Word Test Research Articles

Brain iron deposition and cognitive decline in patients with cerebral small vessel disease : a quantitative susceptibility mapping study

BackgroundQuantitative susceptibility mapping (QSM) can study the susceptibility values of brain tissue which allows for noninvasive examination of local brain iron levels in both normal and pathological conditions.PurposeOur study compares brain iron deposition in gray matter (GM) nuclei between cerebral small vessel disease (CSVD) patients and healthy controls (HCs), exploring factors that affect iron deposition and cognitive function.Materials and methodsA total of 321 subjects were enrolled in this study. All subjects had cognitive examination including the Stroop color word test (SCWT) and MRI including multiecho gradient echo (mGRE) sequence. The patients with CSVD were divided into mild to moderate group (CSVD-M, total CSVD score ≤ 1) and severe group (CSVD-S, total CSVD score > 1). Morphology-enabled dipole inversion with an automated uniform cerebrospinal fluid zero reference algorithm (MEDI + 0) was used to generate brain QSM maps from mGRE data. Deep gray regional susceptibility values and cognitive function were compared among three groups (CSVD-S, CSVD-M, and HC) using multiple linear regression analysis and mediation effect analysis.ResultsThere were significant differences in the SCWT scores and mean susceptibility values of the globus pallidus (GP), putamen (Put), and caudate nucleus (CN) among the three groups (P < 0.05, FDR correction). Age had a significant positive impact on the susceptibility values of GP (p = 0.018), Put (p < 0.001), and CN (p < 0.001). A history of diabetes had a significant positive influence on the susceptibility values of Put (p = 0.011) and CN (p < 0.001). A smoking history had a significant positive association with the susceptibility values of CN (p = 0.019). Mediation effect analysis demonstrated that iron deposition in the neostriatum partially mediated the relationship between hypertension and cognitive function. Age, diabetes, and smoking may increase iron deposition in the basal ganglia, associated with cognitive decline. The mean susceptibility values of the neostriatum played a mediating role in the association between hypertension and cognitive scores.ConclusionsAge, diabetes, and smoking are associated with increased iron deposition in the basal ganglia and also linked to cognitive decline. This can help with understanding CSVD and its prevention and treatment.

The impact of brain-systemic oxygenation coupling in sleep-disordered breathing on cognitive function in elderly

Background: Intermittent hypoxia, a consequence of sleep-disordered breathing (SDB), may contribute to an increased risk of cognitive decline. However, the association between SDB and cognition remains highly variable. Methods: Fifty-two community-dwelling healthy older adults (28 women) were recruited. All participants underwent neuropsychiatric evaluations, simultaneous ambulatory polysomnography (PSG), and near-infrared spectroscopy (NIRS) recordings. We quantified the average coherence between oxy-Hb and SpO2 signals during SDB events to determine whether it could predict cognitive outcomes in healthy older adults, where higher coherence indicates reduced protection against systemic hypoxia. Results: The mean (SD) coherence of oxy-Hb and SpO2 was 0.16 (0.07). Linear regression analysis showed a significant association between mean coherence and worse Stroop Color Word Test scores (t=-0.304, p = .004). In contrast, oxy-Hb reduction alone and conventional SDB parameters did not show a significant association with cognition. Conclusion: This is the first report to demonstrate an association between a novel parameter of brain-systemic oxygenation coherence in SDB and cognition in older adults. A higher coherence rate of cortical oxy-Hb and systemic SpO2 during SDB may reflect a loss of compensatory mechanisms against systemic hypoxia and could help stratify older adults with a higher risk for cognitive decline.

Acute Effects of Unplanned and Planned Hop-Landing Training on Neurocognitive Function and Knee Biomechanics.

