16-slice Multidetector-row Computed Tomography Research Articles

High Prevalence of Intracranial Artery Calcification in Stroke Patients with CKD

Intracranial artery calcification (IAC) is frequently observed on brain computed tomography (CT) scans in stroke patients. This retrospective study was designed to determine the prevalence, risk factors, and clinical relevance of IAC in a cohort of patients with ischemic stroke. We included all eligible patients admitted to Amiens University Hospital for acute ischemic stroke between January and December 2006 and assessed using 64-slice multidetector-row CT (n = 340). Patients were classified according to the presence or absence of IAC in the internal carotid arteries, middle cerebral arteries, vertebral arteries, and basilar artery. GFR was estimated using the MDRD equation. Chronic kidney disease (CKD) was defined as a GFR < 60 ml/min/1.73 m(2). We also studied a control group of patients admitted for neurologic diseases other than stroke. Two hundred fifty-nine stroke patients (76.2%) displayed IAC, which was independently associated with carotid atherosclerosis > 50%, age, and GFR. One hundred three nonstroke patients (60.2%) had IAC, with age, arterial hypertension, and GFR as independently associated factors. For all patients taken together, age, arterial hypertension, stroke, and GFR were independently associated with IAC. These results confirm the high prevalence of IAC in patients with and without ischemic stroke and show for the first time that IAC is associated with the presence of CKD in these patients. The frequency of IAC was significantly higher in stroke patients than in nonstroke patients. The association between IAC and stroke outcome requires further investigation.

Evaluation of Coronary Artery Bypass Grafts in the Early Postoperative Period Using 64-Slice MDCT

Purpose: The aim of this study was to evaluate the accuracy of 64-slice multidetector row CT (MDCT), as compared with conventional coronary angiography (CCA), for as- sessing coronary artery bypass grafts (CABG) in the early (< 1 month) postoperative period. Materials and Methods: Twenty-four patients underwent both 64-slice MDCT (0.6 mm collimation, 0.37s gantry rotation) and CCA within 15 days after CABG. Sixty-five by- pass grafts (20 venous grafts and 45 arterial grafts) and 67 distal runoff arteries in 24 patients were included in the analysis. The bypass grafts and distal runoffs were evalu- ated for the presence of significant stenosis, including obstruction. The CT findings were compared with the CCA findings. Results: CCA confirmed that 62 of the 65 grafts were patent and that 3 had significant stenosis or obstruction. Sixty of the 62 patent grafts were correctly identified by MD- CT. One of the three grafts that had significant stenosis was misinterpreted on the MD- CT images. The sensitivity, specificity and positive and negative predictive values for detecting stenosis were 67%, 97%, 50% and 98%, respectively, with an overall diag- nostic accuracy of 95%. MDCT also correctly detected all the stenotic distal runoff ar- teries (4 of 67). Conclusion: 64-slice MDCT is a promising alternative diagnostic modality for evaluat- ing a CABG in the early postoperative period.

Vascular Disease in Chronic Obstructive Pulmonary Disease

Since the introduction of multi-detector row computed tomography (MDCT), most attention has been directed toward the use of this technique to improve the characterization of anatomic changes at the level of the airways and lung parenchyma in patients with chronic obstructive pulmonary disease. The introduction of fast rotation speed and dedicated cardiac reconstruction algorithms exploiting the multislice acquisition scheme of the data has opened new possibilities for thoracic imaging, starting with the possibility to integrate cardiac functional information into a diagnostic CT scan of the chest. Initiated with 16-slice MDCT, this concept of integrating morphology and function has been further simplified with 64-slice CT scanners, thus allowing radiologists to provide vital information in the management of patients with a wide variety of acute or chronic respiratory disorders. Because this CT technology also offers the possibility of generating high-resolution and motion-free images of the coronary arteries, evaluation of the coronary arteries in asymptomatic patients at risk for coronary artery disease during CT examinations of the chest can widen the clinical applications of CT for respiratory patients. More recently, the introduction of dual-source CT and its subsequent ability to apply dual energy to chest imaging has added another area of clinical interest at the level of the pulmonary capillary level. The purpose of this article is to review the potential applications of these technological developments in the population of patients with chronic obstructive pulmonary disease to provide a noninvasive depiction of the cardiovascular abnormalities known to occur in this subset of patients.

