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Work-related psychosocial factors and inflammatory markers: A systematic review and meta-analysis

ObjectiveWe conducted a systematic review and meta-analysis to evaluate the prospective effect of adverse work-related psychosocial factors on increases in inflammatory markers. MethodsA systematic literature search was conducted in PubMed, Embase, PsycINFO, PsycARTICLES, and the Japan Medical Abstracts Society database. Studies were eligible for inclusion if they examined associations between work-related psychosocial factors and inflammatory markers (interleukin-6, tumor necrosis factor-alpha, and C-reactive protein), used longitudinal or prospective cohort designs, were conducted among workers, were original articles written in English or Japanese, and were published up to 2017 for the first search, October 2020 for the second, and November 2022 for the third. A meta-analysis was conducted using a random-effects model to assess the pooled effect size for the associations. A meta-regression analysis was used to estimate the association between length of follow-up and effect size. The ROBINS-I tool was used to assess risk of bias. ResultsOf the 11,121 studies identified in the first search, 29,135 studies from the second, and 9448 studies from the third, eleven were eligible for this review and meta-analysis. The pooled coefficient between adverse work-related psychosocial factors and inflammatory markers was significant and positive (β = 0.014, 95% confidence interval: 0.005–0.023). However, a clear association was only observed for interleukin-6, and all the studies included had serious risks of bias. Meta-regression showed the effect size decreased depending on the follow-up period. ConclusionThis study revealed a weak positive association between adverse work-related psychosocial factors and increases in inflammatory markers.Trial registration: PROSPERO CRD42018081553 (https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=81553).

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Dynamic resonant frequency control system of ultrasonic transducer for non-sinusoidal waveform excitation

This study verifies the effectiveness of a dynamic resonant frequency control system for transducers. This system enables the resonant frequency of the transducer to match the driving frequency. In general, the resonant frequency of an ultrasonic transducer is fixed based on its design and material properties. Therefore, it is difficult to actively control the frequency when driving the transducer. However, for high-power piezoelectric actuators, it is important to control the ratio of the fundamental and higher-order resonant frequency of the longitudinal vibration precisely at 1:2. A high-power and high mechanical quality factor (high-Q) ultrasonic transducer requires precise control of its resonant frequency. However, the resonant frequency may shift due to changes in boundary conditions or non-linear phenomena in piezoelectric vibration while driving the ultrasonic transducer. To maintain the resonant frequency ratio of the ultrasonic transducer at 1:2, we propose to dynamically control the resonant frequency ratio constant. In this study, we made two main proposals to our dynamic resonant frequency control system. One is the stepped structure of the transducer, and the other is the completely automatic control. In the stepped structure, a Langevin transducer was designed to have a resonant frequency ratio of almost 1:2 for the first and third longitudinal mode in the initial condition. Additionally, this structure could achieve control of only one of two resonant frequencies of the transducer. For the utterly automatic control system, piezoelectric elements were introduced for controlling the resonant frequency ratio precisely. For this propose, switching the electrical boundary conditions of these piezoelectric elements was carried out by MOSFETs connected to the ultrasonic transducer and control its optimum duty ratio automatically by our feedback system. This system realized dynamic control of the resonant frequency. As a result, the resonant frequency of the transducer matched the driving frequency in the frequency band from 23.23 kHz to 23.93 kHz. It was also confirmed that the shape of the excited non-sinusoidal waveform could be controlled by using resonant frequency control.

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