Abstract
Zoapatle aqueous crude extract (ZACE) from Montanoa tomentosa has been used as an oral contraceptive in traditional Mexican medicine for centuries. Kaurenoic acid, as isolated from Montanoa frutescens, and the methyl esters of 15-hydroxy-dihydro-kaurenoic acid and 15-keto-dihydrokaurenoic acid were tested in vitro on human sperm motility and viability. The estimated ED 50 concentrations immobilization were 374, 126 and 58 μg ml , respectively using 15 × 10 6 sperms 500 μl. Kaurenoic acid and both of its derivatives displayed only weak to negligible capacity for killing human sperms.
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