Athletes with decreased baseline neurocognitive function may experience noncontact anterior cruciate ligament (ACL) injury in unanticipated athletic situations. Many ACL injury prevention programs (IPPs) focus on improving closed-skill movements (eg, planned landing). However, the more open-skill movements (eg, unplanned reactive movements) required in unpredictable sports scenarios are commonly absent from ACL IPPs, and the acute effects of open-skill training on neurocognitive function remain unclear. To investigate the acute effects of unplanned versus planned training on neurocognitive function and knee biomechanics associated with ACL injury risk during the side-step cutting motion. Controlled laboratory study. A total of 32 adult recreational athletes (16 female, 16 male) were randomly assigned to either an unplanned training (UT) group or a control (CON) group. The UT group performed unplanned hop-landing training while the CON group performed planned hop-landing training. Both before and after the training, neurocognitive function was evaluated using the Trail Making Test-part B and Stroop Color and Word Test. Additionally, unanticipated and anticipated side-step cutting tasks were performed while 3-dimensional kinematic and kinetic data for the dominant leg were collected. Neurocognitive test scores and biomechanical variables relevant to ACL injury were analyzed using 2-way repeated-measures analysis of variance to determine the main effects of training, group, and training × group interaction. Trail Making Test-part B and Stroop Color and Word Test scores significantly improved from pre- to posttraining in both groups (P < .001 for both). There was a significant training × group interaction for peak knee abduction angle during the unanticipated side-step cutting task (pre- vs posttraining: -8.81°± 7.23° vs -7.40°± 7.24° [UT group]; -8.23°± 9.40° vs -9.99°± 9.83° [CON group]; P = .02) and for peak vertical ground-reaction force during the anticipated side-step cutting task (pre- vs posttraining: 3.86 ± 0.59 vs 4.08 ± 0.74 percentage body weight [%BW] [UT group]; 3.70 ± 0.62 vs 3.34 ± 0.62 %BW [CON group]; P = .04). Study findings showed a significant training × group interaction for knee abduction angle during the unanticipated side-step cutting task with unplanned training and for vertical ground-reaction force during the anticipated side-step cutting task with planned training. Designing ACL IPPs based on the sport type (ie, open skill or closed skill) may contribute to better preparation.

Online Auditory Abilities Screening in Elderly: Initial Considerations

Objective. To analyze the results of AudBility's online screening in the elderly to assess its viability. Methodology. The study included 40 elderly participants (mean age 67.4 years). They underwent online AudBility screening and completed a self-assessment questionnaire along with tests assessing seven auditory skills: sound localization (SL), dichotic digits task, speech perception in noise, auditory closure, staggered dichotic words test (SDW), temporal resolution, and temporal ordering. Descriptive data analysis considered AudBility's reference parameters: &lt;50% = abnormal, 51-79% caution, &gt;80% = normal. Results. The tests with the highest frequency of abnormalities were SL and temporal ordering frequency (TOF), both with 22.5%. On average, these tests were considered as "caution" (SL = 72.75%; TOF = 67.5%). The self-assessment questionnaire had the highest frequency of "caution" results (52.5%), followed by SDW (35%) and TOF (32.5%). On average, the self-assessment questionnaire and TOF showed caution values (74.41% and 67.5%, respectively). SDW had normal average values (81.5%). No test showed abnormal average values. Conclusion. Auditory screening using AudBility can serve as an entry point for assessing auditory and cognitive health in the elderly population, guiding referrals and therapies before in-person interventions.

Assessment of speech sound disorders: Clinical experiences of Speech-language pathologists in Iran.

