Dental caries is the most prevalent chronic infectious disease during childhood both in historical and contemporary times, but research focused on the oral health of non-adults from the past is still scant. As such, this study proposes a multidisciplinary approach to the differential diagnosis of severe dental lesions in a medieval non-adult skeleton. The skeleton of a three-year-old child recovered in the medieval necropolis of Cacela Velha (Portugal) was studied through macroscopic, radiological, elemental and stable isotope analyses. This individual exhibited enamel destruction and dentine exposure in both the maxillary and mandibular teeth, with the latter also showing changes in coloration. Elemental analysis showed that his skull presented lower values of Si, Cl, and Ca and higher of Cu compared to the control, while the concentration of P and S were significantly lower in the teeth. Early childhood caries is the most probable diagnosis for the dental lesions observed, apparently stemming from a reticulate of factors that include potential malnutrition, and the consumption of sugars in complementary feeding - even though historical sources point to the scarcity of sugar in Portugal during most of the Middle Ages.

The purpose of this paper is to explore the applicability of AI marketing for creating data-driven marketing strategies. Notably, the paper illustrates the existing circumstances of artificial intelligence in marketing practice. Besides, this paper argues for awareness of AI for customer satisfaction, employing AI to improve positioning, applying AI for accurate decision-making, and utilizing AI for sales, cost, and risk reductions. Lastly, this paper compares the applicability of AI marketing within two major regions from four regions identified in the study. A two-step approach was used to address the research question. First, a systematic literature review was conducted to identify the knowledge gap. Second, primary research through a survey study was conducted. Respondents of the primary study were represented by 367 marketing practitioners with 22 different marketing professions, representing 11 countries from 18 different industries, mainly from the Baltic and Caucasus regions. Based on findings and analysis, conclusions, limitations, and concepts for the future study were highlighted. The findings synthesized AI drivers, barriers, and outcomes in marketing. Further, outcomes confirmed a positive relationship with unitizing AI marketing in long-term strategic marketing planning. The paper offers practical guidance to the companies or inspires marketing leaders to use AI in data-driven marketing strategies. It has a significant value due to the complexity of the current marketing environment, whether micro or macro. Marketing Practitioners are searching for added value to prove the applicability of AI marketing in everyday strategies for decision-makers.

Establishing a link between mandibular morphology and diet in extant primates has long been a goal in biological anthropology because it should provide important insight into the diets of extinct primates, including fossil hominins. To date, efforts to explore this question have produced mixed results, largely perhaps due to a reliance on the use of 2D morphological data. Here, we report a study where we investigated whether 3D shape data would provide a clearer picture. We used geometric morphometrics to analyse 3D mandibular shape variation in a sample of > 200 primate specimens, representing individuals from 27 species and five families. Two sets of analyses investigated i) whether there was a relationship between mandibular shape and four standard dietary categories and ii) whether there was a relationship between mandibular shape and a well-known index of diet quality. We found an association between mandibular shape and the dietary categories when we employed raw Procrustes coordinates and allometry-free residuals, but the relationship was weak to non-existent when the effects of phylogeny were taken into account. We found no relationship between shape and the diet quality index, no matter whether the data were raw, corrected for the effects of allometry, corrected for the effects of phylogeny, or corrected for the effects of both allometry and phylogeny. Taken together, the results of the two sets of analyses suggest that there is a weak relationship between 3D mandibular shape and diet in extant primates. Allometry and phylogeny appear to be more important influences on the 3D shape of extant primate mandibles than is diet. We conclude from this that 3D analysis of mandibular shape is unlikely to further illuminate the diets of extinct primates, and research efforts should, therefore, be directed elsewhere.

Sex estimation is leading to determine the biological profile in forensic medicine. The aim of this study is to research the effectiveness of logistic regression (LogR) and discriminant function analysis (DFA) to create sex estimation models on femur images obtained with Computed Tomography (CT) angiography and to address the differences of femur, which show sexual dimorphism, among populations. All parameters were measured on three planes by adjusting the 300 CT angiography images from 150 women and 150 men that focused on the left femur to the orthogonal plane with standard magnification. The subgroup, which included 30 images randomly generated from these images, was measured twice with an interval of 3 weeks by the first radiologist and once by the second radiologist. According to the Fisher's Linear Discriminant analysis, which was evaluated with ten parameters in the study, it was concluded that the power of discriminating women was 96.7%, the power of discriminating men was 98.7%, and the total discrimination power was 97.7%; these results were 98%, 99.3%, and 98.7%, respectively according to LogR. In this study, DFA and LogR analysis showed that femur provided a very good rate of sexual dimorphism. A database belonging to the Turkish population was created for the femur, allowing for comparison between populations.

