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EDUCATION FOR MENTALLY RETARDED CHILDREN IN A FAMILY WITH AN ISLAMIC EDUCATION PERSPECTIVE

Mental retardation is a condition of children whose intelligence is far below the average and is characterized by limited intelligence and incompetence in social communication. Islam views children with mental retardation as entities that must be considered for several strong reasons. The most basic is in the name of humanity. One fact that cannot be forgotten is that they are both creatures of God who must be respected. Moreover, the mentally retarded child is also a human being glorified by God. Mentally retarded children also have the same degree and social status as normal children, so in Islamic education, there should be no inequality in obtaining the right to education. This study aims to determine that the family is the most important factor in the education of mentally retarded children. This research is naturalistic qualitative. Documentation, observation, and interviews are the methods used to collect data. The data analysis uses data reduction, data presentation, and verification. The results of this study indicate that the family becomes a model and habituation of good behavior in everyday life as a positive strategy for the education of mentally retarded children, The family also applies several pillars, one of which is the aspect of faith, the aspect of worship and the moral aspect as the basis for educating their children.

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Chilling or chemical induction of dormancy release in blackcurrant (Ribes nigrum) buds is associated with characteristic shifts in metabolite profiles.

This study reveals striking differences in the content and composition of hydrophilic and lipophilic compounds in blackcurrant buds (Ribes nigrum L., cv. Ben Klibreck) resulting from winter chill or chemical dormancy release following treatment with ERGER, a biostimulant used to promote uniform bud break. Buds exposed to high winter chill exhibited widespread shifts in metabolite profiles relative to buds that experience winter chill by growth under plastic. Specifically, extensive chilling resulted in significant reductions in storage lipids and phospholipids, and increases in galactolipids relative to buds that experienced lower chill. Similarly, buds exposed to greater chill exhibited higher levels of many amino acids and dipeptides, and nucleotides and nucleotide phosphates than those exposed to lower chilling hours. Low chill buds (IN) subjected to ERGER treatment exhibited shifts in metabolite profiles similar to those resembling high chill buds that were evident as soon as 3 days after treatment. We hypothesise that chilling induces a metabolic shift which primes bud outgrowth by mobilising lipophilic energy reserves, enhancing phosphate availability by switching from membrane phospholipids to galactolipids and enhancing the availability of free amino acids for de novo protein synthesis by increasing protein turnover. Our results additionally suggest that ERGER acts at least in part by priming metabolism for bud outgrowth. Finally, the metabolic differences presented highlight the potential for developing biochemical markers for dormancy status providing an alternative to time-consuming forcing experiments.

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Publication trends of Leber congenital amaurosis researches: a bibliometric study during 2002-2022

AIM: To analyze the changes in scientific output relating to Leber congenital amaurosis (LCA) and forecast the study trends in this field. METHODS: All of the publications in the field of LCA from 2002 to 2022 were collected from Web of Science (WOS) database. We analyzed the quantity (number of publications), quality (citation and H-index) and development trends (relative research interest, RRI) of published LCA research over the last two decades. Moreover, VOSviewer software was applied to define the co-occurrence network of keywords in this field. RESULTS: A total of 2158 publications were ultimately examined. We found that the focus on LCA kept rising and peaked in 2015 and 2018, which is consistent with the development trend of gene therapy. The USA has contributed most to this field with 1162 publications, 56 674 citations and the highest H-index value (116). The keywords analysis was divided into five clusters to show the hotspots in the field of LCA, namely mechanism-related, genotype-related, local phenotype-related, system phenotype-related, and therapy-related. We also identified gene therapy and anti-retinal degeneration therapy as a major focus in recent years. CONCLUSION: Our study illustrates historical research process and future development trends in LCA field. This may help to guide the orientation for further clinical diagnosis, treatment and scientific research.

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Differential distribution of fibrovascular proliferative membranes in 25-gauge vitrectomy for proliferative diabetic retinopathy

AIM: To analyze the distribution of fibrovascular proliferative membranes (FVPMs) in proliferative diabetic retinopathy (PDR) patients that treated with pars plana vitrectomy (PPV), and to evaluate the outcomes separately. METHODS: This was a retrospective and cross-sectional study. Consecutive 25-gauge (25-G) PPV cases operated for PDR from May 2018 to April 2020. According to the FVPMs images outlined after operations, subjects were assigned into three groups: arcade type group, juxtapapillary type group, and central type group. All patients were followed up for over one year. General characteristics, operation-related variables, postoperative parameters and complications were recorded. RESULTS: Among 103 eyes recruited, the FVPMs distribution of nasotemporal and inferiosuperioral was significantly different (both P<0.01), with 95 (92.23%) FVPMs located in the nasal quadrants, and 74 (71.84%) in the inferior. The eyes with a central FVPM required the longest operation time, with silicon oil used in most patients, generally combined with tractional retinal detachment (RD) and rhegmatogenous RD, the worst postoperative best-corrected visual acuity (BCVA) and the highest rates of recurrent RD (all P<0.05). FVPM type, age of onset diabetes mellitus, preoperative BCVA, and combined with tractional RD and rhegmatogenous RD were significantly associated with BCVA improvement (all P<0.05). Compared with the central type group, the arcade type group had higher rates of BCVA improvement. CONCLUSION: FVPMs are more commonly found in the nasal and inferior mid-peripheral retina in addition to the area of arcade vessels. Performing 25-G PPV for treating PDR eyes with central FVPM have relatively worse prognosis.

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Early polar-orbiting satellite-based fire remote sensing during the 1960s

ABSTRACT Satellite-based sensors such as the Moderate Resolution Imaging Spectroradiometer (MODIS) and the Visible Infrared Imaging Radiometer Suite (VIIRS) now routinely provide a detailed picture of global fire activity on a daily basis. These systems explicitly included biomass burning as a phenomenon of interest, and their design was heavily influenced by experience gained with the comparatively primitive Advanced Very High Resolution Radiometer (AVHRR) first deployed on the TIROS-N satellite in the late 1970s. The AVHRR is generally recognized as the earliest spaceborne sensor to provide a middle infrared (MWIR) channel sensitive to actively burning vegetation fires and other high-temperature, sub-pixel thermal anomalies, forming the basis of countless fire studies before higher quality MODIS data became available. Here, we consider in the context of active fire monitoring a sensor much older than the AVHRR, namely the High Resolution Infrared Radiometer (HRIR) on board NASA’s Nimbus-I, -II, and -III satellites, launched in 1964, 1966, and 1969, respectively. This early imaging sensor had a single MWIR channel primarily intended for night-time meteorological observations (a complementary daytime near-infrared channel was added for Nimbus-III) that could potentially serve as a source of pre-AVHRR active fire data. To this end, we inspected night-time HRIR imagery acquired over the western United States and found unambiguous evidence of multiple confirmed wildfires in 1966. In addition, we found strong evidence of actively burning fires in Africa, specifically the Democratic Republic of the Congo, western Zambia, and northern Namibia, and in northern Australia, commensurate with their fire seasons. Our findings indicate that it was actually the HRIR that acquired the earliest MWIR imagery that could be used for identifying biomass burning from space, well over a decade before the first AVHRR was deployed. We found in addition that the retrieval of fire radiative power (FRP) from higher dynamic-range HRIR observations was potentially possible pending refined calibration.

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