Speech-language pathologists (SLPs) in non-English speaking countries face challenges when assessing children for speech sound disorders (SSD). Exploring their clinical challenges in service delivery-along with their problem-solving approaches-may contribute to the development of instruments for clinical use in such settings. The study aimed to explore assessment methods used by Iranian SLPs to identify children with SSD. A cross-sectional survey took place with 113 SLPs working with children with SSD. The survey comprised 36 items grouped into four main themes-service delivery, types of assessments procedures, challenges of evaluating SSD, and ways of keeping up to date. Results were analysed based on participants' levels of education and experience. Participants used Persian as the primary language in their work, and over 70% provided services in a private setting. Most participants reported having between 10-30% of clients with SSD in their caseload. Most (73.5%) SLPs involve parents in completing the history form. They favour informal traditional articulation tests, with approximately half the sample selecting this approach from the 14 options presented to them, especially those with bachelor's degrees and minimal experience. More experienced SLPs (62.7%) chose the Polysyllabic Words Test. Assessment, whether formal or informal, was found to be time-consuming by the majority of respondents (18.6% always, 42.5% often). Self-study (65.5%) and taking part in workshops/webinars/journal clubs (60.1%) were ways to keep their knowledge current. Our findings are similar to other international survey results on SSD evaluation. Although many Iranian SLPs use informal traditional articulation tests, such assessments are limited in their analysis and the diagnostic information provided. The findings emphasise the need for clear phonological assessment guidelines, valid and reliable 'clinician friendly' instruments, equitable distribution of tools across the country, and suitable tools for bi/multilingual communities.

Digital infrastructure and cognitive ability of children

Digital technologies have become an integral part of most children’s lives, significantly influencing their development. This study takes the Broadband China Pilot Policy as a quasi-experiment, using the data from China Family Panel Studies (CFPS) to analyze the effects of digital infrastructure on children’s cognitive ability. The extended two-way fixed effects estimator was employed to conduct the Staggered Difference-in-Differences estimation. The findings indicate that the average treatment effect of treatment group of “Broadband China” is significantly positive on children’s cognitive ability. Additionally, heterogeneities of gender and urban-rural were found: (1) The Broadband China policy had a significant positive impact on boys only; (2) The policy had a greater and more significant impact on the word test scores results of urban children; (3) The policy had a negative impact on the math test scores of urban children, while showing a positive impact on the math test scores of rural children. Finally, the paper makes the following recommendations: (1) Digital infrastructure development should be emphasized; (2) More emphasis should be placed on rural areas when building digital infrastructure; (3) Gender differences should be considered when formulating policies to help girls benefit from digital technologies.

Long -term multimodal exercise intervention for patients with frontotemporal lobar degeneration: Feasibility and preliminary outcomes

Introduction: After Alzheimer's disease, frontotemporal lobar degeneration (FTLD) is the second most common form of early-onset dementia. Despite the heavy burden of care for FTLD, pharmacological and non-pharmacological treatments with sufficient efficacy remain scarce. This study aimed to evaluate the feasibility of a multimodal exercise program for FTLD and to examine preliminary changes in the clinical outcomes of the program in FTLD. Methods: This single-arm preliminary study was conducted from July 2017 to July 2018 and recruited four male patients with FTLD aged 60–78 years. Patients exercised under the supervision of an exercise instructor once every 2 weeks for 48 weeks. The multimodal exercise program comprised cognitive training, moderate-intensity continuous training, strength training, balance training, and flexibility and relaxation training. Feasibility was measured using dropout and attendance rates. Cognitive, psychological, physical, and behavioral function tests were conducted before and after the intervention. Results: All patients completed the intervention (100%) and attended well (93.6%). Positive changes in scores in the Stroop Color Word Test (cognitive; 5 out of 6 items), Mood Check List-short form 2 (psychological), movement subscales of the Stereotypy Rating Inventory (behavioral), and timed up-and-go (TUG, physical) assessments demonstrated a medium-to-high effect size (open effect size: 0.52–0.97). While there were improvements in some domains, such as recovery self-efficacy and exercise efficacy, the MMSE-J scores showed an overall slight decline, especially in the SD case where a marked decrease was observed. Additionally, three physical function items showed no effect, except for a positive outcome in the TUG test. Functional near-infrared spectroscopy (fNIRS) revealed increased activation in the frontal lobe, indicated by elevated oxygenated hemoglobin levels before and after the exercise intervention. This pattern of activation suggests that the intervention may have stimulated neural activity in the frontal lobe, potentially enhancing cognitive and behavioral functions, including executive function and attention. Conclusion: The long-term multimodal exercise intervention may be feasible and positively change the cognitive, psychological, physical, and behavioral functions in older adults with FTLD. Although the intervention led to improvements in certain areas, there were also declines observed in various functions, which may not necessarily be due to the intervention itself but rather reflect the natural progression of the disease.