Performance evaluation of a computer-aided detection algorithm for solid pulmonary nodules in low-dose and standard-dose MDCT chest examinations and its influence on radiologists

The aim of the study was to evaluate the performance of a computer-aided detection (CAD) algorithm in low-dose and full-dose multidetector-row CT (MDCT) of the thorax and its impact on radiologists' performance. Chest CT examinations of 77 patients were evaluated retrospectively for pulmonary nodules. All patients had undergone a 16-slice MDCT chest examination with a standard acquisition protocol. Artificial image noise was added to the raw data to simulate image acquisition at 10 mAs(eff.) The data were transferred to dedicated lung analysis software (LungCare) with a prototype CAD algorithm (LungCAD). CAD was applied to both dose settings. Images were read by a radiologist and a first-year resident with and without the software at both dose settings. All images were reviewed in consensus by the two radiologists to set the reference standard. Sensitivity results with respect to the reference standard were compared. No statistically significant differences in the detection rate for all pulmonary nodules could be found between low-dose and full-dose settings for the CAD software alone (p = 0.0065). Both radiologists displayed a statistically significant increase in sensitivity with the use of CAD (p<0.0001). In conclusion, CAD is beneficial in both low-dose and standard-dose settings. This may be beneficial in reducing false-negative diagnosis in lung cancer screening, standard chest examinations and the search for metastases.

Integrated assessment of coronary anatomy and myocardial perfusion using a retractable SPECT camera combined with 64-slice CT: initial experience

We evaluated a prototype SPECT system integrated with multidetector row CT (MDCT) for obtaining complementary information on coronary anatomy and hemodynamic lesion significance. Twenty-five consecutive patients with known or suspected coronary artery disease (CAD) underwent routine SPECT myocardial perfusion imaging (MPI). All patients also underwent repeat MPI with a mobile SPECT unit which could be attached to a 64-slice MDCT system. Coronary CT angiography (cCTA) was performed without repositioning the patient. Investigational MPI was compared with routine MPI for detection of myocardial perfusion defects (PD). Two observers diagnosed presence or absence of CAD based on MPI alone, cCTA alone, and based on combined MPI and cCTA with fused image display. In 22/24 patients investigative MPI corresponded with routine MPI (r = 0.80). Stenosis >or= 50% at cCTA was detected in 6/24 patients. Six out of 24 patients had PD at regular MPI. Three of these six patients had no significant stenosis at cCTA. Three out of 19 patients with normal MPI studies had significant stenosis at cCTA. Our initial experience indicates that the integration of SPECT MPI with cCTA is technically feasible and enables the comprehensive evaluation of coronary artery anatomy and myocardial perfusion with a single instrumental setup.

Abstract 5799: Fine-Cell Detector Computed Tomography with 0.3mm-Collimation Improves Quantitative Assessment of Coronary Artery Stenosis: Experimental Study with Coronary Phantom

The purpose of this study was to evaluate whether the prototype fine-cell detector computed tomography (FDCT) could improve smaller coronary artery stenosis measurement compared with 64-slice multidetector-row CT (MDCT). Method and Materials: We developed coronary phantoms of 2mm in diameter with 0%, 25%, 50%, 75% stenosis. Each stenotic part was made by Acrylonitrile-Butadiene-Styrene (ABS: 50 Hounsfield Unit (HU)) and lumen was filled with diluted iodine (380 HU). These coronary phantoms put into the water tank were scanned by both prototype FDCT and 64-slice MDCT. Configuration of FDCT was 32-row*0.3125mm detector collimation with 0.35mm smaller X-ray tube focal spot width, and that of 64-slice MDCT was 16-row*0.625mm detector collimation and 0.7mm X-ray focal spot. All axial images were reconstructed using Standard kernel with 96mm display field-of-view. Minimum lumen diameter and degree of stenosis in these data sets were automatically measured using the Vessel Analysis software (GE Healthcare). Results: Measured coronary lumen at 0%, 25%, 50%, 75% stenosis of 2mm-diameter phantom (corresponding to 2.0mm, 1.5mm, 1.0mm, 0.5mm) were 2.2mm, 1.8mm, 1.4mm, 0.7mm in FDCT, whereas those were 2.5mm, 2.0mm, 1.5mm, 1.4mm in 64-slice MDCT, respectively. Each degree of stenosis was calculated 21%, 38%, 69% in FDCT, while 20%, 38%, 44% in 64-slice MDCT. Measured value of 75% stenosis in FDCT was significantly improved compared with 64-slice MDCT. Conclusion: FDCT improves the accuracy of smaller coronary artery stenosis measurement compared with 64-slice MDCT. Superior spatial resolution of FDCT could be promising for more accurate assessment of the coronary artery stenosis.

