ABSTRACT The observed hemispherical power asymmetry in cosmic microwave background radiation can be explained by long-wavelength mode (long-mode) modulation. In this paper, we study the possibility of detecting this effect in the angular power spectrum of the 21-cm brightness temperature. For this task, we study the effect of the neutral hydrogen distribution on the angular power spectrum. This is done by formulating the bias parameter of the ionized fraction to the underlying matter distribution. We also discuss the possibility that the long-mode modulation is accompanied by a primordial non-Gaussianity of local type. In this case, we obtain the angular power spectrum with two effects of primordial non-Gaussianity and long-mode modulation. Finally, we show that the primordial non-Gaussianity enhances the long-mode modulated power of the 21-cm signal via the non-Gaussian scale-dependent bias up to four orders of magnitude. Accordingly, observations of the 21-cm signal with upcoming surveys, such as the Square Kilometer Array (SKA), will probably be capable of detecting hemispherical power asymmetry in the context of long-mode modulation.
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