Effects of acute rope skipping exercises of different exercise modes on cognitive function in 9–10-year-old children

To explore the effects of acute high-intensity interval rope skipping exercise and acute moderate-intensity continuous rope skipping exercise on cognitive function in 9–10-year-old children, this study aims to inform the selection of appropriate jump rope methods for cognitive training in physical activities. A total of 60 students from two classes of fourth grade in a primary school were selected as research subjects. After matching according to gender, they were randomly divided into HIIT group, MICT group and control group. The Digit Span Test (DST), Attention Network Test (ANT) and Stroop Color Word Test were conducted three days before the intervention and 5 min after the intervention. During the intervention, the HIIT group performed a high-intensity intermittent rope skipping exercise (required fast jumping with feet together, practice for 1 min and rest for 1 min, jump continuously for 5 groups, and the exercise intensity is ≥ 85% of the maximum heart rate), while the MICT group performed a moderate-intensity continuous rope skipping exercise (required to medium jumping with feet together, jump continuously for 5 min, and the exercise intensity is 60–80% of the maximum heart rate), and the control group rests in place. After the intervention, both HIIT and MICT groups showed increased DST total scores, improved executive control network efficiency, and faster inhibitory control response speeds, with no significant changes in accuracy. The HIIT group also exhibited increased orienting network efficiency and no significant changes in accuracy. Acute rope skipping exercises using HIIT and MICT methods can improve the working memory, executive control network efficiency and inhibitory control ability of children aged 9–10 years old. Additionally, conducting acute rope skipping exercises using HIIT method can also enhance their orienting network efficiency.

Influence of the degree of hearing impairment on central auditory processing in people with presbycusis

BackgroundAuditory processing involves decoding auditory impulses along auditory pathways in the central nervous system. Aging causes a decline in hearing and auditory processing abilities. Difficulties in auditory information processing include limitations in transferring, processing, organizing, transforming, analyzing, storing, recalling, and using auditory information. The aim of this research was to examine the influence of hearing impairment on auditory processing abilities in people with presbycusis. In addition, this research aimed to determine whether gender and age affect auditory processing in people with presbycusis.MethodThe research included 43 participants, 59–90 years of age. The PSP-1 Auditory Processing Disorder Test Battery was used to examine auditory processing abilities. We also used liminal tonal audiometry and the Short Portable Mental Status Questionnaire–SPMSQ.ResultsThe participants achieved the worst results on the speech-in-noise test and the dichotic word test. A statistically significant difference was found in auditory processing abilities with regard to age (p < 0.001) and the degree of hearing impairment (p < 0.001). No statistically significant differences were determined in relation to gender. Regression analysis pointed out the degree of hearing impairment as a significant predictor of auditory processing abilities (p < 0.001).ConclusionAuditory processing abilities decline with age, and the degree of hearing impairment significantly affects these abilities.

Effects of 24-Hour Diet- or Exercise-Induced Energy Availability Manipulations on Substrate Utilization and Performance.

