Α-calcium Sulfate Hemihydrate Research Articles

Preparation of α-calcium sulfate hemihydrate with high mechanical strength from natural fibrous gypsum in KCl-mediated glycerol-water solution

Natural fibrous gypsum is a kind of high-quality gypsum resources, whose high-value added utilization pathway is to be transformed to α-calcium sulfate hemihydrate (α-HH), a cementitious material that can react with water to form pastes with mechanical strength. In this work, α-HH was prepared from natural fibrous gypsum in KCl mediated glycerol-water solution under mild condition. KCl played a simultaneous function on regulating the phase-transition kinetics, morphology and comprehensive strength of α-HH. Addition of low concentration of KCl prominently retarded the nucleation and growth rate of α-HH and decreased its aspect ratio due to the formation of syngenite on the side faces. While further increase of KCl concentration accelerated the nucleation and growth rate and decreased the crystal sizes. In the presence of 0.04 M KCl, the prepared α-HH presented a hexagonal prism shape with a length / width of 257.69–579.71 μm / 13.13–36.61 μm, and its dry comprehensive strength had reached 38.1 MPa that was comparable to those prepared in commercial, chloride and nitrate system. Altogether, the foreign ion-free glycerol-water solution contributed to transforming natural fibrous gypsum to α-HH with high purity and high mechanical strength.

Synergistic preparation and application in PCU of α-calcium sulfate hemihydrate whiskers from phosphogypsum and electrolytic manganese residue

The α-calcium sulfate hemihydrate whiskers (α-CSHWs) were first prepared using phosphogypsum (PG) and electrolytic manganese residue (EMR) as raw materials for coating urea, demonstrating excellent controlled-release properties. The effects of different reaction conditions on α-CSHWs, achieved by optimizing the reaction time, the concentrations of NH4+, Mn2+, and other factors, were discussed. Results showed that when the EMR content was 25 wt%, the reaction temperature was 100 °C, and the reaction time was 3 h, α-CSHWs with a length-to-diameter ratio of 39 were obtained. Through experiments and density functional theory (DFT), the mechanism of α-CSHWs preparation was elucidated. The results show that the addition of EMR reduces the content of impurity ions PO43− and F− in PG while introducing NH4+ and Mn2+. Interestingly, both NH4+ and Mn2+ can reduce the nucleation time of α-CSHWs, while PO43−, Mn2+, and F− are more likely to adsorb on the (0 0 6) crystal plane of α-CSHWs, NH4+ readily adsorbs on the (4 0 0) crystal plane. The controlled-release performance of modified α-CSHWs incorporated into polyurethane-coated urea (PCU) was investigated, and it was found that the addition of Mα significantly prolonged the nutrient release period, with the period extending up to 116 days for coatings of 5wt% and above. This work not only enhances the efficiency of PG and EMR utilization but also serves as a reference for the straightforward synthesis and application of α-CSHWs.

Effects of aligned PLGA/SrCSH composite scaffolds on in vitro growth and osteogenic differentiation of human mesenchymal stem cells.

Strontium (Sr) has important functions in bone remodeling. Incorporating strontium-doped α-calcium sulfate hemihydrate (SrCSH) into poly(lactic-co-glycolic acid) (PLGA) fibrous scaffolds were expected to increase its bio-activity and provide a potential material for bone tissue engineering. In the present study, Sr-containing aligned PLGA/SrCSH fibrous scaffolds similar to the architecture of natural bone were prepared via wet spinning. CCK-8 assay revealed that Sr-containing scaffolds possessed better bioactivity and supported favorable cell growth effectively. The aligned PLGA/SrCSH fibers exerted a contact effect on cell attachment, inducing regular cell alignment and influencing a series of cell behaviors. Releasing of high concentration Sr from a-PLGA/SrCSH scaffolds could induce high expression levels of BMP-2, increase ALP activity and upregulate RUNX-2 expression, and further promote the expressions of COL-I and OCN and the maximum mineralization. This study demonstrated that Sr and ordered structure in a-PLGA/SrCSH fibrous scaffolds could synergistically enhance the osteogenic differentiation of umbilical cord mesenchymal stem cells (UCMSCs) by regulating cell arrangement and expressions of osteogenic genes.

