Abstract
AbstractThe Effect Of Two Derivatives Of Kaurenoic Acid Isolated From Montanoa Frutescens Upon The Spontaneous Activity Of Estrogen-Dominated Rat and Guinea Pig Uteri Was Assessed. The Methyl Ester Of 15 A-Hydroxy-Dihydro Kaurenoic Acid Induced A Concentration-Related Decrease Of Spontaneous Activity Of Estrogen-Dominated Rat Uterus (Id 50 = 49.3 μ). This Effect Was Not Modified By The Presence Of Propranolol. The Methyl Ester Of 15-Keto-Dihydro Kaurenoic Acid Induced A Concentration-Dependent Increase Of Spontaneous Activity Of Estrogen-Dominated Rat Uterus (Ed 50 = 83.5 μm). This Increase Was Not Altered By The Presence Of Atropine Or Indomethacin. Both Compounds Induced An Increase Of Spontaneous Activity Of Estrogen-Dominated Guinea Pig Uterus In A Concentration-Related Manner. The Ed 50 Value For 15 α-Hydroxy Derivative Was 48.9 μm, Whereas The Ed 50 Value For 15 Keto Derivative Was 26.3 Yum, I.E. The Latter Was 1.16 Times More Potent Than The Former. These Increases Were Not Modified By Atropine Or ...
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