To examine sex-based differences in substrate oxidation, postprandial metabolism, and performance in response to 24-hour manipulations in energy availability (EA), induced by manipulations to energy intake (EI) or exercise energy expenditure (EEE). In a Latin Square design, 20 endurance athletes (10 females using monophasic oral contraceptives and 10 males) undertook five trials, each comprising three consecutive days. Day one was a standardized period of high EA; EA was then manipulated on day two; post-intervention testing occurred on day three. Day two EA was low/high/higher EA (LEA/HEA/GEA) at 15/45/75 kcal·kg-1FFM·day-1, with conditions of LEA and HEA separately achieved by manipulations of either EI or EEE (LEA REST/EX vs. HEAREST/EX). On day three, fasted peak fat oxidation during cycling and two-hour postprandial (high carbohydrate and energy meal) metabolism were assessed, alongside several performance tests: Wingate, countermovement jump (CMJ), squat jump (SJ), isometric mid-thigh pull (IMTP), and the Stroop Color and Word Test. Highest peak fat oxidation occurred under LEA induced by exercise (p < 0.01), with no difference between sexes. Postprandial glucose (p < 0.01) and insulin (p < 0.05) responses were highest across both sexes when LEA was induced by diet. Relative peak and mean power throughout the Wingate, alongside CMJ height did not differ between EA conditions (p > 0.05), while SJ height was lower during GEA than both LEAREST (p = 0.045) and HEAEX (p = 0.016). IMTP peak force and the Stroop effect did not change with altered EA (p > 0.05). Acute (24-hour) exercise-induced LEA influenced fasted substrate oxidation more than diet-induced LEA, while 24 hours of LEA did not impair strength/power, sprint capacity, or cognitive performance. Finally, the responses to EA manipulations did not differ between sexes.

Alterations of cognitive functions post traumatic upper limb injuries in adults: A longitudinal study

ABSTRACT Recent studies have demonstrated a possible association between cognitive impairments and traumatic upper limb injuries. This study aims to track the cognitive changes in individuals with such injuries. In this longitudinal study, 36 participants with traumatic upper limb injuries and 36 uninjured participants were enrolled. Cognitive functions were assessed using the Rey Auditory Verbal Learning Test (RAVLT) and the Stroop Color and Word Test (SCWT) over a period of 6 months, with evaluations conducted on three occasions: 1 month (T1), 3 months (T2), and 6 months (T3). The results revealed that participants with nerve injuries exhibited significantly lower RAVLT scores overall and at each time point (Overall: Wald χ2 = 7.99, P < .05; T1: Wald χ2 = 7.61, P < .05; T2: Wald χ2 = 5.95, P < .05; T3: Wald χ2 = 5.76, P < .05). In contrast, no significant impairment in RAVLT performance was observed in participants without nerve injuries. Additionally, the SCWT showed no significant differences between injured and uninjured participants over the six-month period (P > .05). In conclusion, traumatic nerve injuries to the upper limbs negatively affect memory, and this impairment does not spontaneously recover within six months.

Active piezoelectric bone conduction implant Osia® 2 - evaluation of surgery and one-year audiological and quality of life benefits.

To present the surgical outcomes and one-year audiological and quality of life results of implantation of the Osia®2 active piezoelectric bone conduction implant. Twenty adults with mixed and conductive hearing loss were implanted with the Osia® 2 system and followed up for at least one year. The surgical course, healing, and soft tissue condition were assessed. Audiometric tests included pure tone audiometry, speech audiometry and direct bone conduction measurements. Participants completed the APHAB and SSQ questionnaires. All surgeries were successful. No soft tissue problems were observed. Pure tone audiometry showed a mean functional gain of 47.4 ± 5.6 dB HL (p = 0.000089). The Polish Monosyllabic Word Test showed mean improvements for silent, medium and loud speech of 59.5 ± 1.8%, 46.5 ± 32.3% and 13.3 ± 20.9% in quiet and 38.5 ± 24.4%, 62.0 ± 9.1%, and 36.5 ± 34.4% in noise (all p < 0.05). The Polish Matrix Test indicated a mean SNR improvement of 8.78 ± 2.31 dB SPL (p = 0.000155). BC in situ measurements were significantly better post-implantation compared to preoperative levels with Baha®6Max on the Softband. APHAB scores showed significant improvements in global, ease of communication, background noise and reverberation scores (all p < 0.001). SSQ scores improved significantly in speech, spatial and quality subscales (all p < 0.000001). The Osia®2 implantation is an effective treatment for patients with mixed and conductive hearing loss. The surgery is relatively easy and safe, with no significant postoperative or magnet pressure-related complications. Osia®2 significantly improves speech understanding in noise and reduces communication problems.