Assessment of Coronary Stenosis by a 16-Slice MDCT Scanner in Asymptomatic Diabetic Patients Starting Dialysis Therapy

Background: The accuracy for the detection of coronary stenosis by multidetector row computed tomography (MDCT) has been getting more recognition. However, the usefulness of MDCT in patients with chronic kidney disease (CKD) has not been confirmed. Methods: Weanalyzed 19 consecutive patients with asymptomatic diabetic CKD who underwent both MDCT and coronary angiography (CAG) at the initiation of dialysis. The definition of stenosis in this study was lesions with ≧50% stenosis by CAG. Results: CAG revealed stenosis in 35 of 76 branches in 19 patients. Vessel diameter could not be evaluated by MDCT in 11 (14%) major vessels because of motion artifacts, pericardial effusion, pleural effusion, and severe calcification. Almost all of such lesions were located in the right coronary (4/11; 36%) or left circumflex (5/11; 45%) artery. The sensitivity, specificity, positive and negative predictive values of MDCT for a diagnosis of stenosis in the 65 evaluable major vessels were 86, 81, 78, and 88%, respectively. The severity of vessel calcification was increased in a stepwise manner with increments in the proportion of major vessels with ≧50% stenosis (p = 0.004 for trend). Conclusion: MDCT seemed to be an effective non-invasive method of screening patients with diabetic CKD for CAD.

Diagnostic role of 64-slice multidetector row CT scan and CT venogram in cases of cerebral venous thrombosis

Retrospective review of patients with cerebral venous thrombosis (CVT) detected by 64-slice multidetector row computed tomography (MDCT). To evaluate the role of CT scan as the primary modality of imaging in suspected cases of CVT. Between October 2006 and September 2007, 53 patients, suspected to have CVT, underwent CT scan of the brain. Out of these, 33 patients were included in the study, who underwent non-contrast CT (NCCT), CT venous angiogram (MDCTA) and magnetic resonance venogram. Two blinded readers evaluated the NCCT and MDCTA. Final diagnosis was obtained after consensus reading of all the imaging by the two readers. Out of the total 33 patients, 20 patients were detected to have thrombosis of one or more of the cerebral venous sinuses or veins, at the concluding consensus reading. MDCTA together with NCCT could identify thrombosis in all of the 20 patients, i.e., 100% sensitivity and specificity. Sixty-four-slice MDCTA together with NCCT provided 100% sensitivity and specificity for the identification of CVT. It can be considered as a cost-effective and widely available, primary imaging modality in emergency situations.

Assessment of vertebral artery stents using 16-slice multi-detector row CT angiography in vivo evaluation: Comparison of a medium-smooth kernel and a sharp kernel

Objectives To assess the lumen visibility of extracranial vertebral artery stents examined with 16-slice multi-detector row computed tomography (MDCT) angiography in vivo using a medium-smooth kernel (B30s) and a sharp kernel (B60s), and to compare these with digital subtraction angiography (DSA) after stent placement. Methods Twenty stents from 20 patients (14 men, 6 women; mean age, 62.7 ± 10.1 years) who underwent CT angiography (CTA) with 16-slice MDCT were retrospectively analyzed. In CT angiograms using a B30s and a B60s, the lumen diameters and CT attenuations of the stented vessels were measured three times by three observers, and artificial luminal narrowing (ALN) was calculated. To assess measurement reliability on CT angiograms, the intraclass correlation coefficient (ICC) was used. DSA served as the reference standard for the in-stent luminal measurements on CT angiography. The median interval between CT angiography and DSA was 1 day (range 1–10). Results For interobserver reliability, intraclass correlation coefficients for the lumen diameters on CT angiograms with a B30s and a B60s were 0.90 and 0.96, respectively. The lumen diameters on CT angiograms using a B30s were consistently smaller than that on CT angiograms using a B60s ( p < 0.01). The mean ALN was 37 ± 7% on CT angiograms using a B30s and 25 ± 9% on CT angiograms using a B60s. The mean CT attenuation in in-stent lumen was 347 ± 55 HU on CT angiograms using a B30s and 295 ± 46 HU on CT angiograms using a B60s. The ALN and CT attenuation within the stented vessels between CT angiograms using a B30s and a B60s was significant ( p < 0.01). Conclusions 16-slice MDCT using a sharp kernel allows good visualization of the stented vessels and is useful in the assessment of vertebral artery stent patency after stent placement.

