Event Abstract Back to Event Hippocampal P300 recorded during a simple auditory reaction time task (intracerebral study) Robert Roman1*, Jan Chladek2, Milan Brazdil3, Ivan Rektor3, Pavel Jurak2 and Miloslav Kukleta4 1 Faculty of Medicine, Masaryk University, Czechia 2 Academy of Science, Czechia 3 St. Anne Hospital, Czechia 4 CEITEC - Central European Institute of Technology, Masaryk University, Czechia This paper attempts to make possible time relationship of hippocampal P300, evoked by 1 kHz tone during a simple sensorimotor task, to stimulus or motor response. In 9 patients with medically intractable epilepsies, depth electrodes were implanted to localize the seizure origin prior to surgical treatment. 19 of 70 electrodes were targeted into the hippocampus. Each subject was instructed to respond to the 1 kHz tone by pressing a button in the dominant hand. P300 components recorded in the hippocampus were analyzed both in stimulus-locked and response-locked averages, which were separately averaged for fast and slow responses. Local generation of hippocampal P300 was demonstrated in all 19 electrodes. The mean latency was 415±58 ms, the mean amplitude was 108±87 mV. Three different types of time relationships of hippocampal P300 were found: 1) time-locked to the stimulus - in 12 cases/6 patients; 2) time-locked to the motor response - in 2 cases/1 patient; and 3) ambiguous time relationship to stimulus and motor response - in 5 cases/3 patients. The three types of relationships were found in both left and right hemispheres. Our results show that the hippocampus in all the patients evoked a response during a simple sensorimotor task. The finding of the three different types of time relationships to stimulus and to motor response is in accordance with the results we obtained during visual oddball task. It may suggest that at least certain parts of this structure are involved in simple sensorimotor tasks in all steps of information processing. Funding: Partially supported by the grant MSM0021622404 and grant P103/11/0933 GACR and EC project CZ.1.05/2.1.00/01.0017. Keywords: Intra-cranial Electrophysiology, P300 Conference: XI International Conference on Cognitive Neuroscience (ICON XI), Palma, Mallorca, Spain, 25 Sep - 29 Sep, 2011. Presentation Type: Poster Presentation Topic: Abstracts Citation: Roman R, Chladek J, Brazdil M, Rektor I, Jurak P and Kukleta M (2011). Hippocampal P300 recorded during a simple auditory reaction time task (intracerebral study). Conference Abstract: XI International Conference on Cognitive Neuroscience (ICON XI). doi: 10.3389/conf.fnhum.2011.207.00059 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 15 Nov 2011; Published Online: 25 Nov 2011. * Correspondence: Dr. Robert Roman, Faculty of Medicine, Masaryk University, Brno, Czechia, roman@med.muni.cz Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Robert Roman Jan Chladek Milan Brazdil Ivan Rektor Pavel Jurak Miloslav Kukleta Google Robert Roman Jan Chladek Milan Brazdil Ivan Rektor Pavel Jurak Miloslav Kukleta Google Scholar Robert Roman Jan Chladek Milan Brazdil Ivan Rektor Pavel Jurak Miloslav Kukleta PubMed Robert Roman Jan Chladek Milan Brazdil Ivan Rektor Pavel Jurak Miloslav Kukleta Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.