Advanced α-CSH/β-TCP-based injectable paste with magnesium hydroxide and vitamin D-incorporated PLGA microspheres for bone repair

With the development of minimally invasive approaches, calcium-based injectable bone paste has attracted attention as a synthetic alternative due to its biodegradability and analogous composition with native bone. However, this approach is associated with the problem of the materials being absorbed before new bone formation has occurred, with a high resorption, and degradation rate. Here, a poly(lactic-co-glycolic acid) (PLGA)/magnesium hydroxide (MH)/vitamin D (Vit D) microsphere-incorporated α-calcium sulfate hemihydrate (α-CSH)/beta-tricalcium phosphate (β-TCP) injectable paste was designed for the regeneration of bone tissue. The combination of the bioceramic particles with α-CSH demonstrated an appropriate setting time for ease of use in clinical practice and enhanced mechanical properties. Additionally, the introduction of a bone paste with the MH and Vit D-incorporated PLGA microsphere induced osteogenic differentiation and alleviated the inflammatory response, which may occur after massive bone surgery. Based on these findings, this paper presents a versatile bone paste that promotes osteogenesis and modulates the osteoimmune microenvironment for effective bone regeneration.

Facile preparation of α-calcium sulfate hemihydrate whisker from by-product gypsum in chloride-free salt solution system

Lactic acid gypsum (LAG), the by-product from lactic acid preparation, has caused land occupation and environmental pollution. Herein, hemihydrate gypsum (HHG) whisker, an inorganic material with excellent performance, prepared using LAG as the raw material via atmospheric pressure salt solution method was investigated. Nitrate enhanced the salt effect of the solution, which increased the solubility of dihydrate gypsum (DDG), and further accelerated the conversion into HHG. NaNO3 was proved to accelerate the formation of α- HHG whisker, while Mg(NO3)2 promoted its aspect ratio. The whiskers with an average length of 75.9 µm and aspect ratio of 17.8 were achieved under optimum conditions of NaNO3/Mg(NO3)2–0.5:1, mass fraction of LAG–15%, reagent concentration–40%, and the reaction temperature–100 °C. Mg2+ was found to bind with SO42- on the side of the whisker, promoting the growth of the whisker along the c-axis orientation and forming the morphology of high aspect ratios. Hence, it was feasible to achieve the recycling of salt medium by adding medicament containing Mg2+. By employing direct recycling, the salt medium was limited to be effective in two cycles. However, with the addition of the medicament, the salt medium can now be effectively recycled up to four times or more. Such technique realized the high-value utilization of industrial by-product gypsum, guided the HHG whisker preparation via the green and convenient method and reduced the environmental hazards.

The study of self-regulating α-TCP based composite by micro/nano scaled silk fibroin and α-CSH on physicochemical and biological properties of bone cement.

A novel self-hardening α-tricalcium phosphate (α-TCP) bone cement complexed with different content of α-calcium sulfate hemihydrate (α-CSH) and micrometer hydroxyapatite mineralized silk fibroin (HA-SF) using micro/SF as curing liquid has been investigated in this work, which was capable of tunable setting time, degradation, mechanical property and ability to anti-washout. After addition 0 ∼ 25% α-CSH to the α-TCP cement with SFFs as curing liquid, it shortened the setting time of the modified composite to 10 ∼ 30min. Furthermore, the addition of SFFs improved the compressive strength of the composite from 5.41MPa to 9.44MPa. The composites with both Na2HPO4 and SFFs as curing liquid showed good anti-collapse performance. The weight loss ratio of bone cement was -0.18 ∼ 12.08% in 4weeks when the content of α-CSH in α-TCP/α-CSH was between 0 ∼ 25wt%. During the degradation of α-CSH, the amorphous α-TCP were deposited as hydroxyapatite to formed a plate-like products on the surface of composite. Compared to the composite with Na2HPO4 solution as the curing liquid, alkaline phosphatase (ALP) activity of the composites using SFFs as curing liquid were maintained at high levels on the 14th day especially when the Ca/P ratio was 1.7. This study provides a theoretical basis for the regeneration of bone defects guided by bone cement materials.