Characterization of Atherosclerotic Plaques in Human Coronary Arteries With 16-Slice Multidetector Row Computed Tomography by Analysis of Attenuation Profiles

We investigated if 16-slice multidetector row computed tomography (MDCT) allows correct classification of coronary plaques into calcified or noncalcified and further subclassification of noncalcified plaques into either lipid-rich with a necrotic core or fibrous. Coronary arteries of 30 isolated hearts were filled postmortem with a contrast medium and scanned with a 16-slice MDCT imager (Light Speed 16 pro, GEMS, Milwaukee, WI). Imaging parameters: collimation 16 x 0.625 mm, pitch 0.325, tube voltage 120 kV, tube current 250 mA, and gantry rotation time 500 milliseconds. The images were reformatted perpendicular to the axis of the coronary arteries (AW 4.2 software, GEMS) and analyzed by establishing attenuation profiles of the coronary cross sections (ImageJ 1.33n software, NIH, Bethesda, MD). Results were compared with the correlating histopathologic sections of the arteries. Analysis of 195 CT cross-sections showed a sensitivity and specificity for the correct classification of calcified plaques of 100% and 97.3% and for noncalcified plaques of 80.8% and 95.1%, respectively. The attenuation of epicardial fat ranged from -119 Hounsfield units (HU) to 23 HU (median -71 HU), and from 93 HU to 625 HU (308 HU) for the contrast medium. Calcified plaques showed an attenuation between 333 HU and 1944 HU (1,089 HU), noncalcified plaques between 26 HU and 124 HU (52 HU). Further subclassification of noncalcified plaques showed attenuation values between 26 HU and 67 HU (median 44 HU) for lipid-rich plaques with a necrotic core and from 37 HU to 124 HU (median 67 HU) for fibrous plaques. Coronary atherosclerotic plaques can be reliably identified and classified as either calcified or noncalcified by 16-slice MDCT in postmortem studies. Further differentiation of noncalcified plaques in either lipid-rich or fibrous is not reliably feasible because of substantial overlap of the attenuation.

Location of the transition zone in CT of small-bowel obstruction: added value of multiplanar reformations

To assess the additional value of multiplanar reformations (MPR) in comparison with axial images alone for location of the transition zone in CT of mechanical small-bowel obstruction (SBO). Sixty-nine consecutive patients with mechanical SBO underwent 16-slice multi detector row CT (MDCT). The gold standard for the precise location of the transition zone was established by two experienced abdominal radiologists, unblinded to clinical and surgical reports, reviewing all CT examinations. On a workstation, two blinded readers independently located the transition zone using first axial slices alone and then 1 month later MPR (axial, coronal, sagittal and oblique views) according to a three-point confidence scale. Diagnostic accuracy and mean confidence score were evaluated for both the transverse and multiplanar data sets. Accuracy of transition zone location for reader 1 and reader 2 was 86% and 84% with axial slices alone, and by using MPR 93% (significant: P = 0.03) and 90% (not significant: P = 0.08), respectively. Mean confidence score was significantly increased for both readers using MPR: 0.3 higher (P = 0.0001) and 0.37 higher (P = 0.0001) respectively. MPR can increase both accuracy and confidence in the location of the transition zone in CT of SBO.

Evaluation of Atherosclerotic Plaque in Patients without Coronary Artery Calcification Using Multidetector Row Computed Tomography: A Preliminary Report of 110 patients

Purpose: We analyzed the frequency and characteristics of atherosclerotic plaques in the patients without coronary artery calcification (CAC) by the use of multidetector row CT (MDCT). In addition, we analyzed patients with negative CAC to guarantee the absence of coronary artery disease (CAD). Materials and Methods: One hundred-ten patients with a suspicion of CAD and no CAC as detected on 16-slice and 64-slice MDCT were enrolled in this retrospective study. We analyzed the frequency of atherosclerotic plaques. For characterizing the atherosclerotic plaques, location, attenuation, volume, the degree of stenosis, and the remodeling index (RI) were analyzed. Results: Atherosclerotic plaques were detected in 8 patients (7.3%). The plaques were located in the right coronary artery (n=3), left anterior descending artery (n=3), and left main coronary artery (n=2). Attenuation, volume, stenosis and RI were 41.4±16.6 HU (range, 20.2 - 69.9 HU), 55±55 mm3 (range, 15-179 mm3), 40.7 ±16.3% (range,16.0-68.0%) and 1.35±0.13 (range, 1.16-1.50). Lipid rich plaque and significant stenosis were detected in 6 patients and in 2 patients, respectively. Conclusion: Despite negative CAC as detected on MDCT, atherosclerotic plaque might have significant stenosis or lipid rich plaque. Therefore, negative CAC does not seem to guarantee the absence of CAD. Coronary CT angiography was recommended for patients with negative CAC.