Effects of thematic art programs on cognitive function and depressive symptoms in older adults

ABSTRACT The rapid aging of the global population underscores the need to employ innovative strategies, such as creative aging, to address the accompanying opportunities and challenges. This study investigated the effects of a thematic art program on cognitive abilities and depressive symptoms in older adults. An 8-week art program was developed. Participants attended weekly 2-hour sessions that focuses on connections with life experiences and the link between music and color. The study recruited 40 older adults aged between 60 and 90 years. Among the recruited older adults, 31 completed the entire program. The adults were recruited from community care centers in Northern Taiwan. The Montreal Cognitive Assessment, Stroop Color and Word Test, and Geriatric Depression Scale were used to assess cognitive and depressive symptoms. Participatory program observations and follow-up interviews were conducted to cross-check the results. Significantly improved cognitive abilities (in the overall cognitive function, visuospatial/executive, and orientation domains), executive function, and selective attention were observed. Additionally, the participants reported significantly reduced depressive symptoms. The intervention maintained and improved the physical and mental health of the participants. The empirical results provide a practical reference for developing art programs for older adults.

Effectiveness of vestibular therapy as an adjunct to cognitive therapy to improve cognition in elderly with mild cognitive impairment (MCI)

The rapid global increase in aging populations is leading to a rise in age-related conditions like mild cognitive impairment (MCI), necessitating new treatment strategies. This study will conduct a double-blinded, three-arm, randomized controlled trial to evaluate the effectiveness of adding vestibular therapy to cognitive therapy (VT+CT) compared to cognitive therapy (CT) alone and a control group. Participants will be assigned to one of three groups: VT+CT, CT only, or a control group. The VT+CT group will receive vestibular rehabilitation exercises along with a computerized brain program, while the CT group will get only the computerized brain program. Primary outcomes will include electroencephalography (EEG), the Digit Symbol Substitution Test (DSST), and event-related potential (ERP-P300). Secondary outcomes will be the Stroop Color Word Test (SCWT), Trail-Making Test (TMT), and European Quality 5 Dimensions (EQ-5D-5L). This research aims to determine if VT+CT improves cognitive function in elderly individuals with MCI.

Comparative effects of cognitive and instability resistance training versus instability resistance training on balance and cognition in elderly women

This study investigates the effects of integrated instability resistance training and cognitive training (IRCT) versus isolated instability resistance training (IRT) on balance, gait, muscle strength, and cognitive functions in elderly women.This randomized controlled trial included 36 participants, with 18 in the IRCT group and 18 in the IRT group. The sample size was estimated to achieve a statistical power of 0.95 with a large effect size (0.40; n = 12 each group). The closed-eye single-leg stand test was measured for static balance, the closed-eye stepping test, and the Timed Up and Go Test (TUGT) were measured for dynamic balance. Dual-task balance was assessed by combining the TUGT with cognitive tasks (TUGT-C) and motor tasks (TUGT-M). Gait performance was evaluated using a gait function system. Lower limb muscle strength was measured with the 30-Second Chair Stand Test. Cognitive function was assessed through the Trail Making Test (TMT), Digit Span Test (DST), Stroop Color and Word Test (Stroop), and Digit Symbol Substitution Test (DSST). Results IRCT group showed better improvements in both cognitive (p < 0.001) and motor (p = 0.812 for baseline; p < 0.001 for post-intervention) dual-task abilities, IRCT also experienced better enhancement in certain cognitive functions, particularly in the TMT (p = 0.001) and DSST (p = 0.022) compared to the IRT group. Both groups demonstrated enhancements in walking abilities as shown on selective markers of the gait performance test (p < 0.05) and leg muscle strength via 30-Second Chair (p < 0.001 for time main effect). These results suggest that combining cognitive exercises with physical training more effectively addresses the complex challenges associated with aging in women. The study highlights the potential of comprehensive training approaches in boosting health and quality of life for the elderly, with implications for developing tailored exercise programs focused on reducing fall risks and enhancing quality of life in this population.

