, to conceptualizing self-understanding as an essential component of resilience, to the development of a family-based preventive intervention for parental depression, which was disseminated, adapted, and incorporated into a growing body of prevention research. Consensus statements on mental health prevention from the National Academies are reviewed, and the importance of a social justice perspective is highlighted throughout. The article concludes with principles for developing effective preventive interventions to promote mental health today, and in the future. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

The 45th anniversary of Cancer Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences

Решение об открытии в Томске филиала Онкологического научного центра Академии медицинских наук СССР было принято 3 января 1979 г. Государственным комитетом СССР по науке и технике, а уже 8 января 1979 г. министром здравоохранения СССР академиком АМН СССР Б.В. Петровским был подписан Приказ № 20 «Об организации в г. Томске Сибирского филиала Онкологического научного центра АМН СССР».

Ukrainian Language and Physics: a Brief Historical Retrospective (to the 150th Anniversary of the Shevchenko Scientific Society)

The history of Ukrainian language as a tool for publishing results of physical research and popularizing physics has been considered. Most important articles on physics that appeared in Ukrainian in 1877–1940 have been analyzed. Special impact was made on the publications of the non-governmental Shevchenko Scientific Society, which acted in Lviv in 1892–1939 as the first Ukrainian national academy of sciences. It is demonstrated that the main goal of the authors of those articles was not to disseminate the obtained results within the international community of physicists but to raise the status of the Ukrainian language, which was officially prohibited in the Russian empire by the acts dated 1863 and 1876, up to the status of the well developed European language by enabling its functioning in the hitherto closed spheres. The prospects of applying the Ukrainian language for publishing the results of physical research and popularizing physics nowadays have been discussed.

The development of pharmaceutical biotechnology in Kharkiv: to the 125th anniversary of “Biolik” enterprise

Aim. To study the development of pharmaceutical biotechnology in Ukraine on the example of the history of the Kharkiv enterprise “Biolik” over the past 125 years. Materials and methods. Analytical and comparative research methods, as well as bibliosemantic review were used in the article. Results and discussion. The development of the scientific and technological school of the enterprise “Biolik” in the production of drugs based on biotechnology, such as vaccines, serums, probiotics, artificial nanoparticles, etc., was studied covering the period from the end of the XIX-th century and to the present time. Conclusions. It has been shown that the enterprise “Biolik” has a significant potential (production areas, equipment, technological documentation, staff, etc.). The enterprise can produce immune-biotechnological and original medicines. We can hope that this potential of the enterprise will allow it to successfully resume the production of high-tech drugs in Ukraine.

Sniffing Out the Sustainable Future: The Renewability Revolution in Fragrance Chemistry.

In this review, the impact of the transition from today's resource-wasting petrochemical economy towards a 100/100 renewable and biodegradable future is discussed with respect to the fragrance families: "citrus", "green", "fruity", "floral", "floriental", "oriental", "woody", "chypre" and "fougère". After benchmark data on ingredients usage, definitions on biodegradation and sustainability are given. Celebrating the 150th anniversary of synthetic vanillin, its historic synthesis from renewable starting materials serves as introduction. In the grand scheme of things, citrus scents upcycled from the beverages industry, are already an ideal case for 100/100 with new opportunities for artificial essential oils. In the fruity domain, transparent and lactonic ingredients are available in a sustainable manner. However, in the domain of green odorants, there is a lack of green chemistry for important key materials. In the floral family, renewability is more critical than biodegradability, but cost is an issue. Thanks to Ambrox and maltol, florientals and orientals will persist, while woody notes severely lack an Iso E Super replacer. In the chypre genre, patchouli became the new moss, but more musks are increasingly in demand. With their high percentage of linalool and dihydromyrcenol, the construction of fougères could well become a precedent for other families, despite challenges in vetiver and salicylates. Still, the challenges exemplified here create immense opportunities for new perfumery materials.