Automated Volumetry of Solid Pulmonary Nodules in a Phantom

The accuracy of automated volumetry for pulmonary nodules in a phantom using different CT scanner technologies from single-slice spiral CT (SSCT) to 64-slice multidetector-row CT (MDCT) was compared. A lung phantom with 5 different categories of pulmonary nodules was scanned using a single-slice spiral CT, a 4-slice MDCT, a 16-slice MDCT and a 64-slice MDCT. Each category comprised of 7-9 nodules each (total n = 40) with different known volumes. Standard dose and low dose protocols were performed using thin and thick collimation. Image data were reconstructed at the thinnest slice thickness. Data sets were analyzed with a dedicated volumetry software. Volumes of all nodules were calculated and compared. Mean absolute percentage error (APE) for all nodules was 8.65% (+/-7.29%) for the SSCT, 10.26% (+/-8.25%) for the 4-slice MDCT, 8.19% (+/-7.57%) for the 16-slice MDCT and 7.89% (+/-7.39%) for the 64-slice MDCT. There was statistically significant influence of the scanner type, protocol, anatomic location, and nodule volume on APE, but overall, APEs were comparable. Computer-aided volumetry showed accurate measurements in all tested scanner types. This finding has important implications for nodule assessment and follow-up.

Accurate estimation of global and regional cardiac function by retrospectively gated multidetector row computed tomography. Comparison with cine magnetic resonance imaging

Retrospective reconstruction of ECG-gated images at different parts of the cardiac cycle allows the assessment of cardiac function by multidetector row CT (MDCT) at the time of noninvasive coronary imaging. We compared the accuracy of such measurements by MDCT to cine magnetic resonance (MR). Forty patients underwent the assessment of global and regional cardiac function by 16-slice MDCT and cine MR. Left ventricular (LV) end-diastolic and end-systolic volumes estimated by MDCT (134±51 and 67±56 ml) were similar to those by MR (137±57 and 70±60 ml, respectively; both P=NS) and strongly correlated (r=.92 and r=.95, respectively; both P<.001).

Multidector CT Imaging of Coronary Artery Stents: Is This Method Ready for Use?

Coronary artery stenting has become the most important nonsurgical treatment for coronary artery disease. However, in-stent restenosis occurs at a relatively high rate and this problem has led to the routine use of invasive angiography for assessing stent patency. Although coronary angiography is the clinical gold standard and it is a very effective diagnostic tool for detecting such in-stent restenosis, it’s clearly an invasive procedure with its associated morbidity and mortality risks. Therefore, a noninvasive technique for detecting in-stent restenosis would be of great interest and use for following up patients after coronary angioplasty. Multidetector-row CT (MDCT) is being increasingly used for noninvasive coronary artery imaging as it has high diagnostic accuracy for detecting coronary artery stenosis in native, non-stented, coronary arteries. However, the application of MDCT to stent imaging is somewhat difficult. It is generally accepted that visualizing the in-stent lumen with using 4-slice MDCT is impossible because of the modality’s low temporal and spatial resolution. There is increased visualization of the stent lumen on 16-slice MDCT, and so in-stent restenosis can be detected in assessable stents. Yet for stents with small diameters (<3 mm) and/or thicker struts, visualization of instent stenosis remains a problem. The recently introduced 64-slice CT offers more improved spatial and temporal resolution than does 16-slice CT and this results in superior visualization of the stent lumen and in-stent restenosis. However, although 64-slice MDCT allows for improved stent visualization, a relevant part (up to 47%) of the stent lumen is still not assessable. There are many factors that interfere with the assessment of the real stent lumen even on 64-slice CT. The metal of the stents can cause blooming artifacts that prevent the accurate interpretation of a lumen’s patency. The blooming effect is caused by a combination of partial volume averaging and beam hardening, and this results in higher CT attenuation values in the stent lumen and this enlarges the apparent size of the stent struts, thus leading to a pseudo-narrowing of the lumen. Regarding the type of stent, the gold or gold-coated stents along with the stents made of tantalum, cause the most severe artifacts, while the stainless steel and cobalt stents can be more accurately visualized. Cardiac motion, poor contrast filling, the oblique course of the coronary vessels and calcification may also decrease the ability to assess a stent’s lumen. To improve a stent’s visualization, numerous methods have been attempted such as dedicated post-processing or the use of dual-source CT. However, because of its presently limited sensitivity and high radiation exposure, MDCT should not be used as the first-line test to screen for in-stent restenosis in asymptomatic patients. Given its high specificity and negative predictive value, MDCT might be valuable for confirming stent occlusion in symptomatic patients. Such stent evaluation should focus on the proximal coronary artery segments and on those stents with a diameter greater than 3 mm. (Korean Circ J 2007;37:521-529)

