Abstract
Zr-catalyzed diastereo- and enantioselective intramolecular cyclizations that afford highly functionalized cyclopentyl structures that bear quaternary carbon centers are presented. Depending on the structure of the substrate diene, exceptional levels of diastereo- (>25:1) and enantioselectivity (>98% ee) can be attained. Furthermore, an unexpected observation is disclosed regarding the formation of aldehyde products (note that processes discussed herein require use of excess of a Grignard reagent). Experiments that shed light on this unusual observation are reported and discussed.
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