Preparation and properties of a new artificial bone composite material

To study the preparation and properties of the hyaluronic acid (HA)/α-calcium sulfate hemihydrate (α-CSH)/β-tricalcium phosphate (β-TCP) material (hereinafter referred to as composite material). Firstly, the α-CSH was prepared from calcium sulfate dihydrate by hydrothermal method, and the β-TCP was prepared by wet reaction of soluble calcium salt and phosphate. Secondly, the α-CSH and β-TCP were mixed in different proportions (10∶0, 9∶1, 8∶2, 7∶3, 5∶5, and 3∶7), and then mixed with HA solutions with concentrations of 0.1%, 0.25%, 0.5%, 1.0%, and 2.0%, respectively, at a liquid-solid ratio of 0.30 and 0.35 respectively to prepare HA/α-CSH/ β-TCP composite material. The α-CSH/β-TCP composite material prepared with α-CSH, β-TCP, and deionized water was used as the control. The composite material was analyzed by scanning electron microscope, X-ray diffraction analysis, initial/final setting time, degradation, compressive strength, dispersion, injectability, and cytotoxicity. The HA/α-CSH/β-TCP composite material was prepared successfully. The composite material has rough surface, densely packed irregular block particles and strip particles, and microporous structures, with the pore size mainly between 5 and 15 μm. When the content of β-TCP increased, the initial/final setting time of composite material increased, the degradation rate decreased, and the compressive strength showed a trend of first increasing and then weakening; there were significant differences between the composite materials with different α-CSH/β-TCP proportion ( P<0.05). Adding HA improved the injectable property of the composite material, and it showed an increasing trend with the increase of concentration ( P<0.05), but it has no obvious effect on the setting time of composite material ( P>0.05). The cytotoxicity level of HA/α-CSH/β-TCP composite material ranged from 0 to 1, without cytotoxicity. The HA/α-CSH/β-TCP composite materials have good biocompatibility. Theoretically, it can meet the clinical needs of bone defect repairing, and may be a new artificial bone material with potential clinical application prospect.

Mussel-inspired dynamic facet-selective capping approach to highly uniform α-calcium sulfate hemihydrate crystals.

We report herein a dynamic facet-selective capping (dFSC) strategy for α-calcium sulfate hemihydrate crystal growth from dihydrate gypsum in the presence of a catechol-derived PEI capping agent (DPA-PEI) with inspiration by the biomineralization process of mussel. The crystal shape is controllable and varies from long and pyramid-tipped prisms to thin hexagonal plate. The highly uniform truncated crystals have extremely high compression and bending strengths after hydration molding.

α-Calcium sulfate hemihydrate bioceramic prepared via salt solution method to enhance bone regenerative efficiency

α-calcium sulfate hemihydrate (α-HH) was synthesized by salt solution methods to prepare a promising biomaterial for bone tissue repair and regeneration. The successful synthesis of α-HH was evaluated by field emission scanning electron microscopy (FE-SEM), thermogravimetric analysis (TGA), X-ray diffraction (XRD), and Fourier transform infrared (FTIR) scanning. The sterility of α-HH before and after irradiation with gamma ray was firstly confirmed by Colonies Forming Units (CFU) counting assay, to target the surgical grade application. In vitro tetrazolium bromide (MTT) assay, crystal violet (CV) and acridine orange (AO) staining was performed to assess the initial cytotoxicity and cell attachment ability of α-HH. Further in vivo implantation into rabbit distal femoral condyles defect exhibited the ability of salt solution-synthesized α-HH to promote the localization of osteocytes and osteoblasts, which improve the bone tissue repair and regeneration. The findings suggested that α-calcium sulfate hemihydrate synthesized by salt solution method is a potential material that can be used as bone substitutes.

A new injectable quick hardening anti-collapse bone cement allows for improving biodegradation and bone repair.

The development of injectable cement-like biomaterials via a minimally invasive approach has always attracted considerable clinical interest for modern bone regeneration and repair. Although α-tricalcium phosphate (α-TCP) powders may readily react with water to form hydraulic calcium-deficient hydroxyapatite (CDHA) cement, its long setting time, poor anti-collapse properties, and low biodegradability are suboptimal for a variety of clinical applications. This study aimed to develop new injectable α-TCP-based bone cements via strontium doping, α-calcium sulfate hemihydrate (CSH) addition and liquid phase optimization. A combination of citric acid and chitosan was identified to facilitate the injectable and anti-washout properties, enabling higher resistance to structure collapse. Furthermore, CSH addition (5%-15%) was favorable for shortening the setting time (5-20min) and maintaining the compressive strength (10-14MPa) during incubation in an aqueous buffer medium. These α-TCP-based composites could also accelerate the biodegradation rate and new bone regeneration in rabbit lateral femoral bone defect models in vivo. Our studies demonstrate that foreign ion doping, secondary phase addition and liquid medium optimization could synergistically improve the physicochemical properties and biological performance of α-TCP-based bone cements, which will be promising biomaterials for repairing bone defects in situations of trauma and diseased bone.