Multidetector-Row Computed Tomography Management of Acute Pulmonary Embolism

The purpose of this study was to evaluate the usefulness and safety of multidetector-row computed tomography (MDCT) pulmonary angiography and indirect venography management of acute pulmonary embolism (PE), including indication for inferior vena cava (IVC) filter. Seventy-one consecutive patients who were clinically suspected of PE and underwent 16-slice MDCT pulmonary angiography and indirect venography were enrolled. Management included indication of IVC filter for patients with extensive deep venous thrombosis (DVT) in submassive or massive PE. A right ventricular to left ventricular short-axis diameter by MDCT>1.0 was judged as submassive PE. All patients were followed for 1 year. MDCT identified 50 patients with venous thromboembolism and 47 patients had acute PE: 4 were judged as massive, 14 as submassive, and 29 as non-massive by MDCT; 3 patients had DVT alone and 7 patients had caval or iliac DVT. Only 1 patient with massive PE and DVT near the right atrium died of recurrence. No other patients died of PE. Management based on MDCT pulmonary angiography combined with indirect venography is considered to be safe and reliable in patients with suspected acute PE.

Diagnostic accuracy of 16-slice multidetector-row CT for detection of in-stent restenosis vs detection of stenosis in nonstented coronary arteries

The purpose of this study was to assess the diagnostic accuracy of 16-slice multidetector-row computed tomography (MDCT) for detecting in-stent restenosis. Fifty patients with 69 previously implanted coronary stents underwent 16-slice MDCT before quantitative coronary angiography (QCA). Diagnostic accuracy of MDCT for detection of in-stent restenosis defined as >50% lumen diameter stenosis (DS) in stented and nonstented coronary segments >1.5-mm diameter was computed using QCA as reference. According to QCA, 18/69 (25%) stented segments had restenosis. In addition, 33/518 (6.4%) nonstented segments had >50% DS. In-stent restenosis was correctly identified on MDCT images in 12/18 stents, and absence of restenosis was correctly identified in 50/51 stents. Stenosis in native coronary arteries was correctly identified in 22/33 segments and correctly excluded in 482/485 segments. Thus, sensitivity (67% vs 67% p=1.0), specificity (98% vs 99%, p=0.96) and overall diagnostic accuracy (90% vs 97%, p=0.68) was similarly high for detecting in-stent restenosis as for detecting stenosis in nonstented coronary segments. MDCT has similarly high diagnostic accuracy for detecting in-stent restenosis as for detecting coronary artery disease in nonstented segments. This suggests that MDCT could be clinically useful for identification of restenosis in patients after coronary stenting.

Coronary artery bypass grafts: assessment of graft patency and native coronary artery lesions using 16-slice MDCT

The objective of this study was to evaluate the accuracy of electrocardiography (ECG)-gated 16-slice multidetector-row computed tomography (MDCT) in detection of stenosis of bypass grafts and native coronary arteries in patients who have undergone coronary artery bypass grafting (CABG). ECG-gated contrast-enhanced MDCT using 12 x 0.75-mm collimation was performed in 20 patients with recurrent angina 4.75 years after undergoing CABG. A total of 50 grafts, 16 arterial and 34 venous, were examined. All graft and coronary segments were evaluated for stenosis in comparison with conventional coronary angiography (CCA). Among the 80 arterial graft segments, 62 could be assessed (77.5%). Sensitivity, specificity, and positive and negative predictive values for stenosis were 96.2%, 97.2%, 96.2%, and 97.2%, respectively. In a total of 180 venous graft segments, 167 could be assessed. Sensitivity, specificity, and positive and negative predictive values for stenosis were 98.5%, 93.9%, 91.8%, and 98.9%, respectively. MDCT could assess 179 of 260 native coronary artery segments (68.8%). Sensitivity, specificity, and positive and negative predictive values for stenosis were 92.1%, 76.9%, 87.5%, and 84.7%, respectively. Sixteen-slice MDCT provides excellent image quality and diagnostic accuracy in detection of graft and coronary artery lesions in patients with suspected graft dysfunction.