AIM: To investigate a novel phacoemulsification system “EVA NEXUS” (D.O.R.C., Dutch Opthalmic Research Center) in comparison to the existing system “EVA” in clinical use. And to compare both phacoemulsification systems in terms of efficiency, safety and postoperative inflammatory activity. METHODS: In this study standardized cataract surgery was performed on both eyes of the study participant, using the “EVA system” (control group, n=20) on one eye and the “EVA NEXUS system” (intervention group, n=20) on the other eye. Only patients with cataract LOCS Grading 1-3 and no accompanying eye diseases were included in this study. A total of 20 patients were included in this study, with each treatment arm including 20 eyes. During surgery a 0.1 mL aqueous humor sample was collected 1min after phacoemulsification to measure the total prostaglanin E2 concentrations using an enzyme-linked immunosorbent assay. The endothelial cell count, visual and refractive outcomes, and anterior chamber flare were evaluated preoperatively, and 1d, 1wk, and 3mo postoperatively. RESULTS: There were no statistically significant differences between both groups regarding intraoperative safety parameters including effective phacoemulsification time (P=0.904), balanced saline solution flow (P=0.701) and total surgery time (P=0.565). Postoperative prostaglandin E2 levels, anterior chamber flare as well as endothelial cell loss tended to be lower in the NEXUS-Group, however not being statistically significant (P=0.718; 0.164; 0.486). Both systems provided similar clinical outcomes, regarding best corrected visual acuity and refractive parameters, showing no statistically significant differences between both groups. CONCLUSION: Both systems show a high level of safety and efficency with similar results in terms of safety parameters including postoperative inflammatory activity and endothelial cell loss as well as visual and refractive outcomes. Although statistically not significant, the EVA NEXUS system tends to cause less postoperative inflammation with lower prostaglandin E2 levels and lower anterior chamber flare values.

AIM: To analyze the changes in scientific output relating to Leber congenital amaurosis (LCA) and forecast the study trends in this field. METHODS: All of the publications in the field of LCA from 2002 to 2022 were collected from Web of Science (WOS) database. We analyzed the quantity (number of publications), quality (citation and H-index) and development trends (relative research interest, RRI) of published LCA research over the last two decades. Moreover, VOSviewer software was applied to define the co-occurrence network of keywords in this field. RESULTS: A total of 2158 publications were ultimately examined. We found that the focus on LCA kept rising and peaked in 2015 and 2018, which is consistent with the development trend of gene therapy. The USA has contributed most to this field with 1162 publications, 56 674 citations and the highest H-index value (116). The keywords analysis was divided into five clusters to show the hotspots in the field of LCA, namely mechanism-related, genotype-related, local phenotype-related, system phenotype-related, and therapy-related. We also identified gene therapy and anti-retinal degeneration therapy as a major focus in recent years. CONCLUSION: Our study illustrates historical research process and future development trends in LCA field. This may help to guide the orientation for further clinical diagnosis, treatment and scientific research.

Cataract is the main cause of visual impairment and blindness worldwide while the only effective cure for cataract is still surgery. Consecutive phacoemulsification under topical anesthesia has been the routine procedure for cataract surgery. However, patients often grumbled that they felt more painful during the second-eye surgery compared to the first-eye surgery. The intraoperative pain experience has negative influence on satisfaction and willingness for second-eye cataract surgery of patients with bilateral cataracts. Intraoperative ocular pain is a complicated process induced by the nociceptors activation in the peripheral nervous system. Immunological, neuropsychological, and pharmacological factors work together in the enhancement of intraoperative pain. Accumulating published literatures have focused on the pain enhancement during the second-eye phacoemulsification surgeries. In this review, we searched PubMed database for articles associated with pain perception differences between consecutive cataract surgeries published up to Feb. 1, 2024. We summarized the recent research progress in mechanisms and interventions for pain perception enhancement in consecutive second-eye phacoemulsification cataract surgeries. This review aimed to provide novel insights into strategies for improving patients’ intraoperative experience in second-eye cataract surgeries.

Owing to the rapid development of modern computer technologies, artificial intelligence (AI) has emerged as an essential instrument for intelligent analysis across a range of fields. AI has been proven to be highly effective in ophthalmology, where it is frequently used for identifying, diagnosing, and typing retinal diseases. An increasing number of researchers have begun to comprehensively map patients’ retinal diseases using AI, which has made individualized clinical prediction and treatment possible. These include prognostic improvement, risk prediction, progression assessment, and interventional therapies for retinal diseases. Researchers have used a range of input data methods to increase the accuracy and dependability of the results, including the use of tabular, textual, or image-based input data. They also combined the analyses of multiple types of input data. To give ophthalmologists access to precise, individualized, and high-quality treatment strategies that will further optimize treatment outcomes, this review summarizes the latest findings in AI research related to the prediction and guidance of clinical diagnosis and treatment of retinal diseases.

ABSTRACT Higher education institutions have always been changing concurrently with larger societal developments. This paper addresses digital transformation in higher education (DTHE) during a disruptive crisis, e.g., the COVID-19 pandemic. Understanding different perspectives on DTHE during the pandemic is important, as the meaning allocated to the unfolding events holds the potential to shape future decision making. We conducted a critical review of 22 academic papers published in the first year of the pandemic. A thematic analysis revealed divergent perspectives of how the pandemic was affecting DTHE, with the material pointing in the direction of the pandemic as an accelerator of ongoing changes in higher education. The papers unanimously understood DTHE as multi-dimensional and as an ongoing, long-time process entangled with digital transformations in other sectors already initiated before the pandemic. Although this review is limited to research carried out during the first year of the pandemic, further studies might address a longer time-period, by studying changes in higher education and research in consequence of a disruptive crisis.

Despite the aging of those in our prisons and the increasing numbers of older incarcerated individuals returning home, much of the research on reentry challenges focuses on the experiences of individuals under the age of 50. Using in-depth interviews with 19 formerly incarcerated individuals who were released after the age of 50, we examined their reentry experience, particularly in regards to finding employment. We found that while this population experienced barriers to finding a job that were similar to their younger counterparts (e.g., stigma, the lack of proper documentation, etc.), they also struggled to find employment due to age-related factors like deteriorating health, ageism, and digital illiteracy. The results from this study can help policymakers better prepare for and appropriately anticipate the needs of its older returning citizens, a group often left out of most reentry discussions.