Preparation of α-High-Strength Hemihydrate from Flue Gas Desulfurization Gypsum in AlCl3–MgCl2 Solution at Atmospheric Pressure

An industrially feasible process was proposed to produce α-calcium sulfate hemihydrate (α-HH) from FGD gypsum without any additives. In this process, an AlCl3 solution was used to promote the conversion of calcium sulfate dihydrate (DH) to hexagonal prismatic α-HH with high strength at atmospheric pressure. The phase transition kinetics of FGD gypsum was experimentally investigated under conditions: AlCl3 (2–2.5 m), MgCl2 (0–0.4 m) existing in raw FGD gypsum, and the solid–liquid ratio (or solid content %) range of 0.1–2 at 363 K. It was found that increasing the concentrations of MgCl2 in AlCl3 solution accelerated the conversion. The uniform large hexagonal prism HH product was obtained at the folowing optimal conditions: 2.5 mol/kg AlCl3, 0.4 mol/kg MgCl2, solid–liquid ratio of 2, and equilibration time of 2 h at 363 K. The phase diagram of the AlCl3-MgCl2-H2O system was determined by measuring solubility of solids. The E-NRTL activity model was used to construct the phase transition diagram of CaSO4 in AlCl3–MgCl2 media and to judge the stable range of DH and HH.

An injectable pH neutral bioactive glass-based bone cement with suitable bone regeneration ability.

BackgroundAs a class of promising bone augmentation materials, bone cements have attracted particular attention. Due to various limitations, the current bone cements are still imperfect. In this study, an injectable pH neutral bioactive bone cement (PSC/CSC) was developed by mixing phosphosilicate bioactive glass (PSC) and α-calcium sulfate hemihydrate (CSH), with the goal of optimizing bone defects repairs.MethodsA range of compositions (PSC/CSC: 10P/90C, 30P/70C, 50P/50C) were developed and their physicochemical properties evaluated. Their bone regeneration ability was compared to those of two widely used bone cements as controls (calcium phosphate cement (CPC) and Genex®) in rabbit femoral condyle bone defect models for 4, 8 and 12 weeks. Based on physicochemical properties and in vivo bone regeneration ability, the PSC/CSC exhibited the best outcomes was selected. Then, in vitro, the effects of selected PSC/CSC, CPC and Genex® extracts on MC3T3-E1 cell proliferation, migration and osteogenesis as well as angiogenesis of HUVECs were examined.ResultsBased on physicochemical properties, the 30P/70C formula exhibited suitable operability and compressive strength (3.5 ± 0.3 MPa), which fulfilled the requirements for cancellous bone substitutes. In vivo, findings from micro-CT and histological analyses showed that the 30P/70C formula better promoted bone regeneration, compared to 10P/90C, 50P/50C, CPC and Genex®. Hence, 30P/70C was selected as the ideal PSC-based cement. In vitro, the 30P/70C extracts showed better promotion of cell viability, alkaline phosphatase (ALP) activity, calcium mineral deposition, mRNA and protein expression levels of osteogenesis in MC3T3-E1 cells, further supporting its superiority. Meanwhile, the 30P/70C extracts also showed better stimulation of HUVECs proliferation and angiogenesis.ConclusionThe new composite cement, 30P/70C, is a favorable bioactive glass-based bone cement with suitable operability, compressive strength and bone regeneration ability.The translational potential of this articleClinically, treatment of large bone defects is still a major challenge for orthopaedic trauma. We showed that 30P/70C has the potential to be clinically used as an injectable cement for rapid bone repairs and reconstruction of critical sized bone defects.