Picture communication symbols and voice symbols: iconicity and preference among healthy older adults in Taiwan

Purpose: Unaided (e.g., speech and gestures) and aided (e.g., symbol corpuses) communication modes facilitate older adults’ expression and comprehension. Adults aged 65 years and above constituted 18.27% of Taiwan’s total population in 2023; hence, prioritizing high-quality healthcare for older adults becomes critical. Commercial symbol corpuses, such as Picture Communication Symbols (PCS) and Voice Symbols (VS), play a vital role in aiding older adults with expression and comprehension in Taiwan. Previous studies on iconicity and preference of symbol corpuses have primarily been conducted in Western and South Asian cultural communities. However, these findings may not apply to all Asian communities. Hence, studies investigating these aspects in specific communities are needed. Through quantitative nonexperimental observations, we explored the iconicity of and preference for PCS and VS among 30 healthy older adults in Taiwan. Materials and Methods: A total of 12 practice words and test words each, familiar to the participants and socially and culturally validated, were selected for the developed VS–PCS iconicity and preference measurement. Verbal choices were made to select one line drawing in both measurements. Results & Conclusions: The findings revealed that VS is significantly more transparent and preferred than PCS. Accounting for the iconicity of and preferences for symbol corpuses is pivotal for symbol selection.

Large-scale structural covariance networks changes relate to executive function deficit in betel quid-dependent chewers.

Previous studies demonstrate deficits in executive function for betel quid-dependent (BQD) patients. Large-scale structural covariance network (SCN) based on gray matter (GM) morphometry may be able to explore the neural mechanism of executive dysfunction in BQD individuals. This study aims to identify spatial covariance patterns of GM volume and to investigate their association with executive dysfunction in BQD individuals. Sixty-four BQD individuals and 48 sex- and age-matched healthy controls (HCs) underwent T1-weighted structural MRI examination and executive function assessments, including the Backward Digit Span (BDS) test and Stroop Color and Word (SCW) test. Seventy SCNs based on GM volume covariance patterns were defined using independent component analysis. An SCN-based classifier was constructed to differentiate between BQD and HC individuals. Receiver operating characteristic (ROC) curves were applied to evaluate the performance of the SCN-based classifier. Linear regression analyses were performed to investigate the association between SCN network indices and executive function indices. Six SCNs had higher classifications for differentiating between BQD and HC individuals. The area under the ROC curve of the SCN-based classifier was 0.812 in the training set and 0.771 in the testing set. Furthermore, linear regression analyses demonstrated that the network indices in the thalamus were associated with BDS scores adjusted for age, sex, and education. Large-scale SCNs could provide potential imaging markers for differentiating BQD and HC groups. The loss of network index in the thalamus was associated with working memory, indicating that SCNs could reveal executive dysfunction in BQD individuals.

Genetically stratified Parkinson's disease with freezing of gait is related to specific pattern of cognitive impairment and non-motor dominant endophenotype.