Integrated cardio-thoracic imaging with ECG-Gated 64-slice multidetector-row CT: initial findings in 133 patients

The purpose of this study was to investigate the possibility of assessing the underlying respiratory disease as well as cardiac function during ECG-gated CT angiography of the chest with 64-slice multidetector-row CT (MDCT). One hundred thirty-three consecutive patients in sinus rhythm with known or suspected ventricular dysfunction underwent an ECG-gated CT angiographic examination of the chest without beta-blockers using the following parameters: (1) collimation: 32 x 0.6 mm with z-flying focal spot for the acquisition of 64 overlapping 0.6-mm slices (Sensation 64; Siemens); rotation time: 0.33 s; pitch: 0.3; 120 kV; 200 mAs; ECG-controlled dose modulation (ECG-pulsing) and (2) 120 ml of a 35% contrast agent. Data were reconstructed: (1) to evaluate the underlying respiratory disease (1-mm thick lung and mediastinal scans reconstructed at 55% of the R-R interval; i.e., "morphologic scans") and (2) to determine right (RVEF) and left (LVEF) ventricular ejection fractions (short-axis systolic and diastolic images; Argus software; i.e., "functional scans"). The mean heart rate was 73 bpm (range: 42-120) and the mean scan time was 18.11 +/- 2.67 s (range: 10-27). A total of 123 examinations (92%) had both lung and mediastinal images rated as diagnostic scans, whereas 10 examinations (8%) had non-diagnostic images altered by the presence of respiratory-motion artifacts (n = 4) or cyclic artifacts related to the use of a pitch value of 0.3 in patients with a very low heart rate during data acquisition (n = 6). Assessment of right and left ventricular function was achievable in 124 patients (93%, 95% CI: 88-97%). For these 124 examinations, the mean RVEF was 46.10% (+/- 9.5; range: 20-72) and the mean LVEF was 58.23% (+/- 10.88; range: 20-83). In the remaining nine patients, an imprecise segmentation of the right and left ventricular cavities was considered as a limiting factor for precise calculation of end-systolic and end-diastolic ventricular volumes. The mean (+/- SD) DLP value of the examinations was 279.86 (+/- 117.50) mGy.cm. Assessment of underlying respiratory disease and cardiac function from the same data set was achievable in 92% of the patients with ECG-gated 64-slice MDCT.

Accurate estimation of global and regional cardiac function by retrospectively gated multidetector row computed tomography

Retrospective reconstruction of ECG-gated images at different parts of the cardiac cycle allows the assessment of cardiac function by multi-detector row CT (MDCT) at the time of non-invasive coronary imaging. We compared the accuracy of such measurements by MDCT to cine magnetic resonance (MR). Forty patients underwent the assessment of global and regional cardiac function by 16-slice MDCT and cine MR. Left ventricular (LV) end-diastolic and end-systolic volumes estimated by MDCT (134+/-51 and 67+/-56 ml) were similar to those by MR (137+/-57 and 70+/-60 ml, respectively; both P=NS) and strongly correlated (r=0.92 and r=0.95, respectively; both P<0.001). Consequently, LV ejection fractions by MDCT and MR were also similar (55+/-21 vs. 56+/-21%; P=NS) and highly correlated (r=0.95; P<0.001). Regional end-diastolic and end-systolic wall thicknesses by MDCT were highly correlated (r=0.84 and r=0.92, respectively; both P<0.001), but significantly lower than by MR (8.3+/-1.8 vs. 8.8+/-1.9 mm and 12.7+/-3.4 vs. 13.3+/-3.5 mm, respectively; both P<0.001). Values of regional wall thickening by MDCT and MR were similar (54+/-30 vs. 51+/-31%; P=NS) and also correlated well (r=0.91; P<0.001). Retrospectively gated MDCT can accurately estimate LV volumes, EF and regional LV wall thickening compared to cine MR.