Crystallization kinetics of large-sized columnar α-hemihydrate gypsum by reaction of waste CaCl2 and Al2(SO4)3 without crystal modifiers

Direct production of high-strength α-calcium sulfate hemihydrate (α-HH) with no additives was accomplished by the reaction of aluminum sulfate and waste CaCl2 discarded from Solvay soda plant. For scaling-up this new process, the crystallization kinetics of α-HH was experimentally investigated under varying conditions including temperature (323–363 K), concentration of CaCl2 (4–7 mol/kg), Al2(SO4)3 (0.6–3.0 mol/kg), and seed loading. The optimal operating conditions are 7 mol/kg CaCl2 solution, 0.8 mol/kg Al2(SO4)3 solution, 5 wt% seed loading, 2 mol/kg AlCl3 existing in the reactor, T = 353 K, and equilibrium time of 3 h. The α-HH with large columnar shape, as desired in industry, was successfully obtained at optimal conditions by use of a continuous stirred tank reactor (CSTR) without the addition of any additives. The stability test of various CaSO4 phases in aqueous AlCl3, CaCl2, and their solution mixtures elucidated that Al3+ ion and total concentration of Cl− ion play an important role in the growth and shape of α-HH crystal.

Experimental Study and Mechanism Analysis of Preparation of α-Calcium Sulfate Hemihydrate from FGD Gypsum with Dynamic Method.

Flue-gas desulphurization (FGD) gypsum is a highly prevalent industrial by-product worldwide, which can be an excellent alternative to natural gypsum due to its high content of CaSO4·2H2O. The preparation of α-calcium sulfate hemihydrate is a high-value pathway for the efficient use of FGD gypsum. Here, a dynamic method, or an improved autoclaved process, was used to produce α-calcium sulfate hemihydrate from FGD gypsum. In this process, the attachment water of the mixture of FGD gypsum and crystal modifiers was approximately 18%, and the pH value was approximately 6.0. The mixture did not need to be pressed into bricks or made into slurry, and it was directly sent into the autoclave reactor for reaction. It was successfully applied to the practical production and application of FGD gypsum, citric acid gypsum and phosphogypsum. In this work, the compositions and morphology of the product at different stages of the reaction were examined and compared. In particular, single-crystal diffraction was used to produce the crystal structure of CaSO4·0.5H2O, and the results were as follows: a = 13.550(3); b = 13.855(3); c = 12.658(3); β = 117.79(3)°; space group C2. The preferential growth along the c-axis and the interaction mechanism between the carboxylate groups and the crystal were discussed throughout the analysis of the crystal structure.

Preparation and characterization of injectable gelatin/alginate/chondroitin sulfate/α-calcium sulfate hemihydrate composite paste for bone repair application.

In this study, a group of injectable composite pastes with a novel formulation consisting of two inorganic components: α-calcium sulfate hemihydrate (α-CSH, P/L = 1.8-2.1g/ml) and calcium-deficient hydroxyapatite (CDHA, P/L = 0.1g/ml) nanoparticles; and three biopolymers: gelatin (2, 4wt. %), alginate (1, 1.5wt. %), and chondroitin sulfate (0.5wt. %) were carefully prepared and thoroughly characterized with commensurate characterizations. The composite sample composed of gelatin (2wt. %), alginate (1.5wt. %), chondroitin sulfate (0.5wt. %), and also CDHA nanoparticles and α-CSH with P/L ratios of 0.1 and 2.1g/ml, respectively, exhibited optimal properties in terms of injectability, anti-washout performance, and rheological characteristics. After 14days of immersion of the chosen sample in the simulated body fluid medium, a dense layer of apatite was formed on the surface of the composite paste. The cellular in vitro tests, such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay (MTT), alkaline phosphatase assay, 4',6-diamidino-2-phenylindole staining, and cellular attachment, revealed the desirable response of MG-63 cells to the composite paste. The chondroitin sulfate significantly improved the injectability, anti-washout performance, and cellular response of the samples. Considering the promising features of the composite paste prepared in this research work, it could be considered as an alternative injectable bioactive material for bone repair applications.[Formula: see text].

The Influence of Impurities on the Dehydration and Conversion Process of Calcium Sulfate Dihydrate to α-Calcium Sulfate Hemihydrate in the Two-Step Wet-Process Phosphoric Acid Production