Freezing of gait (FOG) is an important milestone in the individual disease trajectory of people with Parkinson's disease (PD). Based on the cognitive model of FOG etiology, the mechanism behind FOG implies higher executive dysfunction in PDFOG+. To test this model, we investigated the FOG-related phenotype and cognitive subdomains in idiopathic PD (iPD) patients without genetic variants linked to PD from the Luxembourg Parkinson's study. A cross-sectional analysis comparing iPDFOG+ (n = 118) and iPDFOG- (n = 378) individuals was performed, followed by the application of logistic regression models. Consequently, regression models were fitted for a subset of iPDFOG+ (n = 35) vs. iPDFOG- (n = 126), utilizing a detailed neuropsychological battery to assess the association between FOG and cognitive subdomains. Both regression models were adjusted for sociodemographic confounders and disease severity. iPDFOG+ individuals presented with more motor complications (MDS-UPDRS IV) compared to iPDFOG- individuals. Moreover, iPDFOG+ individuals exhibited a higher non-motor burden, including a higher frequency of hallucinations, higher MDS-UPDRS I scores, and more pronounced autonomic dysfunction as measured by the SCOPA-AUT. In addition, iPDFOG+ individuals showed lower sleep quality along with lower quality of life (measured by PDSS and PDQ-39, respectively). The cognitive subdomain analysis in iPDFOG+ vs. iPDFOG- indicated lower scores in Benton's Judgment of Line Orientation test and CERAD word recognition, reflecting higher impairment in visuospatial, executive function, and memory encoding. We determined a significant association between FOG and a clinical endophenotype of PD with higher non-motor burden. While our results supported the cognitive model of FOG, our findings point to a more widespread cortical impairment across cognitive subdomains beyond the executive domain in PDFOG+ with additional higher impairment in visuospatial function and memory encoding.

Executive function tests: Normative data for Spanish-speaking adults in the United States.

Normative data for Spanish-speaking populations, particularly Hispanics in the U.S., is notably scarce. This study aims to establish normative data for executive function tests (Modified Wisconsin Card Sorting Test and Stroop Color and Word Test) among Spanish-speaking Hispanics in the U.S. We assessed 245 individuals aged 18-80 from eight U.S. states (California, Connecticut, Florida, Indiana, New Jersey, Oregon, Virginia, and Wisconsin) and employed Bayesian regression to estimate norms, considering various sociodemographic factors influencing performance. The posterior distribution suggests a high probability that age impacts SCWT performance, with older adults likely to show greater declines, particularly among those with high proficiency in Spanish. The posterior distribution suggests a stronger effect of age on M-WCST performance among individuals with longer U.S. residency. Educational attainment demonstrates a robust positive impact on M-WCST outcomes, with lower levels of education associated with a higher probability of increased errors. An interaction between education and Spanish proficiency was observed, influencing SCWT scores differently across proficiency levels. Sex and acculturation levels interact to affect SCWT performance, with distinct patterns observed between men and women. This suggests that the impact of acculturation on cognitive test performance may vary by gender. Establishing culturally sensitive normative data can enhance accurate identification of executive dysfunction and reduce misdiagnosis risks. This study underscores the importance of considering sociocultural factors including acculturation and language proficiency in neuropsychological assessments to better serve diverse populations.

Exploring the efficacy of memory specificity training on depression among Iranian adolescents: a comparative analysis of online vs. in-person delivery

Depression in adolescence is common worldwide, with the burden being highest in low- and middle-income countries. This study assessed the efficacy of in-person Memory Specificity Training (MeST) and computerized MeST (c-MeST) as cognitive training programs aimed at addressing depression among Iranian adolescents. A secondary aim was to evaluate the efficacy of MeST and c-MeST on autobiographical memory specificity, emotion regulation and cognitive control. Ninety Iranian male adolescents (aged 13–18 years) with depression were randomly assigned to three groups; MeST group (n = 30), c-MeST group (n = 30) and the non-active control group (n = 30). Participants completed the Beck Depression Inventory-II, Autobiographical Memory Test, Cognitive Emotion Regulation Questionnaire, Wisconsin Card Sorting Test and Stroop Color and Word Test. The groups underwent either MeST and c-MeST. All the assessments were re-conducted after the intervention (post-intervention) and at 1-month post-intervention (follow-up). The in-person MeST group exhibited significantly higher autobiographical memory specificity at post-intervention and follow-up compared to the c-MeST group. Both groups demonstrated significantly lower levels of depression at post-intervention and follow-up. Both groups showed improvements in emotion regulation and cognitive control, which were found to mediate improvements in depression symptomatology. c-MeST and MeST appear promising brief interventions for the treatment of depression among adolescents in Iran.