The dehydration process and kinetics of calcium sulfate dihydrate to α-calcium sulfate hemihydrate were studied under simulated dihydrate–hemihydrate two-step wet-process phosphoric acid, and Fe3+, Al3+, Mg2+, SiF62–, and mixed impurities were introduced to explore their influence on the values of kinetic parameters. The properties of the dehydration conversion product α-calcium sulfate hemihydrate were characterized and analyzed by using scanning electron microscopy, X-ray diffraction, X-ray photoelectron spectroscopy, and thermogravimetric and differential scanning calorimetry to reveal the interaction mechanism between impurities and α-calcium sulfate hemihydrate crystals. Results showed that the dehydration process of calcium sulfate dihydrate to α-calcium sulfate hemihydrate follows the dispersive kinetic model in the wet-process phosphoric acid solution. After Fe3+, Al3+, Mg2+, SiF62–, and mixed impurities were introduced into the system, the activation enthalpy increased, and the activation entropy decreased due to the reduction of the kinetic parameters α and β, causing the nucleation barrier of α-calcium sulfate hemihydrate crystals to increase, thereby inhibiting the dehydration and transformation of calcium sulfate dihydrate to α-calcium sulfate hemihydrate. The order of inhibition is mixed impurities > Al3+ > SiF62– > Fe3+ > Mg2+. Fe3+, Al3+, and Mg2+ impurities were combined with phosphate ions to form phosphate precipitates, which were selectively covered on different crystal surfaces of α-calcium sulfate hemihydrate, thereby hindering the growth of α-calcium sulfate hemihydrate crystals. Several Ca2+ ions existed on the (111) crystal plane in the c-axial direction, and SiF62– ions were combined with Ca2+ ions, thereby hindering the one-dimensional growth in the c-axial direction. Consequently, the aspect ratio of α-calcium sulfate hemihydrate crystal decreased, and the morphology gradually evolved to a short columnar structure.

Effect of maleic acid and pH on the preparation of α-calcium sulfate hemihydrate from phosphogypsum in Mg(NO3)2 solution

Effect of maleic acid and pH on the preparation of α-calcium sulfate hemihydrate from phosphogypsum in Mg(NO3)2 solution

Solubility and Physical Properties of α-Calcium Sulfate Hemihydrate in NaCl and Glycerol Aqueous Solutions at 303.15, 323.15, and 343.15 K

Solubility and Physical Properties of α-Calcium Sulfate Hemihydrate in NaCl and Glycerol Aqueous Solutions at 303.15, 323.15, and 343.15 K

α-calcium sulfate hemihydrate with a 3D hierarchical straw-sheaf morphology for use as a remove Pb2+ adsorbent

Novel three-dimensional hierarchical α-calcium sulfate hemihydrate with a straw-sheaf morphology (3D α-HH straw-sheaves) are synthesized successfully in glycerin aqueous solution by a simple one-pot method, using as an efficient adsorbent for Pb2+ removal from water. The 3D straw-sheaf morphology, that closely depends on the glycerin/water volume ratio (VGly/VH2O), can be accurately fabricated only when VGly/VH2O is not lower than 3/1. 3D α-HH straw-sheaves are generated via multistep-splitting growth coupled with self-assembly. The obtained 3D α-HH straw-sheaves are further used as an adsorbent to remove Pb2+ from water, exhibiting excellent Pb2+ removal performance with an equilibrium adsorption capacity of 79.19 mgPbgα-HH−1 and removal efficiency of 98.98%, that both higher than those of plate- and columnar-like α-HH. Moreover, the experimental adsorption data for the 3D α-HH straw-sheaves is well fitted with pseudo-second-order kinetic model, and the adsorption isotherm is in good agreement with Langmuir model. The Pb2+ adsorption mechanism is thought to be a chemical adsorption process enforced by chemical bonding and ion exchange. This work demonstrates that 3D α-HH straw-sheaves are highly promising in removing Pb2+ from wastewater, thereby broadening the research field for the practical application of gypsum-based materials.

Crystallization Kinetics of α-Hemihydrate Gypsum Prepared by Hydrothermal Method in Atmospheric Salt Solution Medium

α-Calcium sulfate hemihydrate (α-HH) is an important cementitious material, which can be prepared by hydrothermal method from calcium sulfate dihydrate (DH) in an electrolyte solution. Study of the conversion kinetics of DH to α-HH in NaCl solution is helpful for understanding the control process. In this paper, X-ray diffraction (XRD) patterns were applied to study the effect of temperature on the crystallization kinetics of α-HH to determine the kinetic parameters. The research results show that the sigmoidal shape of the α-HH crystallization curve follows the Avrami-Erofeev model, which describes the crystallization kinetics of α-HH formation. Applying Arrhenius law in experimental data and model calculations, an apparent activation energy of 124 kJ/mol for nucleation and an apparent activation energy of 810 kJ/mol for growth were obtained. By adjusting the temperature of the solution, the number of α-HH nucleation and growth steps increases, which can effectively increase the DH-α-HH conversion rate in the NaCI solution.